LUTS: Lower Urinary Tract Symptoms最新文献

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Tolerability and Efficacy of Duloxetine Compared to Amitriptyline in Women With Chronic Pelvic Pain Syndrome: Findings From a Clinical Trial 与阿米替林相比,度洛西汀对女性慢性盆腔疼痛综合征的耐受性和疗效:来自一项临床试验的发现
IF 1.5 4区 医学
LUTS: Lower Urinary Tract Symptoms Pub Date : 2025-07-27 DOI: 10.1111/luts.70023
Maede Mohseni, Rojan Ghaderzadeh, Kimia Bakhtiari, Maryam Zamanirafe, Mona Doostizadeh, Aliasghar Tabatabaeii Mohammadi, Kiumarth Amini, Maryam Mehrpooya
{"title":"Tolerability and Efficacy of Duloxetine Compared to Amitriptyline in Women With Chronic Pelvic Pain Syndrome: Findings From a Clinical Trial","authors":"Maede Mohseni, Rojan Ghaderzadeh, Kimia Bakhtiari, Maryam Zamanirafe, Mona Doostizadeh, Aliasghar Tabatabaeii Mohammadi, Kiumarth Amini, Maryam Mehrpooya","doi":"10.1111/luts.70023","DOIUrl":"https://doi.org/10.1111/luts.70023","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Duloxetine has demonstrated efficacy in treating various types of chronic pain conditions. A double-blind clinical trial was conducted to assess the effectiveness and tolerability of duloxetine compared to amitriptyline in women suffering from chronic pelvic pain (CPP) syndrome.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Sixty-nine eligible women diagnosed with CPP syndrome were randomly assigned to receive either duloxetine or amitriptyline. Duloxetine was initiated at 30 mg/day and amitriptyline at 25 mg/day, with dosages increased to 60 mg/day for duloxetine and 50 mg/day for amitriptyline after the first week and maintained throughout weeks 2 to 8 of the treatment phase. The effectiveness of the treatment was assessed using the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) and its domain scores at weeks 4 and 8 after treatment. The safety and tolerability of the study medications were assessed using an antidepressant side effect checklist and spontaneous participant reports of adverse effects. All analyses were conducted on an Intention-to-Treat (ITT) analysis data set.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Patients undergoing both medications experienced similar improvements in their total NIH-CPSI scores at weeks 4 and 8. The proportions of patients achieving a response, defined as at least a 6-point reduction in the total NIH-CPSI score at both weeks 4 and 8, were also comparable between the duloxetine and amitriptyline treatments. Further, at the end of the study period, a similar proportion of subjects reported marked or moderate overall symptom improvements with both treatments. However, in the analysis of NIH-CPSI domain scores, duloxetine-treated patients exhibited lower pain domain scores at both study endpoints, while amitriptyline-treated patients achieved better scores in the urinary symptoms domain. Regarding quality of life domain scores, no significant differences were observed between the groups. In terms of safety and tolerability, duloxetine demonstrated more favorable outcomes, with fewer patients experiencing adverse effects and a lower withdrawal rate due to adverse effects compared to amitriptyline.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings suggest that duloxetine is as effective as amitriptyline for managing CPP syndrome in women, with the added advantage of a more favorable safety profile.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>The trial was registered at the Iranian Registry of Clinical Trials (identifie","PeriodicalId":18028,"journal":{"name":"LUTS: Lower Urinary Tract Symptoms","volume":"17 4","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144714670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Knowledge, Attitudes, and Practices of Physiotherapists Regarding the Management of Urinary Incontinence in Elderly Patients in France: A Cross-Sectional Study 物理治疗师对法国老年患者尿失禁管理的知识、态度和实践:一项横断面研究
IF 1.5 4区 医学
LUTS: Lower Urinary Tract Symptoms Pub Date : 2025-07-22 DOI: 10.1111/luts.70022
Julie Swiderski, Joëlle Lansonneur Leterme, Fréderic Bloch, François-Régis Sarhan
{"title":"Knowledge, Attitudes, and Practices of Physiotherapists Regarding the Management of Urinary Incontinence in Elderly Patients in France: A Cross-Sectional Study","authors":"Julie Swiderski, Joëlle Lansonneur Leterme, Fréderic Bloch, François-Régis Sarhan","doi":"10.1111/luts.70022","DOIUrl":"https://doi.org/10.1111/luts.70022","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Context</h3>\u0000 \u0000 <p>Studies on nurses' and nursing assistants' perceptions of urinary incontinence (UI) in the elderly are well-documented; however, little to no research focuses specifically on physiotherapists. This study aims to explore physiotherapists' perspectives on UI among elderly patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To assess the knowledge, attitudes, and practices of physiotherapists in France regarding managing UI in elderly patients, and to explore how training influences their confidence and clinical behaviors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional online survey was conducted among physiotherapists practicing in France. The questionnaire addressed sociodemographic characteristics, experience with elderly patients with UI, and training in pelvic-perineal rehabilitation. Descriptive statistics and <i>χ</i><sup>2</sup> analyses were used to identify associations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 106 responses were collected. Among respondents, 80 (75.5%) reported knowing UI in elderly patients, but 62 (58.5%) expressed feeling powerless when managing such cases. Only 62 (58.5%) reported having the skills to help patients with UI, and just 10 (9.4%) used validated assessment tools. Physiotherapists who had received prior training—whether through initial education, continuing education, or self-directed study—were significantly more likely to report confidence, satisfaction, and proper use of tools (<i>p</i> < 0.01). A majority, 75 (70.8%), indicated a need for further training, and 60 (56.6%) expressed the need for clinical guidelines.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>This study reveals a gap between physiotherapists' knowledge of UI and their ability to manage it confidently in elderly patients. Training was significantly associated with greater competence and use of recommended practices. The underuse of assessment tools and expressed need for clearer guidelines suggest structural gaps in support and education.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Improving UI training and access to standardized tools could enhance physiotherapists' confidence and quality of care. Although conducted in France, these findings may inform international strategies to address similar gaps in geriatric continence care.</p>\u0000 </s","PeriodicalId":18028,"journal":{"name":"LUTS: Lower Urinary Tract Symptoms","volume":"17 4","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/luts.70022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is Vaginal Prosthetic Surgery Always to Be Avoided? Analysis of the Efficacy and Safety of Vaginal Mesh With 3 Levels-De Lancey Attachment in Women With Recurrent Vaginal Vault Prolapse 阴道修复手术总是要避免的吗?三级de Lancey附着阴道补片治疗复发性阴道穹窿脱垂的疗效和安全性分析
IF 1.5 4区 医学
LUTS: Lower Urinary Tract Symptoms Pub Date : 2025-07-10 DOI: 10.1111/luts.70021
Lorenzo Campanella, Giovanni Grossi, Passarello Alessandra, Pietro Cignini, Fabio Manganelli, Pierluigi Palazzetti, M. A. Zullo, Andrea Morciano, Carlo Rappa, Francesco Deltetto, M. C. Schiavi
{"title":"Is Vaginal Prosthetic Surgery Always to Be Avoided? Analysis of the Efficacy and Safety of Vaginal Mesh With 3 Levels-De Lancey Attachment in Women With Recurrent Vaginal Vault Prolapse","authors":"Lorenzo Campanella,&nbsp;Giovanni Grossi,&nbsp;Passarello Alessandra,&nbsp;Pietro Cignini,&nbsp;Fabio Manganelli,&nbsp;Pierluigi Palazzetti,&nbsp;M. A. Zullo,&nbsp;Andrea Morciano,&nbsp;Carlo Rappa,&nbsp;Francesco Deltetto,&nbsp;M. C. Schiavi","doi":"10.1111/luts.70021","DOIUrl":"https://doi.org/10.1111/luts.70021","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The purpose of this research is to determine the effectiveness and safety of a vaginal mesh intended to resolve multicompartmental prolapse in individuals with substantial vaginal vault prolapse.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>From 2015 to 2020, 67 patients with recurrent apical prolapse ≥ III stage (POP-Q grading) underwent transvaginal vault repair using the isoelastic mesh InGYNious. Operative time, blood transfusions, spontaneous voiding, perioperative issues, postoperative hospital stay, and postoperative complications (early within 30 days and late after 30 days) were also investigated. Following the first preoperative examination, clinical and QoL questionnaires were examined both before and after surgery at the long-term follow-up (&gt; 60 months).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The average surgery duration was 41 ± 21 min, with an estimated blood loss of 50 ± 21 mL. The total number of surgical complications was eight (11.9%). The study discovered significant reductions in the apical (from 1.88 ± 2.59 to −6.73 ± 1.77) and anterior (from 1.34 ± 1.67 to −2.25 ± 0.95) deficiencies, as well as improvements in PQOL (from 67.72 ± 19.25 to 33.74 ± 7.48), PISQ-12 (from 29 to 36), FSFI (from 20 to 29), and FSDS (from 21 to 8). Finally, we identified three cases of full recurrence and only two occurrences needed reoperation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Transvaginal mesh repair is a safe and effective surgical technique that can treat multi-compartment prolapse, improve anatomical success, and reduce the risk of recurrence in certain patient populations, such as those with significant comorbidities, elderly patients, patients with recurrent POP, or patients with very challenging cases of POP.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18028,"journal":{"name":"LUTS: Lower Urinary Tract Symptoms","volume":"17 4","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144598213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Repeatability Study of Measurement of Micturition With Voiding Sonography and Uroflowmetry of Asymptomatic Women 无症状妇女排尿超声和尿流测量排尿的可重复性研究
IF 1.5 4区 医学
LUTS: Lower Urinary Tract Symptoms Pub Date : 2025-07-08 DOI: 10.1111/luts.70020
Bernadette Dellar, Ryan Stafford, Eric Chung, Gabriel Schaer, Margret Sherburn, Roxanna Turner, Handoo Rhee, Anna Page, Paul W. Hodges
{"title":"A Repeatability Study of Measurement of Micturition With Voiding Sonography and Uroflowmetry of Asymptomatic Women","authors":"Bernadette Dellar,&nbsp;Ryan Stafford,&nbsp;Eric Chung,&nbsp;Gabriel Schaer,&nbsp;Margret Sherburn,&nbsp;Roxanna Turner,&nbsp;Handoo Rhee,&nbsp;Anna Page,&nbsp;Paul W. Hodges","doi":"10.1111/luts.70020","DOIUrl":"https://doi.org/10.1111/luts.70020","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This study aimed to assess the intra- and inter-tester repeatability of voiding sonography measures in asymptomatic women and to examine the effect of perineal transducer placement on uroflowmetry.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A prospective observational study of 32 asymptomatic women was conducted using ultrasound with simultaneous uroflowmetry. Participants completed four voids (two per day). The ultrasound transducer placed on the perineum assessed bladder neck and urethral displacement during micturition. On Day 1, a void with ultrasound and uroflow recorded by a sonographer was compared to a void recorded with uroflowmetry only to determine whether the transducer placement affected voiding. On Day 2, two sonographers evaluated the voids with ultrasound and uroflowmetry. Each sonographer measured their own images. One sonographer also made measures on the images recorded by the second sonographer. Uroflowmetry measures and void patterns were evaluated. The repeatability of ultrasound measures was analyzed using intraclass correlation coefficient (ICC 2,1) and Bland–Altman analysis, and <i>t</i> tests examined the transducer's impact on uroflowmetry.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Some changes in flow rate and flow pattern (20% of participants) were observed with placement of the transducer. Most sonographic measures showed good to excellent inter- and intra-tester repeatability, and between measures made by the different testers on the same image. During void, bladder neck and urethral diameter were more repeatable if measures were made at the time of maximum flow estimated from the simultaneous uroflowmetry.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Voiding sonography is both feasible and repeatable. Perineal transducer placement affected micturition for some individuals. Voiding sonography combined with uroflowmetry shows promise for a noninvasive urogynecology functional assessment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18028,"journal":{"name":"LUTS: Lower Urinary Tract Symptoms","volume":"17 4","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/luts.70020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Urinary Incontinence Occurrence Among Patients With Advanced Pelvic Organ Prolapse After Single Incision Mesh (SIM) and Anterior Mesh (A-Mesh) With Sacrospinous Ligament Fixation (SSF) Surgery at 1 Year Follow-Up Study 单切口补片(SIM)与前路补片(A-Mesh)联合骶棘韧带固定(SSF)手术后晚期盆腔器官脱垂患者尿失禁发生率的1年随访比较
IF 1.5 4区 医学
LUTS: Lower Urinary Tract Symptoms Pub Date : 2025-06-29 DOI: 10.1111/luts.70017
Tsia-Shu Lo, Maherah Kamarudin, Huan-Ka Chiung, Eyal Rom, Louiza Erika Rellora, Wu-Chiao Hsieh
{"title":"Comparison of Urinary Incontinence Occurrence Among Patients With Advanced Pelvic Organ Prolapse After Single Incision Mesh (SIM) and Anterior Mesh (A-Mesh) With Sacrospinous Ligament Fixation (SSF) Surgery at 1 Year Follow-Up Study","authors":"Tsia-Shu Lo,&nbsp;Maherah Kamarudin,&nbsp;Huan-Ka Chiung,&nbsp;Eyal Rom,&nbsp;Louiza Erika Rellora,&nbsp;Wu-Chiao Hsieh","doi":"10.1111/luts.70017","DOIUrl":"https://doi.org/10.1111/luts.70017","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>We aimed to study the incidence of de novo and persistent stress urinary incontinence (SUI), urodynamic stress incontinence (USI) for single incision mesh (SIM) using Calistar-S and anterior mesh (A-mesh) using Surelift-A with sacrospinous fixation (SSF).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients with Stage III or IV POP who underwent Surelift-A + SSF (A-mesh + SSF) or Calistar-S (SIM) were evaluated at 1 year post-operative and compared. The primary outcome was the emergence of post-operative de novo and persistent SUI. Secondary outcomes included the rate of POP recurrence, quality of life, sexual function, and complications.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>One hundred and seven patients underwent SIM and 122 patients with A-mesh + SSF. 12/58 (20.7%) had de novo USI, 15/58 (25.9%) de novo SUI in SIM, while in the A-mesh + SSF group, de novo USI developed in 3/43 (7%) and de novo SUI in 4/43 (9.3%), significantly higher with <i>p</i> = 0.048 and <i>p</i> = 0.035 respectively. Rates of persistent USI and SUI were comparable between groups. Objective cure was comparable between the two groups (96.3% vs. 97.5%, <i>p</i> = 0.428), subjective cure 99/107 (92%) vs. 114/122 (93.8%) for SIM vs. A-mesh + SSF. Quality-of-life measures improved significantly in both groups, with greater perceived improvement in the A-mesh + SSF group. One case of bladder injury occurred in SIM and one mesh erosion was seen in both groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Risk of de novo SUI and de novo USI were three-fold higher in the SIM (Calistar-S), however risk of persistent USI and SUI was similar. Both SIM and A-mesh + SSF confer comparable high objective and subjective cure.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18028,"journal":{"name":"LUTS: Lower Urinary Tract Symptoms","volume":"17 4","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144514852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum Serotonin Levels as a Potential Risk Factor for Overactive Bladder in a Community-Dwelling Population: A Four-Year Longitudinal Study 血清血清素水平是社区居民膀胱过度活动的潜在危险因素:一项为期四年的纵向研究
IF 1.5 4区 医学
LUTS: Lower Urinary Tract Symptoms Pub Date : 2025-06-28 DOI: 10.1111/luts.70019
Takafumi Fukushima, Teppei Okamoto, Tomoko Hamaya, Hirotake Kodama, Naoki Fujita, Hayato Yamamoto, Atsushi Imai, Shigeyuki Nakaji, Shingo Hatakeyama
{"title":"Serum Serotonin Levels as a Potential Risk Factor for Overactive Bladder in a Community-Dwelling Population: A Four-Year Longitudinal Study","authors":"Takafumi Fukushima,&nbsp;Teppei Okamoto,&nbsp;Tomoko Hamaya,&nbsp;Hirotake Kodama,&nbsp;Naoki Fujita,&nbsp;Hayato Yamamoto,&nbsp;Atsushi Imai,&nbsp;Shigeyuki Nakaji,&nbsp;Shingo Hatakeyama","doi":"10.1111/luts.70019","DOIUrl":"https://doi.org/10.1111/luts.70019","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>This study aims to investigate the potential influence of serum serotonin (5-HT) levels on the development of overactive bladder (OAB) in a community-dwelling population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A four-year longitudinal study was conducted involving 615 subjects who participated in the Iwaki Health Promotion Project in Hirosaki, Japan, in both 2015 and 2019. OAB was defined as experiencing urinary urgency at least once a week with an Overactive Bladder Symptom Score (OABSS) of ≥ 3. Baseline data from 2015, including serum 5-HT levels, other laboratory data, and comorbidity information, were used for the analysis. The association between serum 5-HT levels and incident OAB in 2019 (OAB-2019) was examined using multivariate logistic regression analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study included 250 men and 365 women, of whom 74 individuals (29 men and 45 women) met the diagnostic criteria for OAB in 2019. Significant differences were observed between the OAB-2019 and non-OAB-2019 groups, including age, chronic kidney disease, irritable bowel syndrome, hypertension, glycemic status, mental status, and OAB in 2015. Participants in the OAB-2019 group had significantly lower serum 5-HT levels compared to the non-OAB-2019 group (100 vs. 129 ng/mL, <i>p</i> &lt; 0.001). After adjusting for confounders, multivariable analysis revealed that serum 5-HT levels &lt; 134 ng/mL (odds ratio: 2.48, 95% confidence interval: 1.39–5.83, <i>p</i> = 0.004), age, mental status, and OAB in 2015 independently served as risk factors for OAB-2019.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Low serum 5-HT levels may be associated with an increased risk of OAB. Further research is needed to elucidate the underlying mechanisms responsible for this association.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18028,"journal":{"name":"LUTS: Lower Urinary Tract Symptoms","volume":"17 4","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/luts.70019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Overactive Bladder is Positively Associated With the Prevalence and Mortality of Cancer Among US Adults 在美国成年人中,膀胱过度活动与癌症患病率和死亡率呈正相关
IF 1.5 4区 医学
LUTS: Lower Urinary Tract Symptoms Pub Date : 2025-06-22 DOI: 10.1111/luts.70018
Jianing Liu, Kai Wang
{"title":"Overactive Bladder is Positively Associated With the Prevalence and Mortality of Cancer Among US Adults","authors":"Jianing Liu,&nbsp;Kai Wang","doi":"10.1111/luts.70018","DOIUrl":"https://doi.org/10.1111/luts.70018","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Overactive bladder (OAB) is a prevalent urological condition often perceived as negligible or non-threatening, leading to its potential links with severe health conditions being overlooked. Notably, the relationship between OAB and cancer remains unexplored. This study endeavors to elucidate the association of OAB with cancer prevalence and mortality risks.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study utilized data from the 2007 to 2016 cycles of the National Health and Nutrition Examination Survey (NHANES), incorporating linked mortality data up to December 31, 2019. OAB symptoms were quantified using the modified overactive bladder symptom score (OABSS), with scores ≥ 3 confirming diagnosis. Cancer status was self-reported and further clarified for cancer type. We employed multivariate weighted logistic regression to examine the association between OAB and cancer prevalence, and subgroup analysis to identify variations across demographic and clinical characteristics. Cumulative mortality incidence curves, adjusted via inverse probability weighting, and multivariate Cox regression analysis were utilized to investigate the relationship between OAB and cancer-related mortality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 20 468 adults aged 20 and older were involved in this study. After adjusting for potential confounders, OAB was positively associated with the risk of cancer (OR = 1.36, 95% CI: 1.18, 1.57). Subgroup analysis revealed significant interactions between OAB and age (<i>P</i><sub>interaction</sub> = 0.001). Survival analysis suggests that OAB was linked to higher all-cause mortality risks exclusively among cancer patients (HR 1.39, 95% CI: 1.17, 1.65) and elevated cancer-specific mortality across the overall population (HR 1.33, 95% CI: 1.03, 1.73).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>OAB is associated with the prevalence and mortality of cancer among US adults.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18028,"journal":{"name":"LUTS: Lower Urinary Tract Symptoms","volume":"17 4","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrasonography and Clinical Outcomes Following Single-Incision Mid-Urethral Tape Procedure (I-Stop-Mini) for Urodynamic Stress Incontinence at 1 Year 单切口尿道中带手术(I-Stop-Mini)治疗1年尿动力性压力性尿失禁的超声检查和临床结果
IF 1.5 4区 医学
LUTS: Lower Urinary Tract Symptoms Pub Date : 2025-06-03 DOI: 10.1111/luts.70016
Tsia-Shu Lo, Maherah Kamarudin, Lan-Sin Jhang, Huan-Ka Chiung, Wu-Chiao Hsieh, Louiza Erika Rellora
{"title":"Ultrasonography and Clinical Outcomes Following Single-Incision Mid-Urethral Tape Procedure (I-Stop-Mini) for Urodynamic Stress Incontinence at 1 Year","authors":"Tsia-Shu Lo,&nbsp;Maherah Kamarudin,&nbsp;Lan-Sin Jhang,&nbsp;Huan-Ka Chiung,&nbsp;Wu-Chiao Hsieh,&nbsp;Louiza Erika Rellora","doi":"10.1111/luts.70016","DOIUrl":"https://doi.org/10.1111/luts.70016","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate I-Stop-Mini surgery outcomes in urodynamic stress incontinence (USI) patients and its sonographic features at 1 year.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>One hundred one patients with confirmed USI who underwent I-Stop-Mini surgery from March 2019 to February 2023 were recruited. Inclusion criteria include confirmed USI. Pelvic organ prolapse ≥ stage 2, detrusor overactivity, neurogenic bladder, high residual urine, or concomitant prolapse surgery were excluded. Primary outcomes were objective and subjective continence cure. Secondary outcomes were sonography findings of sling mobility (T), bladder neck (BN), sling to urethra percentile, and the presence of dynamic urethral kinking.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Objective cure and subjective cure were 85/92 (92.4%) and 83/92 (90.2%). Significant improvement in UDS diagnosis of USI was seen pre- versus postoperatively 92/92 (100%) versus 7/92 (7.85%) <i>p</i> &lt; 0.001 and change in pad weight from 22.4 ± 29.1 to 1.5 ± 3.8 g, <i>p</i> &lt; 0.001. As for secondary outcome, no change in resting tape position (xt, yt), at 6months and 1 year; (18.2 ± 2.8, 17.3 ± 2.6 mm) versus (18.8 ± 2.2, 17.8 ± 2.8 mm), (<i>p</i> = 0.208, <i>p</i> = 0.237) respectively. During Valsalva (22.4 ± 3.3, 7.0 ± 2.9 mm) versus (22.8 ± 3.7, 7.5 ± 2.4 mm) (<i>p</i> = 0.251, <i>p</i> = 0.135) at 6 months and 1 year. Tape mobility unchanged, 11.3 ± 2.5 versus 11.4 ± 3.0 mm, <i>p</i> = 0.693. Dynamic kinking was maintained at 60% versus 59%, <i>p</i> = 0.877. No major complication was observed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>I-Stop-Mini SIS has high objective and subjective cure. Dynamic kinking, BN position (at rest and Valsalva) and mobility between 6 months and 1 year were maintained, thus promoting its continence effect.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18028,"journal":{"name":"LUTS: Lower Urinary Tract Symptoms","volume":"17 4","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144206755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Saw Palmetto Extract Ameliorates Benign Prostatic Hyperplasia by Regulating 5α-Reductase and Apoptosis In Vitro and In Vivo 锯棕榈提取物通过调节5α-还原酶和细胞凋亡改善良性前列腺增生
IF 1.5 4区 医学
LUTS: Lower Urinary Tract Symptoms Pub Date : 2025-05-21 DOI: 10.1111/luts.70015
Bo Zhang, Hui Wang, Tianyu Ma, Jiangang Yang
{"title":"Saw Palmetto Extract Ameliorates Benign Prostatic Hyperplasia by Regulating 5α-Reductase and Apoptosis In Vitro and In Vivo","authors":"Bo Zhang,&nbsp;Hui Wang,&nbsp;Tianyu Ma,&nbsp;Jiangang Yang","doi":"10.1111/luts.70015","DOIUrl":"https://doi.org/10.1111/luts.70015","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The therapeutic effect of saw palmetto extract (SPE) in benign prostatic hyperplasia (BPH) has been evaluated in clinical trials. However, the molecular mechanisms of SPE in BPH development are not fully understood.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>LNCap cell line treated with dihydrotestosterone (DHT) and SD rats induced with testosterone were used, respectively. TUNEL and Muse Cell Analyzer for apoptosis and CCK8 assay for cell viability were performed to investigate the effects of SPE against BPH. Histological changes were examined by HE staining. Protein expression was analyzed for AR, PSA, SRC-1, and 5AR2 by Western blot, and the levels of DHT and testosterone in rat serum were quantified by ELISA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>SPE treatment could accelerate the apoptosis of cells and decrease the expressions of TNF-α, IL-1β and IL-18. TUNEL staining revealed an increase in positive staining after SPE treatment. Rats treated with SPE exhibited a reduction in prostate weight. SPE treatment led to a decrease in serum DHT and testosterone levels. SPE treatment significantly reduced the protein levels of AR, PSA, SRC-1, and 5AR2 in vitro and in vivo.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>SPE possesses anti-proliferative and pro-apoptotic effects by inhibiting 5α-reductase and DHT expression in vitro and in vivo, thereby mitigating the progression of BPH.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18028,"journal":{"name":"LUTS: Lower Urinary Tract Symptoms","volume":"17 3","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144100813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quality of Life After Augmentation Enterocystoplasty in Children 儿童肠囊成形术后的生活质量
IF 1.5 4区 医学
LUTS: Lower Urinary Tract Symptoms Pub Date : 2025-05-07 DOI: 10.1111/luts.70014
Alicia Gómez Sánchez, Lara Merino Mateo, Cristina Tordable Ojeda, Sara M. Proaño Landázuri, Daniel Cabezalí Barbacho, Andrés Gómez Fraile
{"title":"Quality of Life After Augmentation Enterocystoplasty in Children","authors":"Alicia Gómez Sánchez,&nbsp;Lara Merino Mateo,&nbsp;Cristina Tordable Ojeda,&nbsp;Sara M. Proaño Landázuri,&nbsp;Daniel Cabezalí Barbacho,&nbsp;Andrés Gómez Fraile","doi":"10.1111/luts.70014","DOIUrl":"https://doi.org/10.1111/luts.70014","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate outcomes following bladder augmentation in children at a specialized third-level center concerning quality of life (QoL), continence status, and sexual function.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The study population included bladder augmented patients treated over the last 25 years. We established contact with them and emailed an online survey with three validated questionnaires: QoL (EQ-5D-5L), incontinence (ICIQ-SF) and sexual function (FSH/FSM2).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twenty-four patients, aged between 9 and 44, answered the questionnaire. Among respondents, 54.2% declared experiencing some problem in one or more of the five evaluated dimensions. The mean EQ-VAS score was 80 out of 100, while the mean EQ-5D-5L index was 0,845 out of 1. Based on the ICIQ-SF questionnaire, 58.3% of patients were classified as incontinent. Regarding the bother scale (0–10), the mean score was 4.7 ± 3. Among the 18 patients old enough to answer the sexual function questionnaire, 11 (61.1%) described a low or nonexistent level of sexual satisfaction. Among the male cluster, the average score on the FSH questionnaire was 10.95 ± 6.78 (scale 2–24), while in the female cohort the average score on the FSM-2 questionnaire was 21.5 ± 9.64 (scale 2–32).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Despite the high complication rate and the presence of some degree of incontinence or sexual dysfunction in nearly 60% of patients undergoing bladder augmentation in childhood, our cohort exhibits relatively good QoL scores when compared to those reported for the general population.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18028,"journal":{"name":"LUTS: Lower Urinary Tract Symptoms","volume":"17 3","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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