Lab AnimalPub Date : 2025-04-01DOI: 10.1038/s41684-025-01540-5
Alexandra Le Bras
{"title":"Sex differences in synucleinopathies","authors":"Alexandra Le Bras","doi":"10.1038/s41684-025-01540-5","DOIUrl":"10.1038/s41684-025-01540-5","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"54 4","pages":"76-76"},"PeriodicalIF":5.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lab AnimalPub Date : 2025-04-01DOI: 10.1038/s41684-025-01541-4
Alexandra Le Bras
{"title":"Mapping MS in marmoset brains","authors":"Alexandra Le Bras","doi":"10.1038/s41684-025-01541-4","DOIUrl":"10.1038/s41684-025-01541-4","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"54 4","pages":"76-76"},"PeriodicalIF":5.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lab AnimalPub Date : 2025-04-01DOI: 10.1038/s41684-025-01536-1
Jorge Ferreira
{"title":"Female mice benefit more from exercise","authors":"Jorge Ferreira","doi":"10.1038/s41684-025-01536-1","DOIUrl":"10.1038/s41684-025-01536-1","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"54 4","pages":"75-75"},"PeriodicalIF":5.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lab AnimalPub Date : 2025-04-01DOI: 10.1038/s41684-025-01518-3
Joseph J. Gillard
{"title":"A computational model to support the welfare-based management of a laboratory colony of common marmosets","authors":"Joseph J. Gillard","doi":"10.1038/s41684-025-01518-3","DOIUrl":"https://doi.org/10.1038/s41684-025-01518-3","url":null,"abstract":"<p>Here, a computational model to forecast the population dynamics of a laboratory colony of common marmosets (<i>Callithrix jacchus</i>) is presented. This tool supports decision-making that seeks to maximize welfare and maintain a healthy and genetically diverse colony. The model considers the population in terms of three compartments: breeding adults, their offspring and nonbreeding adults. Natural events are explicitly represented, including births, deaths and the transfer of mature offspring from family housing to adult housing. These events are simulated using rates based on historical data extracted from the colony record-keeping system. Multi-year forecasts of population dynamics are generated, taking full account of interventions such as the implementation of breeding controls, the usage of animals by a portfolio of research projects and relocation to external primate facilities. Model forecasts are validated against real data. Uncertainties in animal usage are propagated through the model. The resulting forecasts provide a realistic range of future stock levels to support colony management and decision-making. The model outputs provide evidence to help assess the impacts of making interventions in the system, for example, breeding control strategies. This evidence-based approach to colony management serves to enhance animal welfare and accountability to regulatory bodies and stakeholders. The model can be adapted to simulate the dynamics of other nonhuman primate colonies.</p>","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"183 1","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lab AnimalPub Date : 2025-03-27DOI: 10.1038/s41684-025-01533-4
Mette Flethøj, Karina Poulsdóttir Debes, Cecilie Larsen, Caroline de Blanck, Trine Pagh Ludvigsen, Jeppe Kirchhoff, Jacob Eifer Møller, Steen Larsen, Jens P. Gøtze, Thomas Jespersen, Lisbeth Høier Olsen
{"title":"Impact of obesity on infarct size, circulating biomarkers, mitochondrial function and mortality in a Göttingen minipig myocardial infarct model","authors":"Mette Flethøj, Karina Poulsdóttir Debes, Cecilie Larsen, Caroline de Blanck, Trine Pagh Ludvigsen, Jeppe Kirchhoff, Jacob Eifer Møller, Steen Larsen, Jens P. Gøtze, Thomas Jespersen, Lisbeth Høier Olsen","doi":"10.1038/s41684-025-01533-4","DOIUrl":"10.1038/s41684-025-01533-4","url":null,"abstract":"Obesity is a risk factor for the development of coronary artery disease and myocardial infarction (MI). However, most large animal studies of MI are performed in lean animals. Here we assessed the impact of obesity on echocardiographic findings, infarct size, circulating biomarkers, mitochondrial respiratory capacity and mortality in a closed-chest minipig model of MI. The initial study population consisted of 20 obese (median 60.0 kg [interquartile range 55.9–64.6 kg]) and 18 lean (25.0 kg [23.4–36.5 kg]) female Göttingen minipigs. The duration of obesity induction using a western-style diet was up to approximately 6 months (156 days [24–162 days]) before the induction of MI. The induction of MI by 120-min balloon occlusion of the left anterior descending coronary artery was feasible in 17 lean and 17 obese animals. Mortality was higher in obese compared with lean animals (53% versus 12%), driven primarily by refractory ventricular fibrillation during occlusion. Electrocardiographic findings showed longer QRS and QT intervals and more extensive ST-segment elevation in obese animals compared with lean animals during occlusion. Plasma concentrations of pro-atrial natriuretic peptide, pro-C-type natriuretic peptide and cardiac troponin T were significantly lower in obese compared with lean animals. Infarct size estimated 8 weeks after MI was significantly smaller in obese (10% [9–11%]) compared with lean animals (13% [13–15%]). Finally, mitochondrial-complex-I-linked respiratory capacity was overall significantly higher in obese animals; however, no group difference was found in intrinsic mitochondrial respiratory capacity. The study shows that, compared with lean animals, obesity significantly impacts echocardiographic findings, infarct size, circulating biomarkers, mitochondrial respiratory capacity and mortality in a minipig model of myocardial infarction.","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"54 4","pages":"103-111"},"PeriodicalIF":5.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41684-025-01533-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
