Lymphatic research and biology最新文献_第5页

Fluid Distribution: Response to Intermittent Pneumatic Compression in People With and Without Primary Lymphedema. 液体分布：有或无原发性淋巴水肿患者对间歇性气动压缩的反应

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2025-04-01 Epub Date: 2025-01-13 DOI: 10.1089/lrb.2024.0087

J Jane Phillips, Susan J Gordon

{"title":"Fluid Distribution: Response to Intermittent Pneumatic Compression in People With and Without Primary Lymphedema.","authors":"J Jane Phillips, Susan J Gordon","doi":"10.1089/lrb.2024.0087","DOIUrl":"10.1089/lrb.2024.0087","url":null,"abstract":"Background: Current understanding of changes in fluid distribution in response to the application of compression in primary lymphedema (PLE) is limited. This study measured fluid distribution before and after one application of standardized intermittent pneumatic compression (IPC) in the lower limbs of people with PLE, compared with those without lymphedema. High-frequency ultrasound (HFU) was used to measure dermal fluid, bioimpedance to measure segmental fluid, and percent water content (PWC) to measure fluid at specific anatomical points. Methods and Results: Fifteen people with PLE aged 11-40 years were matched for age, gender, and ethnicity to a person without lymphedema (NLE). PWC and HFU measures (low echogenic pixels) were taken bilaterally on the posterior leg and dorsum of the foot. Segmental bioimpedance (Extracellular Fluid/Intracellular Fluid, ECF/ICF) was measured in the foot, leg, and lower limb. Differences between groups, using the affected leg of unilateral and the more affected leg of bilateral PLE, were analyzed using the mixed ANOVA. There was significantly less ECF/ICF in the leg of NLE (p = 0.005) and PLE (p = 0.022) following IPC, and in the whole treated lower limb of NLE (p = 0.013), but no change in the treated limb of PLE. In contrast, the untreated limb showed significantly higher ECF/ICF in PLE (p = 0.040), a change not seen in NLE. Conclusions: The lack of response to compression in the foot, commonly affected in PLE, and the increase in fluid in the untreated PLE limb, indicates the need for further investigation of the effect of compression on fluid distribution in PLE.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":" ","pages":"78-87"},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence of Lymphedema and Other Complications in Patients Operated on for Gynecological Cancer Including Utilization of Two Lymph Node Dissection Techniques. 妇科癌症手术患者淋巴水肿及其他并发症的发生率，包括两种淋巴结清扫技术的使用。

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2025-04-01 Epub Date: 2024-10-28 DOI: 10.1089/lrb.2024.0084

Varol Gülseren, Mehmet Dolanbay, İsa Aykut Özdemir, Fulya Çağlı, Ertuğrul Şen, Bülent Özçelik, İbrahim Serdar Serin, Kemal Güngördük

{"title":"Incidence of Lymphedema and Other Complications in Patients Operated on for Gynecological Cancer Including Utilization of Two Lymph Node Dissection Techniques.","authors":"Varol Gülseren, Mehmet Dolanbay, İsa Aykut Özdemir, Fulya Çağlı, Ertuğrul Şen, Bülent Özçelik, İbrahim Serdar Serin, Kemal Güngördük","doi":"10.1089/lrb.2024.0084","DOIUrl":"10.1089/lrb.2024.0084","url":null,"abstract":"Background: To assess the impact of the lymph node dissection (LND) technique on short- and long-term complications. This retrospective review included patients who underwent hysterectomy, oophorectomy, and pelvic ± para-aortic LND for gynecological malignancies (cervical, endometrial, and ovarian) from 2020 to 2022 in our Gynecological Oncology Surgery clinic. Methods and Results: Among 147 patients who underwent pelvic LND for gynecological malignancy, 48 had procedures involving scissors and 99 had procedures involving unipolar cautery. There was no significant difference in the numbers of extracted pelvic and para-aortic lymph nodes between groups. The extents of LND were comparable between the scissors and unipolar cautery groups (p = 0.945). The scissors group exhibited less fluid drainage between days 2 and 5 postoperatively (1300 [600-3100] vs 1800 [600-3400]; p = 0.038). In terms of primary early and late clinical outcomes, there were no significant differences in lymphocele (16.7% vs 15.2%; p = 0.494) and lymphedema (18.8% vs 17.2%; p = 0.491) rates between groups. Conclusions: After retroperitoneal LND for gynecological malignancy, early complications such as lymphocele and late complications such as lower extremity lymphedema did not significantly differ between procedures using cold scissors and procedures using unipolar cautery.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":" ","pages":"101-106"},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142503216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Causal Association Between Childhood Body Mass Index and Phlebitis and Thrombophlebitis: An Analysis Using Mendelian Randomization. 儿童体重指数与静脉炎和血栓性静脉炎的因果关系：孟德尔随机化分析。

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2025-02-01 Epub Date: 2025-01-08 DOI: 10.1089/lrb.2024.0018

Liyan Luo, Yun Yang, Jiahui He, Yunlei Bao, Feng Jiang, Chuyan Wu, Ting Zhang

{"title":"Causal Association Between Childhood Body Mass Index and Phlebitis and Thrombophlebitis: An Analysis Using Mendelian Randomization.","authors":"Liyan Luo, Yun Yang, Jiahui He, Yunlei Bao, Feng Jiang, Chuyan Wu, Ting Zhang","doi":"10.1089/lrb.2024.0018","DOIUrl":"10.1089/lrb.2024.0018","url":null,"abstract":"Background: Research has indicated a link between obesity and a greater likelihood of venous disorders. However, the specific relationship between obesity in children and conditions such as phlebitis and thrombophlebitis remains undetermined. To explore this, we undertook a two-sample Mendelian randomization (MR) study to investigate the possible causal impact of childhood body mass index (BMI) on the development of phlebitis and thrombophlebitis. Methods: This study utilized genome-wide association studies data from European populations. Childhood BMI was assessed in a sample of 39,620 individuals, while data on phlebitis and thrombophlebitis were obtained from 1613 cases and 335,586 controls. We selected 16 single nucleotide polymorphisms significantly associated with childhood BMI as instrumental variables (IVs). The inverse variance weighting (IVW) method was applied as the primary approach, with weighted median, MR-Egger regression, and weighted mode methods used as complementary analyses. Results: The IVW analysis indicates a significant causal link between childhood BMI and the occurrence of phlebitis and thrombophlebitis (Beta = 0.002739, Standard error (SE) = 0.000740, p = 0.0002147). Results from the weighted median method (Beta = 0.002446, SE = 0.001046, p = 0.01933) aligned with the IVW findings. However, the MR-Egger and weighted mode analyses did not show a significant association (p = 0.1051 and p = 0.2525, respectively). Leave-one-out sensitivity tests and heterogeneity assessments were performed, revealing no evidence of horizontal pleiotropy. Conclusion: The findings from the MR analysis suggest a potential causal relationship between childhood BMI and an elevated risk of phlebitis and thrombophlebitis. This study provides new insights into the impact of childhood obesity on venous health, emphasizing the need for early intervention and prevention strategies.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":" ","pages":"31-38"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complex Decongestive Therapy Improves Gait Speed in Patients with Lower Limb Lymphedema. 复合去充血疗法可提高下肢淋巴水肿患者的步速

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2025-02-01 Epub Date: 2024-12-17 DOI: 10.1089/lrb.2024.0021

Evrim Gökçe, Neslişah Gün, Ülkü Düzlü Öztürk, Meltem Dalyan

{"title":"Complex Decongestive Therapy Improves Gait Speed in Patients with Lower Limb Lymphedema.","authors":"Evrim Gökçe, Neslişah Gün, Ülkü Düzlü Öztürk, Meltem Dalyan","doi":"10.1089/lrb.2024.0021","DOIUrl":"10.1089/lrb.2024.0021","url":null,"abstract":"Background: Secondary lymphedema is acquired and caused by obstruction or injury to a normally developed lymphatic system. Loss of mobility is a common problem in patients with secondary lower limb lymphedema (LLL) following cancer treatment. In this study, we examined the effect of complex decongestive therapy (CDT) on motor function and mobility in patients with LLL. Methods and Results: A quasi-experimental study was performed with 24 participants with stage 2 LLL (56.04 ± 14.23 years). Participants received 15 sessions of CDT. Motor function was assessed with a foot tapping test (FTT). Gait speed was measured in single-task (ST) and dual-task (DT) conditions, and DT cost was calculated. All assessments were performed before and after the intervention. The paired t-test and Wilcoxon signed-rank test were used to analyze the effect of CDT on FTT, gait speed, and DT cost. ST and DT gait speed (p = 0.002, p < 0.001) and DT cost (p = 0.001) decreased following the CDT, whereas bilateral FTT scores did not change. Conclusion: CDT improves mobility and dual-tasking in LLL, thereby promoting independence in daily life. Future prospective controlled studies are required to corroborate our results.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":" ","pages":"11-16"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142837205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Utility of Bioimpedance Analysis for Upper Limb Lymphedema with Surgical Treatment. 生物阻抗分析对手术治疗上肢淋巴水肿的临床实用性

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2025-02-01 Epub Date: 2024-11-11 DOI: 10.1089/lrb.2022.0094

Min Gi Kim, Woo Chul Son, Jin Geun Kwon, Joon Pio Hong, Hyun Suk Suh, Sang Ah Kim, Hwayeong Cheon, Ma Nessa Gelvosa, Jae Yong Jeon

{"title":"Clinical Utility of Bioimpedance Analysis for Upper Limb Lymphedema with Surgical Treatment.","authors":"Min Gi Kim, Woo Chul Son, Jin Geun Kwon, Joon Pio Hong, Hyun Suk Suh, Sang Ah Kim, Hwayeong Cheon, Ma Nessa Gelvosa, Jae Yong Jeon","doi":"10.1089/lrb.2022.0094","DOIUrl":"10.1089/lrb.2022.0094","url":null,"abstract":"Background: In lymphedema, the accumulation of subcutaneous interstitial fluid is the most characteristic feature. Bioimpedance analysis (BIA) is a promising technique to measure the amount of body components using a noninvasive method. In this study, we determined the clinical significance of BIA parameters in upper limb lymphedema with surgical treatment such as lymphovenous anastomosis or vascularized lymph node transfer. Methods and Results: A single-center retrospective study using a multifrequency BIA. Perioperative BIA parameters such as extracellular water ratio or fat-free mass (FFM) ratio and limb volume defined as percentage of excess volume (PEV) were measured. The relationships between the magnitude of change in PEV and BIA parameters during surgery were evaluated. Out of 48 unilateral lymphedema patients, 46 were female and the average age was 55.4 years. PEV and all BIA parameters showed a significant decrease after surgery (p < 0.001). There were significant correlations between ΔPEV and the degree of changes in all BIA parameters. ΔFFM ratio showed the highest correlation with the amount of change in PEV (r = 0.599, p < 0.001). Conclusion: BIA parameters correlated well with the volume change after surgery. BIA could be useful as a quick and easy tool for follow-up after lymphedema surgery.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":" ","pages":"39-45"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Measurement Properties and Determinants of the 6-Minute Walk Test in Patients with Lower Limb Lymphedema. 下肢淋巴水肿患者6分钟步行试验的测量特性和决定因素。

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2025-02-01 Epub Date: 2024-12-20 DOI: 10.1089/lrb.2023.0056

Ahmet Burak Cakir, Didem Karadibak, Sukriye Cansu Gultekin, Serap Acar, Pembe Keskinoglu

{"title":"Measurement Properties and Determinants of the 6-Minute Walk Test in Patients with Lower Limb Lymphedema.","authors":"Ahmet Burak Cakir, Didem Karadibak, Sukriye Cansu Gultekin, Serap Acar, Pembe Keskinoglu","doi":"10.1089/lrb.2023.0056","DOIUrl":"10.1089/lrb.2023.0056","url":null,"abstract":"Background: The aim of this study was to investigate the validity and reliability and identify determinants of the 6-minute walk test (6MWT) in patients with lower limb lymphedema (LLL). Methods and Results: The study included 28 patients with LLL and 28 healthy subjects. To investigate the convergent validity and determinants of the 6MWT, patients were assessed using the following measurements: circumference measurement for lymphedema severity, hand-held dynamometry for muscle strength, time up and go for functional mobility, five-time sit-to-stand test for functional lower extremity strength, Lower Extremity Functional Scale for lower extremity functionality, Lymphedema Life Impact Scale for quality of life, and International Physical Activity Questionnaire-Short Form for physical activity level. The test-retest reliability of the 6MWT was assessed using intraclass correlation coefficients (ICCs). 6MWT, a test-retest reliability analysis was carried out with 28 patients within 3-7 days. The receiver operating characteristic (ROC) curve was employed to determine the cut-off point of 6MWT. The test-retest reliability of 6MWT was detected as excellent (ICC [95%] 0.93 [0.87-0.97]). Significant correlations were found between the 6MWT health-related and disease-specific parameters, indicating sufficient convergent validity (r ≥ 0.3). The ROC curve indicated a cut-off point of 504 meters (area under the curve [AUC] 0.712 [95%CI: 0.575-0.849]). Multiple linear regression analysis demonstrated that lymphedema severity, hip abduction muscle strength, and lower limb functionality were the predictors of 6MWT. Conclusions: The 6MWT has been shown to be a reliable and valid tool for assessing the functional capacity of patients with LLL.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":" ","pages":"1-10"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety Evaluation of a Device for Treatment of Lymphedema of the Upper Extremity. 一种治疗上肢淋巴水肿装置的安全性评价。

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2025-02-01 Epub Date: 2024-12-05 DOI: 10.1089/lrb.2023.0070

Evgeniya Molotkova, Seth Jarvis, Leah Thomas, Selah Wangler, Tara Newberry, Christopher Arena, Andre Muelenaer

{"title":"Safety Evaluation of a Device for Treatment of Lymphedema of the Upper Extremity.","authors":"Evgeniya Molotkova, Seth Jarvis, Leah Thomas, Selah Wangler, Tara Newberry, Christopher Arena, Andre Muelenaer","doi":"10.1089/lrb.2023.0070","DOIUrl":"10.1089/lrb.2023.0070","url":null,"abstract":"Lymphedema is a chronic condition characterized by dysfunction of the lymphatic system. There is currently no available cure. The standard of care is complete decongestive physiotherapy performed by a lymphedema therapist. However, lymphedema may flare between appointments, making home care important. There are several medical devices available to treat lymphedema at home, but they can be expensive, noisy, and bulky, restricting patient mobility. Thus, there is a demand for other devices that can be utilized at home, between appointments. The overall goal of this research study is to assess the safety of a newly developed vibratory device that may be utilized to supplement lymphedema treatment. Fourteen healthy subjects were recruited and treated with the device, all while measuring pre-treatment and post-treatment upper extremity circumference/induration, vital signs, pain, side effects, and intra-treatment acceleration produced by the device. There were no significant changes in reported pain or vital signs, and side effects were largely mild and transient. We believe that this device is safe for use in healthy subjects, and further studies should assess the efficacy of this device in treating patients with lymphedema.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":" ","pages":"54-59"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research Matters. 研究很重要。

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2025-02-01 Epub Date: 2025-01-24 DOI: 10.1089/lrb.2024.0095

引用次数: 0

Evaluation of Respiratory Function, Respiratory Muscle Strength, Physical Activity, and Functionality in Patients with Lower Extremity Lymphedema. 下肢淋巴水肿患者呼吸功能、呼吸肌力量、体力活动和功能的评价。

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2025-02-01 Epub Date: 2024-12-26 DOI: 10.1089/lrb.2023.0079

Zehra Demir, Gamze Aydin

{"title":"Evaluation of Respiratory Function, Respiratory Muscle Strength, Physical Activity, and Functionality in Patients with Lower Extremity Lymphedema.","authors":"Zehra Demir, Gamze Aydin","doi":"10.1089/lrb.2023.0079","DOIUrl":"10.1089/lrb.2023.0079","url":null,"abstract":"Background: Lymphedema is a chronic, progressive condition that has major physical and psychological consequences. It was aimed to examine the respiratory functions, respiratory muscle strength, physical activity level, and functionality of patients with lower extremity lymphedema and to compare them with healthy controls. Methods and Results: A total of 82 individuals (29.3% male, 70.7% female, with a mean age of 49.89 ± 15.07 years) with lower extremity lymphedema (Group 1) and healthy individuals (Group 2) were included. Respiratory functions of the participants were evaluated by spirometry, respiratory muscle strength by maximum oral pressure measurements, physical activity levels using the International Physical Activity Questionnaire-Short Form (IPAQ-SF), functionality by Lower Extremity Functional Scale (LEFS) and Timed Up and Go test (TUG test). All respiratory function test measurements were lower in mean Group 1 than in Group 2 (p < 0.05). While inspiratory muscle strength did not differ between the groups (p > 0.05), expiratory muscle strength was lower in Group 1 than Group 2 (p < 0.05). Although spent time and energy for sitting were higher in Group 1 (p < 0.05), IPAQ vigorous-, moderate-, and light-intensity physical activity (MET-min/week) and IPAQ-total score did not differ between groups (p > 0.05). In Group 1, mean of LEFS score was lower and TUG test (seconds) in Group 1 was longer compared to Group 2 (p < 0.05). Conclusions: Respiratory functions, expiratory muscle strength, and functionality in patients with lower extremity lymphedema were adversely affected; however, inspiratory muscle strength and physical activity levels were similar to those of healthy controls.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":" ","pages":"17-22"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing Tissue Dielectric Constant Values in Tumor Bearing and Healthy Breasts. 评估肿瘤和健康乳房组织介电常数值。

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2025-02-01 Epub Date: 2024-12-10 DOI: 10.1089/lrb.2023.0061

Harvey N Mayrovitz, Mary Beth Tomaselli

{"title":"Assessing Tissue Dielectric Constant Values in Tumor Bearing and Healthy Breasts.","authors":"Harvey N Mayrovitz, Mary Beth Tomaselli","doi":"10.1089/lrb.2023.0061","DOIUrl":"10.1089/lrb.2023.0061","url":null,"abstract":"Background: This study aimed to investigate, characterize, and provide quantitative reference data on tissue dielectric constant (TDC) values of female breasts when measurements were made to 5 mm depths and determine the utility of these measurements to differentiate between benign and malignant breast tumors. Methods and Results: Breast TDC was measured bilaterally in 82 women just prior to an ultrasound-guided diagnostic biopsy of one tumor in one breast. TDC was measured in triplicate over the tumor and the contralateral healthy breast. Considering all paired breasts, the average TDC (mean ± SD) for healthy breasts was less than for tumor-bearing breasts (26.7 ± 4.5 vs. 29.9 ± 8.5, p = 0.0003). Conclusions: Breast TDC values measured to 5 mm in 82 healthy nonedematous breasts provide a two-SD threshold reference value of 35.7. This represents a TDC value above which the presence of breast edema/lymphedema may be indicated based on the two-SD threshold criterion. For unilateral cases, an interbreast TDC ratio exceeding 1.275 may be considered a breast edema/lymphedema indicator also based on the two SD criteria used. These thresholds may have utility for early detection and to track breast edema/lymphedema changes. A comparison of these TDC values obtained from benign versus malignant tumors indicates no statistically significant difference between them. However, interbreast TDC ratios were statistically higher for breasts with malignant versus benign tumors. However, the large overlap of the ratio values renders this method of discrimination between benign vs. malignant tumors inadequate based on the present findings.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":" ","pages":"23-30"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0