Lymphatic research and biology最新文献_第7页

Diagnosis of Lymphedema and Subjective Symptoms in the Lower Abdomen and Genital Region. 诊断下腹部和生殖器区域的淋巴水肿和主观症状。

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2024-12-01 Epub Date: 2024-09-24 DOI: 10.1089/lrb.2024.0032

Hisako Hara, Makoto Mihara

{"title":"Diagnosis of Lymphedema and Subjective Symptoms in the Lower Abdomen and Genital Region.","authors":"Hisako Hara, Makoto Mihara","doi":"10.1089/lrb.2024.0032","DOIUrl":"10.1089/lrb.2024.0032","url":null,"abstract":"Background: Lymphedema in the lower abdomen and genitals is unnoticeable and has no established diagnostic methods. In this study, we evaluated it using four examinations. Methods: We evaluated 25 patients with lymphedema in the legs, dividing the abdomen and genitals in four areas (right and left, upper and lower). The mean age was 58.6 years. In lymphoscintigraphy and indocyanine green (ICG) lymphography, we diagnosed lymphedema when dermal backflow was observed. ICG lymphography was performed in 13 patients. In ultrasonography, we determined the presence of edema when cobblestone pattern was observed. Subcutaneous fat thickness was also measured. The patients' subjective symptoms were identified on an interview. We compared the results among the examinations. Results: The positivity rates for lymphedema based on lymphoscintigraphy, ICG lymphography, ultrasonography, and subjective symptoms were 45.0%, 42.3%, 8.0%, and 34.0%, respectively. Two of the 13 patients who underwent all examinations complained of subjective symptoms of edema in areas that showed no abnormalities in the examinations. In contrast, 14 of the 25 patients had areas where they had no subjective symptoms despite having abnormalities in at least one of the tests. Those with subjective symptoms of edema tended to have thinner abdominal fat in both the upper and lower abdomen, but no significant difference was observed. Conclusion: Large differences were observed in the positive rate of edema in subjective symptoms and examinations of lymphedema in the lower abdomen and genitals. It is not important to determine which examination is best but rather to combine multiple examinations.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":" ","pages":"261-266"},"PeriodicalIF":1.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the Editor re: Proposed Framework for Research Case Definitions of Lipedema, by Keith et al. (doi: 10.1089/lrb.2023.0062). 文章通讯："脂肪性水肿研究病例定义的拟议框架"。

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2024-12-01 Epub Date: 2024-10-21 DOI: 10.1089/lrb.2024.0062

Robert J Damstra, Kristiana Gordon, Tobias Bertsch, Hakan Brorson, Denise Hardy, Guenther Klose, Kathleen Francis, Gabriele Erbacher, Ad Hendrickx, Christine Moffatt

引用次数: 0

Effectiveness of Lymphovenular Anastomosis and Complex Decongestive Therapy for the Treatment of Lymphedema in Patients with Breast Cancer: A Systematic Review. 淋巴管吻合术和复合减充血疗法治疗乳腺癌患者淋巴水肿的效果：系统回顾

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2024-10-01 Epub Date: 2024-09-24 DOI: 10.1089/lrb.2024.0014

Alejandro Zapata-Ospina, Catalina Lopera-Muñetón, Silvia P Betancur-Bedoya, Isabel C Ángel-Bustos, María G Vásquez-Montoya

{"title":"Effectiveness of Lymphovenular Anastomosis and Complex Decongestive Therapy for the Treatment of Lymphedema in Patients with Breast Cancer: A Systematic Review.","authors":"Alejandro Zapata-Ospina, Catalina Lopera-Muñetón, Silvia P Betancur-Bedoya, Isabel C Ángel-Bustos, María G Vásquez-Montoya","doi":"10.1089/lrb.2024.0014","DOIUrl":"10.1089/lrb.2024.0014","url":null,"abstract":"Background: Lymphedema is a common breast cancer side effect, with an average incidence of 30%. The gold standard conservative treatment for lymphedema is complex decongestive therapy (CDT), which includes manual lymphatic drainage, compression therapy, skin care, and exercise. Lymphovenular anastomosis (LVA) is a microsurgical technique that intends to redirect excess lymphatic fluid to the venous circulation; this procedure is usually performed when conservative treatment fails. Therefore, the objective of this study is to evaluate the effectiveness of LVA and CDT for the treatment of breast cancer-related lymphedema (BCRL). Methods and Results: The search was performed in CENTRAL, MEDLINE, Embase, PsycINFO, SCOPUS, and LILACS. Inclusion criteria were (1) population: women with BCRL; (2) intervention: treated with LVA and CDT; and (3) outcome: primary outcome was lymphedema reduction. Secondary outcome was quality of life. Risk of bias and quality of study reporting were also assessed. The search found 3872 articles, with 5 articles meeting the PICO (population, intervention, comparison, outcomes) criteria, 4 pre-post studies, and one observational cohort study. The total sample included 2763 patients. Follow-up was variable. The follow-up varies from 7.8 to 120 months, with an average of 35 months. Lymphedema reduction was obtained in the five studies. Conclusion: The present systematic review suggests that for patients with lymphedema secondary to breast cancer, the combination of both treatments is effective in reducing the size of the limb and improving quality of life. Low-quality evidence was found for both limb circumference reduction and quality of life. Additional research effort is needed to reduce bias and improve the quality of evidence, in order to better inform clinical practice and enhance the care and well-being of patients with BCRL.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":" ","pages":"232-240"},"PeriodicalIF":1.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research Matters. 研究事项。

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2024-10-01 DOI: 10.1089/lrb.2024.0081

引用次数: 0

Rosalind Franklin Society Proudly Announces the 2023 Award Recipient for Lymphatic Research and Biology. 罗莎琳德-富兰克林学会自豪地宣布 2023 年淋巴研究与生物学奖得主。

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2024-10-01 DOI: 10.1089/lrb.2024.56378.rfs2023

Christine Joy Moffatt

引用次数: 0

Super-Microsurgery for Vessels with Diameters Smaller Than 0.5 mm. 直径小于 0.5 毫米的血管的超级显微手术。

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2024-10-01 Epub Date: 2024-09-16 DOI: 10.1089/lrb.2024.0042

Satoshi Onoda, Kahori Tsukura, Kyona Taki, Toshihiko Satake

{"title":"Super-Microsurgery for Vessels with Diameters Smaller Than 0.5 mm.","authors":"Satoshi Onoda, Kahori Tsukura, Kyona Taki, Toshihiko Satake","doi":"10.1089/lrb.2024.0042","DOIUrl":"10.1089/lrb.2024.0042","url":null,"abstract":"Introduction: Among super-microsurgical techniques, the anastomosis of vessels smaller than 0.5 mm is very difficult to perform due to the small diameter and thinness of the blood and lymphatic vessel walls. In this article, we report on the main points of super microsurgery, particularly on the anastomosis of veins and lymphatic vessels with diameters smaller than 0.5 mm. Methods and Results: Details of anastomosis of vessels smaller than 0.5 mm. (1) The outer wall of the first blood vessel near the abrupt end hook with the tip of the needle in the needle holder. The entire abrupt end of the first blood vessel was supported by forceps in the surgeon's left-hand. (2) The surgeon decided the entry point and angle of the needle while moving the tip. After the needle was fixed, a force was applied so that the needle could pass through to the vascular wall. (3) After the needle passed through, the tip was confirmed to be located in the lumen of the first blood vessel. (4) The tip of the needle was inserted into the lumen of the second blood vessel, and the bite was adjusted while touching the second blood vessel through the endometrium. (5) Once the tip was properly positioned, counter-traction was applied by holding the entire outer wall with a left-hand forceps. (6) The needle was held near the tip and pulled out along its curvature. The anastomosis time was 11.35 minutes on average (9 to 14 minutes). The patency rate for all 20 anastomosis procedures was also 100%. Conclusion: The important points of LVA for lymphatic vessels and veins smaller than 0.5 mm were reported. Once the surgeons are familiarized with this anastomosis procedure, they can typically perform one anastomosis in about 10 minutes.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":" ","pages":"255-259"},"PeriodicalIF":1.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142290446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors Predicting the Effect of a Complex Decongestive Therapy in Patients with Mild Lymphedema Following Mastectomy for Early Stage Breast Cancer. 早期乳腺癌乳房切除术后轻度淋巴水肿患者接受复合减充血疗法疗效的预测因素。

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2024-10-01 Epub Date: 2024-09-04 DOI: 10.1089/lrb.2023.0021

Ju Hyeon Kim, Han Eum Choi, Jae Hyun Lee, Young-Joo Sim, Ho Joong Jeong, Ghi Chan Kim

{"title":"Factors Predicting the Effect of a Complex Decongestive Therapy in Patients with Mild Lymphedema Following Mastectomy for Early Stage Breast Cancer.","authors":"Ju Hyeon Kim, Han Eum Choi, Jae Hyun Lee, Young-Joo Sim, Ho Joong Jeong, Ghi Chan Kim","doi":"10.1089/lrb.2023.0021","DOIUrl":"10.1089/lrb.2023.0021","url":null,"abstract":"Background: Complex decongestive therapy (CDT) is being used in breast cancer-related lymphedema (BCRL). The degree of initial edema and bioimpedance analysis (BIA) are known to be related with the therapeutic effect of CDT. D-dimer can indirectly reflect lymphangiogenesis because IL-6 regulates D-dimer and vascular endothelial growth factor, which is the most important lymphangiogenic factor. We assessed whether D-dimer could be used for the prediction of therapeutic effect of CDT, as well as BIA and initial edema. Methods: The participants were patients who took inpatient treatment for BCRL from July 2016 to May 2020. Percent excess volume (PEV) was calculated by dividing the difference in volume of both arms by the edema arm, and the difference in PEV before and after 2 weeks of CDT was defined as the CDT effect. BIA and D-dimer tests were performed before treatment. Results: The single frequency bioimpedance analysis (SFBIA) ratio and D-dimer showed significant correlations with β coefficients of 0.581 and 0.402 (p < 0.01), respectively, and the explanatory power of these models was confirmed to be 0.704.The areas under the curve of initial PEV, SFBIA ratio, D-dimer for determining the CDT effect were identified as 0.849, 0.795, and 0.725, respectively. Conclusions: Initial PEV, SFBIA ratio, and blood D-dimer levels could be used as predictors for CDT treatment effect. Their usefulness order was in the order of initial PEV, SFBIA ratio, and D-dimer. These factors could be used as predictors to establish therapeutic plan in patients with mild lymphedema.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":" ","pages":"241-247"},"PeriodicalIF":1.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142126130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relation Between Characteristics of Indocyanine Green Lymphography and Development of Breast Cancer-Related Lymphedema. 吲哚菁绿淋巴造影的特征与乳腺癌相关淋巴水肿发展之间的关系

IF 1.4 4区医学

Lymphatic research and biology Pub Date : 2024-09-10 DOI: 10.1089/lrb.2024.0009

Sarah Thomis,Sophie Ronsse,Beate Bechter-Hugl,Inge Fourneau,Nele Devoogdt

{"title":"Relation Between Characteristics of Indocyanine Green Lymphography and Development of Breast Cancer-Related Lymphedema.","authors":"Sarah Thomis,Sophie Ronsse,Beate Bechter-Hugl,Inge Fourneau,Nele Devoogdt","doi":"10.1089/lrb.2024.0009","DOIUrl":"https://doi.org/10.1089/lrb.2024.0009","url":null,"abstract":"Background: Breast cancer-related lymphedema (BCRL) is a disabling and frequently occurring condition after treatment for breast cancer. Studying lymph anatomy by means of indocyanine green (ICG) lymphography is a promising tool to help better understand BCRL. The aim of this study is to investigate the relation between ICG lymphography characteristics and the risk of developing BCRL. Methods and Results: Patients scheduled for breast surgery with either unilateral axillary lymph node dissection or sentinel lymph node biopsy between November 2017 and May 2019 were included. Patients were assessed at baseline and up to 36 months postsurgery. BCRL was defined as an increase of ≥5% relative arm volume difference compared with the presurgical difference. In total, 128 patients were included. During 36 months of follow-up, 45 patients (35.2%) developed BCRL. The number of lymph vessels before surgery was not a statistically significant risk factor for developing BCRL (p = 0.8485). However, an increase in the number of lymph vessels compared with baseline was a significant protective factor for developing BCRL (odds ratio = 0.8). An increase of one lymph vessel corresponds to a 19% relative risk reduction of developing BCRL. The presence of lymph nodes at baseline and the change in the presence of lymph nodes compared with baseline were no predictors for the development of BCRL (p = 0.0986 and p = 0.8910, respectively). Conclusions: An increase in the number of lymph vessels visualized by ICG lymphography compared with baseline is a protective factor for developing BCRL. Therapies with the ability to increase the number of lymph vessels can thus possibly decrease the risk of developing BCRL.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":"40 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142201242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of Different Lymphedema Assessment Tools in Women with Breast Cancer After Mastectomy. 乳腺癌患者乳房切除术后不同淋巴水肿评估工具的分析。

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2024-08-01 Epub Date: 2024-08-02 DOI: 10.1089/lrb.2024.0004

Rocío Abalo-Núñez, Iria Da Cuña-Carrera, Alejandra Alonso-Calvete, Eva M Lantarón-Caeiro, Mercedes Soto-González

{"title":"Analysis of Different Lymphedema Assessment Tools in Women with Breast Cancer After Mastectomy.","authors":"Rocío Abalo-Núñez, Iria Da Cuña-Carrera, Alejandra Alonso-Calvete, Eva M Lantarón-Caeiro, Mercedes Soto-González","doi":"10.1089/lrb.2024.0004","DOIUrl":"10.1089/lrb.2024.0004","url":null,"abstract":"Background: Lymphedema is a common complication after mastectomy in women with breast cancer. Several methods have been described to assess and diagnose lymphedema, one of the most studied being the perimeter and ultrasonography. However, the reliability of these methods and the correlation between them are still controversial. The aim of this study was to analyze the reliability of cytometry and ultrasound imaging in the assessment of lymphedema after mastectomy in women with breast cancer and to study the correlation between them. Methods and Results: A cross-sectional study was conducted in 29 women with mastectomy after breast cancer. Lymphedema in the arm was measured both with cytometry and ultrasonography. Reliability was calculated with intraclass correlation coefficient. The correlation between the two methods was carried out with the Pearson correlation coefficient. Both cytometry (M1: α = 0.999, ICC = 0.996; M2: = α = 0.998, ICC = 0.994) and ultrasonography (M1: α = 0.992, ICC = 0.976; M2: = α = 0.991, ICC = 0.973) are reliable methods to assess lymphedema in the arm. No significant correlation was found between them (p > 0.05). Conclusions: Cytometry and ultrasonography appear to be adequate for the measurement of edema in women with breast cancer after mastectomy. However, for an accurate measurement of lymphedema, these measurements should not be used interchangeably.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":" ","pages":"224-229"},"PeriodicalIF":1.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Combination of Functional and Anatomical Assessment Represents the New Frontier in Lymphedema Assessment. 功能评估与解剖评估的结合代表了淋巴水肿评估的新前沿。

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2024-08-01 Epub Date: 2024-07-18 DOI: 10.1089/lrb.2024.0034

Michaela Cellina

引用次数: 0