Unraveling ADHD: genes, co-occurring traits, and developmental dynamics.

IF 3.3 2区 生物学 Q1 BIOLOGY
Life Science Alliance Pub Date : 2025-02-25 Print Date: 2025-05-01 DOI:10.26508/lsa.202403029
Catriona J Miller, Evgeniia Golovina, Sreemol Gokuladhas, Joerg S Wicker, Jessie C Jacobsen, Justin M O'Sullivan
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引用次数: 0

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a heterogeneous neurodevelopmental condition with a high prevalence of co-occurring conditions, contributing to increased difficulty in long-term management. Genome-wide association studies have identified variants shared between ADHD and co-occurring psychiatric disorders; however, the genetic mechanisms are not fully understood. We integrated gene expression and spatial organization data into a two-sample Mendelian randomization study for putatively causal ADHD genes in fetal and adult cortical tissues. We identified four genes putatively causal for ADHD in cortical tissues (fetal: ST3GAL3, PTPRF, PIDD1; adult: ST3GAL3, TIE1). Protein-protein interaction databases seeded with the causal ADHD genes identified biological pathways linking these genes with conditions (e.g., rheumatoid arthritis) and biomarkers (e.g., lymphocyte counts) known to be associated with ADHD, but without previously shown genetic relationships. The analysis was repeated on adult liver tissue, where putatively causal ADHD gene ST3GAL3 was linked to cholesterol traits. This analysis provides insight into the tissue-dependent temporal relationships between ADHD, co-occurring traits, and biomarkers. Importantly, it delivers evidence for the genetic interplay between co-occurring conditions, both previously studied and unstudied, with ADHD.

揭示多动症:基因,共同发生的特征,和发展动态。
注意缺陷/多动障碍(ADHD)是一种异质神经发育疾病,具有高发的共同发病条件,增加了长期治疗的难度。全基因组关联研究已经确定了ADHD和并发精神疾病之间共有的变异;然而,遗传机制尚不完全清楚。我们将基因表达和空间组织数据整合到一项双样本孟德尔随机研究中,以研究胎儿和成人皮质组织中可能引起ADHD的基因。我们在皮质组织中发现了四种被认为是ADHD病因的基因(胎儿:ST3GAL3、PTPRF、PIDD1;成人:ST3GAL3, TIE1)。带有ADHD致病基因的蛋白质-蛋白质相互作用数据库确定了将这些基因与已知与ADHD相关的疾病(例如,类风湿关节炎)和生物标志物(例如,淋巴细胞计数)联系起来的生物学途径,但之前没有显示出遗传关系。该分析在成人肝组织中重复进行,其中假定的ADHD致病基因ST3GAL3与胆固醇特征有关。该分析提供了对ADHD、共同发生的特征和生物标志物之间的组织依赖的时间关系的见解。重要的是,它提供了证据,证明了共同发生的条件之间的遗传相互作用,包括以前研究过的和未研究过的,多动症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Life Science Alliance
Life Science Alliance Agricultural and Biological Sciences-Plant Science
CiteScore
5.80
自引率
2.30%
发文量
241
审稿时长
10 weeks
期刊介绍: Life Science Alliance is a global, open-access, editorially independent, and peer-reviewed journal launched by an alliance of EMBO Press, Rockefeller University Press, and Cold Spring Harbor Laboratory Press. Life Science Alliance is committed to rapid, fair, and transparent publication of valuable research from across all areas in the life sciences.
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