Lifestyle Genomics最新文献

{"title":"Contents","authors":"Iwona Rudkowska, M. E. Tejero","doi":"10.1159/000502164","DOIUrl":"https://doi.org/10.1159/000502164","url":null,"abstract":"Selected Abstracts from the 19 3rd European Summer School on Nutrigenomics Jesi, June 25–29, 2018","PeriodicalId":18030,"journal":{"name":"Lifestyle Genomics","volume":"11 1","pages":"I - IV"},"PeriodicalIF":2.6,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000502164","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47353448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic and Oral Tests for the Diagnosis of Lactose Intolerance in Mixed-Ancestry Brazilians with Metabolic Syndrome","authors":"E. Araújo, Luama Araujo dos Santos, Radamés Coutinho, Viviane Assis, N. Brandao, Daniela Almeida, G. Conceição, C. Figueredo, H. Fonseca, Maria de Lourdes Lima, D. Lemaire, D. Rios","doi":"10.1159/000501690","DOIUrl":"https://doi.org/10.1159/000501690","url":null,"abstract":"Background/Aims: Metabolic syndrome (MetS) comprises a cluster of physiological and anthropometric abnormalities. MetS has been linked to lactose intolerance (LI). The aim of this study was to compare the sensitivity and specificity to detect LI using 2 different tests: (1) a genetic test and (2) an oral lactose tolerance test (OLTT). Methods: Two hundred and fifty-four MetS patients, ≥20 years of age, of both genders, were recruited for this comparative study. Nine single nucleotide polymorphisms (SNPs) were selected for genetic investigation: rs182549and rs4988235(both considered “gold standard”); rs56064699; rs148142676; rs562211644; rs59533246; rs3754689; rs2278544,and rs10552864(as potential novel SNPs). Sensitivity and specificity, as well as positive and negative predictive values, were calculated for each genotype using WINPEPI version 11.65. Differences between positive and negative OLTT groups were considered statistically significant when p ≤ 0.05. Results: Among the selected SNPs, only rs182549(p < 0.001) and rs4988235(p < 0.001) gave similar results compared to an OLTT. The sensitivity of both SNPs to detect LI was 87 and 86%, and specificity was 83 and 82.5%, respectively. Conclusion: Genetic tests using rs182549and rs4988235SNPs showed high agreement with OLTT. These genetic tests may be a good option to replace OLTT in MetS patients.","PeriodicalId":18030,"journal":{"name":"Lifestyle Genomics","volume":"12 1","pages":"1 - 9"},"PeriodicalIF":2.6,"publicationDate":"2019-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000501690","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48587958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum","authors":"","doi":"10.1159/000499733","DOIUrl":"https://doi.org/10.1159/000499733","url":null,"abstract":"","PeriodicalId":18030,"journal":{"name":"Lifestyle Genomics","volume":"11 1","pages":"168 - 168"},"PeriodicalIF":2.6,"publicationDate":"2019-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000499733","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45501948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Front & Back Matter","authors":"María Elizabeth Tejero Barrera","doi":"10.1159/000499123","DOIUrl":"https://doi.org/10.1159/000499123","url":null,"abstract":"109 12th Congress of the International Society of Nutrigenetics/Nutrigenomics (ISNN) September 30 to October 3, 2018, Winnipeg, MB, Canada Guest Editors: Jones, P.J.H.; Myrie, S. (Winnipeg, MB) (available online only)","PeriodicalId":18030,"journal":{"name":"Lifestyle Genomics","volume":"11 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47460883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatty Acid Desaturase 3 (FADS3) Is a Specific ∆13-Desaturase of Ruminant trans-Vaccenic Acid.","authors":"Vincent Rioux,&nbsp;Philippe Legrand","doi":"10.1159/000502356","DOIUrl":"https://doi.org/10.1159/000502356","url":null,"abstract":"<p><p>In mammalian species, the Fatty Acid Desaturase (FADS) gene cluster includes FADS1 (∆5-desaturase), FADS2 (∆6-desaturase), and a third gene member, named FADS3. According to its high degree of nucleotide sequence homology with both FADS1and FADS2, FADS3 was promptly suspected by researchers in the field to code for a new mammalian membrane-bound fatty acid desaturase. However, no catalytic activity was attributed to the FADS3 protein for a decade, until the rat FADS3 protein was shown in vitro to be able to catalyze the unexpected ∆13-desaturation of trans-vaccenic acid, producing the trans11,cis13-conjugated linoleic acid isomer. This review summarizes the recent investigations establishing the FADS3 enzyme as a reliable mammalian trans-vaccenate ∆13-desaturase in vivo and tries to identify further unresolved issues that need to be addressed.</p>","PeriodicalId":18030,"journal":{"name":"Lifestyle Genomics","volume":"12 1-6","pages":"18-24"},"PeriodicalIF":2.6,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000502356","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38364423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Front & Back Matter","authors":"María Elizabeth Tejero Barrera","doi":"10.1159/000494150","DOIUrl":"https://doi.org/10.1159/000494150","url":null,"abstract":"Selected Abstracts from the 19 3rd European Summer School on Nutrigenomics Jesi, June 25–29, 2018 Research Articles 40 Serum Lipid Concentrations and FADS Genetic Variants in Young Mexican College Students: The UP-AMIGOS Cohort Study Vazquez-Vidal, I. (Urbana, IL/Kannapolis, NC); Voruganti, V.S. (Kannapolis, NC); Hannon, B.A. (Urbana, IL); Andrade, F.C.D. (Champaign, IL); Aradillas-García, C. (San Luis Potosí); Nakamura, M.T.; Terán-García, M. (Urbana, IL) 49 A Systematic Review of Genetic Testing and Lifestyle Behaviour Change: Are We Using High-Quality Genetic Interventions and Considering Behaviour Change Theory? Horne, J.; Madill, J.; O’Connor, C.; Shelley, J.; Gilliland, J. (London, ON) 64 A High-Protein/Low-Fat Diet May Interact with Vitamin D-Binding Protein Gene Variants to Moderate the Risk of Depression in Apparently Healthy Adults Pooyan, S.; Rahimi, M.H.; Mollahosseini, M.; Khorrami-Nezhad, L.; Nasir, Y.; Maghbooli, Z.; Mirzaei, K. (Tehran)","PeriodicalId":18030,"journal":{"name":"Lifestyle Genomics","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44294307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Front & Back Matter","authors":"","doi":"10.1159/000488292","DOIUrl":"https://doi.org/10.1159/000488292","url":null,"abstract":"","PeriodicalId":18030,"journal":{"name":"Lifestyle Genomics","volume":"10 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44431770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contents Vol.10","authors":"","doi":"10.1159/000487698","DOIUrl":"https://doi.org/10.1159/000487698","url":null,"abstract":"93 11th Congress of the International Society of Nutrigenetics/ Nutrigenomics (ISNN) September 16–19, 2017, Los Angeles, CA Guest Editors: Hartiala, J. (Los Angeles, CA); MartÍnez, J.A. (Navarra); Li, Z.; Allayee, H. (Los Angeles, CA) 136 ISNN Society News 137 ISNN Membership Application Form","PeriodicalId":18030,"journal":{"name":"Lifestyle Genomics","volume":"10 1","pages":"I - IV"},"PeriodicalIF":2.6,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000487698","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49339195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acknowledgement to the Reviewers","authors":"","doi":"10.1159/000485769","DOIUrl":"https://doi.org/10.1159/000485769","url":null,"abstract":"","PeriodicalId":18030,"journal":{"name":"Lifestyle Genomics","volume":"10 1","pages":"194 - 194"},"PeriodicalIF":2.6,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000485769","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46957154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A High-Protein/Low-Fat Diet May Interact with Vitamin D-Binding Protein Gene Variants to Moderate the Risk of Depression in Apparently Healthy Adults.","authors":"Sara Pooyan,&nbsp;Mohammad Hossein Rahimi,&nbsp;Mehdi Mollahosseini,&nbsp;Leila Khorrami-Nezhad,&nbsp;Yasaman Nasir,&nbsp;Zhila Maghbooli,&nbsp;Khadijeh Mirzaei","doi":"10.1159/000492497","DOIUrl":"https://doi.org/10.1159/000492497","url":null,"abstract":"<p><strong>Background: </strong>Recent studies have shown that depression is inversely correlated with high protein and low fat intake and positively correlated with vitamin D-binding protein (VDBP). Therefore, the aim of this study was to examine the interaction between protein/fat dietary patterns and VDBP genotypes with regard to the risk of depression in apparently healthy adults who have not been diagnosed with any chronic disease.</p><p><strong>Methods: </strong>In this study, 265 individuals (126 males and 139 females) aged 18-55 years were recruited from the communities of central and west Tehran based on convenience sampling. Body composition was measured with a body composition analyzer and depression symptoms were categorized as normal, moderate depression, or severe depression using the Depression Anxiety Stress Scales 21 (DASS-21) questionnaire. Dietary patterns were determined by a semiquantitative food frequency questionnaire to assess typical food intake during the 12-month period. Blood samples were collected from and biochemical measurements performed on all participants. An analysis of two polymorphisms (rs7041 and rs4588) in the GC gene, which encodes VDBP, was performed by polymerase chain reaction-restriction fragment length polymorphism.</p><p><strong>Results: </strong>A statistically significant association was found between depression and diet (p = 0.03) after having categorized the participants into three groups: a high-protein/low-fat (HP/LF) group, a moderate-protein/moderate-fat (MP/MF) group, and a low-protein/high-fat (LP/HF) group. Moreover, the findings demonstrated that depression was related to both the rs7041 and the rs4588 polymorphism (p = 0.05 and p = 0.02, respectively). We next used multinomial logistic modeling to investigate the risk of depression. A significant interaction was observed between HP/LF diet and the rs7041 polymorphism in the moderate- and severe-depression groups (β = -0.30, p = 0.05, and β = -0.48, p = 0.01, respectively).</p><p><strong>Conclusion: </strong>This study showed that an HP/LF diet interacts with the rs7041 polymorphism, with T allele carriers having a greater prevalence of moderate and severe depression.</p>","PeriodicalId":18030,"journal":{"name":"Lifestyle Genomics","volume":"11 1","pages":"64-72"},"PeriodicalIF":2.6,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000492497","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36464363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}