{"title":"血清血清素水平是社区居民膀胱过度活动的潜在危险因素：一项为期四年的纵向研究","authors":"Takafumi Fukushima, Teppei Okamoto, Tomoko Hamaya, Hirotake Kodama, Naoki Fujita, Hayato Yamamoto, Atsushi Imai, Shigeyuki Nakaji, Shingo Hatakeyama","doi":"10.1111/luts.70019","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Purpose</h3>\n \n <p>This study aims to investigate the potential influence of serum serotonin (5-HT) levels on the development of overactive bladder (OAB) in a community-dwelling population.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A four-year longitudinal study was conducted involving 615 subjects who participated in the Iwaki Health Promotion Project in Hirosaki, Japan, in both 2015 and 2019. OAB was defined as experiencing urinary urgency at least once a week with an Overactive Bladder Symptom Score (OABSS) of ≥ 3. Baseline data from 2015, including serum 5-HT levels, other laboratory data, and comorbidity information, were used for the analysis. The association between serum 5-HT levels and incident OAB in 2019 (OAB-2019) was examined using multivariate logistic regression analyses.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The study included 250 men and 365 women, of whom 74 individuals (29 men and 45 women) met the diagnostic criteria for OAB in 2019. Significant differences were observed between the OAB-2019 and non-OAB-2019 groups, including age, chronic kidney disease, irritable bowel syndrome, hypertension, glycemic status, mental status, and OAB in 2015. Participants in the OAB-2019 group had significantly lower serum 5-HT levels compared to the non-OAB-2019 group (100 vs. 129 ng/mL, <i>p</i> < 0.001). After adjusting for confounders, multivariable analysis revealed that serum 5-HT levels < 134 ng/mL (odds ratio: 2.48, 95% confidence interval: 1.39–5.83, <i>p</i> = 0.004), age, mental status, and OAB in 2015 independently served as risk factors for OAB-2019.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Low serum 5-HT levels may be associated with an increased risk of OAB. Further research is needed to elucidate the underlying mechanisms responsible for this association.</p>\n </section>\n </div>","PeriodicalId":18028,"journal":{"name":"LUTS: Lower Urinary Tract Symptoms","volume":"17 4","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/luts.70019","citationCount":"0","resultStr":"{\"title\":\"Serum Serotonin Levels as a Potential Risk Factor for Overactive Bladder in a Community-Dwelling Population: A Four-Year Longitudinal Study\",\"authors\":\"Takafumi Fukushima, Teppei Okamoto, Tomoko Hamaya, Hirotake Kodama, Naoki Fujita, Hayato Yamamoto, Atsushi Imai, Shigeyuki Nakaji, Shingo Hatakeyama\",\"doi\":\"10.1111/luts.70019\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Purpose</h3>\\n \\n <p>This study aims to investigate the potential influence of serum serotonin (5-HT) levels on the development of overactive bladder (OAB) in a community-dwelling population.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>A four-year longitudinal study was conducted involving 615 subjects who participated in the Iwaki Health Promotion Project in Hirosaki, Japan, in both 2015 and 2019. OAB was defined as experiencing urinary urgency at least once a week with an Overactive Bladder Symptom Score (OABSS) of ≥ 3. Baseline data from 2015, including serum 5-HT levels, other laboratory data, and comorbidity information, were used for the analysis. The association between serum 5-HT levels and incident OAB in 2019 (OAB-2019) was examined using multivariate logistic regression analyses.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>The study included 250 men and 365 women, of whom 74 individuals (29 men and 45 women) met the diagnostic criteria for OAB in 2019. Significant differences were observed between the OAB-2019 and non-OAB-2019 groups, including age, chronic kidney disease, irritable bowel syndrome, hypertension, glycemic status, mental status, and OAB in 2015. Participants in the OAB-2019 group had significantly lower serum 5-HT levels compared to the non-OAB-2019 group (100 vs. 129 ng/mL, <i>p</i> < 0.001). After adjusting for confounders, multivariable analysis revealed that serum 5-HT levels < 134 ng/mL (odds ratio: 2.48, 95% confidence interval: 1.39–5.83, <i>p</i> = 0.004), age, mental status, and OAB in 2015 independently served as risk factors for OAB-2019.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>Low serum 5-HT levels may be associated with an increased risk of OAB. 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引用次数: 0
摘要
目的探讨血清5-羟色胺（5-HT）水平对社区居民膀胱过动症（OAB）发展的潜在影响。方法对2015年和2019年参加日本hiroaki Iwaki健康促进项目的615名受试者进行了为期4年的纵向研究。OAB定义为每周至少出现一次尿急，且膀胱过度活动症状评分(OABSS)≥3。2015年的基线数据，包括血清5-羟色胺水平、其他实验室数据和合并症信息，用于分析。采用多因素logistic回归分析，研究2019年血清5-HT水平与OAB （OAB-2019）之间的关系。结果该研究包括250名男性和365名女性，其中74人（29名男性和45名女性）在2019年符合OAB的诊断标准。2015年，OAB-2019组与非OAB-2019组在年龄、慢性肾病、肠易激综合征、高血压、血糖状态、精神状态和OAB方面存在显著差异。与非OAB-2019组相比，OAB-2019组的参与者血清5-HT水平显著降低（100对129 ng/mL， p < 0.001）。调整混杂因素后，多变量分析显示，2015年血清5-羟色胺水平134 ng/mL（优势比：2.48,95%可信区间：1.39-5.83,p = 0.004）、年龄、精神状态和OAB是OAB-2019的独立危险因素。结论血清5-羟色胺水平低可能与OAB风险增加有关。需要进一步的研究来阐明这种关联的潜在机制。
Serum Serotonin Levels as a Potential Risk Factor for Overactive Bladder in a Community-Dwelling Population: A Four-Year Longitudinal Study
Purpose
This study aims to investigate the potential influence of serum serotonin (5-HT) levels on the development of overactive bladder (OAB) in a community-dwelling population.
Methods
A four-year longitudinal study was conducted involving 615 subjects who participated in the Iwaki Health Promotion Project in Hirosaki, Japan, in both 2015 and 2019. OAB was defined as experiencing urinary urgency at least once a week with an Overactive Bladder Symptom Score (OABSS) of ≥ 3. Baseline data from 2015, including serum 5-HT levels, other laboratory data, and comorbidity information, were used for the analysis. The association between serum 5-HT levels and incident OAB in 2019 (OAB-2019) was examined using multivariate logistic regression analyses.
Results
The study included 250 men and 365 women, of whom 74 individuals (29 men and 45 women) met the diagnostic criteria for OAB in 2019. Significant differences were observed between the OAB-2019 and non-OAB-2019 groups, including age, chronic kidney disease, irritable bowel syndrome, hypertension, glycemic status, mental status, and OAB in 2015. Participants in the OAB-2019 group had significantly lower serum 5-HT levels compared to the non-OAB-2019 group (100 vs. 129 ng/mL, p < 0.001). After adjusting for confounders, multivariable analysis revealed that serum 5-HT levels < 134 ng/mL (odds ratio: 2.48, 95% confidence interval: 1.39–5.83, p = 0.004), age, mental status, and OAB in 2015 independently served as risk factors for OAB-2019.
Conclusions
Low serum 5-HT levels may be associated with an increased risk of OAB. Further research is needed to elucidate the underlying mechanisms responsible for this association.
期刊介绍：
LUTS is designed for the timely communication of peer-reviewed studies which provides new clinical and basic science information to physicians and researchers in the field of neurourology, urodynamics and urogynecology. Contributions are reviewed and selected by a group of distinguished referees from around the world, some of whom constitute the journal''s Editorial Board. The journal covers both basic and clinical research on lower urinary tract dysfunctions (LUTD), such as overactive bladder (OAB), detrusor underactivity, benign prostatic hyperplasia (BPH), bladder outlet obstruction (BOO), urinary incontinence, pelvic organ prolapse (POP), painful bladder syndrome (PBS), as well as on other relevant conditions. Case reports are published only if new findings are provided.
LUTS is an official journal of the Japanese Continence Society, the Korean Continence Society, and the Taiwanese Continence Society. Submission of papers from all countries are welcome. LUTS has been accepted into Science Citation Index Expanded (SCIE) with a 2011 Impact Factor.
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