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New mouse models for psychedelic studies 迷幻药研究的新小鼠模型
IF 6.8 3区 农林科学
Lab Animal Pub Date : 2026-08-26 DOI: 10.1038/s41684-026-01791-w
Alexandra Le Bras
{"title":"New mouse models for psychedelic studies","authors":"Alexandra Le Bras","doi":"10.1038/s41684-026-01791-w","DOIUrl":"10.1038/s41684-026-01791-w","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"55 9","pages":"329-329"},"PeriodicalIF":6.8,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148816702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Behavioral task performance as a welfare marker 行为任务绩效作为福利标志
IF 6.8 3区 农林科学
Lab Animal Pub Date : 2026-08-26 DOI: 10.1038/s41684-026-01797-4
Jorge Ferreira
{"title":"Behavioral task performance as a welfare marker","authors":"Jorge Ferreira","doi":"10.1038/s41684-026-01797-4","DOIUrl":"10.1038/s41684-026-01797-4","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"55 9","pages":"330-330"},"PeriodicalIF":6.8,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148816707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brain circuit linked to compulsive eating in mice 老鼠的大脑回路与强迫性进食有关
IF 6.8 3区 农林科学
Lab Animal Pub Date : 2026-08-26 DOI: 10.1038/s41684-026-01800-y
Alexandra Le Bras
{"title":"Brain circuit linked to compulsive eating in mice","authors":"Alexandra Le Bras","doi":"10.1038/s41684-026-01800-y","DOIUrl":"10.1038/s41684-026-01800-y","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"55 9","pages":"331-331"},"PeriodicalIF":6.8,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41684-026-01800-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148816684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tracing clonal drift in the aging gut 追踪衰老肠道中的克隆漂移
IF 6.8 3区 农林科学
Lab Animal Pub Date : 2026-08-26 DOI: 10.1038/s41684-026-01792-9
Alexandra Le Bras
{"title":"Tracing clonal drift in the aging gut","authors":"Alexandra Le Bras","doi":"10.1038/s41684-026-01792-9","DOIUrl":"10.1038/s41684-026-01792-9","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"55 9","pages":"329-329"},"PeriodicalIF":6.8,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148816705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex differences in recovery from ketamine anesthesia 氯胺酮麻醉后恢复的性别差异
IF 6.8 3区 农林科学
Lab Animal Pub Date : 2026-08-26 DOI: 10.1038/s41684-026-01801-x
Alexandra Le Bras
{"title":"Sex differences in recovery from ketamine anesthesia","authors":"Alexandra Le Bras","doi":"10.1038/s41684-026-01801-x","DOIUrl":"10.1038/s41684-026-01801-x","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"55 9","pages":"332-332"},"PeriodicalIF":6.8,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41684-026-01801-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148816682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of microglia in depression 小胶质细胞在抑郁症中的作用
IF 6.8 3区 农林科学
Lab Animal Pub Date : 2026-08-26 DOI: 10.1038/s41684-026-01796-5
Jorge Ferreira
{"title":"Role of microglia in depression","authors":"Jorge Ferreira","doi":"10.1038/s41684-026-01796-5","DOIUrl":"10.1038/s41684-026-01796-5","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"55 9","pages":"330-330"},"PeriodicalIF":6.8,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148816703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex-specific resilience and vulnerability after alcohol and stress exposure 酒精和压力暴露后的性别特异性复原力和脆弱性
IF 6.8 3区 农林科学
Lab Animal Pub Date : 2026-08-26 DOI: 10.1038/s41684-026-01802-w
Jorge Ferreira
{"title":"Sex-specific resilience and vulnerability after alcohol and stress exposure","authors":"Jorge Ferreira","doi":"10.1038/s41684-026-01802-w","DOIUrl":"10.1038/s41684-026-01802-w","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"55 9","pages":"333-333"},"PeriodicalIF":6.8,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41684-026-01802-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148816691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel essential factor for male fertility 男性生育能力的新基本因素
IF 6.8 3区 农林科学
Lab Animal Pub Date : 2026-08-26 DOI: 10.1038/s41684-026-01798-3
Jorge Ferreira
{"title":"Novel essential factor for male fertility","authors":"Jorge Ferreira","doi":"10.1038/s41684-026-01798-3","DOIUrl":"10.1038/s41684-026-01798-3","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"55 9","pages":"330-330"},"PeriodicalIF":6.8,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148816704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neural and behavioral correlates of consciousness: the welfare consequences of fatal hypobaric and hypercapnic hypoxia in laboratory mice 意识的神经和行为相关：实验室小鼠致命的低压和高碳酸血症缺氧的福利后果
IF 6.9 3区 农林科学
Lab Animal Pub Date : 2026-08-21 DOI: 10.1038/s41684-026-01788-5
Jasmine M. Clarkson, Dorothy E. F. McKeegan, Ross S. Muers, Matthew C. Leach, Julian Sparrey, Alfredo Gonzalez-Sulser, Jessica E. Martin
{"title":"Neural and behavioral correlates of consciousness: the welfare consequences of fatal hypobaric and hypercapnic hypoxia in laboratory mice","authors":"Jasmine M. Clarkson, Dorothy E. F. McKeegan, Ross S. Muers, Matthew C. Leach, Julian Sparrey, Alfredo Gonzalez-Sulser, Jessica E. Martin","doi":"10.1038/s41684-026-01788-5","DOIUrl":"https://doi.org/10.1038/s41684-026-01788-5","url":null,"abstract":"Understanding an animal’s capacity to experience negative sensations, such as pain and distress, during impaired states of consciousness is critical in many contexts, particularly when animals are being euthanized. Mice remain the predominant species used for scientific research globally, where a prerequisite requires them to be humanely killed at the end of the scientific work. However, whether some of the existing practices and methodologies (for example, exposure to a rising concentration of carbon dioxide) provide these animals with a humane death has been questioned, thus requiring the development of novel, refined methodologies. Here we highlight the potential of hypobaric hypoxia to provide a humane alternative to hypercapnic hypoxia by combining behavioral and neurophysiological assessment (using electroencephalography) to characterize brain activity during the induction of unconsciousness. We found different patterns of brain activity between hypobaric and hypercapnic hypoxia, suggestive of key mechanistic differences in the transition toward unconsciousness. Unlike hypercapnic hypoxia, hypobaric hypoxia resulted in an early shift in peak power to lower delta frequency bands (<4 Hz), suggestive of early cognitive impairment and an anesthetic-like state before loss of posture. As such, mice are likely to have a reduced capacity to have negatively valenced sensory–affective experiences. Hypobaric hypoxia could provide the basis for major refinement to essential killing practices for laboratory mice worldwide.","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"34 1","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148769292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of IL-6’s in depression associated with atopic dermatitis IL-6在特应性皮炎相关抑郁中的作用
IF 6.8 3区 农林科学
Lab Animal Pub Date : 2026-07-29 DOI: 10.1038/s41684-026-01783-w
Jorge Ferreira
{"title":"Role of IL-6’s in depression associated with atopic dermatitis","authors":"Jorge Ferreira","doi":"10.1038/s41684-026-01783-w","DOIUrl":"10.1038/s41684-026-01783-w","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"55 8","pages":"284-284"},"PeriodicalIF":6.8,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148617430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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