Life Science Alliance最新文献_第2页

K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors 与 K48 和 K63 链接的泛素链相互作用组揭示了分支和长度特异性泛素相互作用因子

IF 4.4 2区生物学

Life Science Alliance Pub Date : 2024-05-21 DOI: 10.26508/lsa.202402740

Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Phillip Mertins, Thomas Sommer

引用次数: 0

Dual neutrophil subsets exacerbate or suppress inflammation in tuberculosis via IL-1β or PD-L1 双中性粒细胞亚群通过 IL-1β 或 PD-L1 加重或抑制结核病的炎症反应

IF 4.4 2区生物学

Life Science Alliance Pub Date : 2024-05-21 DOI: 10.26508/lsa.202402623

Emilie Doz-Deblauwe, Badreddine Bounab, F. Carreras, J. Fahel, Sergio C. Oliveira, Mohamed Lamkanfi, Y. Le Vern, P. Germon, Julien Pichon, Florent Kempf, Christophe Paget, Aude Rémot, Nathalie Winter

引用次数: 0

NFAT activation by FKBP52 promotes cancer cell proliferation by suppressing p53 FKBP52 激活的 NFAT 通过抑制 p53 促进癌细胞增殖

IF 4.4 2区生物学

Life Science Alliance Pub Date : 2024-05-21 DOI: 10.26508/lsa.202302426

Shunsuke Hanaki, M. Habara, Haruki Tomiyasu, Yuki Sato, Yosei Miki, T. Masaki, Shusaku Shibutani, M. Shimada

引用次数: 0

Ribosome rescue factor PELOTA modulates translation start site choice for C/EBPα protein isoforms 核糖体拯救因子 PELOTA 可调节 C/EBPα 蛋白同工酶翻译起始位点的选择

IF 4.4 2区生物学

Life Science Alliance Pub Date : 2024-05-21 DOI: 10.26508/lsa.202302501

Samantha G. Fernandez, Lucas Ferguson, Nicholas T. Ingolia

引用次数: 0

Correction: Porphyrin overdrive rewires cancer cell metabolism 更正：卟啉过度驱动重塑癌细胞新陈代谢

IF 4.4 2区生物学

Life Science Alliance Pub Date : 2024-05-20 DOI: 10.26508/lsa.202402816

S. Adapa, Gregory A Hunter, Narmin E. Amin, Christopher Marinescu, Andrew Borsky, Elizabeth M Sagatys, Said M. Sebti, Gary W. Reuther, Gloria C Ferreira, R. H. Jiang

引用次数: 0

Full-length MSP1 is a major target of protective immunity after controlled human malaria infection 全长 MSP1 是控制人类疟疾感染后保护性免疫的主要靶标

IF 4.4 2区生物学

Life Science Alliance Pub Date : 2024-05-20 DOI: 10.26508/lsa.202301910

M. Rosenkranz, I. Nkumama, Rodney Ogwang, Sara Kraker, Marie Blickling, K. Mwai, Dennis O. Odera, J. Tuju, Kristin Fürle, R. Frank, Emily Chepsat, M. Kapulu, CHMI-SIKA Study Team, F. Osier

引用次数: 0

DNA-binding site II is required for RAD51 recombinogenic activity in Arabidopsis thaliana 拟南芥的 RAD51 重组活性需要 DNA 结合位点 II

IF 4.4 2区生物学

Life Science Alliance Pub Date : 2024-05-20 DOI: 10.26508/lsa.202402701

Valentine Petiot, Charles White, O. Da Ines

引用次数: 0

Glycolic acid and D-lactate-putative products of DJ-1-restore neurodegeneration in FUS - and SOD1-ALS. 甘醇酸和D-乳酸--DJ-1的潜在产物--可恢复FUS-ALS和SOD1-ALS的神经退行性变。

IF 3.3 2区生物学

Life Science Alliance Pub Date : 2024-05-17 Print Date: 2024-08-01 DOI: 10.26508/lsa.202302535

Arun Pal, Dajana Grossmann, Hannes Glaß, Vitaly Zimyanin, René Günther, Marica Catinozzi, Tobias M Boeckers, Jared Sterneckert, Erik Storkebaum, Susanne Petri, Florian Wegner, Stephan W Grill, Francisco Pan-Montojo, Andreas Hermann

{"title":"Glycolic acid and D-lactate-putative products of DJ-1-restore neurodegeneration in FUS - and SOD1-ALS.","authors":"Arun Pal, Dajana Grossmann, Hannes Glaß, Vitaly Zimyanin, René Günther, Marica Catinozzi, Tobias M Boeckers, Jared Sterneckert, Erik Storkebaum, Susanne Petri, Florian Wegner, Stephan W Grill, Francisco Pan-Montojo, Andreas Hermann","doi":"10.26508/lsa.202302535","DOIUrl":"10.26508/lsa.202302535","url":null,"abstract":"Amyotrophic lateral sclerosis (ALS) leads to death within 2-5 yr. Currently, available drugs only slightly prolong survival. We present novel insights into the pathophysiology of Superoxide Dismutase 1 (SOD1)- and in particular Fused In Sarcoma (FUS)-ALS by revealing a supposedly central role of glycolic acid (GA) and D-lactic acid (DL)-both putative products of the Parkinson's disease associated glyoxylase DJ-1. Combined, not single, treatment with GA/DL restored axonal organelle phenotypes of mitochondria and lysosomes in FUS- and SOD1-ALS patient-derived motoneurons (MNs). This was not only accompanied by restoration of mitochondrial membrane potential but even dependent on it. Despite presenting an axonal transport deficiency as well, TDP43 patient-derived MNs did not share mitochondrial depolarization and did not respond to GA/DL treatment. GA and DL also restored cytoplasmic mislocalization of FUS and FUS recruitment to DNA damage sites, recently reported being upstream of the mitochondrial phenotypes in FUS-ALS. Whereas these data point towards the necessity of individualized (gene-) specific therapy stratification, it also suggests common therapeutic targets across different neurodegenerative diseases characterized by mitochondrial depolarization.","PeriodicalId":18081,"journal":{"name":"Life Science Alliance","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11101837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140958253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The F-actin bundler SWAP-70 promotes tumor metastasis. F-actin bundler SWAP-70 促进肿瘤转移。

IF 3.3 2区生物学

Life Science Alliance Pub Date : 2024-05-17 Print Date: 2024-08-01 DOI: 10.26508/lsa.202302307

Chao-Yuan Chang, Glen Pearce, Viktoria Betaneli, Tatsiana Kapustsenka, Kamran Hosseini, Elisabeth Fischer-Friedrich, Denis Corbeil, Jana Karbanová, Anna Taubenberger, Björn Dahncke, Martina Rauner, Giulia Furesi, Sven Perner, Fabian Rost, Rolf Jessberger

{"title":"The F-actin bundler SWAP-70 promotes tumor metastasis.","authors":"Chao-Yuan Chang, Glen Pearce, Viktoria Betaneli, Tatsiana Kapustsenka, Kamran Hosseini, Elisabeth Fischer-Friedrich, Denis Corbeil, Jana Karbanová, Anna Taubenberger, Björn Dahncke, Martina Rauner, Giulia Furesi, Sven Perner, Fabian Rost, Rolf Jessberger","doi":"10.26508/lsa.202302307","DOIUrl":"10.26508/lsa.202302307","url":null,"abstract":"Dynamic rearrangements of the F-actin cytoskeleton are a hallmark of tumor metastasis. Thus, proteins that govern F-actin rearrangements are of major interest for understanding metastasis and potential therapies. We hypothesized that the unique F-actin binding and bundling protein SWAP-70 contributes importantly to metastasis. Orthotopic, ectopic, and short-term tail vein injection mouse breast and lung cancer models revealed a strong positive dependence of lung and bone metastasis on SWAP-70. Breast cancer cell growth, migration, adhesion, and invasion assays revealed SWAP-70's key role in these metastasis-related cell features and the requirement for SWAP-70 to bind F-actin. Biophysical experiments showed that tumor cell stiffness and deformability are negatively modulated by SWAP-70. Together, we present a hitherto undescribed, unique F-actin modulator as an important contributor to tumor metastasis.","PeriodicalId":18081,"journal":{"name":"Life Science Alliance","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11101836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140958256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reversal of high-glucose-induced transcriptional and epigenetic memories through NRF2 pathway activation. 通过激活 NRF2 通路逆转高葡萄糖诱导的转录和表观遗传记忆。

IF 3.3 2区生物学

Life Science Alliance Pub Date : 2024-05-16 Print Date: 2024-08-01 DOI: 10.26508/lsa.202302382

Martí Wilson-Verdugo, Brandon Bustos-García, Olga Adame-Guerrero, Jaqueline Hersch-González, Nallely Cano-Domínguez, Maribel Soto-Nava, Carlos A Acosta, Teresa Tusie-Luna, Santiago Avila-Rios, Lilia G Noriega, Victor J Valdes

{"title":"Reversal of high-glucose-induced transcriptional and epigenetic memories through NRF2 pathway activation.","authors":"Martí Wilson-Verdugo, Brandon Bustos-García, Olga Adame-Guerrero, Jaqueline Hersch-González, Nallely Cano-Domínguez, Maribel Soto-Nava, Carlos A Acosta, Teresa Tusie-Luna, Santiago Avila-Rios, Lilia G Noriega, Victor J Valdes","doi":"10.26508/lsa.202302382","DOIUrl":"10.26508/lsa.202302382","url":null,"abstract":"Diabetes complications such as nephropathy, retinopathy, or cardiovascular disease arise from vascular dysfunction. In this context, it has been observed that past hyperglycemic events can induce long-lasting alterations, a phenomenon termed \"metabolic memory.\" In this study, we evaluated the genome-wide gene expression and chromatin accessibility alterations caused by transient high-glucose exposure in human endothelial cells (ECs) in vitro. We found that cells exposed to high glucose exhibited substantial gene expression changes in pathways known to be impaired in diabetes, many of which persist after glucose normalization. Chromatin accessibility analysis also revealed that transient hyperglycemia induces persistent alterations, mainly in non-promoter regions identified as enhancers with neighboring genes showing lasting alterations. Notably, activation of the NRF2 pathway through NRF2 overexpression or supplementation with the plant-derived compound sulforaphane, effectively reverses the glucose-induced transcriptional and chromatin accessibility memories in ECs. These findings underscore the enduring impact of transient hyperglycemia on ECs' transcriptomic and chromatin accessibility profiles, emphasizing the potential utility of pharmacological NRF2 pathway activation in mitigating and reversing the high-glucose-induced transcriptional and epigenetic alterations.","PeriodicalId":18081,"journal":{"name":"Life Science Alliance","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11099870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140958254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0