Association Between Objectively Measured Physical Activity and Lower-Limb Lymphedema Markers in Patients with Lymphedema Secondary to Gynecological Cancer: A Cross-Sectional Study.

IF 1.9 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Yuriko Matsunaga-Myoji, Kimie Fujita, Satomi Tanaka, Miyuki Izumi, Urara Hirata, Kiyoko Kato
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引用次数: 0

Abstract

Background: Lower-limb lymphedema (LLL) secondary to gynecological cancer is a serious health condition that negatively affects physical activity (PA). We investigated the association between objectively measured PA and lymphedema markers in patients with LLL after gynecological cancer treatment. Methods and Results: This cross-sectional study included 56 patients (mean age: 62.0 years) with LLL attending a lymphedema center. The degree of lymphedema was evaluated based on lower-limb water content (extracellular water content/whole body water content: ECW/TBW). The amount and intensity of PA were measured using an accelerometer. Thirty-three patients (61.1%) with ECW/TBW ≥0.4 were older, had significantly more sedentary time, and spent lesser time on moderate-to-vigorous activity than patients with ECW/TBW <0.4 (p < 0.05). A generalized linear model using the rate of change in ECW/TBW showed an association with older age, longer time since cancer diagnosis, and lower activity level. The severity of subjective symptoms measured using a visual analog scale did not differ between patients with high and low ECW/TBW. Conclusions: Patients with LLL spent approximately half of the time in sedentary behavior, with more severe cases exhibiting longer sedentary durations. In older patients who have a long-standing cancer diagnosis, medical professionals should evaluate their activity and self-care status in addition to evaluating LLL and use this information to provide individualized interventions.

客观测量的体力活动与妇科癌症继发淋巴水肿患者下肢淋巴水肿标志物之间的关联:一项横断面研究。
背景:继发于妇科癌症的下肢淋巴水肿(LLL)是一种严重的健康状况,对身体活动(PA)产生负面影响。我们研究了妇科癌症治疗后ll患者客观测量的PA与淋巴水肿标志物之间的关系。方法和结果:这项横断面研究包括56例在淋巴水肿中心就诊的ll患者(平均年龄:62.0岁)。根据下肢含水量(细胞外含水量/全身含水量:ECW/TBW)评估淋巴水肿程度。用加速度计测量PA的量和强度。与ECW/TBW患者相比,ECW/TBW≥0.4的33例患者(61.1%)年龄较大,久坐时间明显增加,中等至剧烈活动时间较少(p < 0.05)。使用ECW/TBW变化率的广义线性模型显示,与年龄较大、癌症诊断后时间较长和活动水平较低有关。使用视觉模拟量表测量主观症状的严重程度在高ECW/TBW患者和低ECW/TBW患者之间没有差异。结论:LLL患者大约有一半的时间处于久坐状态,更严重的患者表现出更长的久坐时间。对于长期患有癌症的老年患者,除了评估LLL外,医疗专业人员还应该评估他们的活动和自我保健状况,并利用这些信息提供个性化的干预措施。
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来源期刊
Lymphatic research and biology
Lymphatic research and biology Medicine-Cardiology and Cardiovascular Medicine
CiteScore
3.10
自引率
7.10%
发文量
85
审稿时长
>12 weeks
期刊介绍: Lymphatic Research and Biology delivers the most current peer-reviewed advances and developments in lymphatic biology and pathology from the world’s leading biomedical investigators. The Journal provides original research from a broad range of investigative disciplines, including genetics, biochemistry and biophysics, cellular and molecular biology, physiology and pharmacology, anatomy, developmental biology, and pathology. Lymphatic Research and Biology coverage includes: -Vasculogenesis and angiogenesis -Genetics of lymphatic disorders -Human lymphatic disease, including lymphatic insufficiency and associated vascular anomalies -Physiology of intestinal fluid and protein balance -Immunosurveillance and immune cell trafficking -Tumor biology and metastasis -Pharmacology -Lymphatic imaging -Endothelial and smooth muscle cell biology -Inflammation, infection, and autoimmune disease
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