Lab Animal最新文献

{"title":"IVF and reproductive aging","authors":"Alexandra Le Bras","doi":"10.1038/s41684-026-01808-4","DOIUrl":"10.1038/s41684-026-01808-4","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"55 10","pages":"375-375"},"PeriodicalIF":6.8,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149068610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AgRP neurons support GLP-1–induced weight loss","authors":"Alexandra Le Bras","doi":"10.1038/s41684-026-01812-8","DOIUrl":"10.1038/s41684-026-01812-8","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"55 10","pages":"376-376"},"PeriodicalIF":6.8,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149068615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current legislation and recommendations on ethical post-experimental care and disposition of laboratory animals: a call for global standards.","authors":"Ji Min Lee, Sang Wha Kim, Seung Hyeok Seok","doi":"10.1038/s41684-026-01803-9","DOIUrl":"https://doi.org/10.1038/s41684-026-01803-9","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148983024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unconventional animal models of Alzheimer’s disease and aging: key insights from the UAMAA 2026 conference","authors":"B. Maximiliano Garduño, Tonatiuh Melgarejo, Patricia Cogram, Todd C. Holmes, Xiangmin Xu","doi":"10.1038/s41684-026-01789-4","DOIUrl":"10.1038/s41684-026-01789-4","url":null,"abstract":"Alzheimer’s disease (AD) remains a major unmet medical challenge, highlighting the need for improved experimental models. The second Unconventional Animal Models of Alzheimer’s Disease and Aging (UAMAA 2026) conference brought together ~150 interdisciplinary researchers to discuss advances across 19 animal models of AD and aging. Six major themes emerged: naturally occurring AD-like pathology, neuroinflammation, population heterogeneity, development of genomic and molecular resources, companion dogs as translational models and the promise of laboratory-amenable species such as the Chilean degu and common marmoset. These discussions highlighted the growing value of cross-species approaches for advancing translational AD research.","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"55 10","pages":"367-370"},"PeriodicalIF":6.8,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41684-026-01789-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148983144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Swine cancer models, ready for prime time?","authors":"Lidia Flor Cuenca, Kyle Schachtschneider, Raimon Duran-Struuck","doi":"10.1038/s41684-026-01790-x","DOIUrl":"10.1038/s41684-026-01790-x","url":null,"abstract":"Small animal models, though extremely valuable, can fail to predict clinical outcomes due to physiological, metabolic and immunological differences with humans. By contrast, swine models offer a clinically relevant platform that addresses key limitations of rodent, canine and nonhuman primate preclinical systems. Pigs share critical anatomical, genetic and immunological features with humans, enabling replication of human malignancies and providing a robust platform to study cancer onset, progression and the evaluation of novel therapeutic strategies. Here, we describe two major categories of swine models used in biomedical research: naturally occurring tumor models and genetically engineered models. Together, they provide a complementary and translationally robust platform for preclinical studies, with meaningful implications for clinical trial design.","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"55 10","pages":"371-374"},"PeriodicalIF":6.8,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148983013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Finding a place for new approach methodologies (NAMs) in biomedical research","authors":"Alexandra Schaffert,Arti Ahluwalia,Jeffrey J. Bajramovic,Nuno H. Franco,Winfried Neuhaus,I. Anna S. Olsson,Ioanna Sandvig","doi":"10.1038/s41684-026-01806-6","DOIUrl":"https://doi.org/10.1038/s41684-026-01806-6","url":null,"abstract":"Abstract New approach methodologies (NAMs) can greatly contribute to the replacement and reduction of animal experiments in biomedical science. However, while NAMs have seen considerable investment and adoption in toxicology, this growth has not found a parallel in basic and translational biomedical research. Here we examine the opportunities and the challenges of systematic implementation of NAMs in biomedical research. We demonstrate that NAMs offer considerable scientific value by enabling tailored investigations into biological mechanisms and disease processes, addressing aspects of human biology that may be difficult to capture or extrapolate from animal models, and harnessing cutting-edge technological innovations. We highlight key areas, such as neuroscience, cardiovascular research and oncology, where NAMs have a distinct advantage and the potential to drive major advancements. However, realizing their full potential requires overcoming critical barriers, including technological limitations, gaps in education and training and insufficient funding. To facilitate broader adoption of NAMs, we propose adapting clinical outcome pathways, originally developed to link mechanistic biology to clinical outcomes, as a framework to guide the selection, combination and interpretation of NAMs in biomedical research. This approach could help to address a central limitation of individual NAMs, namely their restricted ability to capture whole-organism complexity, by enabling the meaningful combination of complementary models. Finally, we outline a stepwise strategy to accelerate the adoption of NAMs, emphasizing interdisciplinary collaboration, parallel studies alongside existing animal models and sustained investment in infrastructure and education.","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"14 1","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148933935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Activating a patient-relevant pathogenic variant of a genetically defined heart disease in a humanized pig model","authors":"Petra Runa-Vochozkova, Michaela Vaskovicova, Josep M. Cambra, Andrea Bähr, Eva-Maria Männer, Mayuko Kurome, Valeri Zakhartchenko, Tuna Güngör, Barbara Kessler, Heinke C. Heymer, Mara L. Corsten, Tarik Bozoglu, Vijayanand Rajendran, Solomon K. Yator, Tatjana Dorn, Jessica K. Hernandez, Ina M. Luksch, Magdalena Harakalova, Peter van Tintelen, Stefan Juhas, Jana Juhasova, Carolina G. Cabrera-Gómez, Susanne Zöls, Steffanie Senf, Francesca Stillitano, Joost P. G. Sluijter, Mathias Ritzmann, Zdenka Ellederova, Motlik Jan, Pieter A. Doevendans, David Drutovic, Pieter C. Glijnis, Eckhard Wolf, Christian Kupatt, Nikolai Klymiuk","doi":"10.1038/s41684-026-01787-6","DOIUrl":"10.1038/s41684-026-01787-6","url":null,"abstract":"Complex diseases such as progressive cardiomyopathies are often insufficiently recapitulated in small animals or in vitro models. Large animal species such as pigs provide a valuable alternative, but constitutive genetic manipulation has not yet been applied to pigs in an effective manner, mainly due to biological and logistical limitations. Here we describe the generation of a humanized pig model for phospholamban-mediated cardiomyopathy and compare different methods for activating a pathogenic R14del mutation by Cre-mediated recombination. Both Cre treatment of pig primary cells before somatic cell nuclear transfer as well as microinjection of Cre-encoding mRNA into zygotes were similarly efficient in delivering piglets with an activated R14del mutation. Alternatively, administration of Cre-encoding adeno-associated virus into piglets was sufficient, albeit to a varying extent. Together, we describe a highly effective process to establish complex inducible genetic traits in pig and demonstrate that the lack of Cre-driver lines can be compensated by various interventions during reproduction or postnatally. The study describes the generation of a humanized pig model carrying an inducible phospholamban R14del mutation for cardiomyopathy modeling and demonstrates Cre-based activation strategies as efficient alternatives to germline Cre-driver lines in large animals.","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"55 10","pages":"386-401"},"PeriodicalIF":6.8,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41684-026-01787-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148933936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Testosterone role in atopic dermatitis","authors":"Jorge Ferreira","doi":"10.1038/s41684-026-01795-6","DOIUrl":"10.1038/s41684-026-01795-6","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"55 9","pages":"330-330"},"PeriodicalIF":6.8,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148816681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CRISPR screen uncovers new suppressors of breast cancer metastasis","authors":"Alexandra Le Bras","doi":"10.1038/s41684-026-01794-7","DOIUrl":"10.1038/s41684-026-01794-7","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"55 9","pages":"329-329"},"PeriodicalIF":6.8,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148816683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in Drosophila immunity","authors":"Alexandra Le Bras","doi":"10.1038/s41684-026-01793-8","DOIUrl":"10.1038/s41684-026-01793-8","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"55 9","pages":"329-329"},"PeriodicalIF":6.8,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148816706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}