LUTS: Lower Urinary Tract Symptoms最新文献

{"title":"Saw Palmetto Extract Ameliorates Benign Prostatic Hyperplasia by Regulating 5α-Reductase and Apoptosis In Vitro and In Vivo","authors":"Bo Zhang,&nbsp;Hui Wang,&nbsp;Tianyu Ma,&nbsp;Jiangang Yang","doi":"10.1111/luts.70015","DOIUrl":"https://doi.org/10.1111/luts.70015","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The therapeutic effect of saw palmetto extract (SPE) in benign prostatic hyperplasia (BPH) has been evaluated in clinical trials. However, the molecular mechanisms of SPE in BPH development are not fully understood.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>LNCap cell line treated with dihydrotestosterone (DHT) and SD rats induced with testosterone were used, respectively. TUNEL and Muse Cell Analyzer for apoptosis and CCK8 assay for cell viability were performed to investigate the effects of SPE against BPH. Histological changes were examined by HE staining. Protein expression was analyzed for AR, PSA, SRC-1, and 5AR2 by Western blot, and the levels of DHT and testosterone in rat serum were quantified by ELISA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>SPE treatment could accelerate the apoptosis of cells and decrease the expressions of TNF-α, IL-1β and IL-18. TUNEL staining revealed an increase in positive staining after SPE treatment. Rats treated with SPE exhibited a reduction in prostate weight. SPE treatment led to a decrease in serum DHT and testosterone levels. SPE treatment significantly reduced the protein levels of AR, PSA, SRC-1, and 5AR2 in vitro and in vivo.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>SPE possesses anti-proliferative and pro-apoptotic effects by inhibiting 5α-reductase and DHT expression in vitro and in vivo, thereby mitigating the progression of BPH.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18028,"journal":{"name":"LUTS: Lower Urinary Tract Symptoms","volume":"17 3","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144100813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of Life After Augmentation Enterocystoplasty in Children","authors":"Alicia Gómez Sánchez,&nbsp;Lara Merino Mateo,&nbsp;Cristina Tordable Ojeda,&nbsp;Sara M. Proaño Landázuri,&nbsp;Daniel Cabezalí Barbacho,&nbsp;Andrés Gómez Fraile","doi":"10.1111/luts.70014","DOIUrl":"https://doi.org/10.1111/luts.70014","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate outcomes following bladder augmentation in children at a specialized third-level center concerning quality of life (QoL), continence status, and sexual function.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The study population included bladder augmented patients treated over the last 25 years. We established contact with them and emailed an online survey with three validated questionnaires: QoL (EQ-5D-5L), incontinence (ICIQ-SF) and sexual function (FSH/FSM2).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twenty-four patients, aged between 9 and 44, answered the questionnaire. Among respondents, 54.2% declared experiencing some problem in one or more of the five evaluated dimensions. The mean EQ-VAS score was 80 out of 100, while the mean EQ-5D-5L index was 0,845 out of 1. Based on the ICIQ-SF questionnaire, 58.3% of patients were classified as incontinent. Regarding the bother scale (0–10), the mean score was 4.7 ± 3. Among the 18 patients old enough to answer the sexual function questionnaire, 11 (61.1%) described a low or nonexistent level of sexual satisfaction. Among the male cluster, the average score on the FSH questionnaire was 10.95 ± 6.78 (scale 2–24), while in the female cohort the average score on the FSM-2 questionnaire was 21.5 ± 9.64 (scale 2–32).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Despite the high complication rate and the presence of some degree of incontinence or sexual dysfunction in nearly 60% of patients undergoing bladder augmentation in childhood, our cohort exhibits relatively good QoL scores when compared to those reported for the general population.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18028,"journal":{"name":"LUTS: Lower Urinary Tract Symptoms","volume":"17 3","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Value of Urethral Pressure Profile Using Air-Charged Catheters in the Diagnosis of Female Bladder Neck Obstruction","authors":"Yan Qin,&nbsp;Fei Wang,&nbsp;Chaohua Zhang,&nbsp;Liyang Wu","doi":"10.1111/luts.70013","DOIUrl":"https://doi.org/10.1111/luts.70013","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Rarely have studies focused on the utilization of urethral pressure profile (UPP) in bladder neck obstruction (BNO). This study aimed to evaluate the parameters of UPP in urodynamic testing (UDS) using air-charged catheters (ACC) and to investigate the value of UPP as a diagnostic tool for female BNO.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Patients and Methods</h3>\u0000 \u0000 <p>We retrospectively collected records of 165 female patients with lower urinary tract symptoms (LUTS) who received UDS at our center from September 2020 to September 2022. The whole patient group was divided into BNO group (<i>n</i> = 92) and non-BNO group (<i>n</i> = 73). The urodynamic data were evaluated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The UPP includes urethral pressures at the bladder neck (b-UP) and urethral sphincter (s-UP). The b-UP was higher in the BNO group than in the non-BNO group [104.50 (40.50) cmH2O vs. 58.00 (33.50) cmH2O, <i>p</i> &lt; 0.001]. According to multivariable logistic regression analysis, b-UP and bladder voiding efficiency (BVE) were independently associated with BNO. The area under the curve (AUC) of the b-UP had the best value for predicting BNO [AUC: 0.878, sensitivity: 88.04%, specificity: 76.71%, 95% confidence interval (CI): 0.819–0.924]; its cut-off value was 72 cmH2O. Meanwhile, Cohen's kappa was 0.65 (95% CI: 0.537–0.770), indicating that UPP as a diagnostic tool was highly consistent with the video-urodynamic study (VUDS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>UPP by air-charged urodynamic catheters can show the pressure of the bladder neck, with predictive value for identifying BNO in women. The predictive method based on UPP and pressure-flow study (PFS) without fluoroscopy will improve the diagnostic accuracy of BNO, which could help urologists in making better clinical decisions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18028,"journal":{"name":"LUTS: Lower Urinary Tract Symptoms","volume":"17 3","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143879945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Thulium Laser Vaporization of the Prostate: A Transurethral Procedure for Benign Prostatic Hyperplasia","authors":"Daisuke Gotoh,&nbsp;Kazumasa Torimoto,&nbsp;Akira Tachibana,&nbsp;Nobutaka Nishimura,&nbsp;Mitsuru Tomizawa,&nbsp;Kenta Onishi,&nbsp;Yosuke Morizawa,&nbsp;Shunta Hori,&nbsp;Yasushi Nakai,&nbsp;Makito Miyake,&nbsp;Kiyohide Fujimoto","doi":"10.1111/luts.70012","DOIUrl":"https://doi.org/10.1111/luts.70012","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To explore the efficacy and safety of thulium laser vaporization of the prostate (ThuVAP) for benign prostatic hyperplasia (BPH) at Nara Medical University from 2022 to 2024.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients with BPH who underwent ThuVAP at the Department of Urology, Nara Medical University, between January 01, 2022 and April 30, 2024, were enrolled. Patient background, presurgical pressure flow study results, treatment efficacy, and safety were retrospectively evaluated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study included 32 patients; the median age was 74.5 years at surgery. The total International Prostate Symptom Score and quality of life were significantly lower at 4 weeks after surgery than at baseline. They continued to decrease at 12 and 24 weeks. The maximum flow rate was significantly higher at 4 weeks after surgery than at baseline; it continued to increase for 12 and 24 weeks. The postvoid residual (PVR) was significantly lower at 4 weeks after surgery than at baseline and continued to decrease at 12 and 24 weeks.</p>\u0000 \u0000 <p>Intravesical prostatic protrusion and prostate volume were positively correlated with the surgery and laser usage times. Two patients experienced temporary urinary retention, and two underwent transurethral electrocoagulation for postoperative bleeding.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our data confirm ThuVAP as an effective and safe treatment for BPH.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18028,"journal":{"name":"LUTS: Lower Urinary Tract Symptoms","volume":"17 3","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of Care-Seeking Behavior for Treatment of Urinary Incontinence in Men","authors":"Dora Jericevic Schwartz,&nbsp;Zoe LaPier,&nbsp;Azadeh Nazemi,&nbsp;Diane Lang,&nbsp;Steven Gregg,&nbsp;Benjamin Brucker,&nbsp;Christina Escobar","doi":"10.1111/luts.70008","DOIUrl":"https://doi.org/10.1111/luts.70008","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To determine factors associated with care-seeking in males with urinary incontinence (UI).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional study was performed using the National Association for Continence (NAFC) sponsored adult patient-reported survey data from November 2018 to January 2019. Descriptive statistics, chi-squared test, and multivariate logistic regression were used to identify factors associated with care-seeking behavior.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Four hundred and forty-six men completed the survey during the study period. 84% of care-seeking men had initiated the discussion with their doctor about their UI, with 57% initially seeing their primary care provider. Statistically significant predictors of care-seeking were greater UI frequency (OR 1.68, CI 1.22–2.33), UI duration (OR 2.91, CI 1.88–4.65), cost of UI management (OR 1.53, CI 1.12–2.10), and comfort discussing UI (OR 2.83, 1.41–5.87). The top reasons cited for not seeking care for UI were embarrassment (29%) and the sentiment that UI is just a normal part of aging (22%). Non-care-seeking men were more likely to have their UI associated with feelings of shame and isolation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The majority of men who sought care for UI initiated the conversation with their PCP. Men with longer UI duration, higher UI frequency, higher cost expenditure on UI management, and those who felt comfortable discussing their UI were more likely to seek care.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18028,"journal":{"name":"LUTS: Lower Urinary Tract Symptoms","volume":"17 2","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective Comparison of Postoperative Outcomes Between Elderly and Non-Elderly Patients With Benign Prostatic Enlargement Using Holmium Laser Enucleation and Transurethral Vaporization of the Prostate at Multiple High-Volume Centers","authors":"Hiroki Ito,&nbsp;Takuma Nirei,&nbsp;Takeshi Fukazawa,&nbsp;Hiroki Takizawa,&nbsp;Mari Hioki,&nbsp;Risa Shinoki,&nbsp;Yutaro Hayashi,&nbsp;Takashi Kawahara,&nbsp;Shuko Yoneyama,&nbsp;Kazuhide Makiyama,&nbsp;Akitoshi Takizawa,&nbsp;Kazuki Kobayashi","doi":"10.1111/luts.70010","DOIUrl":"https://doi.org/10.1111/luts.70010","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This retrospective study aimed to compare the surgical outcomes of holmium laser enucleation of the prostate (HoLEP) and transurethral vaporization techniques between the elderly and nonelderly patients with benign prostatic enlargement (BPE).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrospectively analyzed clinical data from two regional centers that used HoLEP and transurethral vaporization techniques for BPE treatment. The study population consisted of male patients with lower urinary tract symptoms, divided into elderly and nonelderly groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Total 477 of 872 patients remained in the study, of which 198 were classified as elderly (age ≥ 75 years) and 279 as non-elderly (age &lt; 75 years). The postoperative decrease in IPSS was significantly lower in the elderly group, and advanced age was associated with less IPSS decline only after vaporization (<i>p</i> = 0.003) but not after HoLEP. In both surgeries, the duration of postoperative catheterization was significantly longer in the elderly group than in the non-elderly group, and hemoglobin drop at 1 day postoperatively showed no age-related difference. The most common complication after HoLEP was intermittent incontinence, which was more frequent in the elderly group (15.0%) than in the non-elderly group (6.2%, <i>p</i> = 0.038). Regardless of age, the overall rate of need for medication at 6 months postoperatively was significantly higher after HoLEP (32/190, 16.8%) than after transurethral vaporization (30/287, 10.5%) (<i>p</i> = 0.042). The need for medication was higher in the elderly for both HoLEP and vaporization than in the non-elderly group with a specific cutoff of age.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Elderly patients with BPE had relatively worse surgical outcomes, including a higher need for postoperative medications and prolonged catheterization. HoLEP demonstrated a reduction in IPSS regardless of age, and transurethral vaporization did not, although it was associated with a higher rate of intermittent incontinence.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18028,"journal":{"name":"LUTS: Lower Urinary Tract Symptoms","volume":"17 2","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143554290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digit Length Ratio as an Indicator of Fetal Androgen Levels: Relationship to Prostate Volume-Related Men Lower Urinary Tract Symptoms","authors":"İsmail Emre Ergin,&nbsp;Abuzer Öztürk,&nbsp;Aydemir Asdemir","doi":"10.1111/luts.70009","DOIUrl":"https://doi.org/10.1111/luts.70009","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aimed to investigate the relationship between the 2nd and 4th digit ratios, which are associated with fetal androgen exposure, and prostate volume and testosterone levels, both of which are linked to lower urinary tract symptoms (LUTS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Male patients presenting to our urology clinic with increased prostate volume and LUTS were categorized into two groups: those with BPH and those without (non-BPH). For both groups, the right-hand 2D:4D finger ratio, testosterone levels, prostate volume, uroflow parameters, and IPSS scores were recorded.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The 2D:4D ratio, prostate volumes, Qmax, and IPSS scores differed significantly between the BPH and non-BPH groups (<i>p</i> = 0.023, 0.002, 0.000, 0.001). No significant difference was observed in total testosterone levels between the groups (<i>p</i> = 0.381). The 2D:4D ratio was negatively correlated with prostate volume and IPSS (<i>r</i> = −0.389, −0.308) and positively correlated with Qmax (<i>r</i> = 0.301).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our study demonstrates that the 2D:4D ratio is a straightforward and effective tool for assessing BPH patients, as it correlates with the severity of LUTS symptoms. This non-invasive measure offers potential value in evaluating LUTS, and with age standardization, it could be applied more broadly across age groups. Further large-scale studies are needed to refine its standardization and expand upon current findings.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18028,"journal":{"name":"LUTS: Lower Urinary Tract Symptoms","volume":"17 2","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143446878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Providing Video-Animated Information to Female Patients With Stress Urinary Incontinence Before the Urodynamic Study on the Patient's Anxiety, Pain, Satisfaction, and Willingness to Repeat the Procedure","authors":"Recep Burak Degirmentepe,&nbsp;Muammer Bozkurt,&nbsp;Eyyup Danis,&nbsp;Deniz Gul,&nbsp;Yasir Muhammed Akca,&nbsp;Haci Ibrahim Cimen,&nbsp;Fikret Halis","doi":"10.1111/luts.70007","DOIUrl":"10.1111/luts.70007","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To investigate the effect of providing video-animated information to female patients with stress urinary incontinence before urodynamics on the patient's anxiety, pain, satisfaction, and willingness to repeat the procedure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Before the procedure, patients were divided into two groups with 1:1 randomization. While one group was given written and verbal information, the other group was additionally given animated video information accompanied by a doctor. Pre-procedure anxiety, hemodynamic parameters during the procedure, as well as post-procedure pain, satisfaction and willingness to repeat the procedure were compared between the groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>STAI-s levels were found to be statistically significantly lower in the group given video animation information before urodynamics (<i>p</i> &lt; 0.01). It was observed that video information had a positive effect on systolic blood pressure, diastolic blood pressure and heart rate, and the values were measured lower compared to the other group (<i>p</i> &lt; 0.01). While there was no statistically significant difference between the two groups in VAS-pain scores (<i>p</i> = 0.82), VAS-satisfaction and VAS-willingness to repeat the procedure scores were found to be statistically significantly different (<i>p</i> &lt; 0.01). It was observed that video-animated information made a positive contribution to satisfaction and willingness to repeat the procedure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Video-animated information given to female patients before urodynamics has positive effects on the patient's anxiety. It also contributes positively to the patient's satisfaction and their willingness to repeat the procedure. Video-animated information may be used routinely in addition to written and verbal information before urodynamics.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18028,"journal":{"name":"LUTS: Lower Urinary Tract Symptoms","volume":"17 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Usefulness of Mesh Reinforcement in Pubic Fixation Urethral Sling Surgery for Urinary Incontinence After Radical Prostatectomy","authors":"Yasutomo Suzuki,&nbsp;Naoto Hodotsuka,&nbsp;Eigo Kuribayashi,&nbsp;Kyota Suzuki,&nbsp;Yuichiro Honda,&nbsp;Shuma Endo,&nbsp;Yukihiro Kondo","doi":"10.1111/luts.70003","DOIUrl":"10.1111/luts.70003","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>In our institution, a unique sling technique is performed for urinary incontinence after radical prostatectomy. However, in cases of severe urinary incontinence or in the medium to long term, the therapeutic effect may be insufficient. Therefore, a urethral sling technique that provides stronger compression of the bulbar urethra was developed, and its effectiveness was compared with the conventional technique.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Seventeen cases of conventional sling surgery and 16 cases of improved sling surgery were included. The number of pads used per day, safety pad rate, and International Consultation on Incontinence Questionnaire Short Form (ICIQ-SF) were evaluated before and after surgery, and a retrospective comparison was made between the two groups. Furthermore, patients were divided into those who used ≤ 4 pads per day before surgery and those who used ≥ 5 pads per day, and the difference between the two groups was examined. We also examined changes over time between groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Compared with the conventional group, the improved group showed significant improvement in the number of pads per day, safety pad rate, and ICIQ-SF 18 months after surgery. In the group with ≤ 4 preoperative pads, the improved group showed significant improvement in all safety pad rates except at 1 and 12 months after surgery. There were no significant differences in all items between the two groups when the number of preoperative pads was ≥ 5.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The improved urethral sling technique appeared to contribute to improving moderate urinary incontinence by adding a simple procedure, especially for patients using ≤ 4 pads per day.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18028,"journal":{"name":"LUTS: Lower Urinary Tract Symptoms","volume":"17 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting Elevated Postvoid Residual Urine Volume Following OnabotulinumtoxinA Treatment for Overactive Bladder: A Pilot Study","authors":"Israel Franco,&nbsp;Marc Schwartz,&nbsp;Kevin Cline,&nbsp;David Glazier,&nbsp;Anand Patel","doi":"10.1111/luts.70004","DOIUrl":"10.1111/luts.70004","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate possible predictors of elevated postvoid residual volume (PVR) following onabotulinumtoxinA administration in patients with idiopathic overactive bladder (OAB), a condition that may include urinary urgency, frequency, and nocturia, without any identifiable cause or underlying neurological or metabolic condition.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Adults who had been treated with 100–200 U onabotulinumtoxinA for OAB and had previous failure of other OAB treatments were identified by retrospective review of medical chart data from three urology clinics in the United States treating patients with a variety of urological conditions. A total of 211 patients were allocated to cohorts based on posttreatment PVR &lt; 200 mL (<i>n</i> = 173) and ≥ 200 mL (<i>n</i> = 38). Logistic regression analyses were performed to evaluate potential predictors of posttreatment PVR ≥ 200 mL, including pretreatment peak urine flow rate (Qmax), average urine flow rate (Qavg), and Modified Liverpool Qmax and Qavg flow index (FI), and to determine whether patient age and baseline PVR were associated with the likelihood of PVR ≥ 200 mL. Patients were excluded if symptoms of OAB were secondary to a neurological condition, they had a PVR &gt; 200 mL within 2 weeks prior to the index therapy or had been treated with other botulinum toxin formulations for a urinary condition.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In the predictor analyses, neither Qmax nor Qavg alone was a likely predictor. Odds ratios of PVR ≥ 200 mL for Modified Liverpool Qmax FI and Qavg were 0.30 (95% CI: 0.08–0.91; <i>p</i> = 0.0488) and 0.07 (95% CI 0.01–0.40; <i>p</i> = 0.0045), respectively. When patient age and baseline PVR were incorporated into the analyses, results suggested that Qmax, Qavg, Qmax FI, and Qavg FI, as well as increased age and baseline PVR, were likely predictors of elevated posttreatment PVR.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Patients who are older, have high pretreatment PVR values, and have lower pretreatment urine flow indexes and flows may be at increased risk of developing elevated PVR after receiving onabotulinumtoxinA treatment for OAB.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18028,"journal":{"name":"LUTS: Lower Urinary Tract Symptoms","volume":"17 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11725389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}