Lab Animal最新文献_第3页

Role of adipocyte ATF3 in metabolic disorders 脂肪细胞 ATF3 在代谢紊乱中的作用

IF 5.9 3区农林科学

Lab Animal Pub Date : 2024-11-26 DOI: 10.1038/s41684-024-01487-z

Jorge Ferreira

引用次数: 0

Amantadine improves POCD symptoms 金刚烷胺可改善 POCD 症状

IF 5.9 3区农林科学

Lab Animal Pub Date : 2024-11-26 DOI: 10.1038/s41684-024-01478-0

Jorge Ferreira

引用次数: 0

Studying microglia’s role in APOE4-related pathology 研究小胶质细胞在 APOE4 相关病理学中的作用

IF 5.9 3区农林科学

Lab Animal Pub Date : 2024-11-26 DOI: 10.1038/s41684-024-01488-y

Alexandra Le Bras

引用次数: 0

Comparing microglia models 比较小胶质细胞模型

IF 5.9 3区农林科学

Lab Animal Pub Date : 2024-11-26 DOI: 10.1038/s41684-024-01483-3

Alexandra Le Bras

引用次数: 0

COVID-19 affects vitamin D metabolism in the kidney COVID-19 影响肾脏中的维生素 D 代谢

IF 5.9 3区农林科学

Lab Animal Pub Date : 2024-11-26 DOI: 10.1038/s41684-024-01481-5

Jorge Ferreira

引用次数: 0

Stress susceptibility markers 压力易感性标记

IF 5.9 3区农林科学

Lab Animal Pub Date : 2024-11-26 DOI: 10.1038/s41684-024-01489-x

Jorge Ferreira

引用次数: 0

Sex differences in response to stress and alcohol abuse 对压力和酗酒反应的性别差异

IF 5.9 3区农林科学

Lab Animal Pub Date : 2024-11-26 DOI: 10.1038/s41684-024-01486-0

Jorge Ferreira

引用次数: 0

Revisited guidelines for metabolic tolerance tests in mice 重新修订小鼠代谢耐受性试验指南

IF 5.9 3区农林科学

Lab Animal Pub Date : 2024-11-25 DOI: 10.1038/s41684-024-01473-5

Cedric Moro, Christophe Magnan

{"title":"Revisited guidelines for metabolic tolerance tests in mice","authors":"Cedric Moro, Christophe Magnan","doi":"10.1038/s41684-024-01473-5","DOIUrl":"10.1038/s41684-024-01473-5","url":null,"abstract":"Preclinical mouse models are extensively used in biomedical research to gain insight into disease mechanisms and to test new drug treatments. Glucose and insulin tolerance tests are simple experimental tests frequently used worldwide to assess glucose metabolism in mice. Various guidelines and methodological considerations have been published to help researchers standardize procedures and optimize research outcomes. Yet, there is still important experimental heterogeneity in the way these simple procedures are performed, with no real consensus on what the best practices are to achieve high-quality research and reproducible results. Here we critically examine several published guidelines and recent technical reports on how to perform these metabolic tests in laboratory mice and discuss the influence of various confounding factors on test results. We hope this work will help scientists establish more consensual guidelines for maximizing the relevance and clinical translation of studies using mouse models in metabolic research. In this Review, the authors examine current guidelines for metabolic tolerance tests in mice and provide a set of revisited recommendations to improve the reproducibility and clinical translation of the findings.","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"54 1","pages":"16-23"},"PeriodicalIF":5.9,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41684-024-01473-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142697096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A revision to marble burying: video analysis during the marble burying task is imperative to understanding rodent behavior 对埋弹珠任务的修订：要了解啮齿动物的行为，必须对埋弹珠任务进行视频分析

IF 5.9 3区农林科学

Lab Animal Pub Date : 2024-11-22 DOI: 10.1038/s41684-024-01459-3

Lauren A. Burgett, Theres B. Alexander, Haley A. Moya, Marcy A. Kingsbury

{"title":"A revision to marble burying: video analysis during the marble burying task is imperative to understanding rodent behavior","authors":"Lauren A. Burgett, Theres B. Alexander, Haley A. Moya, Marcy A. Kingsbury","doi":"10.1038/s41684-024-01459-3","DOIUrl":"10.1038/s41684-024-01459-3","url":null,"abstract":"The translational value of the marble burying task (MBT) is debatable. Here we performed video analysis of behaviors during the MBT to accurately capture the details of all behaviors displayed during this task. Our results show that a count of marbles buried at the end of the task may not be a good translational correlate of the ‘intentional marble burying’ that the task is assumed to measure. Rather, the number of marbles buried may be measuring accidental marble burying due to ‘rapid digging’. Video analysis during MBT provides a novel approach to characterize the many behaviors displayed during this task and may explain inconsistencies reported in the literature. However, the number of marbles buried at the end of the MBT may still have value as a screening test for anxiogenic or anxiolytic interventions. Any interventions that show significant alterations in the number of marbles buried can be pursued further through more robust and comprehensive behavior scoring methods. The marble burying task (MBT) is used to measure anxiety-like behavior, relying on a snapshot of the number of marbles buried at the end of the test. This Brief Communication introduces a more extensive behavioral analysis to improve the translational value of MBT for clinical psychological phenotypes.","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"53 12","pages":"387-389"},"PeriodicalIF":5.9,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142684290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vivo optical tissue clearing using light-absorbing dyes 使用光吸收染料进行体内光学组织清除

IF 5.9 3区农林科学

Lab Animal Pub Date : 2024-11-15 DOI: 10.1038/s41684-024-01472-6

Maria Victoria Gómez-Gaviro, Vicente Llorente

引用次数: 0