Macromolecular Chemistry and Physics最新文献_第3页

End-Group-Dependent Host–Guest Complexation of Poly(2-ethyl-2-oxazoline) with β-Cyclodextrin 聚（2-乙基-2-恶唑啉）与β-环糊精的端基依赖主客体络合

IF 2.7 4区化学

Macromolecular Chemistry and Physics Pub Date : 2026-03-17 DOI: 10.1002/macp.202500369

Sema Karslioglu

{"title":"End-Group-Dependent Host–Guest Complexation of Poly(2-ethyl-2-oxazoline) with β-Cyclodextrin","authors":"Sema Karslioglu","doi":"10.1002/macp.202500369","DOIUrl":"https://doi.org/10.1002/macp.202500369","url":null,"abstract":"<div>\u0000 \u0000 <p>Poly(2-ethyl-2-oxazoline) (PEtOx) represents a versatile platform for developing supramolecular polymer systems. In this study, propargyl-terminated PEtOx was synthesized via cationic ring-opening polymerization and subsequently functionalized at the γ-chain end with either adamantane or phenyl groups using thiol–yne click chemistry. Monoazide-functionalized β-cyclodextrin (β-CD-N<sub>3</sub>) was then covalently conjugated to these polymers through Cu(I)-catalyzed azide–alkyne cycloaddition. Comprehensive characterization by 1H NMR, NOESY NMR, FTIR, GPC, and MALDI-TOF MS confirmed successful synthesis and precise end-group modifications. Notably, 2D NOESY NMR spectroscopy provided direct evidence of supramolecular host–guest interactions between the adamantane moiety and the β-CD cavity in the P1/CD conjugate, while no significant inclusion complexation was observed for the phenyl-terminated counterpart (P2/CD), highlighting the critical influence of end-group identity on supramolecular complexation behavior in PEtOx-based systems. Overall, this work introduces a versatile strategy for designing supramolecular polymer architectures through end-group engineering and cyclodextrin conjugation, offering new perspectives for advanced functional materials with tunable self-assembly properties.</p>\u0000 </div>","PeriodicalId":18054,"journal":{"name":"Macromolecular Chemistry and Physics","volume":"227 6","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147566394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Ball-Milled Carbon Black Composite Ink Based on Chlorinated Polypropylene-Lauric Acid System and Its Positive Temperature Coefficient Characteristics 氯化聚丙烯-月桂酸体系球磨炭黑复合油墨及其正温度系数特性

IF 2.7 4区化学

Macromolecular Chemistry and Physics Pub Date : 2026-03-17 DOI: 10.1002/macp.202500483

Zhen Cheng, Zhichao Zhang, Shengfei Hu, Qingting Liu, Xudong Fu, Rong Zhang

{"title":"Ball-Milled Carbon Black Composite Ink Based on Chlorinated Polypropylene-Lauric Acid System and Its Positive Temperature Coefficient Characteristics","authors":"Zhen Cheng, Zhichao Zhang, Shengfei Hu, Qingting Liu, Xudong Fu, Rong Zhang","doi":"10.1002/macp.202500483","DOIUrl":"https://doi.org/10.1002/macp.202500483","url":null,"abstract":"<div>\u0000 \u0000 <p>Effective thermal management is crucial for flexible wearable electronics. This study presents a high-performance Positive Temperature Coefficient (PTC) conductive ink using a chlorinated polypropylene (CPP)/lauric acid (LA) matrix and oxidized carbon black (OCB). Spectroscopic analyses (x-ray photoelectron spectroscopy/fourier-transform infrared spectroscopy) confirm that hydrogen bonding between oxidized fillers and the matrix optimizes dispersion, synergizing with the sharp solid–liquid phase transition of LA (∼43°C) to trigger rapid resistance changes. Crucially, rheological tests reveal significant shear-thinning behavior, establishing superior screen-printing adaptability for flexible substrates. The ink exhibits a PTC intensity spanning three orders of magnitude with reproducible stability over nine thermal cycles. A wearable knee pad prototype successfully demonstrated autonomous overheating protection, highlighting the material's potential for safe, smart clothing and biomedical applications.</p>\u0000 </div>","PeriodicalId":18054,"journal":{"name":"Macromolecular Chemistry and Physics","volume":"227 6","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147566603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Issue Information: Macromol. Chem. Phys. 6/2026 发布信息：Macromol。化学。理论物理的6/2026

IF 2.7 4区化学

Macromolecular Chemistry and Physics Pub Date : 2026-03-17 DOI: 10.1002/macp.70244

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Amine-Functionalized Amphiphilic Polyester-Based Nanocarriers for Drug Delivery and Mitochondria Targeting in Cancer Cells 基于胺功能化两亲性聚酯的纳米载体在肿瘤细胞中的药物传递和线粒体靶向

IF 2.7 4区化学

Macromolecular Chemistry and Physics Pub Date : 2026-03-17 DOI: 10.1002/macp.202600001

Ankita Banerjee, Subhendu Biswas, Anindita Das

{"title":"Amine-Functionalized Amphiphilic Polyester-Based Nanocarriers for Drug Delivery and Mitochondria Targeting in Cancer Cells","authors":"Ankita Banerjee, Subhendu Biswas, Anindita Das","doi":"10.1002/macp.202600001","DOIUrl":"https://doi.org/10.1002/macp.202600001","url":null,"abstract":"<div>\u0000 \u0000 <p>Cationic polymeric nanoaggregates having widespread applications in the biological domain majorly suffer from their non-degradable nature, leading to cytotoxicity and bioaccumulation. Herein, we have synthesized an amphiphilic polyester, <b>P1</b> through a facile condensation polymerization reaction between an activated pentafluorophenyl diester, <b>A1</b> with three different functionalized diols, <b>B1</b>, <b>B2</b>, and <b>B3</b>, where <b>B1</b> is a biotin-functionalized diol that imparts selectivity toward cancerous cells, while <b>B2</b> is a naphthalene monoimide moiety that induces fluorescent property to <b>P1</b>, and <b>B3</b> is a tertiary amine-functionalized PEGylated diol featuring pH-induced charge modulation property. <b>P1</b> is capable of forming neutral micellar nanoaggregates in aqueous medium under physiological conditions and can acquire a positive surface-charge by virtue of the quaternization of the amine group at mildly acidic pH, mimicking the cancerous extracellular microenvironment. These biotin-functionalized nanoaggregates are nontoxic and exhibit higher cellular uptake in cancerous HeLa cells compared to the non-cancerous NIH 3T3 cells. The acquired surface charge in cancerous microenvironment enabled higher cellular uptake of <b>P1</b> nanoaggregates along with mitochondria-targeting ability, driven by the mitochondrial negative membrane potential. Additionally, the hydrophobic nature of the nanoaggregate core allowed encapsulation of the chemotherapeutic drug doxorubicin for their successful intracellular delivery upon the degradation of the polyester linkages.</p>\u0000 </div>","PeriodicalId":18054,"journal":{"name":"Macromolecular Chemistry and Physics","volume":"227 6","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147566601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Tough PVA/Cellulose Gels Constructed by Synergistic Freeze-Thaw, Drying, and Solvent Exchange Strategy 通过协同冻融、干燥和溶剂交换策略构建坚韧的PVA/纤维素凝胶

IF 2.7 4区化学

Macromolecular Chemistry and Physics Pub Date : 2026-03-17 DOI: 10.1002/macp.70237

Miaoqian Zhang, Ang Lu

{"title":"Tough PVA/Cellulose Gels Constructed by Synergistic Freeze-Thaw, Drying, and Solvent Exchange Strategy","authors":"Miaoqian Zhang, Ang Lu","doi":"10.1002/macp.70237","DOIUrl":"https://doi.org/10.1002/macp.70237","url":null,"abstract":"<div>\u0000 \u0000 <p>To address the insufficient mechanical properties of poly(vinyl alcohol) (PVA) gels, this study designed a synergistic strategy combining multiple freeze-thaw cycles, drying densification, and solvent exchange. By introducing cellulose as a rigid reinforcing phase, a PVA/cellulose composite gel with enhanced mechanical properties was prepared. First, freeze-thaw cycling induces microcrystalline crosslinking in PVA and concurrently promotes a hydrogen-bonding network between cellulose and PVA chains. Subsequently, drying removes free water, driving the polymer chains into close packing and significantly increasing network density and crystallinity. Finally, solvent exchange with a glycerol aqueous solution is performed, in which glycerol molecules form hydrogen bonds with the gel network, effectively inhibiting water-induced swelling disruption and stabilizing the dense structure formed after drying. The resulting gel exhibits excellent mechanical properties, with a tensile strength of 2.82 MPa and a fracture strain of 698%. Further annealing treatment leads to additional improvement in performance, increasing the strength to 3.98 MPa and the strain to 764%. This study provides an effective and scalable strategy for fabricating high-performance PVA-based composite gels through component reinforcement and the design of physically crosslinked networks.</p>\u0000 </div>","PeriodicalId":18054,"journal":{"name":"Macromolecular Chemistry and Physics","volume":"227 6","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147566596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Front Cover: Polymeric Delivery of DNA-Encoded Biologics 封面：dna编码生物制剂的聚合传递

IF 2.7 4区化学

Macromolecular Chemistry and Physics Pub Date : 2026-03-12 DOI: 10.1002/macp.70235

Jeffrey M. Ting, Peter A. Dykeman-Bermingham, Caroline E. Cairns, Shannon R. Petersen, Nathaniel J. Snell, Rakshitha Pandulal Miskin, John D. Fisher, Shashi K. Murthy, Sean H. Kevlahan, Gustavo Guzman, Thomas X. Neenan

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Front Cover: Polymeric Delivery of DNA-Encoded Biologics 封面：dna编码生物制剂的聚合传递

IF 2.7 4区化学

Macromolecular Chemistry and Physics Pub Date : 2026-03-12 DOI: 10.1002/macp.70235

Jeffrey M. Ting, Peter A. Dykeman-Bermingham, Caroline E. Cairns, Shannon R. Petersen, Nathaniel J. Snell, Rakshitha Pandulal Miskin, John D. Fisher, Shashi K. Murthy, Sean H. Kevlahan, Gustavo Guzman, Thomas X. Neenan

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Charge Regulation and Swelling of Weak Polyelectrolyte Nanogels in Divalent Salt Solutions 弱聚电解质纳米凝胶在二价盐溶液中的电荷调节和膨胀

IF 2.7 4区化学

Macromolecular Chemistry and Physics Pub Date : 2026-03-12 DOI: 10.1002/macp.202500476

David Beyer, Christian Holm

{"title":"Charge Regulation and Swelling of Weak Polyelectrolyte Nanogels in Divalent Salt Solutions","authors":"David Beyer, Christian Holm","doi":"10.1002/macp.202500476","DOIUrl":"https://doi.org/10.1002/macp.202500476","url":null,"abstract":"<p>We use computer simulations to investigate the behavior of a weak polyelectrolyte nanogel in a solution containing divalent salt. In our simulations, we systematically vary the bulk pH value and the bulk concentration of divalent salt, allowing us to study the influence of charge regulation and divalent ions on the ionization behavior, ion partitioning, and nanogel swelling. With regard to the ionization behavior, we observe that, with an increasing concentration of divalent salt, the suppression of ionization becomes weaker. Moreover, we find that the strongly non-uniform ionization profile observed in the absence of divalent counterions becomes increasingly uniform as the concentration of divalent salt is increased. We also study the partitioning of monovalent and divalent counterions between the nanogel and the bulk solution; our analysis shows that the uptake of divalent ions may be enhanced by up to tenfold as compared to the mean-field prediction. Finally, we consider the influence of divalent ions on the pH-dependent swelling behavior of the nanogel. Here, we observe a two-stage swelling driven by charge regulation and ion partitioning. Overall, our results highlight the complex interplay of ionization equilibria, valency effects, and ion partitioning in weak polyelectrolyte systems.</p>","PeriodicalId":18054,"journal":{"name":"Macromolecular Chemistry and Physics","volume":"227 5","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/macp.202500476","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147565543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Charge Regulation and Swelling of Weak Polyelectrolyte Nanogels in Divalent Salt Solutions 弱聚电解质纳米凝胶在二价盐溶液中的电荷调节和膨胀

IF 2.7 4区化学

Macromolecular Chemistry and Physics Pub Date : 2026-03-12 DOI: 10.1002/macp.202500476

David Beyer, Christian Holm

{"title":"Charge Regulation and Swelling of Weak Polyelectrolyte Nanogels in Divalent Salt Solutions","authors":"David Beyer, Christian Holm","doi":"10.1002/macp.202500476","DOIUrl":"https://doi.org/10.1002/macp.202500476","url":null,"abstract":"<p>We use computer simulations to investigate the behavior of a weak polyelectrolyte nanogel in a solution containing divalent salt. In our simulations, we systematically vary the bulk pH value and the bulk concentration of divalent salt, allowing us to study the influence of charge regulation and divalent ions on the ionization behavior, ion partitioning, and nanogel swelling. With regard to the ionization behavior, we observe that, with an increasing concentration of divalent salt, the suppression of ionization becomes weaker. Moreover, we find that the strongly non-uniform ionization profile observed in the absence of divalent counterions becomes increasingly uniform as the concentration of divalent salt is increased. We also study the partitioning of monovalent and divalent counterions between the nanogel and the bulk solution; our analysis shows that the uptake of divalent ions may be enhanced by up to tenfold as compared to the mean-field prediction. Finally, we consider the influence of divalent ions on the pH-dependent swelling behavior of the nanogel. Here, we observe a two-stage swelling driven by charge regulation and ion partitioning. Overall, our results highlight the complex interplay of ionization equilibria, valency effects, and ion partitioning in weak polyelectrolyte systems.</p>","PeriodicalId":18054,"journal":{"name":"Macromolecular Chemistry and Physics","volume":"227 5","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/macp.202500476","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147565272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strain-Induced Morphological Transitions in Model Amphiphilic Polymer Conetwork Bulk Melts: A Computational Study 模型两亲聚合物网络体熔体中应变诱导的形态转变：计算研究

IF 2.7 4区化学

Macromolecular Chemistry and Physics Pub Date : 2026-03-12 DOI: 10.1002/macp.202500356

Konstantinos Andronikou, Costas S. Patrickios

{"title":"Strain-Induced Morphological Transitions in Model Amphiphilic Polymer Conetwork Bulk Melts: A Computational Study","authors":"Konstantinos Andronikou, Costas S. Patrickios","doi":"10.1002/macp.202500356","DOIUrl":"https://doi.org/10.1002/macp.202500356","url":null,"abstract":"<p>We present a Flory-Huggins-based computational model to predict morphological transitions in amphiphilic polymer conetwork (APCN) bulk melts, imparted by externally-imposed tensile and compressive deformations. We observe primarily that APCN extension favors the formation of / transformation into normal lamellae (lamellae oriented perpendicularly to the direction of the applied external force), whereas APCN compression leads to (parallel) cylinder (cylinders whose axis coincides with the direction of applied force) formation. These changes are due to the fact that the interfacial area is reduced when a normal lamella is extended and when a (parallel) cylinder is compressed. The main results of this study are summarized in a morphology phase diagram with axes the deformation ratio and polymer composition, which shows that normal lamellae dominate for most polymer compositions, provided that the tensile deformation ratio is higher than 1–2. The diagram also shows that cylinders dominate for almost all polymer compositions when the compressive deformation ratio is between 0.1–0.9. Two morphologies appear as intermediate states under deformation: the spheroidal morphology (appearing at relatively extreme polymer compositions) and the parallel lamellae (appearing at balanced compositions), with the latter indicating the preference for lamellae, either normal or parallel, close to the balanced polymer composition.</p>","PeriodicalId":18054,"journal":{"name":"Macromolecular Chemistry and Physics","volume":"227 5","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/macp.202500356","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147565458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0