Immunological Reviews最新文献_第5页

Single domain antibody: Development and application in biotechnology and biopharma. 单域抗体：生物技术和生物制药领域的开发与应用。

IF 7.5 2区医学

Immunological Reviews Pub Date : 2024-08-21 DOI: 10.1111/imr.13381

Ting Yu, Fang Zheng, Wenbo He, Serge Muyldermans, Yurong Wen

{"title":"Single domain antibody: Development and application in biotechnology and biopharma.","authors":"Ting Yu, Fang Zheng, Wenbo He, Serge Muyldermans, Yurong Wen","doi":"10.1111/imr.13381","DOIUrl":"https://doi.org/10.1111/imr.13381","url":null,"abstract":"Heavy-chain antibodies (HCAbs) are a unique type of antibodies devoid of light chains, and comprised of two heavy chains-only that recognize their cognate antigen by virtue of a single variable domain also referred to as VHH, single domain antibody (sdAb), or nanobody (Nb). These functional HCAbs, serendipitous discovered about three decades ago, are exclusively found in camelids, comprising dromedaries, camels, llamas, and vicugnas. Nanobodies have become an essential tool in biomedical research and medicine, both in diagnostics and therapeutics due to their beneficial properties: small size, high stability, strong antigen-binding affinity, low immunogenicity, low production cost, and straightforward engineering into more potent affinity reagents. The occurrence of HCAbs in camelids remains intriguing. It is believed to be an evolutionary adaptation, equipping camelids with a robust adaptive immune defense suitable to respond to the pressure from a pathogenic invasion necessitating a more profound antigen recognition and neutralization. This evolutionary innovation led to a simplified HCAb structure, possibly supported by genetic mutations and drift, allowing adaptive mutation and diversification in the heavy chain variable gene and constant gene regions. Beyond understanding their origins, the application of nanobodies has significantly advanced over the past 30 years. Alongside expanding laboratory research, there has been a rapid increase in patent application for nanobodies. The introduction of commercial nanobody drugs such as Cablivi, Nanozora, Envafolimab, and Carvykti has boosted confidence among in their potential. This review explores the evolutionary history of HCAbs, their ontogeny, and applications in biotechnology and pharmaceuticals, focusing on approved and ongoing medical research pipelines.","PeriodicalId":178,"journal":{"name":"Immunological Reviews","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142015737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibody-mediated control mechanisms of viral infections. 抗体介导的病毒感染控制机制。

IF 7.5 2区医学

Immunological Reviews Pub Date : 2024-08-20 DOI: 10.1111/imr.13383

Samantha R Mackin, Alan Sariol, Michael S Diamond

引用次数: 0

A newborn's perspective on immune responses to food 新生儿对食物免疫反应的观点。

IF 7.5 2区医学

Immunological Reviews Pub Date : 2024-08-20 DOI: 10.1111/imr.13376

Valerie Verhasselt

{"title":"A newborn's perspective on immune responses to food","authors":"Valerie Verhasselt","doi":"10.1111/imr.13376","DOIUrl":"10.1111/imr.13376","url":null,"abstract":"In this review, we will highlight infants' immune responses to food, emphasizing the unique aspects of early-life immunity and the critical role of breast milk as a food dedicated to infants. Infants are susceptible to inflammatory responses rather than immune tolerance at the mucosal and skin barriers, necessitating strategies to promote oral tolerance that consider this susceptibility. Breast milk provides nutrients for growth and cell metabolism, including immune cells. The content of breast milk, influenced by maternal genetics and environmental exposures, prepares the infant's immune system for the outside world, including solid foods. To do this, breast milk promotes immune system development through antigen-specific and non-antigen-specific immune education by exposing the newborn to food and respiratory allergens and acting on three key targets for food allergy prevention: the gut microbiota, epithelial cells, and immune cells. Building knowledge of how the maternal exposome and human milk composition influence offspring's healthy immune development will lead to recommendations that meet the specific needs of the developing immune system and increase the chances of promoting an appropriate immune response to food in the long term.","PeriodicalId":178,"journal":{"name":"Immunological Reviews","volume":"326 1","pages":"117-129"},"PeriodicalIF":7.5,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imr.13376","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142003218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DNA sensors in metabolic and cardiovascular diseases: Molecular mechanisms and therapeutic prospects. 代谢和心血管疾病中的 DNA 传感器：分子机制和治疗前景。

IF 7.5 2区医学

Immunological Reviews Pub Date : 2024-08-19 DOI: 10.1111/imr.13382

Hyosang Kwak, Ein Lee, Rajendra Karki

{"title":"DNA sensors in metabolic and cardiovascular diseases: Molecular mechanisms and therapeutic prospects.","authors":"Hyosang Kwak, Ein Lee, Rajendra Karki","doi":"10.1111/imr.13382","DOIUrl":"https://doi.org/10.1111/imr.13382","url":null,"abstract":"DNA sensors generally initiate innate immune responses through the production of type I interferons. While extensively studied for host defense against invading pathogens, emerging evidence highlights the involvement of DNA sensors in metabolic and cardiovascular diseases. Elevated levels of modified, damaged, or ectopically localized self-DNA and non-self-DNA have been observed in patients and animal models with obesity, diabetes, fatty liver disease, and cardiovascular disease. The accumulation of cytosolic DNA aberrantly activates DNA signaling pathways, driving the pathological progression of these disorders. This review highlights the roles of specific DNA sensors, such as cyclic AMP-GMP synthase and stimulator of interferon genes (cGAS-STING), absent in melanoma 2 (AIM2), toll-like receptor 9 (TLR9), interferon gamma-inducible protein 16 (IFI16), DNA-dependent protein kinase (DNA-PK), and DEAD-box helicase 41 (DDX41) in various metabolic disorders. We explore how DNA signaling pathways in both immune and non-immune cells contribute to the development of these diseases. Furthermore, we discuss the intricate interplay between metabolic stress and immune responses, offering insights into potential therapeutic targets for managing metabolic and cardiovascular disorders. Understanding the mechanisms of DNA sensor signaling in these contexts provides a foundation for developing novel interventions aimed at mitigating the impact of these pervasive health issues.","PeriodicalId":178,"journal":{"name":"Immunological Reviews","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141999065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Living in LALA land? Forty years of attenuating Fc effector functions. 生活在 LALA 土地上？削弱 Fc 效应器功能四十年

IF 7.5 2区医学

Immunological Reviews Pub Date : 2024-08-19 DOI: 10.1111/imr.13379

Geoff Hale

引用次数: 0

Therapeutic monoclonal antibodies in allergy: Targeting IgE, cytokine, and alarmin pathways. 过敏症中的治疗性单克隆抗体：针对 IgE、细胞因子和过敏原途径。

IF 7.5 2区医学

Immunological Reviews Pub Date : 2024-08-19 DOI: 10.1111/imr.13380

Alexander Eggel, Luke F Pennington, Theodore S Jardetzky

{"title":"Therapeutic monoclonal antibodies in allergy: Targeting IgE, cytokine, and alarmin pathways.","authors":"Alexander Eggel, Luke F Pennington, Theodore S Jardetzky","doi":"10.1111/imr.13380","DOIUrl":"https://doi.org/10.1111/imr.13380","url":null,"abstract":"The etiology of allergy is closely linked to type 2 inflammatory responses ultimately leading to the production of allergen-specific immunoglobulin E (IgE), a key driver of many allergic conditions. At a high level, initial allergen exposure disrupts epithelial integrity, triggering local inflammation via alarmins including IL-25, IL-33, and TSLP, which activate type 2 innate lymphoid cells as well as other immune cells to secrete type 2 cytokines IL-4, IL-5 and IL-13, promoting Th2 cell development and eosinophil recruitment. Th2 cell dependent B cell activation promotes the production of allergen-specific IgE, which stably binds to basophils and mast cells. Rapid degranulation of these cells upon allergen re-exposure leads to allergic symptoms. Recent advances in our understanding of the molecular and cellular mechanisms underlying allergic pathophysiology have significantly shaped the development of therapeutic intervention strategies. In this review, we highlight key therapeutic targets within the allergic cascade with a particular focus on past, current and future treatment approaches using monoclonal antibodies. Specific targeting of alarmins, type 2 cytokines and IgE has shown varying degrees of clinical benefit in different allergic indications including asthma, chronic spontaneous urticaria, atopic dermatitis, chronic rhinosinusitis with nasal polyps, food allergies and eosinophilic esophagitis. While multiple therapeutic antibodies have been approved for clinical use, scientists are still working on ways to improve on current treatment approaches. Here, we provide context to understand therapeutic targeting strategies and their limitations, discussing both knowledge gaps and promising future directions to enhancing clinical efficacy in allergic disease management.","PeriodicalId":178,"journal":{"name":"Immunological Reviews","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141999067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibodies against endogenous retroviruses. 针对内源性逆转录病毒的抗体。

IF 7.5 2区医学

Immunological Reviews Pub Date : 2024-08-17 DOI: 10.1111/imr.13378

Mihaela Chisca, Jean-David Larouche, Qi Xing, George Kassiotis

{"title":"Antibodies against endogenous retroviruses.","authors":"Mihaela Chisca, Jean-David Larouche, Qi Xing, George Kassiotis","doi":"10.1111/imr.13378","DOIUrl":"https://doi.org/10.1111/imr.13378","url":null,"abstract":"The human genome harbors hundreds of thousands of integrations of ancient retroviruses, amassed over millions of years of evolution. To reduce further amplification in the genome, the host prevents transcription of these now endogenous retroviruses (ERVs) through epigenetic repression and, with evolutionary time, ERVs are incapacitated by accumulating mutations and deletions. However, several members of recently endogenized ERV groups still retain the capacity to produce viral RNA, retroviral proteins, and higher order structures, including virions. The retention of viral characteristics, combined with the reversible nature of epigenetic repression, particularly as seen in cancer, allow for immunologically unanticipated ERV expression, perceived by the adaptive immune system as a genuine retroviral infection, to which it has to respond. Accordingly, antibodies reactive with ERV antigens have been detected in diverse disorders and, occasionally, in healthy individuals. Although they are part of self, the retroviral legacy of ERV antigens, and association with and, possibly, causation of disease states may set them apart from typical self-antigens. Consequently, the pathogenic or, indeed, host-protective capacity of antibodies targeting ERV antigens is likely to be context-dependent. Here, we review the immunogenicity of typical ERV proteins, with emphasis on the antibody response and its potential disease implications.","PeriodicalId":178,"journal":{"name":"Immunological Reviews","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141994846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensory sentinels: Neuroimmune detection and food allergy 感官哨兵：神经免疫检测和食物过敏。

IF 7.5 2区医学

Immunological Reviews Pub Date : 2024-08-02 DOI: 10.1111/imr.13375

Peri R. Matatia, Elena Christian, Caroline L. Sokol

{"title":"Sensory sentinels: Neuroimmune detection and food allergy","authors":"Peri R. Matatia, Elena Christian, Caroline L. Sokol","doi":"10.1111/imr.13375","DOIUrl":"10.1111/imr.13375","url":null,"abstract":"<div>\u0000 \u0000 Food allergy is classically characterized by an inappropriate type-2 immune response to allergenic food antigens. However, how allergens are detected and how that detection leads to the initiation of allergic immunity is poorly understood. In addition to the gastrointestinal tract, the barrier epithelium of the skin may also act as a site of food allergen sensitization. These barrier epithelia are densely innervated by sensory neurons, which respond to diverse physical environmental stimuli. Recent findings suggest that sensory neurons can directly detect a broad array of immunogens, including allergens, triggering sensory responses and the release of neuropeptides that influence immune cell function. Reciprocally, immune mediators modulate the activation or responsiveness of sensory neurons, forming neuroimmune feedback loops that may impact allergic immune responses. By utilizing cutaneous allergen exposure as a model, this review explores the pivotal role of sensory neurons in allergen detection and their dynamic bidirectional communication with the immune system, which ultimately orchestrates the type-2 immune response. Furthermore, it sheds light on how peripheral signals are integrated within the central nervous system to coordinate hallmark features of allergic reactions. Drawing from this emerging evidence, we propose that atopy arises from a dysregulated neuroimmune circuit.\u0000 </div>","PeriodicalId":178,"journal":{"name":"Immunological Reviews","volume":"326 1","pages":"83-101"},"PeriodicalIF":7.5,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141873742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contribution of T cell subsets to different food allergic diseases T 细胞亚群对不同食物过敏性疾病的贡献。

IF 7.5 2区医学

Immunological Reviews Pub Date : 2024-07-25 DOI: 10.1111/imr.13368

Lisa Hung, Brianna Zientara, M. Cecilia Berin

引用次数: 0

Oral tolerance to dietary antigens and Foxp3+ regulatory T cells 对饮食抗原和 Foxp3+ 调节性 T 细胞的口服耐受性。

IF 7.5 2区医学

Immunological Reviews Pub Date : 2024-07-25 DOI: 10.1111/imr.13370

Mariana C. G. Miranda-Waldetario, Maria A. Curotto de Lafaille

引用次数: 0