Macromolecular Chemistry and Physics最新文献_第2页

Hydrophilic Cyclic Poly(oxa)Norbornene Platforms via Ring-Expansion Metathesis Polymerization (REMP) for Lectin Binding Inhibition 通过环扩张复分解聚合（REMP）抑制凝集素结合的亲水环聚降冰片烯平台

IF 2.8 4区化学

Macromolecular Chemistry and Physics Pub Date : 2026-09-17 DOI: 10.1002/macp.70337

Clément Gonnot, Mathieu Scalabrini, Benoit Roubinet, Fabien Boeda, David Deniaud, Ludovic Landemarre, Sébastien G. Gouin, Laurent Fontaine, Véronique Montembault

{"title":"Hydrophilic Cyclic Poly(oxa)Norbornene Platforms via Ring-Expansion Metathesis Polymerization (REMP) for Lectin Binding Inhibition","authors":"Clément Gonnot, Mathieu Scalabrini, Benoit Roubinet, Fabien Boeda, David Deniaud, Ludovic Landemarre, Sébastien G. Gouin, Laurent Fontaine, Véronique Montembault","doi":"10.1002/macp.70337","DOIUrl":"https://doi.org/10.1002/macp.70337","url":null,"abstract":"<div>\u0000 \u0000 This study presents the synthesis of cyclic poly(oxanorbornenyl azlactone) (c-PONBSAzl) and poly(norbornenyl azlactone) (c-PNBSAzl) via ring-expansion metathesis polymerization (REMP). These polymers differ by a single oxygen-for-carbon substitution in the backbone, offering a unique platform to investigate how this structural variation influences REMP kinetics, solubility, and lectin-binding properties. Reactivity studies revealed distinct polymerization behaviors, underscoring the significant impact of the oxanorbornene backbone on REMP efficiency. Subsequent post-polymerization modification (PPM) by aminolysis with heptyl mannose yielded cyclic glycopolymers with a number-average degree of polymerization (DPn) ≈ 140. In aqueous solution, both cyclic architectures showed excellent solubility, with the oxanorbornene backbones demonstrating higher local mobility and reduced intermolecular association. Binding assays were performed against five therapeutically relevant mannose-binding lectins (FimH, Bc2L-A, ConA, DC-SIGN, and Langerin). Notably, the increased local mobility imparted by the oxanorbornene backbone did not translate into a measurable enhancement in lectin inhibition relative to the norbornene analogue. Instead, both cyclic architectures exhibited strong multivalent interactions and achieved nanomolar-range inhibition against both lectins. These results reinforce cyclic glycopolymers as potent multivalent lectin binders and broaden their structural and functional scope, establishing them as promising platforms for hydrophilic glycomaterial design.\u0000 </div>","PeriodicalId":18054,"journal":{"name":"Macromolecular Chemistry and Physics","volume":"227 18","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148981476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Co-Localized Multimodal Imaging of Polymer Ring-Banded Spherulites Using an AFM-Raman System 基于AFM-Raman系统的聚合物环状球粒共定域多模态成像

IF 2.8 4区化学

Macromolecular Chemistry and Physics Pub Date : 2026-09-17 DOI: 10.1002/macp.70341

Yasushi Maeda, Koichi Matsuo, Atsushi Matsumoto, Shinji Sugihara

{"title":"Co-Localized Multimodal Imaging of Polymer Ring-Banded Spherulites Using an AFM-Raman System","authors":"Yasushi Maeda, Koichi Matsuo, Atsushi Matsumoto, Shinji Sugihara","doi":"10.1002/macp.70341","DOIUrl":"https://doi.org/10.1002/macp.70341","url":null,"abstract":"This study investigated the mesoscopic structures and properties of ring-banded spherulites (RBS) in crystalline polymers using a newly developed atomic force microscopy (AFM)-Raman spectrometer capable of co-localized multimodal imaging. Using poly(ethylene adipate) (PEA) as a model system, we integrated polarized optical microscopy (POM), AFM, and polarized Raman spectroscopy to achieve a deep understanding of how lamellar arrangements affect mesoscopic morphologies. The AFM height profiles revealed rhythmic variations that correlated with the optical patterns observed in POM. Furthermore, polarized Raman mapping exhibited distinct mode-dependent intensity distributions, such as bowtie and concentric ring patterns. By comparing these experimental results with theoretical estimates, we evaluated three rotation models for the lamellar structure. Our findings support the helicoidal twisting model, confirming that ring banding in PEA originates from the continuous twisting of lamellae around the radial growth axis. This multimodal approach provides a powerful tool for resolving long-standing debates regarding polymer hierarchical structures.","PeriodicalId":18054,"journal":{"name":"Macromolecular Chemistry and Physics","volume":"227 18","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/macp.70341","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148981478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Imaging Studies of Temperature-Dependent Photodegradation and Self-Healing in Air Force 455 Dye-Doped PMMA 空军455染料掺杂PMMA的温度依赖性光降解和自修复成像研究

IF 2.8 4区化学

Macromolecular Chemistry and Physics Pub Date : 2026-09-17 DOI: 10.1002/macp.70335

Benjamin R. Anderson, Sheng-Ting Hung, Mark G. Kuzyk

引用次数: 0

Issue Information: Macromol. Chem. Phys. 18/2026 发布信息：Macromol。化学。理论物理的18/2026

IF 2.8 4区化学

Macromolecular Chemistry and Physics Pub Date : 2026-09-17 DOI: 10.1002/macp.70342

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New Insights Into Bonding Within Chalcogen-Rich Polymers via Temperature-Dependent Solid-State NMR 通过依赖温度的固态核磁共振对富硫聚合物内键合的新见解

IF 2.8 4区化学

Macromolecular Chemistry and Physics Pub Date : 2026-09-17 DOI: 10.1002/macp.70339

Christopher A. Klug, Vinh Q. Nguyen, Joel B. Miller, Igor V. Schweigert, Mark O. Bovee, Nishani K. Jayakody, Cynthia G. Pyles, Collin C. McClain, Daniel J. Gibson, Woohong Kim, Jasbinder S. Sanghera, Darryl A. Boyd

{"title":"New Insights Into Bonding Within Chalcogen-Rich Polymers via Temperature-Dependent Solid-State NMR","authors":"Christopher A. Klug, Vinh Q. Nguyen, Joel B. Miller, Igor V. Schweigert, Mark O. Bovee, Nishani K. Jayakody, Cynthia G. Pyles, Collin C. McClain, Daniel J. Gibson, Woohong Kim, Jasbinder S. Sanghera, Darryl A. Boyd","doi":"10.1002/macp.70339","DOIUrl":"https://doi.org/10.1002/macp.70339","url":null,"abstract":"<div>\u0000 \u0000 Inverse vulcanization (InV) is a process in which sulfur-rich polymers can be synthesized by combining elemental sulfur (or sulfur/selenium blended compounds) with reactive comonomers. The resulting materials possess properties that are beneficial in several materials science-based applications, including infrared optics and rechargeable battery technology. Bonding within polymers synthesized via InV has been the subject of much discussion within this young field, with recent conclusions on the molecular bonding diverging dramatically from those initially proposed. For this present study, the comonomer 1,3-diisopropenyl benzene (DIB) was combined with chalcogen counterparts via InV to form organically modified chalcogenide (ORMOCHALC) polymers. Solid-state NMR spectroscopy of the resulting sulfur-rich and sulfur/selenium-rich polymers was used as a tool to assess the bonding within these types of polymers, and to determine whether the incorporation of selenium into the polymer backbone has an impact on the bonding. The bonding was further assessed using computational analysis and Raman spectroscopy. The results indicated that a single crosslinking molecule of DIB likely binds four sulfurs simultaneously, and that although selenium-carbon bonds may be possible, selenium likely did not directly bind to the DIB crosslinker when it was included in the polymer backbone chain for the polymers investigated in this study.\u0000 </div>","PeriodicalId":18054,"journal":{"name":"Macromolecular Chemistry and Physics","volume":"227 18","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148981477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Tuning the Properties of Wet-Spun SA/GelMA Fiber-Like Microgels Through Processing and Polymer Composition 通过加工和聚合物组成调整湿纺SA/GelMA类纤维微凝胶的性能

IF 2.8 4区化学

Macromolecular Chemistry and Physics Pub Date : 2026-09-12 DOI: 10.1002/macp.70336

Keerthi Subramanian Iyer, Jiao Jiao Li, Chaitali Dekiwadia, Lei Bao, Jiali Zhai, Haiyan Li

{"title":"Tuning the Properties of Wet-Spun SA/GelMA Fiber-Like Microgels Through Processing and Polymer Composition","authors":"Keerthi Subramanian Iyer, Jiao Jiao Li, Chaitali Dekiwadia, Lei Bao, Jiali Zhai, Haiyan Li","doi":"10.1002/macp.70336","DOIUrl":"https://doi.org/10.1002/macp.70336","url":null,"abstract":"Microgels offer modular building blocks for injectable and biofabricated materials, yet tuning their geometry and internal physicochemical properties remains challenging, particularly for anisotropic architectures. Here, we investigate a wet-spinning strategy for fabricating fiber-like sodium alginate/gelatin methacryloyl (SA/GelMA) microgels and systematically examine the respective contributions of processing conditions and polymer composition to their structural and rheological properties. Variation of needle size and extrusion flow rate showed that macroscopic fiber geometry was governed predominantly by hydrodynamic processing conditions, with smaller needle diameters and higher flow rates producing thinner fibers. In contrast, polymer composition exerted a stronger influence on internal microporous structure and rheological behavior, with increasing SA content generally promoting denser microstructures and more elastic, shear-thinning responses. Needle size also introduced secondary effects on microstructure and rheology, indicating that processing and material parameters are not completely independent but contribute differently to the resulting properties. These findings provide practical guidance for tuning the geometry, internal architecture, and bulk rheological behavior of anisotropic SA/GelMA hydrogel microstructures through processing and polymer composition, supporting their subsequent use in granular hydrogel and biofabrication systems.","PeriodicalId":18054,"journal":{"name":"Macromolecular Chemistry and Physics","volume":"227 17","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/macp.70336","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148942850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Issue Information: Macromol. Chem. Phys. 17/2026 发布信息：Macromol。化学。理论物理的17/2026

IF 2.8 4区化学

Macromolecular Chemistry and Physics Pub Date : 2026-09-04 DOI: 10.1002/macp.70334

引用次数: 0

Toward the Synthesis of Nanoparticles-Hydrogel Composites by Magnetron Sputtering onto Liquids and Subsequent Photopolymerization 磁控溅射制备纳米颗粒-水凝胶复合材料及其光聚合研究

IF 2.8 4区化学

Macromolecular Chemistry and Physics Pub Date : 2026-09-04 DOI: 10.1002/macp.70319

Anastasiya Sergievskaya, France-Emmanuelle Bol, Matthis Lefranc, Polona Umek, Martin Radtke, Ana Guilherme Buzanich, Kirill V. Yusenko, Glen J. Smales, Carla Bittencourt, Jean-Marie Raquez, Jérémy Odent, Stephanos Konstantinidis

{"title":"Toward the Synthesis of Nanoparticles-Hydrogel Composites by Magnetron Sputtering onto Liquids and Subsequent Photopolymerization","authors":"Anastasiya Sergievskaya, France-Emmanuelle Bol, Matthis Lefranc, Polona Umek, Martin Radtke, Ana Guilherme Buzanich, Kirill V. Yusenko, Glen J. Smales, Carla Bittencourt, Jean-Marie Raquez, Jérémy Odent, Stephanos Konstantinidis","doi":"10.1002/macp.70319","DOIUrl":"https://doi.org/10.1002/macp.70319","url":null,"abstract":"<div>\u0000 \u0000 We report a strategy for fabricating ultra-pure nanoparticles–hydrogel composites by combining low-pressure plasma-based magnetron sputtering onto liquids with subsequent free radical photopolymerization. In a first step, various photocurable host liquids were screened for vacuum compatibility, viscosity, and stability under plasma exposure, highlighting poly(ethylene glycol) methyl ether acrylate (PEGMEA) as the most suitable candidate. A copper target was accordingly sputtered by an argon plasma onto PEGMEA, yielding stable colloidal suspensions of monomodal copper oxide (CuO) nanoparticles with a radius of 1.23 ± 0.015 nm. Careful outgassing procedure and sputtering conditions are critical to prevent undesired plasma-induced reactions (e.g., premature polymerization). The total copper concentration was controlled by adjusting the deposition time and sputtering power during sputtering. Further addition of polyethylene glycol diacrylate crosslinker and diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide photoinitiator into the CuO NPs–PEGMEA colloids enables ex situ near-UV photopolymerization to form transparent nanoparticles-hydrogel composites. The composites contain small particles (7.38 ± 0.32 nm), and larger aggregates (67.47 ± 0.53 nm). Characterization by SEM, TEM, UV–vis spectrophotometry, photo-rheology, and x-ray absorption near-edge spectroscopy confirmed the nanostructure and composition of the materials. This work opens new opportunities for developing surfactant-free NP/hydrogel composites compatible with manufacturing techniques such as 3D printing.\u0000 </div>","PeriodicalId":18054,"journal":{"name":"Macromolecular Chemistry and Physics","volume":"227 17","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148878235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Photo- and Thermo-Dual-Responsive Polymer Micelles With Partially Reversible Core Crosslinking for Controlled Drug Delivery 具有部分可逆核心交联的光和热双响应聚合物胶束用于受控药物递送

IF 2.8 4区化学

Macromolecular Chemistry and Physics Pub Date : 2026-08-26 DOI: 10.1002/macp.70332

Xuan Zhang, Huanle Fang, Xue Liang, Jing Yang

{"title":"Photo- and Thermo-Dual-Responsive Polymer Micelles With Partially Reversible Core Crosslinking for Controlled Drug Delivery","authors":"Xuan Zhang, Huanle Fang, Xue Liang, Jing Yang","doi":"10.1002/macp.70332","DOIUrl":"https://doi.org/10.1002/macp.70332","url":null,"abstract":"<div>\u0000 \u0000 A dual-responsive amphiphilic diblock copolymer, poly(ethylene oxide)-b-poly((7-(4-vinyl-benzyloxyl)-4-methylcoumarin)-co-(4-vinylbenzyl methyl-diethanol ammonium boronate)) (PEO45-b-P(VBC2-co-VMAB9)), is designed and synthesized via free radical polymerization for constructing partially reversible core cross-linking polymer micelles (PM). The coumarin moieties in the hydrophobic core undergo [2 + 2] photocycloaddition under 365 nm irradiation and partial photoscission under 254 nm irradiation, enabling tunable core crosslinking density. The ammonium‑boronate zwitterionic pairs in PVMAB segments exhibit temperature‑dependent inter‑ and intra‑chain association changes, dynamically modulating core hydrophobicity and compactness. UV‑-vis absorption and fluorescence emission spectroscopy, dynamic light scattering (DLS), and transmission electron microscopy (TEM) collectively corroborate the partially reversible photo-crosslinking and thermo-responsive zwitterionic association. PM possess a slightly positive charge, which may enhance colloidal stability while facilitating cellular uptake. The resulting micelles can also efficiently encapsulate doxorubicin (DOX) and show finely controlled drug release by varying irradiation duration and temperature. Blank PM demonstrate excellent biocompatibility, while DOX‑loaded PEO45-b-P(VBC2-co-VMAB9) polymer micelles (DOX-PM) exhibit significantly enhanced cytotoxicity against HeLa and MCF‑7 cells under short-term 365 nm irradiation and hyperthermic conditions (42 °C). This work provides a simple and versatile strategy for spatiotemporally controllable, reusable, and efficient dual‑responsive drug delivery.\u0000 </div>","PeriodicalId":18054,"journal":{"name":"Macromolecular Chemistry and Physics","volume":"227 16","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148849096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Controlled Preparation of Uniform Nanofibers Containing a π-Conjugated Core and a Charged Corona by Self-Seeding Approach: Effect of Length and Charge Contents of Corona Chains 自播种法控制制备含π共轭核和带电电晕的均匀纳米纤维：电晕链长度和电荷含量的影响

IF 2.8 4区化学

Macromolecular Chemistry and Physics Pub Date : 2026-08-25 DOI: 10.1002/macp.70333

Jialing Dong, Fangyuan Li, Xinghao Du, Kun Cui, Yuhe Dong, Tian Zhong, Xiaoyu Huang, Guolin Lu, Chun Feng

{"title":"Controlled Preparation of Uniform Nanofibers Containing a π-Conjugated Core and a Charged Corona by Self-Seeding Approach: Effect of Length and Charge Contents of Corona Chains","authors":"Jialing Dong, Fangyuan Li, Xinghao Du, Kun Cui, Yuhe Dong, Tian Zhong, Xiaoyu Huang, Guolin Lu, Chun Feng","doi":"10.1002/macp.70333","DOIUrl":"https://doi.org/10.1002/macp.70333","url":null,"abstract":"<div>\u0000 \u0000 π-Conjugated-polymer-containing nanofibers have been considered as appealing building blocks of high-performance functional materials with broad applications from nanomedicine to microelectronics. Self-seeding of living crystallization-driven self-assembly (CDSA) has emerged as a facile approach toward controlled preparation of π-conjugated nanofibers. Despite impressive advances in self-seeding of π-conjugated block copolymers, the reports on the generation of π-conjugated-polymer-containing nanofibers with a charged corona are scarce. Herein, we report the synthesis of a series of block copolymers containing a π-conjugated BT-OPE7-BT (BT = benzothiadiazole, OPE = oligo(p-phenylene ethynylene)) segments and either neutral poly(N-(2-(methylthio)ethyl) acrylamide) (PMTEAM) of varying chain lengths or positively charged PMTEAM-derived segments with different contents of sulfonium units. The solvent, PMTEAM chain length, and sulfonium content significantly affected CDSA behavior with a direct heating/cooling protocol. Uniform fiber-like micelles with positively charged shells of varying contents of sulfonium units can be generated by a self-seeding approach. It was disclosed that the resistance of seed micelles to dissolution upon heating increased with the decrease of PMTEAM chain length and increase of contents of sulfonium units. This work not only offers a facile strategy toward controlled preparation of π-conjugated nanofiber, but also deepens our understanding on self-seeding behavior of π-conjugated block copolymers with charged corona-forming chains.\u0000 </div>","PeriodicalId":18054,"journal":{"name":"Macromolecular Chemistry and Physics","volume":"227 16","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148849085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0