Life sciences最新文献_第6页

Insight into adenosine pathway in psoriasis: Elucidating its role and the potential therapeutical applications 洞察银屑病中的腺苷通路：阐明其作用和潜在的治疗应用。

IF 5.2 2区医学

Life sciences Pub Date : 2024-09-21 DOI: 10.1016/j.lfs.2024.123071

{"title":"Insight into adenosine pathway in psoriasis: Elucidating its role and the potential therapeutical applications","authors":"","doi":"10.1016/j.lfs.2024.123071","DOIUrl":"10.1016/j.lfs.2024.123071","url":null,"abstract":"<div><div>Psoriasis is an inflammatory skin disease, that can manifest as different phenotypes, however its most common form is <em>psoriasis vulgaris</em> (plaque psoriasis), characterized by abnormal keratinocyte proliferation, leading to characteristic histopathological signs of acanthosis, hyperkeratosis and parakeratosis.</div><div>For many years, there has been a debate regarding whether keratinocyte dysfunction leads to immune system dysregulation in psoriasis or vice versa. It is now understood that epidermal hyperplasia results from immune system activation. Besides epidermal hyperplasia, psoriatic skin shows leukocyte infiltration, evident angiogenesis in the papillary dermis, characterized by tortuous, dilated capillaries, as well as oedema.</div><div>There is substantial early evidence that adenosine is a key mediator of the immune response; it derives from ATP hydrolysis and accumulates into tissue in response to systemic and local stress conditions, hypoxia, metabolic stress, inflammation. Adenosine controls several cell functions by signalling through its 4 receptor subtypes, A<sub>1</sub>, A<sub>2A</sub>, A<sub>2B</sub> and A<sub>3</sub>. Evidence suggests that adenosine may play a role in psoriasis pathogenesis by controlling several immune cell functions, keratinocyte proliferation, neo-angiogenesis. Expression of adenosine receptor varies in psoriatic skin, and this can significantly impact on tissue homeostasis. Indeed, an altered adenosine receptor profile may contribute to the dysregulation observed in psoriasis, affecting immune responses and inflammatory pathways.</div><div>Here, we discuss the role of adenosine in regulating the functions of the main cell populations implied in the pathogenesis of psoriasis. Furthermore, we give evidence for adenosine signalling pathway as target for therapeutic intervention in psoriasis.</div></div>","PeriodicalId":18122,"journal":{"name":"Life sciences","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142290425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intragastric botulinum toxin injection directly regulates ghrelin expression via reactive oxygen species and NF-κB signaling 胃内注射肉毒杆菌毒素可通过活性氧和NF-κB信号传导直接调节胃泌素的表达。

IF 5.2 2区医学

Life sciences Pub Date : 2024-09-21 DOI: 10.1016/j.lfs.2024.123074

{"title":"Intragastric botulinum toxin injection directly regulates ghrelin expression via reactive oxygen species and NF-κB signaling","authors":"","doi":"10.1016/j.lfs.2024.123074","DOIUrl":"10.1016/j.lfs.2024.123074","url":null,"abstract":"<div><h3>Aims</h3><div>One effective clinical strategy to combat obesity is intragastric botulinum toxin (BTX) injection, which increases gastric emptying time and regulates appetite. However, it remains unknown if and how BTX affects ghrelin levels.</div></div><div><h3>Materials and methods</h3><div>An obese animal model was established by feeding male mice with high-fat diet (HFD). BTX was administered by subserosal injection in the antrum via an upper midline laparotomy. The mice were monitored in terms of body weight and blood biochemical parameters. Glucose utility and insulin sensitivity were measured by intraperitoneal glucose and insulin tolerance tests. Additionally, stomach and liver were histologically examined after BTX treatment. AGS gastric adenocarcinoma cells were used to investigate the molecular mechanism by which BTX affects ghrelin expression.</div></div><div><h3>Key findings</h3><div>In HFD-fed mice, BTX injection significantly decreased both food intake and body weight over a 3-week monitoring period. Moreover, HFD-induced hyperglycemia, hyperinsulinemia, dyslipidemia and obesity readouts were improved after BTX injection. Importantly, mice also exhibited decreased plasma and gastric ghrelin levels after BTX injection. In cultured AGS cells, BTX significantly increased reactive oxygen species (ROS) levels and activated nuclear factor-κB (NF-κB), which led to decreased ghrelin expression. Pre-treatment with inhibitors of either ROS or NF-κB reversed the effects of BTX on ghrelin expression in the cultured cells.</div></div><div><h3>Significance</h3><div>BTX decreases ghrelin expression in HFD-fed animals and in AGS cells through an ROS/NF-κB-dependent pathway. This mechanism may contribute to decreased food intake in obese subjects receiving intragastric BTX injection for weight control.</div></div>","PeriodicalId":18122,"journal":{"name":"Life sciences","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut microbiota and renal fibrosis 肠道微生物群与肾脏纤维化

IF 5.2 2区医学

Life sciences Pub Date : 2024-09-21 DOI: 10.1016/j.lfs.2024.123072

引用次数: 0

Retraction notice to "LncRNA PCAT1 promotes metastasis of endometrial carcinoma through epigenetical downregulation of E-cadherin associated with methyltransferase EZH2" [Life Sci. 243 (2020) 117295]. LncRNA PCAT1通过与甲基转移酶EZH2相关的E-cadherin表观遗传下调促进子宫内膜癌转移》的撤稿通知 [Life Sci. 243 (2020) 117295]。

IF 5.2 2区医学

Life sciences Pub Date : 2024-09-20 DOI: 10.1016/j.lfs.2024.123069

Chunhua Zhang, Shasha Shao, Yujian Zhang, Liyang Wang, Jianzhong Liu, Fang Fang, Peiquan Li, Bo Wang

引用次数: 0

Exosomes from mesenchymal stem cells: Potential applications in wound healing 间充质干细胞的外泌体：在伤口愈合中的潜在应用。

IF 5.2 2区医学

Life sciences Pub Date : 2024-09-19 DOI: 10.1016/j.lfs.2024.123066

{"title":"Exosomes from mesenchymal stem cells: Potential applications in wound healing","authors":"","doi":"10.1016/j.lfs.2024.123066","DOIUrl":"10.1016/j.lfs.2024.123066","url":null,"abstract":"<div><div>Wound healing is a continuous and complex process regulated by multiple factors, which has become an intractable clinical burden. Mesenchymal stem cell-derived exosomes (MSC-exos) possess low immunogenicity, easy preservation, and potent bioactivity, which is a mirror to their parental cells MSC-exos are important tools for regulating the biological behaviors of wound healing-associated cells, including fibroblasts, keratinocytes, immune cells, and endothelial cells. MSC-exos accelerate the wound healing process at cellular and animal levels by modulating inflammatory responses, promoting collagen deposition and vascularization. MSC-exos accelerate wound healing at the cellular and animal levels by modulating inflammatory responses and promoting collagen deposition and vascularization. This review summarizes the roles and mechanisms of MSC-exos originating from various sources in promoting the healing efficacy of general wounds, diabetic wounds, burn wounds, and healing-related scars. It also discusses the limitations and perspectives of MSC-exos in wound healing, in terms of exosome acquisition, mechanistic complexity, and exosome potentiation modalities. A deeper understanding of the properties and functions of MSC-exos is beneficial to advance the therapeutic approaches for achieving optimal wound healing.</div></div>","PeriodicalId":18122,"journal":{"name":"Life sciences","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142290423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A multidisciplinary approach to assessment and management of long COVID cognitive concerns 评估和管理长期 COVID 认知问题的多学科方法

IF 5.2 2区医学

Life sciences Pub Date : 2024-09-18 DOI: 10.1016/j.lfs.2024.123068

引用次数: 0

A comprehensive review on the role of PIWI-interacting RNA (piRNA) in gynecological cancers 全面回顾 PIWI-interacting RNA (piRNA) 在妇科癌症中的作用

IF 5.2 2区医学

Life sciences Pub Date : 2024-09-17 DOI: 10.1016/j.lfs.2024.123065

引用次数: 0

Exploring the role of exosomes in the pathogenesis and treatment of cardiomyopathies: A comprehensive literature review 探索外泌体在心肌病发病机制和治疗中的作用：综合文献综述

IF 5.2 2区医学

Life sciences Pub Date : 2024-09-17 DOI: 10.1016/j.lfs.2024.123063

{"title":"Exploring the role of exosomes in the pathogenesis and treatment of cardiomyopathies: A comprehensive literature review","authors":"","doi":"10.1016/j.lfs.2024.123063","DOIUrl":"10.1016/j.lfs.2024.123063","url":null,"abstract":"<div><p>Exosomes, a subset of small extracellular vesicles that play a crucial role in intercellular communication, have garnered significant attention for their potential applications in the diagnosis and treatment of cardiomyopathies. Cardiomyopathies, which encompass a spectrum of heart muscle disorders, present complex challenges in diagnosis and management. Understanding the role of exosomes in the etiology of cardiomyopathies such as dilated cardiomyopathy (DCM), restrictive cardiomyopathy (RCM), arrhythmogenic cardiomyopathy (AC), and hypertrophic cardiomyopathy (HCM) may open new possibilities for therapeutic intervention and diagnosis. Exosomes have indeed demonstrated promise as diagnostic biomarkers, particularly in identifying cardiac conditions such as atrial fibrillation (AF) and in the timely classification of high-risk patients with different forms of cardiomyopathy. In DCM, exosomes have been implicated in mediating pathological responses in cardiomyocytes, potentially exacerbating disease progression. Moreover, in RCM, AC, and HCM, exosomes present significant potential as diagnostic biomarkers and therapeutic targets, offering insights into disease pathogenesis and potential avenues for intervention. Understanding the influence of exosomes on disease progression and identifying the specific molecular pathways involved in cardiomyopathy pathogenesis may significantly advance diagnostic and treatment strategies. While key findings highlight the multifaceted role of exosomes in cardiomyopathy, they also emphasize the need for further research to elucidate molecular mechanisms and translate findings into clinical practice. This review highlights the evolving landscape of exosome research in cardiomyopathies and underscores the importance of ongoing investigations to harness the full potential of exosomes in improving patient outcomes.</p></div>","PeriodicalId":18122,"journal":{"name":"Life sciences","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0024320524006532/pdfft?md5=f69e82811668f34d0be70f89df04f899&pid=1-s2.0-S0024320524006532-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142242184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NADPH oxidase 1/4 dual inhibitor setanaxib suppresses platelet activation and thrombus formation NADPH 氧化酶 1/4双重抑制剂塞他尼抑制血小板活化和血栓形成

IF 5.2 2区医学

Life sciences Pub Date : 2024-09-17 DOI: 10.1016/j.lfs.2024.123061

{"title":"NADPH oxidase 1/4 dual inhibitor setanaxib suppresses platelet activation and thrombus formation","authors":"","doi":"10.1016/j.lfs.2024.123061","DOIUrl":"10.1016/j.lfs.2024.123061","url":null,"abstract":"<div><h3>Aims</h3><p>The production of reactive oxygen species (ROS) by NADPH oxidase (NOX) is able to induce platelet activation, making NOX a promising target for antiplatelet therapy. In this study, we examined the effects of setanaxib, a dual NOX1/4 inhibitor, on human platelet function and ROS-related signaling pathways.</p></div><div><h3>Materials and methods</h3><p>In collagen-stimulated human platelets, aggregometry, assessment of ROS and Ca<sup>2+</sup>, immunoblotting, ELISA, flow cytometry, platelet adhesion assay, and assessment of mouse arterial thrombosis were performed in this study.</p></div><div><h3>Key findings</h3><p>Setanaxib inhibited both intracellular and extracellular ROS production in collagen-activated platelets. Additionally, setanaxib significantly inhibited collagen-induced platelet aggregation, P-selectin exposure from α-granule release, and ATP release from dense granules. Setanaxib blocked the specific tyrosine phosphorylation-mediated activation of Syk, LAT, Vav1, and Btk within collagen receptor signaling pathways, leading to reduced activation of PLCγ2, PKC, and Ca<sup>2+</sup> mobilization. Setanaxib also inhibited collagen-induced activation of integrin αIIbβ3, which is linked to increased cGMP levels and VASP phosphorylation. Furthermore, setanaxib suppressed collagen-induced p38 MAPK activation, resulting in decreased phosphorylation of cytosolic PLA<sub>2</sub> and reduced TXA<sub>2</sub> generation. Setanaxib also inhibited ERK5 activation, affecting the exposure of procoagulant phosphatidylserine. Setanaxib reduced thrombus formation under shear conditions by preventing platelet adhesion to collagen. Finally, <em>in vivo</em> administration of setanaxib in animal models led to the inhibition of arterial thrombosis.</p></div><div><h3>Significance</h3><p>This study is the first to show that setanaxib suppresses ROS generation, platelet activation, and collagen-induced thrombus formation, suggesting its potential use in treating thrombotic or cardiovascular diseases.</p></div>","PeriodicalId":18122,"journal":{"name":"Life sciences","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142274133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SETD3 functions beyond histidine methylation SETD3 的功能不仅限于组氨酸甲基化

IF 5.2 2区医学

Life sciences Pub Date : 2024-09-17 DOI: 10.1016/j.lfs.2024.123064

引用次数: 0