新版本血栓性抗磷脂综合征损伤指数(DIAPSV2)的开发和初步内容验证。

IF 1.9 4区 医学 Q3 RHEUMATOLOGY
Lupus Pub Date : 2025-09-24 DOI:10.1177/09612033251379310
María Victoria Goycochea Robles, Gabriela Medina García, Claudia Mendoza Pinto, Claudia Meléndez Mercado, Laura Aline Martínez Martínez, Pamela Medina San Millán, Silvia Guzmán Vázquez, Angélica Aurora Pérez Ruiz, Mary-Carmen Amigo
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引用次数: 0

摘要

背景:抗磷脂综合征(APS)是最常见的获得性高凝障碍,主要以血栓事件和产科发病率为特征。量化APS引起的慢性损伤对患者管理至关重要。最初的血栓性APS损伤指数(DIAPS)是为了满足这一需求而开发的,但需要更新以提高其全面性和特异性。目的报告新版损伤指数DIAPSv2的初步内容验证过程。方法采用改进的德尔菲面板法,分两阶段进行。第一阶段涉及对DIAPS研究进行系统的范围审查,从问卷中提取数据并由领导委员会确认。这些问卷确定了原始仪器中需要修改、删除或用新的候选项目替换的项目。第二阶段采用改进的德尔菲法,经过三轮,考虑专家组成员的意见,选择纳入DIAPSv2的概念。结果在第一阶段,证据支持原始DIAPS的有效性,但强调了反映慢性损伤的缺失情况,如肺泡出血和抗凝治疗引起的明显出血。在第二阶段,来自不同工作组的参与者达成共识,对领导委员会提出的用于准确测量APS慢性损伤的67个项目中的41个项目进行评估。最终协商一致包括32个项目。所有项目的定义都根据专家的输入和国际建议更新。结论采用多学科协作、多学科共识的方法,构建了包含11个域、32个条目的新版本损伤指数(更新了原版本的10个域、38个条目)。DIAPSv2为评估血栓性APS患者的不可逆损伤提供了更具体的工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Development and initial content validation of a new version of the damage index in thrombotic antiphospholipid syndrome (DIAPSV2).

BackgroundAntiphospholipid syndrome (APS) is the most common acquired hypercoagulable disorder characterized mainly by thrombotic events and obstetric morbidity. Quantifying chronic damage caused by APS is crucial for patient management. The original Damage Index for Thrombotic APS (DIAPS) was developed to address this need, but required updates to improve its comprehensiveness and specificity.ObjectiveTo report the initial content validation process of a new version of the damage index: DIAPSv2.MethodsA modified Delphi panel was conducted in two stages. Stage 1 involved a systematic scoping review of DIAPS studies, with data extracted from questionnaires and confirmed by the leading committee. These questionnaires identified items from the original instrument that needed modification, elimination, or replacement with new candidate items. Stage 2 employed the modified Delphi method over three rounds, considering expert panelists' opinions to select concepts for inclusion in DIAPSv2.ResultsIn Stage 1, evidence supported the validity of the original DIAPS but highlighted missing conditions reflecting chronic damage, such as alveolar hemorrhage and significant bleeding due to anticoagulation therapy. In Stage 2, participants from different working groups reached a consensus to evaluate 41 of the 67 items that the leading committee proposed for accurately measuring chronic damage in APS. A final consensus included 32 items. Definitions of all items were updated according to specialists' input and international recommendations for each domain.ConclusionsA collaborative and multidisciplinary consensus-based approach developed a new version of the damage index, comprising 11 domains and 32 items (an update from 10 domains and 38 items in the original version). DIAPSv2 offers a more specific tool for evaluating irreversible damage in patients with thrombotic APS.

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来源期刊
Lupus
Lupus 医学-风湿病学
CiteScore
4.20
自引率
11.50%
发文量
225
审稿时长
1 months
期刊介绍: The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…
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