Learning & memory最新文献_第3页

Emotional intensity produces a linear relationship on conditioned learning but an inverted U-shaped effect on episodic memory. 情绪强度对条件学习的影响呈线性关系，对情景记忆的影响呈倒u型关系。

IF 1.8 4区医学

Learning & memory Pub Date : 2024-12-16 Print Date: 2024-12-01 DOI: 10.1101/lm.053982.124

Lingwei Ouyang, Joseph E Dunsmoor

{"title":"Emotional intensity produces a linear relationship on conditioned learning but an inverted U-shaped effect on episodic memory.","authors":"Lingwei Ouyang, Joseph E Dunsmoor","doi":"10.1101/lm.053982.124","DOIUrl":"10.1101/lm.053982.124","url":null,"abstract":"Emotional intensity can produce both optimal and suboptimal effects on learning and memory. While emotional events tend to be better remembered, memory performance can follow an inverted U-shaped curve with increasing intensity. The strength of Pavlovian conditioning tends to increase linearly with the intensity of the aversive outcome, but leads to greater stimulus generalization. Here, we combined elements of episodic memory and Pavlovian conditioning into a single paradigm to investigate the effects of varying outcome intensities on conditioned fear responses and episodic memory. Participants encoded trial-unique images from two semantic categories as conditioned stimuli (CS+ and CS-) before (preconditioning), during, and after (extinction) acquisition. We systematically varied the intensity of the unconditioned stimulus (US) during acquisition between-groups as a nonaversive tone, a low-intensity electrical shock, or a high-intensity electrical shock paired with a loud static noise. Results showed that conditioned skin conductance responses scaled linearly with US intensity during acquisition, with a high-intensity US leading to greater resistance to extinction and stronger 24 h fear recovery. However, 24 h recognition memory produced an inverted U-shaped relationship, with better recognition memory for CSs encoded before (retroactive), during, and following conditioning using a low-intensity US. These findings suggest a dissociation between optimal levels of emotional intensity on explicit and implicit learning and memory performance.","PeriodicalId":18003,"journal":{"name":"Learning & memory","volume":"31 12","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11662143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142835981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shaping behaviors through social experience and their proposed sensitivity to stress. 通过社会经验塑造行为及其对压力的敏感性。

IF 1.8 4区医学

Learning & memory Pub Date : 2024-12-16 Print Date: 2024-12-01 DOI: 10.1101/lm.053926.124

J Amiel Rosenkranz

引用次数: 0

High and low current perceived stress associated with enhanced emotional mnemonic discrimination. 当前感知到的高压力和低压力与情绪记忆辨别力增强有关。

IF 1.8 4区医学

Learning & memory Pub Date : 2024-12-16 Print Date: 2024-12-01 DOI: 10.1101/lm.053989.124

Rishi Vas, Taylor Phillips, Lorena A Ferguson, Amritha Harikumar, Madelyn Castro, Stephanie L Leal

{"title":"High and low current perceived stress associated with enhanced emotional mnemonic discrimination.","authors":"Rishi Vas, Taylor Phillips, Lorena A Ferguson, Amritha Harikumar, Madelyn Castro, Stephanie L Leal","doi":"10.1101/lm.053989.124","DOIUrl":"10.1101/lm.053989.124","url":null,"abstract":"Stress can have profound impacts on memory. However, the directionality of stress effects on memory varies widely across studies, some showing enhancement while others showing impairment. This variability has been attributed to the Yerkes-Dodson Law, which proposes a U-shaped pattern such that too little or too much stress may be associated with cognitive dysfunction. The impact of stress on memory may also depend on what aspects of memory are being measured (e.g., emotional content, gist vs. detail) and how stress is measured (e.g., physiological measures, self-report). Here, we aimed to examine how self-reported perceived stress in the current moment was associated with memory performance. We used an emotional memory task designed to tap into potential gist versus detail trade-offs of stress impacting memory (e.g., target recognition, lure discrimination). Participants (ages 18-35) reported their current level of perceived stress. We replicated prior work showing impaired emotional relative to neutral lure discrimination in young adults in support of a gist versus detail trade-off in emotional memory. However, those with low and high current perceived stress showed better emotional lure discrimination compared to those with moderate current perceived stress. These results are in line with the Yerkes-Dodson Law but suggest that the directionality of the impact of stress on memory may depend on the type of memory measured. Low and high current perceived stress was associated with greater detailed memory, especially for emotional information, which may be maladaptive given gist vs. detail trade-offs in emotional memory.","PeriodicalId":18003,"journal":{"name":"Learning & memory","volume":"31 12","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11662142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142836473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Special issue on stress, emotion, and memory. 压力、情绪和记忆特刊。

IF 1.8 4区医学

Learning & memory Pub Date : 2024-12-16 Print Date: 2024-12-01 DOI: 10.1101/lm.054084.124

引用次数: 0

Lateral entorhinal cortex neurons that project to nucleus accumbens mediate contextual associative memory. 外侧内黑质皮层神经元投射到阿库仑核，介导情境联想记忆。

IF 1.8 4区医学

Learning & memory Pub Date : 2024-11-26 Print Date: 2024-10-01 DOI: 10.1101/lm.054026.124

Hayley M Kuhn, Luis Colon Serrano, Grace A Stys, Brianna L Smith, Julia Speckmaier, Brenique D Dawson, Brooklynn R Murray, Jin He, Alfred J Robison, Andrew L Eagle

{"title":"Lateral entorhinal cortex neurons that project to nucleus accumbens mediate contextual associative memory.","authors":"Hayley M Kuhn, Luis Colon Serrano, Grace A Stys, Brianna L Smith, Julia Speckmaier, Brenique D Dawson, Brooklynn R Murray, Jin He, Alfred J Robison, Andrew L Eagle","doi":"10.1101/lm.054026.124","DOIUrl":"10.1101/lm.054026.124","url":null,"abstract":"The lateral entorhinal cortex (LEC) contains glutamatergic projections that innervate the nucleus accumbens (NAc) and may be involved in the encoding of contextual associations with both positive and negative valences, such as those encountered in drug cues or fear conditioning. To determine whether LEC-NAc neurons are activated by the encoding and recall of contexts associated with cocaine or footshock, we measured c-fos expression in these neurons and found that LEC-NAc neurons are activated in both contexts. Specifically, activation patterns of the LEC-NAc were observed in a novel context and reexposure to the same context, highlighting the specific role for LEC-NAc neurons in encoding rather than the valence of a specific event-related memory. Using a combination of circuit-specific chemogenetic tools and behavioral assays, we selectively inactivated LEC-NAc neurons in mice during the encoding and retrieval of memories of contexts associated with cocaine or footshock. Chemogenetic inactivation of LEC-NAc neurons impaired the formation of both positive and negative context-associated memories without affecting the retrieval of an established memory. This finding suggests a critical role for this circuit in the initial encoding of contextual associations. In summary, LEC-NAc neurons facilitate the encoding of contextual information, guiding motivational behaviors without directly mediating the hedonic or aversive properties of these associations.","PeriodicalId":18003,"journal":{"name":"Learning & memory","volume":"31 10-11","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11606517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The influence of categorical stimuli on relational memory binding. 分类刺激对关系记忆约束力的影响。

IF 1.8 4区医学

Learning & memory Pub Date : 2024-10-31 Print Date: 2024-10-01 DOI: 10.1101/lm.054006.124

Hillary Schwarb, Michael Dulas, Neal Cohen

{"title":"The influence of categorical stimuli on relational memory binding.","authors":"Hillary Schwarb, Michael Dulas, Neal Cohen","doi":"10.1101/lm.054006.124","DOIUrl":"10.1101/lm.054006.124","url":null,"abstract":"Binding of arbitrary information into distinct memory representations that can be used to guide behavior is a hallmark of relational memory. What is and is not bound into a memory representation and how those things influence the organization of that representation remain topics of interest. While some information is intentionally and effortfully bound-often the information that is consistent with task goals or expectations about what information may be required later-other information appears to be bound automatically. The present set of experiments sought to investigate whether spatial memory would be systematically influenced by the presence and absence of distinct categories of stimuli on a spatial reconstruction task. In this task, participants must learn multiple item-location bindings and place each item back in its studied location after a short delay. Across three experiments, participants made significantly more within-category errors (i.e., misassigning one item to the location of a different item from the same category) than between-category errors (i.e., misassigning one item to the location of an item from a different category) when categories were perceptually or semantically distinct. These data reveal that category information contributed to the organization of the memory representation and influenced spatial reconstruction performance. Together, these results suggest that categorical information can influence memory organization, and not always to the benefit of overall task performance.","PeriodicalId":18003,"journal":{"name":"Learning & memory","volume":"31 10-11","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11606515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dysregulating mTORC1-4E-BP2 signaling in GABAergic interneurons impairs hippocampus-dependent learning and memory. GABA能中间神经元中的mTORC1-4E-BP2信号失调会损害海马依赖性学习和记忆。

IF 1.8 4区医学

Learning & memory Pub Date : 2024-10-28 Print Date: 2024-10-01 DOI: 10.1101/lm.054018.124

Ziying Huang, Shane Wiebe, Anmol Nagpal, Junghyun Choi, Caleb Walters, Niaz Mahmood, Arkady Khoutorsky, Jean-Claude Lacaille, Nahum Sonenberg

{"title":"Dysregulating mTORC1-4E-BP2 signaling in GABAergic interneurons impairs hippocampus-dependent learning and memory.","authors":"Ziying Huang, Shane Wiebe, Anmol Nagpal, Junghyun Choi, Caleb Walters, Niaz Mahmood, Arkady Khoutorsky, Jean-Claude Lacaille, Nahum Sonenberg","doi":"10.1101/lm.054018.124","DOIUrl":"10.1101/lm.054018.124","url":null,"abstract":"Memory formation is contingent on molecular and structural changes in neurons in response to learning stimuli-a process known as neuronal plasticity. The initiation step of mRNA translation is a gatekeeper of long-term memory by controlling the production of plasticity-related proteins in the brain. The mechanistic target of rapamycin complex 1 (mTORC1) controls mRNA translation, mainly through phosphorylation of the eukaryotic initiation factor 4E (eIF4E)-binding proteins (4E-BPs) and ribosomal protein S6 kinases (S6Ks). mTORC1 signaling decreases throughout brain development, starting from the early postnatal period. Here, we discovered that in mice, the age-dependent decrease in mTORC1 signaling occurs selectively in excitatory but not inhibitory neurons. Using a gene conditional knockout (cKO) strategy, we demonstrate that either up- or downregulating the mTORC1-4E-BP2 axis in GAD65 inhibitory interneurons, but not excitatory neurons, results in long-term object recognition and object location memory deficits. Our data indicate that the mTORC1 pathway in inhibitory but not excitatory neurons plays a key role in memory formation.","PeriodicalId":18003,"journal":{"name":"Learning & memory","volume":"31 10-11","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11606516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reactivation-dependent transfer of fear memory between contexts requires M1 muscarinic receptor stimulation in dorsal hippocampus of male rats. 雄性大鼠海马背侧的恐惧记忆在不同情境间的转移需要M1毒蕈碱受体的刺激。

IF 1.8 4区医学

Learning & memory Pub Date : 2024-10-09 Print Date: 2024-09-01 DOI: 10.1101/lm.054039.124

Karim H Abouelnaga, Andrew E Huff, Kristen H Jardine, Olivia S O'Neill, Boyer D Winters

{"title":"Reactivation-dependent transfer of fear memory between contexts requires M1 muscarinic receptor stimulation in dorsal hippocampus of male rats.","authors":"Karim H Abouelnaga, Andrew E Huff, Kristen H Jardine, Olivia S O'Neill, Boyer D Winters","doi":"10.1101/lm.054039.124","DOIUrl":"10.1101/lm.054039.124","url":null,"abstract":"Memory updating is essential for integrating new information into existing representations. However, this process could become maladaptive in conditions like post-traumatic stress disorder (PTSD), when fear memories generalize to neutral contexts. Previously, we have shown that contextual fear memory malleability in rats requires activation of M1 muscarinic acetylcholine receptors in the dorsal hippocampus. Here, we investigated the involvement of this mechanism in the transfer of contextual fear memories to other contexts using a novel fear memory updating paradigm. Following brief reexposure to a previously fear conditioned context, male rats (n = 8-10/group) were placed into a neutral context to evaluate the transfer of fear memory. We also infused the selective M1 receptor antagonist pirenzepine into the dorsal hippocampus before memory reactivation to try to block this effect. Results support the hypothesis that fear memory can be updated with novel contextual information, but only if rats are reexposed to the originally trained context relatively recently before the neutral context; evidence for transfer was not seen if the fear memory reactivation was omitted or if it occurred 6 h before neutral context exposure. The transferred fear persisted for 4 weeks, and the effect was blocked by M1 antagonism. These findings strongly suggest that fear transfer requires reactivation and destabilization of the original fear memory. The novel preclinical model introduced here, and its implication of muscarinic receptors in this process, could therefore inform therapeutic strategies for PTSD and similar conditions.","PeriodicalId":18003,"journal":{"name":"Learning & memory","volume":"31 9","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11472233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Domain-selective and sex-dependent regulation of learning and memory in mice by GIRK channel activity in CA1 pyramidal neurons of the dorsal hippocampus. 海马背侧 CA1 锥体神经元 GIRK 通道活性对小鼠学习和记忆的领域选择性和性别依赖性调控

IF 1.8 4区医学

Learning & memory Pub Date : 2024-10-07 Print Date: 2024-09-01 DOI: 10.1101/lm.054022.124

Haichang Luo, McKinzie Frederick, Ezequiel Marron Fernandez de Velasco, Jenna Osterlund Oltmanns, Courtney Wright, Kevin Wickman

引用次数: 0

Sex and the facilitation of cued fear by prior contextual fear conditioning in rats. 大鼠的性别与先前情境恐惧条件反射对诱发恐惧的促进作用

IF 1.8 4区医学

Learning & memory Pub Date : 2024-09-26 Print Date: 2024-09-01 DOI: 10.1101/lm.054010.124

Katherine Vazquez, Kehinde E Cole, Ryan G Parsons

{"title":"Sex and the facilitation of cued fear by prior contextual fear conditioning in rats.","authors":"Katherine Vazquez, Kehinde E Cole, Ryan G Parsons","doi":"10.1101/lm.054010.124","DOIUrl":"10.1101/lm.054010.124","url":null,"abstract":"Previous studies have shown that the formation of new memories can be influenced by prior experience. This includes work using Pavlovian fear conditioning in rodents that has shown that an initial fear conditioning experience can become associated with and facilitate the acquisition of new fear memories, especially when they occur close together in time. However, most of the prior studies used only males as subjects, resulting in questions about the generalizability of the findings from this work. Here we tested whether prior contextual fear conditioning would facilitate later learning of cued fear conditioning in both male and female rats, and if there were differences based on the interval between the two conditioning episodes. Our results showed that levels of cued fear were not influenced by prior contextual fear conditioning or by the interval between training; however, females showed lower levels of cued fear. Freezing behavior in the initial training context differed by sex, with females showing lower levels of contextual fear, and by the type of initial training, with rats given delayed shock showing higher levels of fear than rats given immediate shock during contextual fear conditioning. These results indicate that contextual fear conditioning does not prime subsequent cued fear conditioning and that female rats express lower levels of cued and contextual fear conditioning than males.","PeriodicalId":18003,"journal":{"name":"Learning & memory","volume":"31 9","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11472234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0