Lupus最新文献

{"title":"The problem of pain in systemic lupus erythematosus: A comprehensive analysis of pain distribution using the CHOIR body map and PROMIS measures.","authors":"Tiffany En Jiang, Sean Mackey, Beth D Darnall, Julia F Simard, Titilola Falasinnu","doi":"10.1177/09612033241301176","DOIUrl":"10.1177/09612033241301176","url":null,"abstract":"<p><strong>Background: </strong>Our study investigates the associations between pain distribution, biopsychosocial factors, and Patient-Reported Outcomes Measurement Information System (PROMIS) measures in patients with systemic lupus erythematosus (SLE). Employing self-reported pain body maps, we aim to characterize the distribution of pain and its impact on biopsychosocial measures.</p><p><strong>Methods: </strong>We retrospectively analyzed the electronic health records (EHR) of 332 adult patients with SLE attending pain clinics at an academic medical center. The study included demographics, pain distribution assessed via self-reported body maps, and PROMIS assessments of biopsychosocial experiences. We used linear regression models adjusted for age and sex to investigate associations between pain distribution and PROMIS outcomes.</p><p><strong>Results: </strong>Men, on average, indicated pain in 3.2 regions, whereas women reported pain in 5.6 regions. Women predominantly highlighted the hip, buttock, and leg region, whereas men primarily emphasized the shoulder and arm region. We found a positive correlation between pain widespreadness and worse PROMIS measures, including pain interference, behavior, fatigue, depression, anxiety, sleep disturbance, and social isolation. Additionally, widespread pain was associated with lower physical function, emotional support, and satisfaction in roles and activities. Female patients reported higher levels of pain and PROMIS measures compared to males.</p><p><strong>Conclusion: </strong>Our findings highlight the multidimensional impact of pain on SLE patients' lives underscoring the need for holistic pain management approaches. The intricate associations between pain distribution and biopsychosocial factors emphasize the importance of considering spatial dimensions of pain in clinical interventions. Further research is warranted to explore effective interventions addressing psychosocial aspects of pain in SLE, aiming to enhance patient symptom management and quality of life.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"47-56"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11663094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current smoking is related to severe damage in systemic lupus erythematosus patients.","authors":"M A Cosatti, S A Muñoz, M T Tamborenea, M García, A Curti, A Cappuccio, O Rillo, P M Imamura, E Schneeberger, F Dal Pra, M Ballent, M L Cousseau, J Velasco Zamora, V Saurit, S Toloza, M C Danielsen, V I Bellomio, C Graf, S Paira, J Cavallasca, B Pons Estel, J L Cristian Moreno, M Díaz, P Alba, M Verando, G Tate, E Mysler, J Sarano, E E Civit, F Risueño, P Álvarez Sepúlveda, M S Larroude, M F Méndez, A Conforti, D Sohn, C A Helling, S Roverano, S Malm-Green, D Medina Bornachera, A Alvarez, A Eimon, G Pendón, M Mayer, J Marin, C N Pisoni","doi":"10.1177/09612033241301182","DOIUrl":"10.1177/09612033241301182","url":null,"abstract":"<p><strong>Objective: </strong>To assess the relationship between smoking exposure and organ damage accrual measured by Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index for Systemic Lupus Erythematosus score (SLICC-SDI) in consecutive patients with systemic lupus erythematosus (SLE) from Argentina.</p><p><strong>Methods: </strong>623 consecutive SLE patients (fulfilling ≥4, 1997 ACR criteria) were included in this cross-sectional study. Sociodemographic and disease related variables including SLICC-SDI score and smoking status were collected. Patients currently smoking were considered \"smokers\", and \"non-smokers\" those who never smoked and former smokers. SLICC-SDI was divided into two categories: <3 and ≥3 was defined as severe damage.</p><p><strong>Results: </strong>Six hundred and 23 patients were included in the analysis, 89% women. Eighty-four per cent were non-smokers and 16 % were current smokers 83 percent of patients had SLICC-SDI <3 and 17 % had SLICC-SDI ≥3. Twenty one percent of patients with SLICC-SDI ≥3 and 15% with <3 SLICC-SDI were current smokers (<i>p</i> 0.081). In the multiple regression analysis, current smoking (OR 1.82, CI 95% 1.01-3.31, <i>p</i> 0.046), older age (OR 1.04, CI 95% 1.00-1.05, <i>p</i> 0.034), disease duration (OR 1.03, CI 95% 1.00-1.07, <i>p</i> 0.021) and cyclophosphamide exposure (OR 2.97, CI 95% 1.49-5.88, <i>p</i> 0.002) were related to SLICC-SDI ≥3.</p><p><strong>Conclusion: </strong>In our sample of patients, current smoking, older age, disease duration and cyclophosphamide were related to severe damage (SLICC-SDI ≥3).</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"28-33"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early subclinical macular disease in asymptomatic patients with primary antiphospholipid syndrome: A quantitative multimodal retinal evaluation.","authors":"Leandro Cabral Zacharias, Taurino Dos Santos Rodrigues Neto, Epitácio Dias da Silva Neto, Mário Luiz Ribeiro Monteiro, Gustavo Guimarães Moreira Balbi, Flávio Signorelli, Alex Haruo Higashi, Eloisa Bonfá, Danieli Castro Oliveira de Andrade","doi":"10.1177/09612033241307895","DOIUrl":"10.1177/09612033241307895","url":null,"abstract":"<p><strong>Purpose: </strong>To perform a quantitative multimodal evaluation in 25 patients with primary antiphospholipid syndrome (PAPS) without ocular complaints and to compare them with 25 healthy individuals.</p><p><strong>Methods: </strong>A structural and functional ophthalmological evaluation using optical coherence tomography angiography (OCTA) and microperimetry (MP) exam in 25 patients with PAPS, followed at a tertiary rheumatology outpatient clinic, was performed. All ophthalmologic manifestations were documented and subsequent statistical analysis was performed for comparative purposes, with significance set at <i>p</i> < 0.05.</p><p><strong>Results: </strong>We included 100 eyes of 50 subjects (25 patients with PAPS without ocular complaints and 25 healthy individuals). Quantitative OCTA assessment revealed significant differences between PAPS patients and controls in both the superficial vascular complex (SVC) and deep vascular complex (DVC) using high-speed protocol, as well as in the SVC in the high-resolution protocol. Analysis of the foveal avascular zone (FAZ) parameters showed a larger area of FAZ in the DVC in PAPS patients using the high-speed method compared to the control group (<i>p</i> = 0.047). In MP quantitative analysis, the PAPS group exhibited lower central (<i>p</i> = 0.041) and global (<i>p</i> < 0.001) retinal sensitivity compared to the control group, along with sectoral differences, except in the inferior sector.</p><p><strong>Conclusions: </strong>PAPS patients present lower vascular density and retinal sensitivity compared to the control group, even in patients without paracentral acute middle maculopathy (PAMM). Our findings underscore the significance of ocular evaluation beyond symptomatic assessment in these patients.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"79-87"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diving deep into lupus: Gastrointestinal involvement insights from the Oman lupus study.","authors":"Nasra K Al-Adhoubi, Issa Al Salmi, Juma Al Kaabi, Farida Al-Balushi, Maha Ali, Talal Al Lawati, Bsh Al Lawati, Reem Abdwani, Ali Al Shamsi, Musallam Al Mashaani, Divij Krishna Jha, Sherin Sayed, Tariq Al-Araimi, Prabha Liyanage, Hilal Al Kalbani, Humaid A Al Wahshi","doi":"10.1177/09612033241292704","DOIUrl":"10.1177/09612033241292704","url":null,"abstract":"<p><strong>Objectives: </strong>This multicenter longitudinal study investigated the prevalence of gastrointestinal (GI) manifestations in lupus patients and determined the risk factors associated with mortality.</p><p><strong>Methods: </strong>This study is part of the Oman Lupus Study, which included 1160 patients who met the classification criteria for systemic lupus erythematosus (SLE) from January 2006 to February 2020. All patients were screened for GI symptoms and involvement.</p><p><strong>Results: </strong>We identified 91 patients with GI manifestations, with a prevalence rate of 8.53% in the pediatric group and 7.75% in the adult group, and this difference was not statistically significant (<i>p</i> = .755). Ischemic colitis was significantly associated with longer disease duration (<i>p</i> < .001) and positivity for B2-glycoprotein I (B2GPI) autoantibodies (<i>p</i> < .0001). Moreover, a significant correlation was found between ischemic colitis and hematologic manifestations (<i>p</i> = .001), lupus nephritis (<i>p</i> = .007), pulmonary complications (<i>p</i> = .000-.039), and some cardiac complications (<i>p</i> = .012-.269). Mortality rates were greater in patients with GI involvement (24.37%), including those with ischemic colitis (<i>p</i> = .005), chronic peritonitis (<i>p</i> < .001), and spleen/liver infarction (<i>p</i> = .001). Sepsis, thrombocytopenia, and different internal organ involvement rates were significantly associated with increased mortality.</p><p><strong>Conclusion: </strong>This research provides significant insights into GI manifestations in lupus patients. A higher mortality rate was found to be associated with organ involvement, disease duration, autoantibody profile, and specific complications. Considering this fact, it is vital to prioritize management strategies to improve clinical outcomes in this group of patients.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"1637-1644"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From the Editor.","authors":"Graham Rv Hughes","doi":"10.1177/09612033241302577","DOIUrl":"https://doi.org/10.1177/09612033241302577","url":null,"abstract":"","PeriodicalId":18044,"journal":{"name":"Lupus","volume":"33 14","pages":"1525"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral mononuclear cells and systemic lupus erythematosus association: Integrated study of single-cell sequencing and mendelian randomization analysis.","authors":"Shi Jian, Han Li","doi":"10.1177/09612033241292705","DOIUrl":"10.1177/09612033241292705","url":null,"abstract":"<p><strong>Objective: </strong>Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease predominantly affecting women. Despite advances in treatment, recent developments in single-cell RNA sequencing (scRNA-seq) and Mendelian randomization (MR) continue to facilitate the need for precision medicine.</p><p><strong>Methods: </strong>Data obtained from the GSE135779 dataset underwent quality control, normalization, and dimensionality reduction using Seurat and MonacoImmuneData. Marker genes identified subgroups for analysis with CellChat and ClusterProfilerR. MR analysis of these genes' eQTLs was performed to establish causal relationships with SLE using IEU Open GWAS project data.</p><p><strong>Results: </strong>Single-cell analysis revealed distinct cellular subtypes and highlighted increased monocyte levels in patients with SLE. MR analysis revealed 12 genes, particularly interferon induced protein with tetratricopeptide repeats 3 (IFIT3), causally related to SLE. Gene ontology and the Kyoto encyclopedia of genes and genomes analyses identified pathways significant to SLE pathogenesis. Visualization of these genes at the single-cell level revealed their role in disease progression. Cell communication differences between IFIT3-positive and -negative groups were also observed.</p><p><strong>Conclusion: </strong>This study demonstrates the potential of scRNA-seq and MR in identifying critical factors in SLE pathogenesis, thereby supporting the need for targeted therapies. Identifying IFIT3, among other genes, as central to SLE progression opens new avenues for precision medicine approaches in SLE management.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"1526-1537"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do novel inflammation biomarkers arising from routine complete blood count play a role in patients with systemic lupus erythematosus?","authors":"Thilo Gambichler, Zenaida Numanovic, Imke Apel, Schapoor Hessam, Laura Susok, Xenofon Baraliakos, Philipp Sewerin","doi":"10.1177/09612033241295865","DOIUrl":"10.1177/09612033241295865","url":null,"abstract":"<p><strong>Background: </strong>Laboratory-based biomarkers accurately presenting systemic lupus erythematosus (SLE) disease activity may have a practical value in clinical routine. As shown in many other conditions, complete blood count (CBC)-derived biomarkers may also play a role in SLE.</p><p><strong>Objectives: </strong>We aimed to study for the first time the pan-immune-inflammation value (PIV, monocytes x platelets x neutrophils/lymphocytes) and the more established systemic immune-inflammation index (SII, neutrophils x platelets /lymphocytes) in SLE patients and correlate it with serological and clinical findings including disease outcomes.</p><p><strong>Methods: </strong>In this retrospective multicentric investigation, we reviewed the clinical records of 148 SLE who had an available CBC at baseline. The latter served for the determination of the neutrophil-to-lymphocyte ratio (NLR), SII, and the PIV. Control groups were studied as well. Univariable as well as multivariable statistics were employed.</p><p><strong>Results: </strong>The values for baseline systemic immune-inflammation biomarkers (SIIB) studied were significantly (<i>p</i> < 0.0001) higher than those observed in healthy controls but comparable to those obtained from patients with other inflammatory conditions. Multivariable analysis revealed that ANA titer > 1:640 remained the only significant (<i>p</i> < 0.0001) baseline predictor of SLE flare (odds ratio: 7.6, 95% CI 3.1 to 18.8). Improvement of SLE following treatment was associated with the absence of lymphopenia as well as ANA > 1:640 (<i>p</i> = 0.041). The SLEDAI-2K significantly correlated with NLR, SII, CRP, lymphocytes, and monocytes only on univariable testing.</p><p><strong>Conclusions: </strong>Compared to healthy controls the CBC-based SIIB investigated are significantly increased in SLE patients. However, SIIB do not appear to be useful in managing SLE clinically. Nevertheless, we confirm that higher ANA titers can predict flares of SLE.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"1556-1561"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health seeking behaviour and diagnostic delays in SLE: A multi-ethnic Malaysian cohort study.","authors":"Fatimah Zanirah Nordin, Syahrul Sazliyana Shaharir, Mohd Shahrir Mohamed Said, Rozita Mohd, Rajalingham Sakthiswary, Tengku Amatullah Madeehah Tengku Mohd, Mohd Hafiz Jaafar, Wong Chin Yew","doi":"10.1177/09612033241297548","DOIUrl":"10.1177/09612033241297548","url":null,"abstract":"<p><strong>Introduction: </strong>Heterogeneity of the clinical manifestations of systemic lupus erythematosus (SLE) may lead to diagnostic delays. This study is aimed at determining the health-seeking behaviour patterns and factors associated with diagnostic delays in a multi-ethnic SLE cohort in Malaysia.</p><p><strong>Methodology: </strong>This was a cross-sectional study involving SLE patients who visited our institute between January 2020 and June 2021. A review of the medical records and face-to-face interviews were conducted to obtain sociodemographics, SLE disease characteristics and the intervals from the first symptoms to the diagnosis. Health-seeking behaviours were assessed by asking about the patients' first action during the initial symptoms and were divided into: (i) seeking professional health personnel; (ii) self-treatment; and (iii) the use of the internet as a primary source of information. Diagnostic delays were defined as the interval between initial symptoms and SLE diagnosis of more than 6 months. Low-level disease activity state (LLDAS) at 12 months was assessed from the medical records. Univariate and multivariate logistic regression analysis was subsequently conducted to determine factors associated with diagnostic delays.</p><p><strong>Results: </strong>Among the 154 patients included in the study, 24% (<i>n</i> = 37) had delayed diagnosis. The delay was significantly higher among the Indian versus Malay versus Chinese (42.9% vs 28% vs 10.8%, <i>p</i> = 0.037). Patients with rash tend to have delayed diagnosis (37.8% vs 22.2%, <i>p</i> = 0.08) while fewer patients with frothy urine had delayed diagnosis (8.1% vs 21.4%, <i>p</i> = 0.09). No significant association was found between health-seeking behaviours and diagnostic delays. The rate of LLDAS at 12 months was significantly lower among patients with delayed diagnosis (43.2% vs 70.0%, <i>p</i> = 0.006). Chinese ethnicity remained the only significant factor associated with lesser diagnostic delays in the multivariate analysis, with OR 0.30 (CI 0.09-0.93), <i>p</i> = 0.037.</p><p><strong>Conclusion: </strong>There were ethnic disparities in the early diagnosis of SLE in Malaysia, with Indian patients having a longer interval between the first symptom and diagnosis while the Chinese were associated with lower diagnostic delays. Early diagnosis predicted early attainment of LLDAS, suggesting that prompt recognition of the initial SLE symptoms is important.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"1645-1653"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rituximab in lupus anticoagulant hypoprothrombinemia syndrome: A case report.","authors":"Jacopo Agnelli Giacchello, Nicol Francesca Trincheri, Patrizia Sciancalepore, Laura Contino, Roberto Mario Santi, Vittorio Pengo","doi":"10.1177/09612033241299619","DOIUrl":"10.1177/09612033241299619","url":null,"abstract":"<p><strong>Background: </strong>Lupus anticoagulant hypoprothrombinemia syndrome (LAHPS) is a rare autoimmune condition characterized by acquired prothrombin (FII) deficiency associated with antiphospholipid syndrome (APS) and life-threatening bleeding. We present the case of a 34-year-old woman with heavy menstrual bleeding (HMB), positive Lupus anticoagulant (LA) test, and high titer anticardiolipin antibodies Immunoglobulin G (ACA IgG) and anti-β2 glycoprotein I antibodies IgG (antiB2GPI IgG). Severe iron deficiency anemia necessitated recurrent blood transfusions and intravenous iron infusions from 2018 to 2021.</p><p><strong>Results: </strong>In January 2022, she was admitted to our clinic. Von Willebrand disease screening and platelet function analysis (PFA100) were normal. FII and FIX deficiencies were detected, without factor IX inhibitors. Anti-phosphatidylserine/prothrombin antibodies were confirmed by Padua University lab. To reduce antibody titers and menstrual bleeding, immunosuppressive therapy (Rituximab 375 mg/m2 weekly ×4 weeks) and hormonal therapy (desogestrel 75 mcg/day) were initiated.</p><p><strong>Conclusion: </strong>After 1-year, complete remission of clinical symptoms was achieved, with normalization of FII and FIX values and moderate reduction of aPS/PT titers, especially IgM isotype.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"1611-1614"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LncRNA NRIR serves as a biomarker for systemic lupus erythematosus and participates in the disease progression.","authors":"Qingfeng Ma, Li Li, Youzhong Xing","doi":"10.1177/09612033241294032","DOIUrl":"10.1177/09612033241294032","url":null,"abstract":"<p><strong>Background: </strong>Systemic lupus erythematosus (SLE) is a complex autoimmune disorder characterized by a malfunction of the body's immune defense system.</p><p><strong>Objective: </strong>The objective of the present investigation was to examine the expression and diagnostic significance of NRIR in SLE and to prove whether it is involved in the progression of SLE.</p><p><strong>Methods: </strong>The study involved 110 participants, including 55 healthy individuals and 55 SLE patients. The expression levels of NRIR, miR-31-5p, and ICAM-1 were measured using qRT-PCR. The ROC curve was performed to assess the diagnostic significance of NRIR in SLE patients. Pearson correlation analysis was utilized to explore the relationship between NRIR and other indicators. Cytokines including IL-4, IL-6, and IL-21, along with IgG levels, were assessed using ELISA. The interaction between NRIR and miR-31-5p was validated using a dual-luciferase reporter assay.</p><p><strong>Result: </strong>Upregulated expression of NRIR was observed in individuals with SLE, serving a diagnostic function for SLE. Additionally, abnormal expression of NRIR impacted the viability of CD4⁺ T cells within SLE patients. NRIR could negatively modulate the expression of miR-31-5p.</p><p><strong>Conclusion: </strong>LncRNA NRIR may be a potential biomarker for SLE and is likely involved in the progression of SLE.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"1538-1546"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}