Paul J Tejada-Llacsa, Graciela S Alarcón, Manuel F Ugarte-Gil
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Then a negative binomial regression was performed to estimate the prevalence ratio (PR) and evaluate factors associated with the prevalence of SLE.ResultsThe national prevalence of SLE was 40.2 per 100,000 people. Two age groups had the highest prevalence: 12-17 years and 30-59 years. Females exhibited a higher prevalence than males, particularly in the 30-59 age group (113.9 vs 16.1 per 100,000, respectively). An inverse relationship was observed between the age- and sex-adjusted prevalence in each department and altitude (PR 0.97; 95% CI: 0.94-0.99). On the other hand, there was a direct relationship with physician density (PR: 1.04; 95% CI: 1.01-1.07). No association was found between the adjusted prevalence and environmental temperature or latitude.ConclusionThe prevalence of SLE in Peru aligns with global estimates. The inverse relationship with altitude and the direct association with physician density suggest that environmental and healthcare access factors may influence disease distribution. Further research is needed to explore the underlying mechanisms driving these associations.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"9612033251379313"},"PeriodicalIF":1.9000,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Prevalence of systemic lupus erythematosus in Peru and its association with environmental and healthcare factors: An ecological study.\",\"authors\":\"Paul J Tejada-Llacsa, Graciela S Alarcón, Manuel F Ugarte-Gil\",\"doi\":\"10.1177/09612033251379313\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>ObjectiveTo estimate the prevalence of Systemic Lupus Erythematosus (SLE) in Peru in 2017 and its association with altitude, environmental temperature, and physician density.MethodsThis ecological study was performed using population data from the 2017 Peruvian census. The number of SLE cases for each department was obtained from the National Health Registries using the ICD-10 code M32. Altitude, environmental temperature and physician density were obtained for each department from the National Institute of Statistics and Informatic (<i>Instituto Nacional de Estadística e Informática)</i> registries. The prevalence for each department was calculated adjusting for age and sex. Then a negative binomial regression was performed to estimate the prevalence ratio (PR) and evaluate factors associated with the prevalence of SLE.ResultsThe national prevalence of SLE was 40.2 per 100,000 people. Two age groups had the highest prevalence: 12-17 years and 30-59 years. Females exhibited a higher prevalence than males, particularly in the 30-59 age group (113.9 vs 16.1 per 100,000, respectively). An inverse relationship was observed between the age- and sex-adjusted prevalence in each department and altitude (PR 0.97; 95% CI: 0.94-0.99). On the other hand, there was a direct relationship with physician density (PR: 1.04; 95% CI: 1.01-1.07). No association was found between the adjusted prevalence and environmental temperature or latitude.ConclusionThe prevalence of SLE in Peru aligns with global estimates. The inverse relationship with altitude and the direct association with physician density suggest that environmental and healthcare access factors may influence disease distribution. 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引用次数: 0
摘要
目的评估2017年秘鲁系统性红斑狼疮(SLE)患病率及其与海拔、环境温度和医师密度的关系。方法利用2017年秘鲁人口普查的人口数据进行生态研究。每个科室的SLE病例数使用ICD-10代码M32从国家卫生登记处获得。从国家统计和信息研究所(Instituto Nacional de Estadística e Informática)登记处获得每个科室的海拔高度、环境温度和医生密度。每个科室的患病率根据年龄和性别进行了调整。然后采用负二项回归来估计患病率(PR)并评估与SLE患病率相关的因素。结果全国SLE患病率为40.2 / 10万人。两个年龄组患病率最高:12-17岁和30-59岁。女性的患病率高于男性,特别是在30-59岁年龄组(分别为113.9 vs 16.1 / 100,000)。各科室经年龄和性别调整的患病率与海拔高度呈负相关(PR = 0.97; 95% CI: 0.94-0.99)。另一方面,与医师密度有直接关系(PR: 1.04; 95% CI: 1.01-1.07)。调整后的患病率与环境温度或纬度之间没有关联。结论:秘鲁SLE患病率与全球估计相符。与海拔高度呈负相关,与医师密度呈正相关,表明环境和卫生保健可及性因素可能影响疾病分布。需要进一步的研究来探索驱动这些关联的潜在机制。
Prevalence of systemic lupus erythematosus in Peru and its association with environmental and healthcare factors: An ecological study.
ObjectiveTo estimate the prevalence of Systemic Lupus Erythematosus (SLE) in Peru in 2017 and its association with altitude, environmental temperature, and physician density.MethodsThis ecological study was performed using population data from the 2017 Peruvian census. The number of SLE cases for each department was obtained from the National Health Registries using the ICD-10 code M32. Altitude, environmental temperature and physician density were obtained for each department from the National Institute of Statistics and Informatic (Instituto Nacional de Estadística e Informática) registries. The prevalence for each department was calculated adjusting for age and sex. Then a negative binomial regression was performed to estimate the prevalence ratio (PR) and evaluate factors associated with the prevalence of SLE.ResultsThe national prevalence of SLE was 40.2 per 100,000 people. Two age groups had the highest prevalence: 12-17 years and 30-59 years. Females exhibited a higher prevalence than males, particularly in the 30-59 age group (113.9 vs 16.1 per 100,000, respectively). An inverse relationship was observed between the age- and sex-adjusted prevalence in each department and altitude (PR 0.97; 95% CI: 0.94-0.99). On the other hand, there was a direct relationship with physician density (PR: 1.04; 95% CI: 1.01-1.07). No association was found between the adjusted prevalence and environmental temperature or latitude.ConclusionThe prevalence of SLE in Peru aligns with global estimates. The inverse relationship with altitude and the direct association with physician density suggest that environmental and healthcare access factors may influence disease distribution. Further research is needed to explore the underlying mechanisms driving these associations.
期刊介绍:
The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…