Lifestyle Genomics最新文献

{"title":"Knowledge and Interest in Nutritional Genomics Among Clinical Dietitians in Kuwait: A Cross-Sectional Study.","authors":"Mohammad M H Abdullah, Fatemah Osama Al-Muaili, Esra Shishtar, Peter Eck, Marie-Claude Vohl, Ahmad Alsaber","doi":"10.1159/lfg/adlag003","DOIUrl":"https://doi.org/10.1159/lfg/adlag003","url":null,"abstract":"<p><strong>Introduction: </strong>The evolution of nutritional genomics informs promising opportunities to improve the efficacy of personalized dietary protocols through the interplay between genetics and nutrition. As the primary healthcare providers of nutrition services, dietetic practitioners can play a critical role in translating genomic knowledge into clinical practice for optimized health and quality of life. The objective of this study was to assess the knowledge and interest in nutritional genomics among clinical dietitians in Kuwait.</p><p><strong>Methods: </strong>A total of 319 dietitians practicing in public and private hospitals completed an online survey of a validated, structured questionnaire. Data were processed by using chi-square tests, ANOVA, and regression modeling.</p><p><strong>Results: </strong>The majority of study participants were females and had diploma or BSc degree in nutrition. Overall, 87% of dietitians showed low-to-moderate knowledge in nutritional genomics, with an entire cohort mean knowledge score of 5.2 ± 1.9 out of a possible 10. Notably, dietitians with higher baseline knowledge levels in nutritional genomics also expressed a significantly greater interest in the field (p < 0.05). Furthermore, while 82.1% of dietitians perceived personalized nutrition as highly important and 55.2% agreed that nutritional genomics could improve clinical outcomes of the dietetic profession, 79.6% either remained neutral or indicated a lack of adequate knowledge to successfully integrate the science into everyday practice. Concurrently, 39.8% showed high interest in advanced training programs.</p><p><strong>Conclusion: </strong>These findings invite action toward establishing institutional policies and specialized educational programs to enhance nutritional genomics literacy and integration into the dietetic practice in Kuwait.</p>","PeriodicalId":18030,"journal":{"name":"Lifestyle Genomics","volume":" ","pages":"1"},"PeriodicalIF":2.3,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149039548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Hypoxia-Inducible Factor-1α Gene Polymorphisms on Renal Cell Carcinoma Susceptibility in a Chinese Han Population.","authors":"Xinxin Liao, Haibin Zhou, Peng Huang","doi":"10.1159/000548643","DOIUrl":"10.1159/000548643","url":null,"abstract":"<p><strong>Introduction: </strong>Previous studies have reported the impact of the hypoxia inducible factor-1α (HIF1α) gene on risk of renal cell carcinoma (RCC). However, the results of these previous studies were inconsistent. Hence, this study aimed to verify the influence of single-nucleotide polymorphisms (SNPs) in the HIF1α gene and their interaction with environmental factors on RCC risk.</p><p><strong>Methods: </strong>PCR-based restriction fragment length polymorphism was used to genotype four SNPs. Logistic regression was utilized to test the association between HIF1α SNPs and RCC risk. A generalized multifactor dimensionality reduction model was employed to evaluate the potential interaction of the four SNPs in the HIF1α gene with environmental factors.</p><p><strong>Results: </strong>The rs11549465-CT, rs11549465-TT, and rs11549465-CT+TT genotypes were all associated with increased risk of RCC; the adjusted ORs (95% CI) were 1.74 (1.38-2.12) (CT vs. CC), 1.93 (1.47-2.43) (TT vs. CC), and 1.78 (1.41-2.18) (CT+TT vs. CC), respectively. We also found that the rs11549467-GA and rs11549467-GA+AA genotypes were associated with increased RCC risk, and adjusted ORs (95% CI) were 1.81 (1.49-2.16) (GA vs. GG), 1.79 (1.47-2.13) (GA+AA vs. GG), respectively. We found a statistically significant combination (including rs11549465 and smoking). Compared to non-smokers with the rs11549465-CC genotype, current or ever smokers with rs11549465-CT+TT genotype had the highest RCC risk; the OR (95% CI) was 3.68 (1.97-5.41).</p><p><strong>Conclusion: </strong>This study demonstrated a significant impact of HIF1α polymorphisms on RCC risk. Additionally, this impact could be influenced by environmental factors, such as smoking status.</p>","PeriodicalId":18030,"journal":{"name":"Lifestyle Genomics","volume":" ","pages":"1-8"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12721716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145557173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the Scale: How Metabolic Context Reveals Hidden Genetic Risks.","authors":"Joo Yeon Lusia Lee","doi":"10.1159/000549691","DOIUrl":"10.1159/000549691","url":null,"abstract":"","PeriodicalId":18030,"journal":{"name":"Lifestyle Genomics","volume":" ","pages":"42-45"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12810959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145743367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum.","authors":"","doi":"10.1159/lfg/adlag002","DOIUrl":"https://doi.org/10.1159/lfg/adlag002","url":null,"abstract":"<p><p>This is a correction to: Oxana Gavriluk, Igor Snapkow, Jean-Christophe Thalabard, Lars Holden, Marit Holden, Hege M. Bøvelstad, Eiliv Lund; Gene Expression Profiling of Peripheral Blood and Endometrial Cancer Risk Factors: Systems Epidemiology Approach in the NOWAC Postgenome Cohort Study. Lifestyle Genomics. 2026; 19(1):83-93. https://doi.org/10.1159/000550409.In the originally published version of this manuscript, there is an error in the Funding Sources section. Specifically, Norwegian Cancer Society (Kreftforeningen), project no. 215851 was inadvertently omitted. The correct funding information should read as follows:Funding SourcesThis study was supported by funding from the Northern Norway Regional Health Authority (Helse-Nord RHF), the Norwegian Cancer Society (Kreftforeningen), project no. 215851, and by a grant from the European Research Council (ERC-AdG 232997 TICE).</p>","PeriodicalId":18030,"journal":{"name":"Lifestyle Genomics","volume":"19 1","pages":"128"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149039551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redefining Malignant Hyperthermia: Multi-Omics Insights into a Complex Anesthetic Disorder.","authors":"Cassandra Thachuk, Darragh Barry, Jackie Trink","doi":"10.1159/000548601","DOIUrl":"10.1159/000548601","url":null,"abstract":"<p><strong>Background: </strong>Malignant hyperthermia (MH) is a rare but serious pharmacogenetic disorder triggered by specific anesthetic agents, leading to a rapid and often fatal hypermetabolic response. While its genetic roots - primarily involving RYR1 and CACNA1S mutations - are well documented, many susceptible individuals remain undiagnosed until they are exposed to the triggering anesthetic. Despite dantrolene being an instrumental drug in combatting MH mortality, global access remains inconsistent, and morbidity rates remains high. Current diagnostic tools are invasive and limited to specialized centers, and routine screening is rarely feasible.</p><p><strong>Summary: </strong>This review explores how recent advances in multi-omics - genomics, proteomics, metabolomics, transcriptomics, and radiomics - are reshaping our understanding of MH pathophysiology. From chronic calcium dysregulation and mitochondrial dysfunction to shifts in energy metabolism and subtle muscle changes, a complex picture is emerging. Integrative analyses reveal promising biomarkers for early detection, while CRISPR-based gene editing and machine learning offer potential pathways for future targeted interventions. Noninvasive imaging, blood-based metabolic profiling, and genomic risk prediction may soon offer safer, more effective screening tools for anesthesia planning.</p><p><strong>Key messages: </strong>Ultimately, a shift from reactive crisis management to proactive risk identification could redefine how we approach MH - potentially improving patient outcomes and saving lives.</p>","PeriodicalId":18030,"journal":{"name":"Lifestyle Genomics","volume":" ","pages":"76-82"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dairy Product Intake Alters the Correlations between Circulating Bile Acids and Short-Chain Fatty Acids with the Bacterial Taxa <italic>Roseburia</italic>, <italic>Faecalibacterium</italic>, <italic>Flavonifractor</italic>, and Verrucomicrobia.","authors":"Atena Mahdavi, Karine Greffard, Jocelyn Trottier, Olivier Barbier, Jean-François Bilodeau, Michel Lebel, Iwona Rudkowska","doi":"10.1159/000550224","DOIUrl":"10.1159/000550224","url":null,"abstract":"<p><strong>Introduction: </strong>Type 2 diabetes (T2D) risk factors are associated with gut microbiota dysregulation that can alter circulating metabolite levels such as bile acids (BAs) and short-chain fatty acids (SCFAs). The objective was to investigate how the high dairy (HD) (≥4 servings/day) product intake compared to adequate dairy (AD) (≤2 servings/day) intake influences the correlations between Roseburia, Faecalibacterium, Flavonifractor, as well as Verrucomicrobia and circulating BAs and SCFAs in subjects at risk of T2D.</p><p><strong>Methods: </strong>In a randomized crossover trial, 10 hyperinsulinemic adults were randomized to HD or AD for 6 weeks separated by a 6-week washout period. Gut microbiota were measured with 16S rRNA-based high-throughput sequencing. BA profiling in plasma was performed by high-performance liquid chromatography-tandem mass spectrometry. Serum SCFAs were determined using headspace gas chromatography.</p><p><strong>Results: </strong>No significant differences were observed in mean circulating BA or SCFA levels between AD and HD consumption. Verrucomicrobia and Flavonifractor showed positive correlations with secondary BAs following HD and AD intake, respectively. Additionally, Flavonifractor correlated positively with acetic and propionic acids after HD intake. Roseburia correlated positively with primary BAs, propionate, and butyrate after HD intake. Faecalibacterium was positively correlated with cholic acid after AD intake and with hexanoic acid after HD intake.</p><p><strong>Conclusion: </strong>These findings suggest that HD intake may modulate microbiota-metabolite interactions without altering circulating metabolite concentrations, highlighting a potential role for dietary patterns in shaping gut-derived metabolic signals in individuals at risk of T2D.</p>","PeriodicalId":18030,"journal":{"name":"Lifestyle Genomics","volume":" ","pages":"46-62"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12863728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145827876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Insights into the Functional Roles of Variants in the <italic>FADS</italic> Gene Cluster on Omega-3 Long-Chain Polyunsaturated Fatty Acid Synthesis.","authors":"Makaila Coulson, David M Mutch","doi":"10.1159/000549658","DOIUrl":"10.1159/000549658","url":null,"abstract":"<p><strong>Background: </strong>Omega-3 long-chain polyunsaturated fatty acids (n3-LCPUFAs) have strong triglyceride-lowering and anti-inflammatory properties, and high levels of these fatty acids have been associated with reduced risk of cardiovascular disease. The synthesis of n3-LCPUFA, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and n6-LCPUFA, arachidonic acid, share a common pathway mediated by fatty acid desaturase genes, FADS1 and FADS2. LCPUFA synthesis is regulated by both modifiable and non-modifiable factors. Of particular interest is the role of genetic variants in the FADS gene cluster, which are associated with altered FADS1 and FADS2 expression, as well as LCPUFA levels. However, the specific functional variants and the precise molecular mechanisms by which these variants regulate FADS gene expression remain to be elucidated. Variation in the FADS gene cluster is thought to have arisen through natural selection and changing dietary patterns. Available evidence suggests these variants, either individually or as a haplotype, may alter FADS gene expression by modifying DNA methylation in regulatory regions, as well as microRNA and transcription factor binding sites.</p><p><strong>Summary: </strong>This review explores the current state of knowledge regarding the functional roles of these variants on LCPUFA synthesis and how these new insights will help support precision nutrition strategies aimed at improving an individual's n3-LCPUFA status and health.</p><p><strong>Key messages: </strong>Identifying specific functional variants in or near the FADS gene cluster and elucidating the mechanisms by which these variants impact LCPUFA synthesis requires further investigation. However, hypothesis generating in vitro studies have revealed roles for epigenetics, non-coding RNAs, and modification of transcription factor binding sites. This knowledge will generate new insights that will help improve our understanding of the genetic basis underlying LCPUFA synthesis and how this may differ across populations.</p>","PeriodicalId":18030,"journal":{"name":"Lifestyle Genomics","volume":" ","pages":"9-22"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12774425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145635034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Perspective on the Relationship between Female Reproductive Traits, Exercise, and Bone Health Outcomes: Evidence from a National Database.","authors":"Bo-Kai Chen, Jansen Marcos Cambia, Chien-An Shih, Meng-Che Tsai","doi":"10.1159/000553353","DOIUrl":"10.1159/000553353","url":null,"abstract":"<p><strong>Introduction: </strong>Female reproductive traits influence bone mineral density (BMD) and fracture risks through estrogen exposure. However, these causal relationships remain unclear due to confounding. Understanding these relationships is crucial for osteoporosis prevention strategies. This study aimed to investigate the causal impact of age at natural menopause (ANM) and age at menarche (AAM) on BMD and osteoporosis risk, and to explore gene-exercise interactions influencing bone health in East Asian women.</p><p><strong>Methods: </strong>We conducted two-sample Mendelian randomization (MR) using 15 genetic variants for AAM and 36 variants for ANM in 51,049 women from the Taiwan Biobank, split into discovery (n = 25,549) and validation (n = 25,500) cohorts. Outcomes were BMD Z scores, T scores, and clinical osteoporosis. We performed univariable and multivariable MR, followed by regression analyses, focusing on exercise effects on BMD and genetic predisposition scores for AAM and ANM.</p><p><strong>Results: </strong>In multivariable MR, genetically determined later ANM was associated with higher BMD Z scores (β = 0.045, 95% confidence interval [0.021, 0.069]), higher T scores (β = 0.046, [0.020, 0.072]), and lower osteoporosis risk (β = -0.106, [-0.154, -0.058]). No consistent causal effect was observed for AAM due to genetic pleiotropy. ANM polygenic risk score and regular exercise were independently associated with improved BMD Z- and T scores and reduced risk of osteoporosis. Specific gene-exercise interactions were identified in which the AAM polygenic risk score interacted significantly with gymnastics, while the ANM polygenic risk score interacted with lower-limb exercise and swimming.</p><p><strong>Conclusion: </strong>Late ANM provides causal protection against osteoporosis in East Asian women, while the effects of AAM remain insignificant. Exercise benefits bone health with activity-specific genetic interactions. These findings support personalized osteoporosis prevention strategies incorporating both genetic risk assessment and targeted exercise recommendations, particularly for women with early menopause predisposition.</p>","PeriodicalId":18030,"journal":{"name":"Lifestyle Genomics","volume":" ","pages":"116-127"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148422223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Tri-Source Microbiome Dataset from Human Sleep Environments: Saliva, Pillow Dust, and Bedroom Air.","authors":"Jeong Yun Jang, Jaeha Lee, Hyunjun Yun, Jinho Yang","doi":"10.1159/lfg/adlag001","DOIUrl":"10.1159/lfg/adlag001","url":null,"abstract":"<p><strong>Introduction: </strong>Despite the recognized importance of the human microbiome, integrated microbial exposures within sleep environments remain poorly understood. Sleep represents a prolonged period of close contact with indoor microbial reservoirs, yet the connectivity between environmental sources and the human oral microbiome has not been comprehensively examined.</p><p><strong>Methods: </strong>We conducted a pilot study involving eight healthy adults, collecting paired saliva, pillow dust, and bedroom air samples under standardized conditions. Microbial communities were characterized using 16S rRNA gene amplicon sequencing targeting the V3-V4 region. Sequence data were processed using Cutadapt for primer removal and DADA2 for amplicon sequence variant inference, followed by taxonomic assignment and diversity analyses.</p><p><strong>Results: </strong>Pillow dust exhibited significantly higher alpha diversity, including species richness and phylogenetic diversity, compared to saliva and air (p < 0.05). Beta diversity analysis revealed distinct clustering by sample type, with pillow dust and air showing greater similarity to each other than to saliva. At the genus level, significant correlations were observed between air and pillow dust (e.g., Brevitalea, Gardnerella) and between pillow dust and saliva (e.g., Actinomyces, Bifidobacterium). These patterns suggest potential microbial transfer pathways mediated by gravitational settling and direct physical contact. Given the small sample size, findings should be interpreted as exploratory.</p><p><strong>Conclusion: </strong>This study provides a novel tri-source microbiome dataset linking human and environmental microbial communities in real-world sleep settings. The results highlight the sleep environment as a relevant exposomic factor influencing oral microbiome dynamics and support further large-scale investigations into host-environment microbial interactions.</p>","PeriodicalId":18030,"journal":{"name":"Lifestyle Genomics","volume":" ","pages":"0"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148795056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Determinants of Creatine Bioavailability and Responsiveness: Emphasis on Common Low-Impact Variants.","authors":"Sergej M Ostojic, Ivana Kavecan","doi":"10.1159/000551090","DOIUrl":"10.1159/000551090","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Creatine is a central regulator of cellular energy homeostasis and one of the most extensively studied dietary supplements in human nutrition. Although creatine supplementation consistently increases tissue creatine availability and supports performance and health across diverse populations, substantial interindividual variability in responsiveness persists. Approximately one-quarter of individuals demonstrate minimal increases in tissue creatine or functional benefit following supplementation. While nongenetic factors such as baseline creatine status, diet, age, sex, and training load contribute to this heterogeneity, the role of common genetic variation remains insufficiently explored. Importantly, creatine bioavailability and functional responsiveness are related but distinct outcomes, and both may be modified by genetic background. This paper aimed to reframe creatine responsiveness as a quantitative, polygenic trait shaped by common low-impact genetic variants rather than a binary responder-nonresponder phenomenon driven by rare pathogenic mutations. The review synthesizes evidence on genetic variation affecting creatine transport, endogenous synthesis, and downstream energy metabolism, with an emphasis on population-relevant mechanisms.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Summary: &lt;/strong&gt;A narrative, mechanism-oriented review was conducted integrating data from human genetics databases, biochemical pathways, and physiological studies. The analysis focused on (1) common low-impact variants in genes directly regulating creatine transport (SLC6A8) and biosynthesis (GATM, GAMT), and (2) modifier genes involved in mitochondrial function, phosphagen buffering, and muscle or neural energetic phenotype. Variant classification frameworks from expert curation initiatives were used to distinguish pathogenic from low-impact population variants. Low-impact variants in the creatine transporter gene SLC6A8 are highly prevalent and likely contribute to a continuum of creatine transport efficiency, with sex-dependent effects due to X-linked inheritance. Similarly, common polymorphisms in creatine biosynthetic enzymes (GATM and GAMT) may subtly alter synthetic efficiency or methyl-group demand, increasing dietary creatine dependence while not causing overt deficiency. Beyond creatine-specific pathways, genetic variation in mitochondrial regulators, electron transport chain components, creatine kinase isoforms, and muscle fiber-type determinants can act as effect modifiers, amplifying or dampening the functional benefits of creatine despite comparable tissue uptake. Collectively, small additive effects across transport, synthesis, and utilization pathways may prevent supplementation from exceeding the threshold required for measurable benefit in certain individuals.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Key messages: &lt;/strong&gt;Creatine non-responsiveness in the general population is more plausibly explained by the cumulative influence of common low-impact genetic variants","PeriodicalId":18030,"journal":{"name":"Lifestyle Genomics","volume":" ","pages":"94-100"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13065303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146258549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}