Life Science Alliance最新文献_第2页

Sequencing, annotation and analysis of the genome of Oxycarenus hyalinipennis, the cotton seed bug. 棉籽虫透明质氧虫（oxycareus hyalinipennis）基因组测序、注释与分析。

IF 3.1 2区生物学

Life Science Alliance Pub Date : 2026-05-19 Print Date: 2026-08-01 DOI: 10.26508/lsa.202503598

Sam D Heraghty, Sheina B Sim, Scott M Geib, Renee L Corpuz, Christina D Hoddle, Mark S Hoddle, Colin S Brent, Dawn E Gundersen-Rindal, Michael E Sparks

{"title":"Sequencing, annotation and analysis of the genome of Oxycarenus hyalinipennis, the cotton seed bug.","authors":"Sam D Heraghty, Sheina B Sim, Scott M Geib, Renee L Corpuz, Christina D Hoddle, Mark S Hoddle, Colin S Brent, Dawn E Gundersen-Rindal, Michael E Sparks","doi":"10.26508/lsa.202503598","DOIUrl":"10.26508/lsa.202503598","url":null,"abstract":"The cotton seed bug, Oxycarenus hyalinipennis Costa (Hemiptera: Lygaeidae), is an invasive cotton pest detected in California, United States, in 2019. This report details the assembly and annotation of a reference genome for O. hyalinipennis, which will assist with the development of control strategies and provide evolutionary insight into this pest and hemipterans in general. The genome was sequenced from an adult male specimen using PacBio HiFi long reads and Element short-read sequencing of a HiC library. The assembly is 727,196,238 bp long with an N50 of 116 Mb. A total of 28,646 genes were identified by a customized annotation pipeline. Comparative genomics results suggest that chromosomal rearrangements may be common within Pentatomomorpha, based on syntenic analyses across all superfamilies. Comparison between available heteropteran genomes was used to identify changes in gene family size, as well as evolutionary differences, between taxa with different feeding strategies. Notably, herbivorous taxa had significantly larger genomes than predatory taxa. These genomic resources will be useful in efforts to understand and control this pest and advance the understanding of hemipteran evolution.","PeriodicalId":18081,"journal":{"name":"Life Science Alliance","volume":"9 8","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13187118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147973576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A potential mechanism for tetraspanin CD82-mediated regulation of EGFR. 四球蛋白cd82介导的EGFR调控的潜在机制。

IF 3.1 2区生物学

Life Science Alliance Pub Date : 2026-05-13 Print Date: 2026-07-01 DOI: 10.26508/lsa.202503426

Elisa Lamottke, T Harma C Brondijk, Piet Gros

引用次数: 0

Cross-species transcriptomic integration reveals a MIRO1-mediated macrophage-T cell axis in glioma. 跨物种转录组整合揭示了胶质瘤中miro1介导的巨噬细胞- t细胞轴。

IF 3.1 2区生物学

Life Science Alliance Pub Date : 2026-05-13 Print Date: 2026-08-01 DOI: 10.26508/lsa.202603749

Zehui Du, Menghan Li, Brandon H Bergsneider, Andy P Tsai, Kwang Bog Cho, Lily H Kim, John Choi, Gordon Li, Tony Wyss-Coray, Michael Lim, Xinnan Wang

{"title":"Cross-species transcriptomic integration reveals a MIRO1-mediated macrophage-T cell axis in glioma.","authors":"Zehui Du, Menghan Li, Brandon H Bergsneider, Andy P Tsai, Kwang Bog Cho, Lily H Kim, John Choi, Gordon Li, Tony Wyss-Coray, Michael Lim, Xinnan Wang","doi":"10.26508/lsa.202603749","DOIUrl":"10.26508/lsa.202603749","url":null,"abstract":"Mitochondrial regulators are increasingly recognized for their influence on immune signaling within the tumor microenvironment (TME). In glioma, where immunosuppression limits therapeutic efficacy, we investigate how targeting the mitochondrial protein MIRO1 alters the TME. We combine single-nucleus RNA sequencing of murine gliomas treated in vivo with an MIRO1-binding compound and bulk RNA sequencing of human glioma resections treated with the same compound ex vivo. Cross-species transcriptomic integration reveals an MIRO1-responsive program in the TME. Among shared targets, we identify PARP11/Parp11 as a consistently up-regulated gene in glioma, which is down-regulated after MIRO1-binding compound treatment in both human and mouse gliomas. Cell-cell communication analysis shows that a specific cluster of macrophages (MAC1), which exhibits robust Parp11 and Pdl1 (encoding PD-L1) expression, sends immunosuppressive signals to CD8+ cytotoxic T cells, and may receive prostaglandin E2 signals from another cluster of macrophages (MAC4). Targeting MIRO1 eliminates this cell circuitry and reduces the tumor cell population. Our study provides a transcriptomic framework for understanding mitochondria-immune crosstalk and nominates MIRO1-PARP11 as a potential effector axis of brain immune dysfunction.","PeriodicalId":18081,"journal":{"name":"Life Science Alliance","volume":"9 8","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13171295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147930958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural and biochemical comparison of the FLVCR and CTL membrane protein families in eukaryotes. 真核生物FLVCR和CTL膜蛋白家族的结构和生化比较。

IF 3.1 2区生物学

Life Science Alliance Pub Date : 2026-05-11 Print Date: 2026-07-01 DOI: 10.26508/lsa.202503583

Lynette Nel, Jan H Driller, Ronja Driller, Kelly M Frain, Bjørn P Pedersen

{"title":"Structural and biochemical comparison of the FLVCR and CTL membrane protein families in eukaryotes.","authors":"Lynette Nel, Jan H Driller, Ronja Driller, Kelly M Frain, Bjørn P Pedersen","doi":"10.26508/lsa.202503583","DOIUrl":"10.26508/lsa.202503583","url":null,"abstract":"The organic cation choline is essential for eukaryotic metabolism. Recently, the feline leukemia virus subgroup C receptor-related (FLVCR, SLC49) family was demonstrated as central for basal choline transport, questioning the role of the choline transporter-like (CTL, SLC44) family in this capacity. Here, we use Xenopus laevis oocytes to confirm that FLVCR1 (SLC49A1) and FLVCR2 (SLC49A2) proteins are choline transporters. CTL1 (SLC44A1) does not transport choline under the same conditions, supported by other CTL proteins, Arabidopsis thaliana CherI and Saccharomyces cerevisiae PNS1, which also display no choline transport activity. We present the atomic structures of FLVCR2, CTL1, and PNS1. The 3.4 Å cryo-EM structure of FLVCR2 has choline in the binding pocket. The 3.3 Å cryo-EM structure of CTL1 and the 2.7 Å crystal structure of PNS1 reveal an unusual protein fold, weakly related to the mitochondrial carrier family (SLC25). The unusual fold appears incompatible with transmembrane transport and implies a different and, so far, unknown function for CTL proteins. Our results support FLVCR proteins as choline transporters and suggest a nontransport role for CTL proteins.","PeriodicalId":18081,"journal":{"name":"Life Science Alliance","volume":"9 7","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13160678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147874725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vsb1, Ypq1, and Ypq2 control dynamic cationic amino acid storage in the yeast vacuole. vsv1、Ypq1和Ypq2控制酵母液泡中动态阳离子氨基酸的储存。

IF 3.1 2区生物学

Life Science Alliance Pub Date : 2026-05-11 Print Date: 2026-07-01 DOI: 10.26508/lsa.202503520

Evi Zaremba, Fabienne Vierendeels, Raphaël Dutoit, Elisabeth Bodo, Ersilia Bifulco, Catherine Tricot, Elad Noor, Bruno André, Evgeny Onischenko, Melody Cools

{"title":"Vsb1, Ypq1, and Ypq2 control dynamic cationic amino acid storage in the yeast vacuole.","authors":"Evi Zaremba, Fabienne Vierendeels, Raphaël Dutoit, Elisabeth Bodo, Ersilia Bifulco, Catherine Tricot, Elad Noor, Bruno André, Evgeny Onischenko, Melody Cools","doi":"10.26508/lsa.202503520","DOIUrl":"10.26508/lsa.202503520","url":null,"abstract":"Although the yeast vacuole plays a crucial role in storing and mobilizing cationic amino acids (CAA), CAA transport at the vacuolar membrane remains only partially characterized. Here, by combining analysis of CAA pools, uptake and permeabilization assays, we establish Vsb1 as the principal vacuolar lysine transporter, enabling its strong accumulation in the vacuole when mitigating its toxicity. We further show that, although Ypq1 can mediate proton-independent vacuolar lysine import, it mainly functions as a lysine exporter necessary for lysine mobilization under conditions of lysine scarcity and is down-regulated as lysine stores are exhausted. Using quantitative models based on dynamic metabolic labeling, we further show that, surprisingly, in growing cells, CAA rapidly exchange between vacuolar and cytosolic compartments, a process involving the export activity of Ypq1 and its paralogue Ypq2, specific for lysine and arginine, respectively. Together, our findings reveal the unexpectedly complex function of Vsb1 and Ypq1/2 as the key transporters mediating dynamic vacuolar CAA storage.","PeriodicalId":18081,"journal":{"name":"Life Science Alliance","volume":"9 7","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13160679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147874702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of Nrf2 in thyroid maturation and hormone synthesis in vertebrate models. Nrf2在脊椎动物甲状腺成熟和激素合成中的作用。

IF 3.1 2区生物学

Life Science Alliance Pub Date : 2026-05-07 Print Date: 2026-07-01 DOI: 10.26508/lsa.202603687

Pierre Gillotay, Sushant Bangru, Benjamin Dassy, Benoit Haerlingen, Meghna P Shankar, Barbara F Fonseca, Panos G Ziros, Sumeet P Singh, Gerasimos P Sykiotis, Mirian Romitti, Sabine Costagliola

{"title":"The role of Nrf2 in thyroid maturation and hormone synthesis in vertebrate models.","authors":"Pierre Gillotay, Sushant Bangru, Benjamin Dassy, Benoit Haerlingen, Meghna P Shankar, Barbara F Fonseca, Panos G Ziros, Sumeet P Singh, Gerasimos P Sykiotis, Mirian Romitti, Sabine Costagliola","doi":"10.26508/lsa.202603687","DOIUrl":"10.26508/lsa.202603687","url":null,"abstract":"In vertebrates, the thyroid gland synthesizes hormones that act on almost all tissues and are essential for normal growth and metabolism. Thyroid hormone production relies on iodination of thyroglobulin and requires H2O2, which contributes to a relatively high basal oxidative stress in the thyroid that must be tightly controlled to prevent cellular damage. The thyroid has efficient antioxidant and detoxifying enzymes that help it resist H2O2-induced oxidative stress maintaining the homeostasis necessary for hormone synthesis. By regulating the expression of genes involved in cellular detoxification, NRF2 acts as a master regulator of the cellular defense against oxidative stress. Using zebrafish embryos and mouse ESC-derived thyroid organoids, we generated nrf2a/Nrf2 loss-of-function and identified a common dyshormonogenesis phenotype. Although in zebrafish, the driving mechanisms are possibly related to thyroglobulin iodination defects, in thyroid organoids, it is likely due to a reduction in Tg production, consequently affecting folliculogenesis and thyroid hormone production.","PeriodicalId":18081,"journal":{"name":"Life Science Alliance","volume":"9 7","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13153729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147839678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A microRNA generated via lysosomal processing of ribosomal RNA suppresses proinflammatory responses. 通过溶酶体加工核糖体RNA产生的microRNA抑制促炎反应。

IF 3.1 2区生物学

Life Science Alliance Pub Date : 2026-05-04 Print Date: 2026-07-01 DOI: 10.26508/lsa.202503536

Dan Michael, Ester Feldmesser, K Shanmugha Rajan, Yoav Lubelsky, Anat Bashan, Alexandros Damalas, Shiri Ben Zvi, Aya Friedberg, Netta Eitan, Shachar Erez, Ada Yonath, Igor Ulitsky, Moshe Oren

{"title":"A microRNA generated via lysosomal processing of ribosomal RNA suppresses proinflammatory responses.","authors":"Dan Michael, Ester Feldmesser, K Shanmugha Rajan, Yoav Lubelsky, Anat Bashan, Alexandros Damalas, Shiri Ben Zvi, Aya Friedberg, Netta Eitan, Shachar Erez, Ada Yonath, Igor Ulitsky, Moshe Oren","doi":"10.26508/lsa.202503536","DOIUrl":"10.26508/lsa.202503536","url":null,"abstract":"ER stress underlies numerous severe pathologies. We have metabolically perturbed normal fibroblasts to study the biological roles of microRNAs (miRs) under mild and extended ER stress. We now report that miR-4488 quenches inflammation-associated gene expression in such metabolically perturbed cells. Remarkably, generation of miR-4488 is Drosha-independent. Furthermore, we define miR-4488 as a noncanonical miRNA derived from the expansion segment ES7L of the 28S ribosomal RNA. Moreover, its generation involves the autophagy-lysosome route and is inhibited when this pathway is blocked, thus unveiling an anti-inflammatory role for ribosomal RNA and lysosomes, engaged at the onset of stress. Mechanistically, miR-4488 suppresses the expression of NFKB2 and RELB, whose mRNAs specifically associate with miR-4488 exclusively upon stress. This selectivity suggests that miR-4488 may bear promise for treating mild ER stress-associated diseases.","PeriodicalId":18081,"journal":{"name":"Life Science Alliance","volume":"9 7","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13139743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147839709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine learning method for the prediction of Bedaquiline-resistant Mycobacterium tuberculosis. 贝达喹啉耐药结核分枝杆菌预测的机器学习方法。

IF 3.1 2区生物学

Life Science Alliance Pub Date : 2026-04-30 Print Date: 2026-07-01 DOI: 10.26508/lsa.202503539

Stuti Ghosh, Sudipto Bhattacharjee, Sudipto Saha

{"title":"Machine learning method for the prediction of Bedaquiline-resistant Mycobacterium tuberculosis.","authors":"Stuti Ghosh, Sudipto Bhattacharjee, Sudipto Saha","doi":"10.26508/lsa.202503539","DOIUrl":"10.26508/lsa.202503539","url":null,"abstract":"The study addresses the increasing resistance to the FDA-approved drug Bedaquiline (BDQ) in Mycobacterium tuberculosis (MTB). The absence of any defined resistance locus and the wide variation in the drug targets across clinical isolates have raised a big question about our understanding of the molecular basis of BDQ resistance acquisition. Using machine learning (ML) methods, BDQ resistance was predicted from whole-genome sequencing data for MTB clinical isolates. Variant calling format data generation involved several steps, including adapter trimming and alignment to the H37Rv reference genome. The ML models, namely, Multilayer Perceptron and Random Forest (RF), achieved high accuracies of 83.60% and 79.64%, respectively. The top 50 features were mapped to the H37Rv reference genome, and several new drug targets were identified. In addition to the coding regions, some non-coding intergenic regions were also obtained. Mapping of these features to the H37Rv genome revealed 15 new antibiotic-resistant genes. In addition, the use of explainable AI (XAI) methods, such as SHapley Additive exPlanations, facilitated the identification of mutations associated with BDQ resistance. In conclusion, the ML models demonstrated effective predictive capabilities for BDQ resistance, whereas XAI contributed to understanding key resistance features.","PeriodicalId":18081,"journal":{"name":"Life Science Alliance","volume":"9 7","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147816495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alveolar macrophage subtypes express cholesterol and inflammation genes in cystic fibrosis. 囊性纤维化中肺泡巨噬细胞亚型表达胆固醇和炎症基因。

IF 3.1 2区生物学

Life Science Alliance Pub Date : 2026-04-30 Print Date: 2026-07-01 DOI: 10.26508/lsa.202503482

Xin Li, Fred W Kolling, Daniel Aridgides, Lorraine Gwilt, Diane Mellinger, Claudia V Jakubzick, Alix Ashare

{"title":"Alveolar macrophage subtypes express cholesterol and inflammation genes in cystic fibrosis.","authors":"Xin Li, Fred W Kolling, Daniel Aridgides, Lorraine Gwilt, Diane Mellinger, Claudia V Jakubzick, Alix Ashare","doi":"10.26508/lsa.202503482","DOIUrl":"10.26508/lsa.202503482","url":null,"abstract":"Cystic fibrosis (CF) is a genetic disease that causes lung inflammation. Although new treatments have improved the quality of life of people with CF, inflammation remains a problem. Alveolar macrophages have been shown to be important mediators of CF lung inflammation although the interactions between macrophages and other immune cells in CF are poorly understood. To identify and compare the cellular composition between CF and healthy airspace macrophages and monocytes, healthy control and CF subjects underwent bronchoscopy and single-cell RNA sequencing was performed on the BAL fluid. Unbiased clustering identified 12 macrophage subtypes. We found up-regulation of macrophages expressing CDKN1A and LDLR, both of which are known to alter cholesterol metabolism and promote inflammation. Pathway analysis revealed important interactions between macrophages and monocytes in CF that likely contribute to overall inflammation and adaptation of recruited monocytes to the CF lung. Some of the top pathways identified were related to inflammation and lipid metabolism, which may contribute to persistent inflammation in CF. Our results may identify novel potential therapeutic targets to treat CF lung inflammation.","PeriodicalId":18081,"journal":{"name":"Life Science Alliance","volume":"9 7","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13139742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147816420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporal analysis of two inducible human genes reveals post-transcriptional H3K4me3 deposition. 两个可诱导的人类基因的时间分析揭示了转录后H3K4me3沉积。

IF 3.1 2区生物学

Life Science Alliance Pub Date : 2026-04-30 Print Date: 2026-07-01 DOI: 10.26508/lsa.202503511

Komal Paresh Walvekar, Sabarinadh Chilaka

{"title":"Temporal analysis of two inducible human genes reveals post-transcriptional H3K4me3 deposition.","authors":"Komal Paresh Walvekar, Sabarinadh Chilaka","doi":"10.26508/lsa.202503511","DOIUrl":"10.26508/lsa.202503511","url":null,"abstract":"Histone H3 lysine 4 trimethylation (H3K4me3) is an established hallmark of active promoters, yet the temporal hierarchy between its deposition and transcriptional initiation remains incompletely understood. Here, we employ temporal dynamic analysis of inducible human inflammatory genes to demonstrate that H3K4me3 accumulation lags significantly behind transcriptional onset. At the TNF-α and IL-1β loci, H3K4me3 enrichment succeeds the rapid recruitment of RNA polymerase II, NF-κB, and p300, appearing kinetically decoupled from the initial establishment of histone acetylation. We find that H3K4me3 deposition is attenuated by transcriptional inhibition, characterizing it as a downstream event rather than a prerequisite for initial activation. Furthermore, MLL1-mediated reduction of H3K4me3 does not impair transcriptional induction, demonstrating that this mark is dispensable for the primary onset of expression at these loci. At the constitutively active MYC locus, H3K4me3 persists after transcriptional inhibition, indicating temporal uncoupling between transcription and H3K4me3 maintenance. Our findings provide a detailed kinetic characterization of H3K4me3 loading and suggest that at these inducible genes, this modification serves as a consequence of, rather than a trigger for, transcriptional initiation.","PeriodicalId":18081,"journal":{"name":"Life Science Alliance","volume":"9 7","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147816596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0