Lupus Science & Medicine最新文献

{"title":"Impact of pregnancy on organ damage in systemic lupus erythematosus: a multicentre study.","authors":"Dina Zucchi, Giancarlo Cascarano, Greta Hulej, Maria Laura Manca, Elena Elefante, Francesca Monacci, Martina Benvenuti, Chiara Ietto, Sabrina Gori, Maddalena Larosa, Margherita Zen, Marta Mosca, Chiara Tani","doi":"10.1136/lupus-2026-002269","DOIUrl":"https://doi.org/10.1136/lupus-2026-002269","url":null,"abstract":"","PeriodicalId":18126,"journal":{"name":"Lupus Science & Medicine","volume":"13 2","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149245206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic Immune-Inflammation Index (SII) correlates with disease activity but not with interferon-associated chemokines in SLE.","authors":"Diana Estefania Campos-Andaluz, Regina Sánchez-Montes, Laura Barragán-Huerta, Ricardo Márquez-Velasco, Luis M Amezcua-Guerra","doi":"10.1136/lupus-2026-002246","DOIUrl":"https://doi.org/10.1136/lupus-2026-002246","url":null,"abstract":"","PeriodicalId":18126,"journal":{"name":"Lupus Science & Medicine","volume":"13 2","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149245224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatigue outcomes with anifrolumab in low-disease-activity SLE: DNA damage in plasmacytoid dendritic cells as a candidate biomarker for responders.","authors":"Eitaro Yoshida, Taiga Kuga, Yusuke Yanagimoto, Emi Nakanishi, Ayako Makiyama, Goh Murayama, Kentaro Minowa, Makio Kusaoi, Ken Yamaji, Naoto Tamura","doi":"10.1136/lupus-2026-002234","DOIUrl":"10.1136/lupus-2026-002234","url":null,"abstract":"","PeriodicalId":18126,"journal":{"name":"Lupus Science & Medicine","volume":"13 2","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13684201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149228115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective evaluation assessing the influence of outcome definition, cohort inclusion and DORIS remission in predicting adverse pregnancy outcomes in women with systemic lupus erythematosus.","authors":"Camila Hernández-Blanco, Philip M Carlucci, Erin Carter, Blake Lippman, Peter Izmirly, Alexis Engel, Jane Salmon, Jessica Dai, Mala Masson, H Michael Belmont, Amit Saxena, Justin S Brandt, Jill P Buyon","doi":"10.1136/lupus-2026-002210","DOIUrl":"10.1136/lupus-2026-002210","url":null,"abstract":"","PeriodicalId":18126,"journal":{"name":"Lupus Science & Medicine","volume":"13 2","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149207420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric validation of the Bengali Lupus-QoL and its correlation with disease activity, damage and low disease activity state: a two-centre cross-sectional study.","authors":"Ritasman Baisya, Jyotisubhra Das, Vikas Dagar, Sourav Garai, Parasar Ghosh","doi":"10.1136/lupus-2026-002213","DOIUrl":"10.1136/lupus-2026-002213","url":null,"abstract":"","PeriodicalId":18126,"journal":{"name":"Lupus Science & Medicine","volume":"13 2","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149207357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PTGS2/COX-2 is associated with neurovascular and blood-brain barrier changes in behaviourally classified MRL/lpr mice.","authors":"Jianbin Li, Mengxia Liu, Haicheng Wen, Yuxin Yan, Shujiao Yu, Rui Wu","doi":"10.1136/lupus-2026-002208","DOIUrl":"10.1136/lupus-2026-002208","url":null,"abstract":"","PeriodicalId":18126,"journal":{"name":"Lupus Science & Medicine","volume":"13 2","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13662092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149167518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suboptimal attainment of SLE treat-to-target goals based on persistently high physician global assessment: an analysis of German SPOCS patients.","authors":"Martin Aringer, Peter Korsten, Tobias Alexander, Falk Hiepe, Marc Schmalzing, Lioba Pieterse, Mareike Giefer, Julius Brandenburg, Bo Ding, Julia Weinmann-Menke","doi":"10.1136/lupus-2026-002168","DOIUrl":"10.1136/lupus-2026-002168","url":null,"abstract":"","PeriodicalId":18126,"journal":{"name":"Lupus Science & Medicine","volume":"13 2","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13662087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149169757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"B-cell landscape remodelling following dual BAFF/APRIL inhibition with telitacicept in lupus nephritis: extrafollicular axis clearance and its association with clinical response.","authors":"Wenqian Yi, Xiaojun Tang, Hua Wei, Juan Wu, Xiaoman Jiang, Zirui Yang, Jieting Jia, Tao Han, Saisai Huang, Xiaolei Ma, Zi-Yi Jin, Qingfeng Zhang, Yun Zhu, Xuebing Feng, Lingyun Sun","doi":"10.1136/lupus-2026-002160","DOIUrl":"10.1136/lupus-2026-002160","url":null,"abstract":"","PeriodicalId":18126,"journal":{"name":"Lupus Science & Medicine","volume":"13 2","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149137435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Belimumab prevention against organ damage over 8 years and safety up to 13 years: three pooled open-label, long-term extension SLE studies.","authors":"Zahi Touma, Cristina Arriens, Maria G Tektonidou, Ricard Cervera, Roger A Levy, Anne Hammer, Daniel J Wallace","doi":"10.1136/lupus-2026-002199","DOIUrl":"10.1136/lupus-2026-002199","url":null,"abstract":"<p><strong>Objective: </strong>Examine long-term glucocorticoid usage, safety and prevention of organ damage in patients with SLE treated with belimumab plus standard therapy (ST).</p><p><strong>Methods: </strong>This <i>post hoc</i> analysis from three global long-term extension (LTE) studies (BEL112233, BEL112234 and BEL112626) included patients who completed parent studies BLISS-52, BLISS-76 or LBSL02. All patients in the LTEs received open-label belimumab (10 mg/kg) intravenously every 28 days plus ST. Endpoints included long-term SLE medication use any time after first belimumab dose (in parent or LTE study), organ damage accrual (up to 8 years) and safety (up to 13 years).</p><p><strong>Results: </strong>Altogether, 1304 patients enrolled in the LTE studies; 1299 received ≥1 dose of belimumab and were included in the modified intent to treat population. Of these, 1221 (94%) patients were female and at enrolment had a mean (SD) age and disease duration of 39.7 (11.6) and 7.2 (6.7) years, respectively. Mean (SD) baseline Safety of Estrogens in Lupus Erythematosus National Assessment-SLE Disease Activity Index (SELENA-SLEDAI) and Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) scores were 8.2 (4.3) and 0.7 (1.2), respectively. The most frequently used SLE concomitant medications at any time after first dose of belimumab were glucocorticoid (GC) (94.1%), antimalarials (74.6%) and immunosuppressants (56.4%). Approximately 50% of patients reduced their GC dose to ≤7.5 mg/day in the first 3 years, increasing to 73.6% by the end of year 8. Mean (SD) changes in SDI score to year 8 did not exceed 0.3 (0.6). Overall, 97.5% of patients had ≥1 adverse event (AE) up to 13 years. While 40.4% had ≥1 serious AE, the incidence of AEs leading to belimumab discontinuation generally remained low over time (10.7%).</p><p><strong>Conclusions: </strong>Patients with SLE treated with belimumab reduced GC use and had minimal to no organ damage progression over 8 years. Robust and consistent safety data up to 13 years support the well-established favourable safety profile of belimumab, with no new safety concerns.</p>","PeriodicalId":18126,"journal":{"name":"Lupus Science & Medicine","volume":"13 2","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149111704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced humoral response to recombinant zoster vaccine in patients with SLE: a prospective cohort study across immune-mediated inflammatory diseases.","authors":"Tiphaine Goulenok, Valentine Marie Ferré, Dalil Bouzid, Gaelle Letang, Bernadette Antoine, Jean-Francois Alexandra, Marie-Paule Chauveheid, Julie Chezel, Antoine Dossier, Andrea Pizzuto, Diane Rouzaud, Thomas Papo, Arthur Mageau, Karim Sacre","doi":"10.1136/lupus-2026-002305","DOIUrl":"https://doi.org/10.1136/lupus-2026-002305","url":null,"abstract":"","PeriodicalId":18126,"journal":{"name":"Lupus Science & Medicine","volume":"13 2","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13630064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149111719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}