Lymphatic research and biology最新文献_第8页

Usefulness of Tapered Cutting Needles for Lymphaticovenular Anastomosis. 锥形切针在淋巴小囊吻合中的应用。

IF 1.9 4区医学

Lymphatic research and biology Pub Date : 2025-06-01 Epub Date: 2025-01-29 DOI: 10.1089/lrb.2024.0057

Satoshi Onoda, Kahori Tsukura, Kyona Taki, Toshihiko Satake

{"title":"Usefulness of Tapered Cutting Needles for Lymphaticovenular Anastomosis.","authors":"Satoshi Onoda, Kahori Tsukura, Kyona Taki, Toshihiko Satake","doi":"10.1089/lrb.2024.0057","DOIUrl":"10.1089/lrb.2024.0057","url":null,"abstract":"Introduction: We report the usefulness of a tapered cutting needle, which has a polyhedral tip similar to that of a square needle and transitions to a round tip in the middle, for super-microsurgery. Methods: We have performed more than 500 lymphaticovenular anastomoses (LVAs) using tapered cutting needles. Therefore, we investigated the caliber of the anastomosed lymphatic vessels and veins, characteristics of the lymphatic vessels, the time required to perform the anastomosis, damage to the lymphatic vessels and veins during anastomosis, and patency of 30 recently performed consecutive anastomoses. Results: The mean caliber of the anastomosed lymphatic vessels was 0.68 mm (range, 0.4-1.2 mm), and the mean caliber of the veins was 0.87 mm (range, 0.5-1.5 mm). Regarding the progression of fibrosis, 14 cases were classified as no degeneration, 13 cases were classified as mild degeneration, 2 cases were classified as moderate degeneration, and 1 case was classified as severe degeneration. The average time required to perform the anastomosis was 10.53 minutes (range, 8-13 minutes). No cases of lymphatic or venous injury or laceration occurred during the anastomosis procedure. After the anastomosis was created, intraoperative patency was observed in all patients. Conclusion: The tapered cutting needle is useful for LVAs because of its excellent thread-ability and protective properties for blood vessels. Furthermore, the tapered cutting needle is useful for short anastomoses, regardless of the diameter or condition of the lymphatic vessels. In the future, the tapered cutting needle is expected to become the needle of choice for LVAs.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":" ","pages":"178-183"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Intermittent Pneumatic Compression Influences Edema Fluid Movement and Promotes the Compensatory Drainage Pathways in Patients with Breast Cancer Related Lymphedema. 间歇性气压压缩影响水肿液体运动并促进乳腺癌相关淋巴水肿患者代偿引流通路

IF 1.9 4区医学

Lymphatic research and biology Pub Date : 2025-06-01 Epub Date: 2025-01-27 DOI: 10.1089/lrb.2024.0061

Marzanna T Zaleska, Natalia E Krzesniak

{"title":"The Intermittent Pneumatic Compression Influences Edema Fluid Movement and Promotes the Compensatory Drainage Pathways in Patients with Breast Cancer Related Lymphedema.","authors":"Marzanna T Zaleska, Natalia E Krzesniak","doi":"10.1089/lrb.2024.0061","DOIUrl":"10.1089/lrb.2024.0061","url":null,"abstract":"Introduction: Upper limb lymphedema is the most common complication after breast cancer therapy. Suddenly disturbed lymphatic transport in the affected arm causes tissue fluid accumulation in tissue spaces, limb enlargement, and secondary changes in tissue. Early compression therapy is necessary. We aim to evaluate the effectiveness of intermittent pneumatic compression (IPC) in fluid movement along the limb and the possibility of creating compensatory drainage pathways. Methods and Results: We investigated 25 patients with Breast Cancer Related Lymphedema (BCRL) stages II and III. Indocyanine green observation and measurement of skin water concentration and skin and subcutaneous tissue stiffness were done before and after a single 45-minute session of IPC. After IPC, we observed the movement of edema fluid upper in the arm (92%) and in three main directions not seen before IPC: to the ipsilateral supraclavicular lymph node (30%), to the ipsilateral axilla (22%), and to the axilla, chest, and scapula (26%). We noticed two changes in fluorescent intensity along the entire limb: a decrease in the hand and forearm, an increase in the arm (64%), and a decrease along some parts or the entire limb (36%). Skin and subcutaneous tissue stiffness decreased at all limb levels. The highest, statistically significant reduction of subcutaneous tissue stiffness was noticed in the middle forearm and elbow (36.4% and 33.4%, respectively). Conclusions: IPC can effectively move edema fluid from the distal to the proximal part of the limb, promote compensatory drainage pathways, and decrease tissue stiffness. This compression type should be applied even in the early stages to prevent limb enlargement and secondary tissue changes.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":" ","pages":"160-168"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment Tools to Quantify the Physical Aspects of Lipedema: A Systematic Review. 评估工具量化的物理方面的脂肪水肿：一个系统的审查。

IF 1.9 4区医学

Lymphatic research and biology Pub Date : 2025-06-01 Epub Date: 2025-03-05 DOI: 10.1089/lrb.2024.0102

Helen E Eason, Sharon L Kilbreath, Nicola Fearn, Elizabeth S Dylke

{"title":"Assessment Tools to Quantify the Physical Aspects of Lipedema: A Systematic Review.","authors":"Helen E Eason, Sharon L Kilbreath, Nicola Fearn, Elizabeth S Dylke","doi":"10.1089/lrb.2024.0102","DOIUrl":"10.1089/lrb.2024.0102","url":null,"abstract":"Lipedema diagnosis is heavily reliant on patient history. Various objective assessments have been suggested; however, a standardized measurement process is lacking. A systematic review was undertaken to identify which imaging and measurement tools are used in lipedema quantification and to review their protocols. Six databases were searched with two reviewers screening citations for inclusion. Full peer-reviewed publications that included defined lipedema diagnosis criteria, no male cases within comparative cohorts, and used an imaging or measurement tool to quantify lipedema were included. Twenty studies met the inclusion criteria using 13 different tools to quantify individual physical lipedema characteristics to either enable differential diagnosis, and/or quantify treatment effect: tape measure, perometry, durometry, tonometry, bioimpedance spectroscopy, tissue di-electric constant, ultrasound, Dual-Energy X-ray Absorptiometry, magnetic resonance imaging (MRI), noncontrast MRI lymphangiography, Indocyanine green lymphography, lymphoscintigraphy, and dynamic lymphangiography. Eight imaging and five measurement tools assessed lymphatic transport disturbances (n = 8), limb size/volume (n = 4), adipose tissue thickness/mass/volume (n = 3), and tissue fluid presence (n = 2). Multiple tools were only used in studies completed in 2020 or later. A lack of consistency exists in tool protocols, measurement locations, and outcome analysis. Limited reporting of clinimetrics with data derived from small cohorts and heterogenous populations impacted the ability to recommend tools for clinical practice and research. Various tools were used for objective lipedema assessment; however, consistency in approach was lacking. Further investigations are required to establish the validity and reliability of measurement and imaging tools, protocols, measurement points, and outcome reporting/interpretation to quantify the physical attributes of lipedema.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":" ","pages":"139-159"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research Matters. 研究事项。

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2025-06-01 Epub Date: 2025-03-18 DOI: 10.1089/lrb.2025.0020

引用次数: 0

Hypoxia Impairs Migration of Human Dermal Lymph Endothelial Cells: Implications for Lymphedema Pathogenesis. 缺氧损害人真皮淋巴内皮细胞的迁移：对淋巴水肿发病的影响。

IF 1.9 4区医学

Lymphatic research and biology Pub Date : 2025-06-01 Epub Date: 2025-02-10 DOI: 10.1089/lrb.2024.0019

Chihiro Matsui, Hiroshi Koide, Hatan Mortada, Reiko Tsukuura, Toko Miyazaki, Hayahito Sakai, Hiroshi Mizuno, Takumi Yamamoto

{"title":"Hypoxia Impairs Migration of Human Dermal Lymph Endothelial Cells: Implications for Lymphedema Pathogenesis.","authors":"Chihiro Matsui, Hiroshi Koide, Hatan Mortada, Reiko Tsukuura, Toko Miyazaki, Hayahito Sakai, Hiroshi Mizuno, Takumi Yamamoto","doi":"10.1089/lrb.2024.0019","DOIUrl":"10.1089/lrb.2024.0019","url":null,"abstract":"Introduction: Lymphedema, characterized by abnormal lymph circulation, is a chronic debilitating condition often associated with chronic inflammation and hypoxia in lymphedematous tissue. Previously, using videocapillaroscopy, we found that the severity of lymphedema damages vasa vasorum vessels on the surface of lymph vessels, significantly compromising the oxygen supply environment to lymph endothelial cells. While previous research has indicated the inhibitory effects of hypoxic conditions on the proliferation of human dermal lymph endothelial cells (HDLECs), the impact on HDLEC migration remains unclear. This study aims to investigate the migration ability of HDLECs under hypoxic conditions, shedding light on the potential mechanisms underlying lymphedema progression and offering insights into therapeutic strategies. Materials and Methods and Results: Purchased HDLECs were cultured under normoxic (2% O2) and hypoxic (1% O2) conditions. Migration assays were performed using a scratch assay to assess the migratory capabilities of HDLECs. The experiment monitored cell migration over a period of 6 hours. Experiments were performed in triplicate. HDLECs were cultured to full confluence before the scratch assay. The results revealed a significant reduction in HDLEC migration under hypoxic conditions compared to normoxic conditions after 6 hours (p < 0.001). This suggests that hypoxic environments directly impair HDLEC migration. Conclusion: Hypoxia negatively affects HDLEC migration, potentially exacerbating lymphedema. Protecting vasa vasorum may preserve HDLEC migration and lymphangiogenesis. Further exploration of hypoxia-HDLEC interactions is crucial for understanding lymphedema pathogenesis and developing therapies.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":" ","pages":"184-187"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristic Computed Tomography Findings in Female Patients with Secondary Genital Lymphedema. 女性继发性生殖器淋巴水肿的特征性ct表现。

IF 1.9 4区医学

Lymphatic research and biology Pub Date : 2025-06-01 Epub Date: 2025-02-12 DOI: 10.1089/lrb.2024.0006

Ryusuke Sumiya, Takashi Kageyama, Hayahito Sakai, Reiko Tsukuura, Takumi Yamamoto

{"title":"Characteristic Computed Tomography Findings in Female Patients with Secondary Genital Lymphedema.","authors":"Ryusuke Sumiya, Takashi Kageyama, Hayahito Sakai, Reiko Tsukuura, Takumi Yamamoto","doi":"10.1089/lrb.2024.0006","DOIUrl":"10.1089/lrb.2024.0006","url":null,"abstract":"Background: Female genital lymphedema (FGL) is a challenging disease, and appropriate preoperative evaluation is crucial before surgical treatments. Computed tomography (CT) is expected useful for FGL evaluation, but little is known. This study aimed to clarify characteristic CT findings of FGL with a case report of CT findings-guided lymphaticovenous anastomosis (LVA). Methods: Medical charts of secondary lower extremity lymphedema patients who underwent CT and indocyanine green (ICG) lymphography were reviewed. Genital regions with dermal backflow patterns on ICG lymphography were diagnosed as FGL. Prevalence of characteristic CT findings of lymphedema was compared between genitalia regions with and without FGL. A case of genital lymphedema treated with LVA under the guidance of CT findings was presented. Results: A total of 51 patients (32 with FGL, and 19 without FGL) were included in this study. Genital ICG included stages 0/I/II/III/IV/V in 19 (37.3%)/5 (9.8%)/11 (21.6%)/9 (17.6%)/7 (13.7%)/0 (0%) cases, respectively. Characteristic CT findings included thick skin in 14 (27.5%), thick fascia in 17 (33.3%), high density of the superficial fat in 11 (21.6%), high density of the deep fat in 13 (25.5%), fluid collection in 8 (15.7%), detectable inguinal lymph node in 42 (82.4%), and honeycomb appearance in 7 regions (13.7%). Between genital regions with and without FGL, there were statistically significant differences in all the characteristic CT findings (p < 0.05). Conclusions: Characteristic CT findings of secondary FGL were identified. Preoperative CT evaluation may be useful for selecting appropriate LVA sites for optimal results.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":" ","pages":"188-193"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Use of Ultrasonography to Detect Lymphatic Dysfunction. 使用超声波检测淋巴功能障碍。

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2025-04-01 Epub Date: 2025-03-28 DOI: 10.1089/lrb.2025.0039

Stanley G Rockson

引用次数: 0

Lymphedema, Fatigue, and Quality of Life in Breast Cancer Survivors with Axillary Lymph Node Dissection. 腋窝淋巴结清扫后乳腺癌幸存者的淋巴水肿、疲劳和生活质量。

IF 1.9 4区医学

Lymphatic research and biology Pub Date : 2025-04-01 Epub Date: 2025-01-08 DOI: 10.1089/lrb.2024.0047

Seyma Acikgoz Orhan, Esma Ozsaker

{"title":"Lymphedema, Fatigue, and Quality of Life in Breast Cancer Survivors with Axillary Lymph Node Dissection.","authors":"Seyma Acikgoz Orhan, Esma Ozsaker","doi":"10.1089/lrb.2024.0047","DOIUrl":"10.1089/lrb.2024.0047","url":null,"abstract":"Introduction: Health-related quality of life (QOL) has gained importance due to the increasing incidence of breast cancer and the survival rate of breast cancer patients. We aimed to investigate the relationship between lymphedema, fatigue, and QOL in breast cancer survivors with axillary lymph node dissection. Methods: A total of 122 female breast cancer survivors with axillary lymph node dissection who applied to the oncology center of a teaching and research hospital between April 1, 2022, and July 1, 2022, were included in the cross-sectional study. An individual identification form, the EQ-5D General Quality of Life Scale, and the Cancer Fatigue Scale were used to collect data. Mann-Whitney U test, Kruskal-Wallis H test, Bonferroni post hoc test, and Spearman's correlation were used to assess differences between the survivor groups. Results: The study found that 40.2% of breast cancer survivors experienced lymphedema. The mean scores on the EQ-5D index, Visual Analogue Scale (VAS), and Cancer Fatigue Scale were 0.27 ± 0.25, 71.12 ± 14.21, and 35.86 ± 6.98, respectively. The Cancer Fatigue Scale total score and the EQ-5D VAS showed a strong positive correlation (r = 0.630; p < 0.05). Conversely, the total Cancer Fatigue Scale and the EQ-5D VAS scores showed a significant negative correlation (r = -0.626; p < 0.05). Conclusions: The study found that almost half of the breast cancer survivors experienced lymphedema. They also had excellent general health, moderate fatigue, and a good overall QOL.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":" ","pages":"107-114"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Concept of Palliative Lymphaticovenular Anastomosis. 姑息性淋巴-小静脉吻合的概念。

IF 1.9 4区医学

Lymphatic research and biology Pub Date : 2025-04-01 Epub Date: 2025-01-10 DOI: 10.1089/lrb.2024.0079

Kahori Tsukura, Satoshi Onoda, Toshihiko Satake, Erika Hamada

{"title":"The Concept of Palliative Lymphaticovenular Anastomosis.","authors":"Kahori Tsukura, Satoshi Onoda, Toshihiko Satake, Erika Hamada","doi":"10.1089/lrb.2024.0079","DOIUrl":"10.1089/lrb.2024.0079","url":null,"abstract":"Introduction: Lymphaticovenular anastomosis (LVA) is the first-line surgical treatment for lymphedema. The therapeutic effects of LVA, including edema reduction and cellulitis prevention, vary among patients. We examined cases of palliative LVA in patients with lymphedema who were in the terminal stage due to recurrence or distant metastasis of the primary disease, with a focus on the course and usefulness of palliative LVA. Methods and Results: A total of 13 palliative LVAs were performed in 12 patients undergoing palliative treatment. LVA was performed without interfering with chemotherapy or radiation. Data on site and stage of edema, compression treatment status, number of anastomoses, percentage change in circumferential diameter (the total circumference at six locations was compared), treatment efficacy, and patient prognosis were collected. Edema was present in the upper and lower extremities of 10 and 2 patients, respectively. The average postoperative decrease in circumferential diameter was 8.6%. Psychological evaluation was based on the self-reports of patients, and 11 out of 12 patients showed improvement in their mental state. Two patients died during the observation period due to deterioration in the underlying disease. Conclusion: We reported our experience with palliative LVA in patients with advanced malignancies. Many patients had favorable physical and psychological outcomes. Surgery can be performed safely with appropriate planning based on the condition of the patients. Palliative LVA may be a treatment option for patients with recurrent or distant metastases of the primary disease who are refractory to edema treatment.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":" ","pages":"71-77"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Screening Lymphatic Ultrasound to Detect Lymphatic Dysfunction. 筛选淋巴超声检测淋巴功能障碍。

IF 1.9 4区医学

Lymphatic research and biology Pub Date : 2025-04-01 Epub Date: 2025-01-08 DOI: 10.1089/lrb.2024.0064

Hisako Hara, Makoto Mihara

{"title":"Screening Lymphatic Ultrasound to Detect Lymphatic Dysfunction.","authors":"Hisako Hara, Makoto Mihara","doi":"10.1089/lrb.2024.0064","DOIUrl":"10.1089/lrb.2024.0064","url":null,"abstract":"Background: We currently perform noncontrast lymphatic ultrasound, which has a higher resolution and is less invasive than contrast lymphatic ultrasound. This study aimed to clarify the usefulness of screening lymphatic ultrasound (SLUS) to evaluate lymphatic function. Methods: A retrospective study was conducted on 22 patients with leg lymphedema. We performed SLUS by dividing the leg into four areas (thigh and calf, lateral and medial) and the dorsum of the foot. Lymphatic findings were recorded according to NECST (Normal, Ectasis, Contraction, and Sclerosis type) classification. If no lymphatics were found, we recorded them as \"not found.\" To differentiate between lymphatic vessels and veins, we referred to D-CUPS (Doppler, Crossing, Uncollapsible, Parallel, and Superficial fascia). The time required for SLUS was recorded. Indocyanine green (ICG) lymphography was also performed in 10 patients. Results: The mean age of the 22 patients was 63.9 years (range 50-86 years). The average time required for SLUS was 6 minutes 45 seconds for both legs. The identification rate of the lymphatic vessels was 95.5% for the medial thigh and medial calf, but decreased in the lateral calf and dorsum of the foot. When examining the distribution of the NECST classification, the ectasis type tended to be more common on the medial side than on the lateral side. Combined with the ICG lymphographic findings, dermal backflow (DB)-positive areas had significantly more ectasis type, and DB-negative areas had significantly more normal type and were not found (p < 0.01). Conclusion: SLUS should be useful for screening lymphatic vessel function.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":" ","pages":"64-70"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0