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Monitoring Contaminants of Emerging Concern (CECs) in the Environment 监测环境中新出现的关注污染物(CECs)
4区 化学
Lc Gc North America Pub Date : 2023-09-01 DOI: 10.56530/lcgc.na.gg1687n3
{"title":"Monitoring Contaminants of Emerging Concern (CECs) in the Environment","authors":"","doi":"10.56530/lcgc.na.gg1687n3","DOIUrl":"https://doi.org/10.56530/lcgc.na.gg1687n3","url":null,"abstract":"LCGC spoke to Leon Barron from Imperial College London, UK, about his work developing a fully miniaturized workflow incorporating a three-dimensional-printed passive sampler device (3D-PSD) to monitor contaminants of emerging concern (CECs) in river water.","PeriodicalId":17992,"journal":{"name":"Lc Gc North America","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135427709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Validation of an Aqueous Normal Phase Chromatography Method for the Analysis of Ergothioneine in Commercial Mushrooms 正相色谱法分析商品蘑菇中麦角硫因的验证
4区 化学
Lc Gc North America Pub Date : 2023-09-01 DOI: 10.56530/lcgc.na.zi2474s4
Joseph J. Pesek, Maria T. Matyska, Tanya Hiltz, Gary Takeoka
{"title":"Validation of an Aqueous Normal Phase Chromatography Method for the Analysis of Ergothioneine in Commercial Mushrooms","authors":"Joseph J. Pesek, Maria T. Matyska, Tanya Hiltz, Gary Takeoka","doi":"10.56530/lcgc.na.zi2474s4","DOIUrl":"https://doi.org/10.56530/lcgc.na.zi2474s4","url":null,"abstract":"An analytical HPLC method for the identification and quantification of ergothioneine (EGT) has been developed using a silica hydride-based column. A simplified sample preparation method was developed. Several types of commercially available mushrooms were analyzed for quantification of ergothioneine using a Cogent Diamond Hydride column (100 x 4.6 mm) at a flow rate of 1 mL/min, with a deionized water:acetonitrile:0.1% formic acid mobile phase using an aqueous normal phase (ANP) gradient. EGT was detected at 254 nm and was identified by matching retention times of the verified standard. The standard ergothioneine content ranged from 0.01 mg to 0.1 mg/mL with excellent linearity correlation (R2 = 0.99999). EGT recoveries were within 96.5–100.3%. The developed HPLC method was simple, accurate, reproducible, sensitive and rugged.","PeriodicalId":17992,"journal":{"name":"Lc Gc North America","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135427864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Evolution of LC Troubleshooting: Protective Devices and Column Repair LC故障排除的演变:保护装置和柱修复
4区 化学
Lc Gc North America Pub Date : 2023-09-01 DOI: 10.56530/lcgc.na.ao6286i9
Dwight R. Stoll
{"title":"The Evolution of LC Troubleshooting: Protective Devices and Column Repair","authors":"Dwight R. Stoll","doi":"10.56530/lcgc.na.ao6286i9","DOIUrl":"https://doi.org/10.56530/lcgc.na.ao6286i9","url":null,"abstract":"As chromatography technologies change, our approaches to using them in ways that value reliability, as well as the ways we should approach troubleshooting and fixing problems, should also change. In this installment, we survey several protective and troubleshooting strategies, and discuss which approaches have changed over time, and which ones have not. Understanding how the use of these approaches has evolved is helpful both for designing reliability into new methods and when considering updates to legacy methods that have been in use for decades.","PeriodicalId":17992,"journal":{"name":"Lc Gc North America","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135388745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How Software Is Defining the New Era of Laboratory Science 软件如何定义实验室科学的新时代
4区 化学
Lc Gc North America Pub Date : 2023-09-01 DOI: 10.56530/lcgc.na.ij7373a1
Jonathan Edelman
{"title":"How Software Is Defining the New Era of Laboratory Science","authors":"Jonathan Edelman","doi":"10.56530/lcgc.na.ij7373a1","DOIUrl":"https://doi.org/10.56530/lcgc.na.ij7373a1","url":null,"abstract":"Chromatography is an essential analytical tool used in many industries, including pharmaceuticals, foodstuffs, and chemistry. It is the most employed technique for separating, identifying, and quantifying components of a mixture. While there are different types of chromatography, the success of all chromatography systems largely depends on the accuracy and precision of their instruments. For the length of my career, nearly every year ushers in giant steps in the systemic improvement of commercial systems’ accuracy, precision, and overall efficiencies. These “leaps” have frequently been attributable to the physical changes in our systems, such as materials, miniaturization, and chemistries. Today, we turn our attention to software, an essential component of chromatography instruments. This article discusses software’s dynamic and growing role in chromatography, its benefits, and the belief that it will profoundly change our jobs and industry.","PeriodicalId":17992,"journal":{"name":"Lc Gc North America","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135427858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tackling PFAS Complexity with HRMS and Bioanalytical Techniques 利用HRMS和生物分析技术解决PFAS的复杂性
4区 化学
Lc Gc North America Pub Date : 2023-09-01 DOI: 10.56530/lcgc.na.nr4267c9
Carrie McDonough, Wesley Scott
{"title":"Tackling PFAS Complexity with HRMS and Bioanalytical Techniques","authors":"Carrie McDonough, Wesley Scott","doi":"10.56530/lcgc.na.nr4267c9","DOIUrl":"https://doi.org/10.56530/lcgc.na.nr4267c9","url":null,"abstract":"Per- and polyfluoroalkyl substances (PFASs) are highly persistent anthropogenic compounds that are widespread in the environment. There are thousands of PFASs, yet few neat standards exist for unequivocal identification, quantification, or toxicity assays. The bioanalytical study of complex commercial PFAS mixtures is an innovative route to better understand novel PFAS exposure and toxicity. Here, we highlight efforts using high-resolution mass spectrometry (HRMS) and exposure-relevant mixtures to prioritize PFASs based on their potential to accumulate in living organisms.","PeriodicalId":17992,"journal":{"name":"Lc Gc North America","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134995597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New Technologies That Accelerate Persistent Organic Pollutant (POP) Sample Preparation 加速持久性有机污染物(POP)样品制备的新技术
4区 化学
Lc Gc North America Pub Date : 2023-09-01 DOI: 10.56530/lcgc.na.fu6271f8
Chris Shevlin, Rahmat Ullah
{"title":"New Technologies That Accelerate Persistent Organic Pollutant (POP) Sample Preparation","authors":"Chris Shevlin, Rahmat Ullah","doi":"10.56530/lcgc.na.fu6271f8","DOIUrl":"https://doi.org/10.56530/lcgc.na.fu6271f8","url":null,"abstract":"Despite best efforts in 2004 to ban their use, persistent organic pollutants (POPs) remain prevalent across the globe, including in soil. To protect human health, agricultural and environmental soil require careful investigation, but preparing samples for gas chromatography–mass spectrometry (GC–MS) analysis is time-consuming, and mostly done manually. Accelerated solvent extraction (ASE) has been the preferred preparation method for the past few decades, and while we have seen advancements, the method remains manual. Now, new technology offers parallel sample processing, combined extraction and evaporation, and automation—leading to faster analysis, reduced risk of error, and freed-up time for personnel.","PeriodicalId":17992,"journal":{"name":"Lc Gc North America","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134994585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Per- and Polyfluoroalkyl Substances (PFAS) or Interference? Using High-Resolution Mass Spectrometry as an Investigative Tool in Food Analysis 全氟和多氟烷基物质(PFAS)或干扰?高分辨率质谱法在食品分析中的应用
4区 化学
Lc Gc North America Pub Date : 2023-09-01 DOI: 10.56530/lcgc.na.av7785a5
Brian Ng, Christine M. Fisher, Susan Genualdi, Wendy Young, Elsie Peprah, Ann M. Knolhoff, Lowri deJager
{"title":"Per- and Polyfluoroalkyl Substances (PFAS) or Interference? Using High-Resolution Mass Spectrometry as an Investigative Tool in Food Analysis","authors":"Brian Ng, Christine M. Fisher, Susan Genualdi, Wendy Young, Elsie Peprah, Ann M. Knolhoff, Lowri deJager","doi":"10.56530/lcgc.na.av7785a5","DOIUrl":"https://doi.org/10.56530/lcgc.na.av7785a5","url":null,"abstract":"Accurate quantification of per- and polyfluoroalkyl substances (PFAS) in food is necessary to understand potential dietary exposure. While beneficial for most applications, quantification of PFAS using low-resolution triple quadrupole instruments can be complicated by the presence of co-eluted interferences, which can result in false positives or inaccurate PFAS concentrations. This article discusses the use of high-resolution mass spectrometry (HRMS) to distinguish between matrix interferences and PFAS compounds in a variety of food matrices, and incorporation of these interferences into routine triple quadrupole methods for monitoring.","PeriodicalId":17992,"journal":{"name":"Lc Gc North America","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134995607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analytical Techniques in Exploring the Persistent Global PFAS Problem 探讨全球持久性PFAS问题的分析技术
4区 化学
Lc Gc North America Pub Date : 2023-09-01 DOI: 10.56530/lcgc.na.da4881y5
Simon Hird, Warren Potts, Ken Rosnack
{"title":"Analytical Techniques in Exploring the Persistent Global PFAS Problem","authors":"Simon Hird, Warren Potts, Ken Rosnack","doi":"10.56530/lcgc.na.da4881y5","DOIUrl":"https://doi.org/10.56530/lcgc.na.da4881y5","url":null,"abstract":"Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals with unique properties. They are used in a wide range of different industries because they repel water and oil, and they are heat-resistant. However, PFAS contamination has become a widespread global concern because of their ubiquitous occurrence, persistence in the environment and living organisms, and potential health risks. Governments around the world are continuously introducing and updating regulatory limits for PFAS in drinking water, other types of water, biota, and, most recently, food. Analyzing such a wide range of sample types for PFAS requires high sensitivity and selectivity, typically provided by methods based on advanced liquid chromatography–tandem quadrupole mass spectrometry (LC–MS/MS) instrumentation. However, one critical aspect to sampling and analyzing PFAS accurately is to avoid PFAS contamination during these processes. This paper emphasizes the significance of robust and reliable PFAS analysis to support efforts to mitigate the global PFAS crisis. Collaboration, research, and advanced analytical solutions are essential to safeguard food, water, and the environment, thusly reducing the impact of PFAS on public health and the environment.","PeriodicalId":17992,"journal":{"name":"Lc Gc North America","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134994968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What Are Employers Looking For When Hiring Separation Scientists? 当雇主雇佣分离科学家时，他们在寻找什么?
4区 化学
Lc Gc North America Pub Date : 2023-08-01 DOI: 10.56530/lcgc.na.ym2073i4
Caroline McGregor, Justin Pennington
{"title":"What Are Employers Looking For When Hiring Separation Scientists?","authors":"Caroline McGregor, Justin Pennington","doi":"10.56530/lcgc.na.ym2073i4","DOIUrl":"https://doi.org/10.56530/lcgc.na.ym2073i4","url":null,"abstract":"Per the U.S. National Academies of Science (NAS) 2019 report “A Research Agenda for Transforming Separation Science,” the number of America’s academic positions in separation science has decreased considerably in recent years, with a number of universities choosing to stop hiring faculty in this area. Specifically, since 1987 (the year of the previous NAS report on this field), the number of faculty members readily identifiable as “separations researchers” has dropped by 40% in the top chemistry departments, and by 30% in the top chemical engineering departments. At the same time, national government funding organizations (such as the National Science Foundation [NSF]) have significantly reduced funding for separation science. All this occurs despite the continuing demand for separation scientists and engineers in the largest economic sectors of the United States. LCGC North America spoke to Caroline McGregor and Justin Pennington of Merck Research Laboratories regarding the effects of the aforementioned occurrences on their firm’s hiring practices, and what employers in general are looking for in candidates they are considering for open separation scientist positions.","PeriodicalId":17992,"journal":{"name":"Lc Gc North America","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136300227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The 2023 LCGC Salary Survey: How Workers Are Navigating A Tough Economic Landscape 2023年LCGC薪资调查:工人如何在艰难的经济环境中生存
4区 化学
Lc Gc North America Pub Date : 2023-08-01 DOI: 10.56530/lcgc.na.jq6284c9
Will Wetzel
{"title":"The 2023 LCGC Salary Survey: How Workers Are Navigating A Tough Economic Landscape","authors":"Will Wetzel","doi":"10.56530/lcgc.na.jq6284c9","DOIUrl":"https://doi.org/10.56530/lcgc.na.jq6284c9","url":null,"abstract":"The fallout from the Covid-19 global pandemic remains in progress in 2023. Because of the current ongoing global recession, we anticipated that many workers would be concerned about their current jobs and how to adjust to rising inflation. In this year’s LCGC Salary Survey, we sought to explore these topics. In addition to compiling information about the average salary trends and reported on how these trends compare to previous years, we focused this edition of our questionnaire on the current economy, asking respondents to offer their opinions on whether a recession is taking place where they reside, and what impact it is having on them mentally and financially. The results from our survey indicate that anxiety about the current state of the economy was on respondents’ minds in 2023.","PeriodicalId":17992,"journal":{"name":"Lc Gc North America","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135053244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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