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Microbial metabolite affects CKD progression 微生物代谢物影响慢性肾脏病的进展
IF 5.9 3区 农林科学
Lab Animal Pub Date : 2024-08-30 DOI: 10.1038/s41684-024-01429-9
Alexandra Le Bras
{"title":"Microbial metabolite affects CKD progression","authors":"Alexandra Le Bras","doi":"10.1038/s41684-024-01429-9","DOIUrl":"10.1038/s41684-024-01429-9","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142100826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Resveratrol improves rat infertility 白藜芦醇可改善大鼠不育症
IF 5.9 3区 农林科学
Lab Animal Pub Date : 2024-08-30 DOI: 10.1038/s41684-024-01434-y
Jorge Ferreira
{"title":"Resveratrol improves rat infertility","authors":"Jorge Ferreira","doi":"10.1038/s41684-024-01434-y","DOIUrl":"10.1038/s41684-024-01434-y","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142100820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex differences in microbiota 微生物群的性别差异
IF 5.9 3区 农林科学
Lab Animal Pub Date : 2024-08-30 DOI: 10.1038/s41684-024-01430-2
Alexandra Le Bras
{"title":"Sex differences in microbiota","authors":"Alexandra Le Bras","doi":"10.1038/s41684-024-01430-2","DOIUrl":"10.1038/s41684-024-01430-2","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142100822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenges and future directions of SUDEP models SUDEP 模型的挑战和未来方向。
IF 5.9 3区 农林科学
Lab Animal Pub Date : 2024-08-26 DOI: 10.1038/s41684-024-01426-y
JiaXuan Gu, WeiHui Shao, Lu Liu, YuLing Wang, Yue Yang, ZhuoYue Zhang, YaXuan Wu, Qing Xu, LeYuan Gu, YuanLi Zhang, Yue Shen, HaiTing Zhao, Chang Zeng, HongHai Zhang
{"title":"Challenges and future directions of SUDEP models","authors":"JiaXuan Gu, WeiHui Shao, Lu Liu, YuLing Wang, Yue Yang, ZhuoYue Zhang, YaXuan Wu, Qing Xu, LeYuan Gu, YuanLi Zhang, Yue Shen, HaiTing Zhao, Chang Zeng, HongHai Zhang","doi":"10.1038/s41684-024-01426-y","DOIUrl":"10.1038/s41684-024-01426-y","url":null,"abstract":"Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death among patients with epilepsy, causing a global public health burden. The underlying mechanisms of SUDEP remain elusive, and effective prevention or treatment strategies require further investigation. A major challenge in current SUDEP research is the lack of an ideal model that maximally mimics the human condition. Animal models are important for revealing the potential pathogenesis of SUDEP and preventing its occurrence; however, they have potential limitations due to species differences that prevent them from precisely replicating the intricate physiological and pathological processes of human disease. This Review provides a comprehensive overview of several available SUDEP animal models, highlighting their pros and cons. More importantly, we further propose the establishment of an ideal model based on brain–computer interfaces and artificial intelligence, hoping to offer new insights into potential advancements in SUDEP research. In doing so, we hope to provide valuable information for SUDEP researchers, offer new insights into the pathogenesis of SUDEP and open new avenues for the development of strategies to prevent SUDEP. This Review provides a comprehensive overview of several available animal models of sudden unexpected death in epilepsy (SUDEP), highlighting their pros and cons to elucidate SUDEP causes and mechanisms.","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A closer look at the Laboratory Animal Genetic Reporting (LAG-R) guidelines 实验动物遗传学报告 (LAG-R) 指南详解
IF 5.9 3区 农林科学
Lab Animal Pub Date : 2024-08-19 DOI: 10.1038/s41684-024-01427-x
Alexandra Le Bras
{"title":"A closer look at the Laboratory Animal Genetic Reporting (LAG-R) guidelines","authors":"Alexandra Le Bras","doi":"10.1038/s41684-024-01427-x","DOIUrl":"10.1038/s41684-024-01427-x","url":null,"abstract":"The Laboratory Animal Genetic Reporting (LAG-R) framework, developed by a team of international experts, was recently published in Nature Communications. The LAG-R framework proposes a collection of guidelines to improve the reporting of genetic information for animal models. Lab Animal spoke with corresponding authors Lydia Teboul and Guillaume Pavlovic to know more about the motivation for these recommendations, the benefits for researchers and how to accelerate their adoption.","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142002715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The highly pathogenic H5N1 virus found in U.S. dairy cattle has some characteristics that could enhance infection and transmission among mammals 在美国奶牛身上发现的高致病性 H5N1 病毒具有一些特征，可增强哺乳动物之间的感染和传播能力
IF 5.9 3区 农林科学
Lab Animal Pub Date : 2024-08-14 DOI: 10.1038/s41684-024-01425-z
Fabien Filaire, Sander Herfst
{"title":"The highly pathogenic H5N1 virus found in U.S. dairy cattle has some characteristics that could enhance infection and transmission among mammals","authors":"Fabien Filaire, Sander Herfst","doi":"10.1038/s41684-024-01425-z","DOIUrl":"10.1038/s41684-024-01425-z","url":null,"abstract":"A highly pathogenic H5N1 influenza virus is spreading in U.S. dairy cattle and has been transmitted to other species, including humans, probably through contaminated milk. Understanding how the virus spreads among cattle and its potential for mammalian adaptation and airborne transmission is crucial for effective outbreak control and public health safety.","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41684-024-01425-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141980956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of volume management on free flap perfusion and metabolism in a large animal model study 在一项大型动物模型研究中，容量管理对游离皮瓣灌注和新陈代谢的影响
IF 6.9 3区 农林科学
Lab Animal Pub Date : 2024-08-09 DOI: 10.1038/s41684-024-01410-6
Daniel G. E. Thiem, Daniel Stephan, Alexander Ziebart, Robert Ruemmler, Julian Riedel, Shankeeth Vinayahalingam, Bilal Al-Nawas, Sebastian Blatt, Peer W. Kämmerer
{"title":"Effects of volume management on free flap perfusion and metabolism in a large animal model study","authors":"Daniel G. E. Thiem, Daniel Stephan, Alexander Ziebart, Robert Ruemmler, Julian Riedel, Shankeeth Vinayahalingam, Bilal Al-Nawas, Sebastian Blatt, Peer W. Kämmerer","doi":"10.1038/s41684-024-01410-6","DOIUrl":"https://doi.org/10.1038/s41684-024-01410-6","url":null,"abstract":"<p>Free flap failure represents a substantial clinical burden. The role of intraoperative volume management remains controversial, with valid studies lacking. Here, using a large animal model, we investigated the influence of volume management on free flap perfusion and metabolism. Autotransfer of a musculocutaneous gracilis flap was performed on 31 German domestic pigs, with arterial anastomosis and catheterization of the pedicle vein for sequential blood sampling. Flap reperfusion was followed by induction of a hemorrhagic shock with maintenance for 30 min and subsequent circulation stabilization with crystalloid solution, crystalloid solution and catecholamine, autotransfusion or colloidal solution. Flap perfusion and oxygenation were periodically assessed using hyperspectral imaging. Flap metabolism was assessed via periodic blood gas analyses. Hyperspectral imaging revealed no difference in either superficial or deep tissue oxygen saturation, tissue hemoglobin or tissue water content between the test groups at any time point. Blood gas analyses showed that lactate levels were significantly increased in the group that received crystalloid solution and catecholamine, after circulatory stabilization and up to 2 h after. We conclude that, in hemorrhagic shock, volume management impacts acid–base balance in free flaps. Crystalloid solutions with norepinephrine increase lactate levels, yet short-term effects on flap perfusion seem minimal, suggesting that vasopressors are not detrimental.</p>","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":null,"pages":null},"PeriodicalIF":6.9,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hepatic stress in acute kidney injury 急性肾损伤的肝脏压力
IF 5.9 3区 农林科学
Lab Animal Pub Date : 2024-08-01 DOI: 10.1038/s41684-024-01415-1
Jorge Ferreira
{"title":"Hepatic stress in acute kidney injury","authors":"Jorge Ferreira","doi":"10.1038/s41684-024-01415-1","DOIUrl":"10.1038/s41684-024-01415-1","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Humidity and heat cause anxiety in mice 潮湿和高温会导致小鼠焦虑。
IF 5.9 3区 农林科学
Lab Animal Pub Date : 2024-08-01 DOI: 10.1038/s41684-024-01418-y
Alexandra Le Bras
{"title":"Humidity and heat cause anxiety in mice","authors":"Alexandra Le Bras","doi":"10.1038/s41684-024-01418-y","DOIUrl":"10.1038/s41684-024-01418-y","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New guidelines for rodent cancer models 啮齿动物癌症模型新指南。
IF 5.9 3区 农林科学
Lab Animal Pub Date : 2024-08-01 DOI: 10.1038/s41684-024-01419-x
Alexandra Le Bras
{"title":"New guidelines for rodent cancer models","authors":"Alexandra Le Bras","doi":"10.1038/s41684-024-01419-x","DOIUrl":"10.1038/s41684-024-01419-x","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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