系统性红斑狼疮患者血清25(OH)D3水平及其与免疫指标的相关性分析。

IF 1.9 4区 医学 Q3 RHEUMATOLOGY
Lupus Pub Date : 2025-09-26 DOI:10.1177/09612033251380872
Shasha Xu, Xiaoheng Guo, Yan Wu, Changgeng Zhang
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引用次数: 0

摘要

目的分析25(OH)D3对系统性红斑狼疮(SLE)患者免疫功能的影响,并阐明其与免疫指标的相关性。方法收集2022年1月~ 2024年1月在该院风湿病免疫科收治的新诊断SLE患者158例。检测25(OH)D3、免疫球蛋白IgA、IgG、IgM、补体C3、C4、CD3+T细胞、CD4+T细胞、CD8+T细胞及CD4+/CD8+。鉴定抗核抗体(ANA)和ENA抗体谱;收集患者的临床资料。我们根据25(OH)D3水平将SLE组分为三组:缺乏、不足和充足。比较几组SLE患者的临床症状、免疫指标、自身抗体,探讨25(OH)D3水平与免疫指标的关系。结果SLE患者血清IgA、IgG、CD8+T淋巴细胞水平均高于正常对照组。与25(OH) d3不足和充足组相比,25(OH) d3缺乏组狼疮肾炎、贫血和关节炎的发生率以及抗sm抗体的阳性率更高。在SLE患者中,25(OH)D3与C3呈正相关,而与IgG、CD8+T细胞呈负相关。结论SLE患者通常缺乏25(OH)D3。25(OH)D3缺乏对SLE患者免疫系统的影响如狼疮肾炎、贫血和关节炎,表明维生素D缺乏的风险增加,需要临床考虑。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Analysis of the serum 25(OH)D3 level and its correlation with immunological indexes in patients with systemic lupus erythematosus.

ObjectiveTo analysis the impact of 25(OH)D3 on immune function in patients with Systemic lupus erythematosus (SLE) and elucidate its correlation with immunological indexes.MethodsA total of 158 newly diagnosed SLE patients admitted to the Rheumatology and Immunology Department of the hospital from January 2022 to January 2024 were collected. 25(OH)D3, immunoglobulin IgA, IgG, IgM, complement C3 and C4,CD3+T cells, CD4+T cells, CD8+T cells and CD4+/CD8+ were detected. Antinuclear antibody (ANA) and ENA antibody spectrum were identified; Clinical data of patients were collected. We separated the SLE group into three groups based on the levels of 25(OH)D3: deficient, insufficient, and sufficient. The clinical symptoms, immunological indexes, and autoantibodies of SLE patients across several groups were compared, and the association between the levels of 25(OH)D3 and immunological indexes was investigated.ResultsThe levels of IgA, IgG, and CD8+T lymphocytes in patients with SLE were higher compared to those in the healthy control group. The incidence of lupus nephritis, anemia, and arthritis, as well as the positive rate of anti-Sm antibody, was greater in the 25(OH) D3-deficient group compared to the 25(OH) D3-insufficient and sufficient groups. In individuals with SLE, 25(OH)D3 had a positive cor- relation with C3、while showing a negative correlation with IgG, CD8+T cells.Conclusion25(OH)D3 is typically insufficient in patients with SLE. Deficiency of 25(OH)D3 impacts the immune system of patients with SLE; such as lupus nephritis, anemia, and arthritis signify an elevated risk of vitamin D deficiency, requiring clinical consideration.

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来源期刊
Lupus
Lupus 医学-风湿病学
CiteScore
4.20
自引率
11.50%
发文量
225
审稿时长
1 months
期刊介绍: The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…
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