Macromolecular Chemistry and Physics最新文献_第4页

Issue Information: Macromol. Chem. Phys. 3/2025

IF 2.5 4区化学

Macromolecular Chemistry and Physics Pub Date : 2025-02-06 DOI: 10.1002/macp.202570006

引用次数: 0

Fabrication of Core-Crosslinked Polymer Micelles via Photoinduced Azide Crosslinking

IF 2.5 4区化学

Macromolecular Chemistry and Physics Pub Date : 2025-02-06 DOI: 10.1002/macp.202400473

Betül Sena Baysoy, İrem Günaydın, Hatice Kubra Batu, Dilek Ozturk Civelek, Binnur Aydogan Temel

{"title":"Fabrication of Core-Crosslinked Polymer Micelles via Photoinduced Azide Crosslinking","authors":"Betül Sena Baysoy, İrem Günaydın, Hatice Kubra Batu, Dilek Ozturk Civelek, Binnur Aydogan Temel","doi":"10.1002/macp.202400473","DOIUrl":"https://doi.org/10.1002/macp.202400473","url":null,"abstract":"Polymer micelles have shown significant promise as drug delivery systems, particularly for poorly water-soluble chemotherapeutic agents such as doxorubicin (DOX). However, their instability in biological environments and the potential for easy drug release remain major challenges. This study investigates the fabrication of core-crosslinked polymer micelles using photoinduced azide crosslinking to enhance stability and achieve controlled drug release. Amphiphilic copolymers are synthesized using reversible addition-fragmentation chain transfer (RAFT) polymerization, incorporating poly(ethylene glycol) methyl ether (PEG) as the hydrophilic block and a styrene-based azide monomer for the hydrophobic core. The micelles are crosslinked via photoinduced azide crosslinking and characterized for size, morphology, and drug loading capacity (DLC). DOX-loaded micelles demonstrated pH-responsive release, with minimal release at physiological pH (7.4) due to strong π–π stacking interactions between DOX and the hydrophobic core. At acidic pH (5), these interactions weakened, resulting in enhanced drug release, mimicking the conditions of the tumor microenvironment. Core-crosslinked micelles exhibited superior stability, reduced drug leakage, and improved release control compared to non-crosslinked micelles. These results highlight the potential of photo-crosslinked polymer micelles as a robust platform for the delivery of hydrophobic anticancer drugs, addressing key limitations of conventional micelle-based systems.","PeriodicalId":18054,"journal":{"name":"Macromolecular Chemistry and Physics","volume":"226 7","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143770195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Front Cover: Macromol. Chem. Phys. 3/2025

IF 2.5 4区化学

Macromolecular Chemistry and Physics Pub Date : 2025-02-06 DOI: 10.1002/macp.202570005

引用次数: 0

Balancing the Mechanical Toughness and Electrical Insulation of Polypropylene by Blending and Grafting Modifications

IF 2.5 4区化学

Macromolecular Chemistry and Physics Pub Date : 2025-02-02 DOI: 10.1002/macp.202500029

Shengkun Niu, Tiandong Zhang, Huiyang Zhang, Changhai Zhang, Yue Zhang, Chao Yin, Yongquan Zhang, Guanglei Wu, Qingguo Chi

{"title":"Balancing the Mechanical Toughness and Electrical Insulation of Polypropylene by Blending and Grafting Modifications","authors":"Shengkun Niu, Tiandong Zhang, Huiyang Zhang, Changhai Zhang, Yue Zhang, Chao Yin, Yongquan Zhang, Guanglei Wu, Qingguo Chi","doi":"10.1002/macp.202500029","DOIUrl":"https://doi.org/10.1002/macp.202500029","url":null,"abstract":"Balancing the mechanical toughness and electrical insulation of polypropylene (PP) for recyclable cable insulation application has attracted increasing attention. Due to the different molecular conformation, isotactic polypropylene (IPP) always delivers excellent electrical insulation but poor mechanical toughness, while block polypropylene (BPP) has been dramatically opposed properties. Blending IPP with BPP at an appropriate content may be beneficial to reconcile the toughness and insulation. In this study, the blending ratio of IPP and BPP is first investigated, and it is found that 60: 40 wt.% is the optimized ratio for achieving outstanding overall performance. Furthermore, polyolefin elastomer (POE) and styrene-grafted POE (POE-g-St) are incorporated into IPP/BPP blends respectively to intensify the toughness as well as the insulation property. The microstructure, electrical properties, mechanical properties, and thermal properties of the composites are systematically analyzed and discussed. The results demonstrate that the composite with a grafting ratio of 1.21 wt.% styrene exhibits superior overall performances, the enhanced breakdown field strength of 314.02 kV mm−1, and reduced elastic modulus of 352.54 MPa are achieved. Additionally, the modified composites also possess a high melting temperature, high volume resistivity, and excellent space charge suppression capability, achieving the synergistic improvements of the electrical, mechanical, and thermal properties.","PeriodicalId":18054,"journal":{"name":"Macromolecular Chemistry and Physics","volume":"226 6","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143688648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urea-Modified Lignin-Derived Nitrogen-Doped Porous Carbon Materials: Synthesis and CO2 Adsorption Properties

IF 2.5 4区化学

Macromolecular Chemistry and Physics Pub Date : 2025-02-02 DOI: 10.1002/macp.202400427

Siriguleng Bao, Yong Sheng Bao, Agula Bao

引用次数: 0

Structural Modulation in Viologen-Based Ionic Porous Organic Polymers for Catalytic Non-Redox CO2 Fixation

IF 2.5 4区化学

Macromolecular Chemistry and Physics Pub Date : 2025-01-31 DOI: 10.1002/macp.202400373

Tapolabdha Lodh, G. Shreeraj, Abhijit Patra

{"title":"Structural Modulation in Viologen-Based Ionic Porous Organic Polymers for Catalytic Non-Redox CO2 Fixation","authors":"Tapolabdha Lodh, G. Shreeraj, Abhijit Patra","doi":"10.1002/macp.202400373","DOIUrl":"https://doi.org/10.1002/macp.202400373","url":null,"abstract":"The rational design of metal-free, porous, and heterogeneous catalysts with large specific surface areas for efficient CO2 capture and utilization has remained a significant challenge. In this study, two structurally distinct viologen-based novel ionic porous organic polymers (iPOPs) featuring a triazine core are developed, employing different polymerization methods to modulate their porosity and catalytic properties. The alkyne-linked SC-iPOP, synthesized through Sonogashira polycondensation, exhibits high porosity (specific BET surface area: 616 ± 9 m2 g−1) over BHC-iPOP with secondary amine linkages fabricated by Buchwald-Hartwig polymerization. SC-iPOP demonstrates superior catalytic efficiency in the metal-free cycloaddition of CO2 with epoxides to form cyclic organic carbonates under atmospheric pressure and solvent-free conditions, with excellent recyclability. This enhanced catalytic performance, compared to BHC-iPOP, is attributed to the high porosity of SC-iPOP and the presence of abundant CO2-philic ionic active sites. The current study emphasizes the role of structural modifications in designing efficient porous catalysts for metal-free CO2 fixation.","PeriodicalId":18054,"journal":{"name":"Macromolecular Chemistry and Physics","volume":"226 6","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-Assembly of Amphiphilic Polyphenylene Dendrimers with Different Surface Functionalization in Solvent/Non-Solvent Mixtures

IF 2.5 4区化学

Macromolecular Chemistry and Physics Pub Date : 2025-01-30 DOI: 10.1002/macp.202400431

Svenja Weigold, Kerstin Brödner, Torsten John, Jan Freudenberg, Uwe H. F. Bunz, Tanja Weil, George Fytas, Klaus Müllen

{"title":"Self-Assembly of Amphiphilic Polyphenylene Dendrimers with Different Surface Functionalization in Solvent/Non-Solvent Mixtures","authors":"Svenja Weigold, Kerstin Brödner, Torsten John, Jan Freudenberg, Uwe H. F. Bunz, Tanja Weil, George Fytas, Klaus Müllen","doi":"10.1002/macp.202400431","DOIUrl":"https://doi.org/10.1002/macp.202400431","url":null,"abstract":"This work compares the self-assembly of nanometer-sized amphiphilic Janus-type and patched polyphenylene dendrimers (PPDs) in solvent/non-solvent mixtures utilizing static and dynamic light-scattering measurements. First- and second-generation (G1 and G2) dendrimers are functionalized with substituents of different polarity, i.e., polar neo-pentyl sulfonate or sulfonic acid groups are combined with non-polar propyl groups. Neo-pentyl sulfonate PPDs give rise to defined supramolecular assembly structures, irrespective of their amphiphilic surface functionalization or size. In contrast, the self-assembly of PPDs with sulfonic acid substitution exhibits a pronounced dependence upon substitution pattern and generation. In particular, the Janus dendrimers demonstrate an increased tendency toward self-assembly compared to their patched counterparts. This trend is more pronounced for G2 than for G1 PPDs.","PeriodicalId":18054,"journal":{"name":"Macromolecular Chemistry and Physics","volume":"226 6","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/macp.202400431","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of Amphiphilic Polymer Co-Networks via the Growth of a Living RAFT Network

IF 2.5 4区化学

Macromolecular Chemistry and Physics Pub Date : 2025-01-30 DOI: 10.1002/macp.202500004

Ziyi Liu, Yihan Zhang, Costas S. Patrickios, Jianyong Jin

{"title":"Synthesis of Amphiphilic Polymer Co-Networks via the Growth of a Living RAFT Network","authors":"Ziyi Liu, Yihan Zhang, Costas S. Patrickios, Jianyong Jin","doi":"10.1002/macp.202500004","DOIUrl":"https://doi.org/10.1002/macp.202500004","url":null,"abstract":"In this study, a different approach for synthesizing amphiphilic polymer co-networks (APCNs) via the growth of a living RAFT (reversible addition–fragmentation chain transfer) network, is presented. For the hydrophilic parent RAFT network, 2-(Dimethylamino)ethyl methacrylate (DMAEMA) is used as the hydrophilic/polar monomer, poly(ethylene glycol) diacrylate 700 (PEGDA 700) as the hydrophilic cross-linker, S,S-Dibenzyl trithiocarbonate (DBTTC) as the RAFT agent, and 5,10,15,20-Tetraphenyl-21H,23H-porphine zinc (ZnTPP) as the photocatalyst. Subsequently, the hydrophobic monomer methyl methacrylate (MMA) is incorporated into the parent network to form the amphiphilic daughter network, following the network growth protocol established by the group in 2019. Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), and scanning electron microscopy (SEM) are employed to characterize the resulting APCN daughter network. Most importantly, the amphiphilicity of the APCN network is evaluated through swelling tests in water and n-hexane. This approach offers advantages in tuning the network's amphiphilicity by simply adjusting the photogrowth time or the crosslinking density of the parent gel. Also, this technique can reduce the time and effort required to produce APCNs.","PeriodicalId":18054,"journal":{"name":"Macromolecular Chemistry and Physics","volume":"226 6","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/macp.202500004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thermoresponsive Behaviors of Core-Crosslinked Star Polymers Composed of Amino Acid-Derived Vinyl Polymers in an Aqueous Solution

IF 2.5 4区化学

Macromolecular Chemistry and Physics Pub Date : 2025-01-27 DOI: 10.1002/macp.202400485

Shin-nosuke Nishimura, Momoka Kamiya, Nobuyuki Higashi, Tomoyuki Koga

{"title":"Thermoresponsive Behaviors of Core-Crosslinked Star Polymers Composed of Amino Acid-Derived Vinyl Polymers in an Aqueous Solution","authors":"Shin-nosuke Nishimura, Momoka Kamiya, Nobuyuki Higashi, Tomoyuki Koga","doi":"10.1002/macp.202400485","DOIUrl":"https://doi.org/10.1002/macp.202400485","url":null,"abstract":"Amino acid-derived vinyl polymers are of great interest as bio-based thermoresponsive soft materials with diverse applications in the industrial, biomedical, and cosmetic fields. In this study, 14 distinct core-crosslinked stars (CCS) polymers are synthesized by reversible addition–fragmentation chain transfer polymerization of N-acryloyl amino acid (X)-methyl esters (X = alanine, β-alanine, or glycine), followed by a core–gel approach. These CCS polymers have the following systematic variations in their molecular architecture: i) three types of amino acid-based polymer arms with the same chain lengths but different arm numbers, ii) different combinations of amino acid species in the arm and core segments, and iii) heteroarm composition (i.e., miktoarm type). All CCS polymers are water-soluble and exhibited lower critical solution temperature (LCST) behaviors. The thermal responses are strongly dependent on structural factors, such as arm species (hydrophobicity), arm number, and polymer shape. The transition temperatures of the CCS polymers are lower than those of the corresponding linear polymers with almost the same molecular weight, particularly when the arm polymers has relatively high hydrophilicity. Furthermore, tunable LCST behaviors (20–55 °C) are achieved for miktoarm-type CCS polymers by adjusting heteroarm composition. These findings provide useful insights into the thermoresponsive behaviors of bio-based CCS polymers.","PeriodicalId":18054,"journal":{"name":"Macromolecular Chemistry and Physics","volume":"226 6","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Front Cover: Macromol. Chem. Phys. 2/2025

IF 2.5 4区化学

Macromolecular Chemistry and Physics Pub Date : 2025-01-23 DOI: 10.1002/macp.202570003

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