Macromolecular bioscience最新文献_第7页

Mucin-Inspired Polymeric Fibers for Herpes Simplex Virus Type 1 Inhibition 用于抑制 1 型单纯疱疹病毒的粘蛋白激发聚合物纤维。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2024-05-27 DOI: 10.1002/mabi.202400120

Justin Arenhoevel, Ann-Cathrin Schmitt, Yannic Kerkhoff, Vahid Ahmadi, Elisa Quaas, Kai Ludwig, Katharina Achazi, Chuanxiong Nie, Raju Bej, Rainer Haag

{"title":"Mucin-Inspired Polymeric Fibers for Herpes Simplex Virus Type 1 Inhibition","authors":"Justin Arenhoevel, Ann-Cathrin Schmitt, Yannic Kerkhoff, Vahid Ahmadi, Elisa Quaas, Kai Ludwig, Katharina Achazi, Chuanxiong Nie, Raju Bej, Rainer Haag","doi":"10.1002/mabi.202400120","DOIUrl":"10.1002/mabi.202400120","url":null,"abstract":"Mucus lines the epithelial cells at the biological interface and is the first line of defense against multiple viral infections. Mucins, the gel-forming components of mucus, are high molecular weight glycoproteins and crucial for preventing infections by binding pathogens. Consequently, mimicking mucins is a promising strategy for new synthetic virus inhibitors. In this work, synthetic mucin-inspired polymers (MIPs) as potential inhibitors of herpes simplex virus 1 (HSV-1) are investigated. By using a telechelic reversible addition-fragmentation chain-transfer (RAFT) polymerization technique, a new dendronized polysulfate p(G1AAm-OSO3)PDS with an amide-backbone similar to the native mucin glycoproteins is synthesized. p(G1AAm-OSO3)PDS shows mucin-like elongated fiber structure, as revealed in cryo-electron microscopy (cryo-EM) imaging, and its HSV-1 inhibition activity together with its previously reported methacrylate analogue p(G1MA-OSO3)PDS is tested. Both of the sulfated MIPs show strong HSV-1 inhibition in plaque reduction assays with IC50 values in lower nanomolar range (<3 × 10−9 m) and demonstrate a high cell compatibility (CC50 > 1.0 mg mL−1) with lower anticoagulant activity than heparin. In addition, the prophylactic and therapeutic activity of both MIPs is assessed in pre- and post-infection inhibition assays and clearly visualize their high potential for application using fluorescent microscopy imaging of infected cells.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mabi.202400120","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141155295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advances in the Fabrication and Performance Optimization of Polyvinyl Alcohol Based Vascular Grafts 聚乙烯醇基血管移植物制造和性能优化的最新进展。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2024-05-27 DOI: 10.1002/mabi.202400093

Yixuan Liu, Zichun Gao, Xinrong Yu, Wenjiao Lin, He Lian, Zhaoxu Meng

{"title":"Recent Advances in the Fabrication and Performance Optimization of Polyvinyl Alcohol Based Vascular Grafts","authors":"Yixuan Liu, Zichun Gao, Xinrong Yu, Wenjiao Lin, He Lian, Zhaoxu Meng","doi":"10.1002/mabi.202400093","DOIUrl":"10.1002/mabi.202400093","url":null,"abstract":"Cardiovascular disease is one of the diseases with the highest morbidity and mortality rates worldwide, and coronary artery bypass grafting (CABG) is a fast and effective treatment. More researchers are investigating in artificial blood vessels due to the limitations of autologous blood vessels. Despite the availability of large-diameter vascular grafts (Ø > 6 mm) for clinical use, small-diameter vascular grafts (Ø < 6 mm) have been a challenge for researchers to overcome in recent years. Vascular grafts made of polyvinyl alcohol (PVA) and PVA-based composites have excellent biocompatibility and mechanical characteristics. In order to gain a clearer and more specific understanding of the progress in PVA vascular graft research, particularly regarding the preparation methods, principles, and functionality of PVA vascular graft, this article discusses the mechanical properties, biocompatibility, blood compatibility, and other properties of PVA vascular graft prepared or enhanced with different blends using various techniques that mimic natural blood vessels. The findings reveal the feasibility and promising potential of PVA or PVA-based composite materials as vascular grafts.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141155300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-Inflammatory Potential of Beclometasone-Loaded Filomicelles on Activated Human Monocytes 贝氯米松负载丝胶对活化人单核细胞的抗炎潜力

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2024-05-23 DOI: 10.1002/mabi.202400179

Elena Gardey, Juliane Eberhardt, Stephanie Hoeppener, Fabian H. Sobotta, Johannes C. Brendel, Andreas Stallmach

{"title":"Anti-Inflammatory Potential of Beclometasone-Loaded Filomicelles on Activated Human Monocytes","authors":"Elena Gardey, Juliane Eberhardt, Stephanie Hoeppener, Fabian H. Sobotta, Johannes C. Brendel, Andreas Stallmach","doi":"10.1002/mabi.202400179","DOIUrl":"10.1002/mabi.202400179","url":null,"abstract":"Polymeric micelles with a hydrophobic core represent versatile nanostructures for encapsulation and delivery of water-insoluble drugs. Here, water-insoluble beclometasone dipropionate (BDP) which is a potent anti-inflammatory therapeutic agent but limited to topical applications so far, is encapsulated. Therefore, this work used an amphiphilic block copolymer self-assembling into flexible polymeric filomicelles, which have recently proven to selectively target inflamed areas in patients with inflammatory bowel disease (IBD). The small diameter and flexibility of these filomicelles is considered beneficial for transepithelial passages, while their length minimizes the unspecific uptake into nontargeted cells. This work successfully establishes a protocol to load the water-insoluble BDP into the core of the filomicelles, while maintaining the particle stability to prevent any premature drug release. The anti-inflammatory efficacy of BDP-loaded filomicelles is further investigated on lipopolysaccharide (LPS) stimulated human monocytes. In these ex vivo assays, the BDP-loaded filomicelles significantly reduce TNF-α, IL-6, IL-1ß, IL-12p70, IL-17a, and IL-23 release after 24 h. Additional time course study of drug-loaded filomicelles and their comparison with a common water-soluble and unspecific corticosteroid demonstrate promising results with significant immune response suppression in stimulated monocytes after 2 and 6 h. These findings demonstrate the potential of polymeric filomicelles as a vehicle for potent water-insoluble corticosteroids.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mabi.202400179","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141081946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Injectable Photothermal PDA/Chitosan/β-Glycerophosphate Thermosensitive Hydrogels for Antibacterial and Wound Healing Promotion. 用于抗菌和促进伤口愈合的可注射光热PDA/壳聚糖/β-甘油磷酸酯热敏水凝胶

IF 4.6 4区医学

Macromolecular bioscience Pub Date : 2024-05-16 DOI: 10.1002/mabi.202400080

Dingkun Liu, Jinbing Chen, Linjuan Gao, Xing Chen, Liujun Lin, Xia Wei, Yuan Liu, Hui Cheng

{"title":"Injectable Photothermal PDA/Chitosan/β-Glycerophosphate Thermosensitive Hydrogels for Antibacterial and Wound Healing Promotion.","authors":"Dingkun Liu, Jinbing Chen, Linjuan Gao, Xing Chen, Liujun Lin, Xia Wei, Yuan Liu, Hui Cheng","doi":"10.1002/mabi.202400080","DOIUrl":"10.1002/mabi.202400080","url":null,"abstract":"Controlling infections while reducing the use of antibiotics is what doctors as well as researchers are looking for. As innovative smart materials, photothermal materials can achieve localized heating under light excitation for broad-spectrum bacterial inhibition. A polydopamine/chitosan/β-glycerophosphate temperature-sensitive hydrogel with excellent antibacterial ability is synthesized here. Initially, the hydrogel has good biocompatibility. In vitro experiments reveal its noncytotoxic property when cocultured with gingival fibroblasts and nonhemolytic capability. Concurrently, the in vivo biocompatibility is confirmed through liver and kidney blood markers and staining of key organs. Crucially, the hydrogel has excellent photothermal conversion performance, which can realize the photothermal conversion of hydrogel up to 3 mm thickness. When excited by near-infrared light, localized heating is attainable, resulting in clear inhibition impacts on both Staphylococcus aureus and Escherichia coli, with the inhibition rates of 91.22% and 96.69%, respectively. During studies on mice's infected wounds, it is observed that the hydrogel can decrease S. aureus' presence in the affected area when exposed to near-infrared light, and also lessen initial inflammation and apoptosis, hastening tissue healing. These findings provide valuable insights into the design of antibiotic-free novel biomaterials with good potential for clinical applications.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140945208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Masthead: Macromol. Biosci. 5/2024 刊头：Macromol.Biosci.5/2024

IF 4.6 4区医学

Macromolecular bioscience Pub Date : 2024-05-15 DOI: 10.1002/mabi.202470012

引用次数: 0

Tannic Acid Incorporated Antibacterial Polyethylene Glycol Based Hydrogel Sponges for Management of Wound Infections 加入单宁酸的抗菌聚乙二醇基水凝胶海绵用于治疗伤口感染。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2024-05-15 DOI: 10.1002/mabi.202400101

Basak Akin, Busra Akgul, Semra Tasdurmazli, Emrah Sefik Abamor, Tulin Ozbek, Berkay Ozcelik, Esra Su, Mehmet Murat Ozmen

{"title":"Tannic Acid Incorporated Antibacterial Polyethylene Glycol Based Hydrogel Sponges for Management of Wound Infections","authors":"Basak Akin, Busra Akgul, Semra Tasdurmazli, Emrah Sefik Abamor, Tulin Ozbek, Berkay Ozcelik, Esra Su, Mehmet Murat Ozmen","doi":"10.1002/mabi.202400101","DOIUrl":"10.1002/mabi.202400101","url":null,"abstract":"Conventional wound dressings fail to provide features that can assist the healing process of chronic wounds. Multifunctional wound dressings address this issue by incorporating attributes including antibacterial and antioxidant activity, and the ability to enhance wound healing. Herein, polyethylene glycol (PEG)-based antibacterial hydrogel sponge dressings are prepared by a rapid and facile gas foaming method based on an acid chloride/alcohol reaction where tannic acid (TA) is included as a reactant to impart antibacterial efficacy as well as to enhance the mechanical properties of the samples. The results reveal that the TA-integrated sponges possess excellent antibacterial properties against both Escherichia coli and Staphylococcus aureus with approximately 6–8 log reduction in the microbial colony count after 6 h, indicating their high potential for management of infection-prone wounds. Compared to the control sample, TA incorporation increases the elastic modulus by twofold. As the samples also exhibit biocompatibility, antioxidant activity, and wound healing capacity, the novel TA-incorporated hydrogels can be an alternative to traditional wound dressings for wounds with low-to-moderate exudate.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mabi.202400101","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140945212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a Tri-Layered Vascular Construct and In Vitro Evaluation of Endothelization 三层血管结构的开发和体外内皮化评估

IF 4.6 4区医学

Macromolecular bioscience Pub Date : 2024-05-15 DOI: 10.1002/mabi.202470013

Gozde E. Kole, Vasif Hasirci, Deniz Yucel

引用次数: 0

Self-Degrading Multifunctional PEG-Based Hydrogels—Tailormade Substrates for Cell Culture 自降解多功能 PEG 水凝胶--用于细胞培养的尾端基质

IF 4.6 4区医学

Macromolecular bioscience Pub Date : 2024-05-15 DOI: 10.1002/mabi.202470011

Kathrin Kowalczuk, Anindita Dasgupta, Francisco Páez Larios, Hans F. Ulrich, Valentin Wegner, Johannes C. Brendel, Christian Eggeling, Alexander S. Mosig, Felix H. Schacher

引用次数: 0

Nanostructured Biopolymer-Based Constructs for Cartilage Regeneration: Fabrication Techniques and Perspectives 用于软骨再生的纳米生物聚合物结构：制造技术和前景。

IF 4.4 4区医学

Macromolecular bioscience Pub Date : 2024-05-15 DOI: 10.1002/mabi.202400125

Deepika Sharma, Bhabani K. Satapathy

{"title":"Nanostructured Biopolymer-Based Constructs for Cartilage Regeneration: Fabrication Techniques and Perspectives","authors":"Deepika Sharma, Bhabani K. Satapathy","doi":"10.1002/mabi.202400125","DOIUrl":"10.1002/mabi.202400125","url":null,"abstract":"The essential functions of cartilage, such as shock absorption and resilience, are hindered by its limited regenerative capacity. Although current therapies alleviate symptoms, novel strategies for cartilage regeneration are desperately needed. Recent developments in three-dimensional (3D) constructs aim to address this challenge by mimicking the intrinsic characteristics of native cartilage using biocompatible materials, with a significant emphasis on both functionality and stability. Through fabrication methods such as 3D printing and electrospinning, researchers are making progress in cartilage regeneration; nevertheless, it is still very difficult to translate these advances into clinical practice. The review emphasizes the importance of integrating various fabrication techniques to create stable 3D constructs. Meticulous design and material selection are required to achieve seamless cartilage integration and durability. The review outlines the need to address these challenges and focuses on the latest developments in the production of hybrid 3D constructs based on biodegradable and biocompatible polymers. Furthermore, the review acknowledges the limitations of current research and provides perspectives on potential avenues for effectively regenerating cartilage defects in the future.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140922615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetically Active Bicontinuous Polymer Structures for Multiple Controlled Drug Delivery. 用于多重可控药物输送的磁活性双连续聚合物结构。

IF 4.6 4区医学

Macromolecular bioscience Pub Date : 2024-05-11 DOI: 10.1002/mabi.202400084

Elisa Lacroce, Fabio Pizzetti, Nicolás M Barbosa Urrego, Giuseppe Nunziata, Maurizio Masi, Filippo Rossi

引用次数: 0