利用HRMS和生物分析技术解决PFAS的复杂性

IF 0.7 4区化学 Q4 CHEMISTRY, ANALYTICAL

Lc Gc North America Pub Date : 2023-09-01 DOI:10.56530/lcgc.na.nr4267c9

Carrie McDonough, Wesley Scott

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引用次数: 0

摘要

全氟和多氟烷基物质(PFASs)是广泛存在于环境中的高度持久性人为化合物。有成千上万的全氟辛烷磺酸，但很少有整洁的标准存在明确的鉴定，定量，或毒性分析。复杂的商业PFAS混合物的生物分析研究是更好地了解新型PFAS暴露和毒性的创新途径。在这里，我们强调了使用高分辨率质谱(HRMS)和暴露相关混合物的努力，以优先考虑PFASs在生物体中积累的潜力。

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Tackling PFAS Complexity with HRMS and Bioanalytical Techniques

Per- and polyfluoroalkyl substances (PFASs) are highly persistent anthropogenic compounds that are widespread in the environment. There are thousands of PFASs, yet few neat standards exist for unequivocal identification, quantification, or toxicity assays. The bioanalytical study of complex commercial PFAS mixtures is an innovative route to better understand novel PFAS exposure and toxicity. Here, we highlight efforts using high-resolution mass spectrometry (HRMS) and exposure-relevant mixtures to prioritize PFASs based on their potential to accumulate in living organisms.

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来源期刊

Lc Gc North America 化学-分析化学

CiteScore

1.00

自引率

55.60%

发文量

审稿时长

2 months

期刊介绍： Founded in 1983, LCGC is the leading provider of digital and print content to the separation science market, enhancing the productivity, efficiency, and the overall value of separation techniques globally. Founded in 1983, LCGC is the leading provider of digital and print content to the separation science market, enhancing the productivity, efficiency, and the overall value of separation techniques globally. With our commitment to editorial excellence we have pioneered innovation across a broad portfolio of digital and print platforms.