Immunological Reviews最新文献_第4页

Antibodies in breast milk: Pro-bodies designed for healthy newborn development 母乳中的抗体为新生儿健康成长而设计的原生抗体。

IF 7.5 2区医学

Immunological Reviews Pub Date : 2024-10-22 DOI: 10.1111/imr.13411

Valerie Verhasselt, Julie Tellier, Rita Carsetti, Burcu Tepekule

{"title":"Antibodies in breast milk: Pro-bodies designed for healthy newborn development","authors":"Valerie Verhasselt, Julie Tellier, Rita Carsetti, Burcu Tepekule","doi":"10.1111/imr.13411","DOIUrl":"10.1111/imr.13411","url":null,"abstract":"This manuscript sheds light on the impact of maternal breast milk antibodies on infant health. Milk antibodies prepare and protect the newborn against environmental exposure, guide and regulate the offspring's immune system, and promote transgenerational adaptation of the immune system to its environment. While the transfer of IgG across the placenta ceases at birth, milk antibodies are continuously replenished by the maternal immune system. They reflect the mother's real-time adaptation to the environment to which the infant is exposed. They cover the infant's upper respiratory and digestive mucosa and are perfectly positioned to control responses to environmental antigens and might also reach their circulation. Maternal antibodies in breast milk play a key role in the immune defense of the developing child, with a major impact on infectious disease susceptibility in both HIC and LMIC. They also influence the development of another major health burden in children—allergies. Finally, emerging evidence shows that milk antibodies also actively shape immune development. Much of this is likely to be mediated by their effect on the seeding, composition and function of the microbiota, but not only. Further understanding of the bridge that maternal antibodies provide between the child and its environment should enable the best interventions to promote healthy development.","PeriodicalId":178,"journal":{"name":"Immunological Reviews","volume":"328 1","pages":"192-204"},"PeriodicalIF":7.5,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imr.13411","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142454232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comprehensive review of sensors of radiation-induced damage, radiation-induced proximal events, and cell death 全面回顾辐射诱发损伤、辐射诱发近端事件和细胞死亡的传感器。

IF 7.5 2区医学

Immunological Reviews Pub Date : 2024-10-19 DOI: 10.1111/imr.13409

Saurabh Saini, Prajwal Gurung

{"title":"A comprehensive review of sensors of radiation-induced damage, radiation-induced proximal events, and cell death","authors":"Saurabh Saini, Prajwal Gurung","doi":"10.1111/imr.13409","DOIUrl":"10.1111/imr.13409","url":null,"abstract":"Radiation, a universal component of Earth's environment, is categorized into non-ionizing and ionizing forms. While non-ionizing radiation is relatively harmless, ionizing radiation possesses sufficient energy to ionize atoms and disrupt DNA, leading to cell damage, mutation, cancer, and cell death. The extensive use of radionuclides and ionizing radiation in nuclear technology and medical applications has sparked global concern for their capacity to cause acute and chronic illnesses. Ionizing radiation induces DNA damage either directly through strand breaks and base change or indirectly by generating reactive oxygen species (ROS) and reactive nitrogen species (RNS) via radiolysis of water. This damage triggers a complex cellular response involving recognition of DNA damage, cell cycle arrest, DNA repair mechanisms, release of pro-inflammatory cytokines, and cell death. This review focuses on the mechanisms of radiation-induced cellular damage, recognition of DNA damage and subsequent activation of repair processes, and the critical role of the innate immune response in resolution of the injury. Emphasis is placed on pattern recognition receptors (PRRs) and related receptors that detect damage-associated molecular patterns (DAMPs) and initiate downstream signaling pathways. Radiation-induced cell death pathways are discussed in detail. Understanding these processes is crucial for developing strategies to mitigate the harmful effects of radiation and improve therapeutic outcomes.","PeriodicalId":178,"journal":{"name":"Immunological Reviews","volume":"329 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11742653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142454231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulation of the NLRP3 inflammasome by autophagy and mitophagy 自噬和有丝分裂对 NLRP3 炎症小体的调控。

IF 7.5 2区医学

Immunological Reviews Pub Date : 2024-10-17 DOI: 10.1111/imr.13410

Suman Gupta, Suzanne L. Cassel, Fayyaz S. Sutterwala, Jargalsaikhan Dagvadorj

{"title":"Regulation of the NLRP3 inflammasome by autophagy and mitophagy","authors":"Suman Gupta, Suzanne L. Cassel, Fayyaz S. Sutterwala, Jargalsaikhan Dagvadorj","doi":"10.1111/imr.13410","DOIUrl":"10.1111/imr.13410","url":null,"abstract":"<div>\u0000 \u0000 The NLRP3 inflammasome is a multiprotein complex that upon activation by the innate immune system drives a broad inflammatory response. The primary initial mediators of this response are pro-IL-1β and pro-IL-18, both of which are in an inactive form. Formation and activation of the NLRP3 inflammasome activates caspase-1, which cleaves pro-IL-1β and pro-IL-18 and triggers the formation of gasdermin D pores. Gasdermin D pores allow for the secretion of active IL-1β and IL-18 initiating the organism-wide inflammatory response. The NLRP3 inflammasome response can be beneficial to the host; however, if the NLRP3 inflammasome is inappropriately activated it can lead to significant pathology. While the primary components of the NLRP3 inflammasome are known, the precise details of assembly and activation are less well defined and conflicting. Here, we discuss several of the proposed pathways of activation of the NLRP3 inflammasome. We examine the role of subcellular localization and the reciprocal regulation of the NLRP3 inflammasome by autophagy. We focus on the roles of mitochondria and mitophagy in activating and regulating the NLRP3 inflammasome. Finally, we detail the impact of pathologic NLRP3 responses in the development and manifestations of pulmonary disease.\u0000 </div>","PeriodicalId":178,"journal":{"name":"Immunological Reviews","volume":"329 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142454134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammasome-mediated pyroptosis in defense against pathogenic bacteria 炎症体介导的热蛋白沉积在抵御病原菌的过程中。

IF 7.5 2区医学

Immunological Reviews Pub Date : 2024-10-15 DOI: 10.1111/imr.13408

Changhoon Oh, Todd J. Spears, Youssef Aachoui

引用次数: 0

Stellabody: A novel hexamer-promoting mutation for improved IgG potency Stellabody：一种新型六聚体促进突变，可提高 IgG 的效力。

IF 7.5 2区医学

Immunological Reviews Pub Date : 2024-10-04 DOI: 10.1111/imr.13400

Clarissa A. Whitehead, Bruce D. Wines, Anna M. Davies, James M. McDonnell, Halina M. Trist, Sandra E. Esparon, P. Mark Hogarth

{"title":"Stellabody: A novel hexamer-promoting mutation for improved IgG potency","authors":"Clarissa A. Whitehead, Bruce D. Wines, Anna M. Davies, James M. McDonnell, Halina M. Trist, Sandra E. Esparon, P. Mark Hogarth","doi":"10.1111/imr.13400","DOIUrl":"10.1111/imr.13400","url":null,"abstract":"Advances in antibody engineering are being directed at the development of next generation immunotherapeutics with improved potency. Hexamerisation of IgG is a normal physiological aspect of IgG biology and recently described mutations that facilitate this process have a substantial impact upon monoclonal antibody behavior resulting in the elicitation of dramatically enhanced complement-dependent cytotoxicity, Fc receptor function, and enhanced antigen binding effects, such as targeted receptor agonism or microbe neutralization. Whereas the discovery of IgG hexamerisation enhancing mutations has largely focused on residues with exposure at the surface of the Fc-Fc and CH2-CH3 interfaces, our unique approach is the engineering of the mostly buried residue H429 in the CH3 domain. Selective substitution at position 429 forms the basis of Stellabody technology, where the choice of amino acid results in distinct hexamerisation outcomes. H429F results in monomeric IgG that hexamerises after target binding, so called “on-target” hexamerisation, while the H429Y mutant forms pH-sensitive hexamers in-solution prior to antigen binding. Moreover, Stellabody technologies are broadly applicable across the family of antibody-based biologic therapeutics, including conventional mAbs, bispecific mAbs, and Ig-like biologics such as Fc-fusions, with applications in diverse diseases.","PeriodicalId":178,"journal":{"name":"Immunological Reviews","volume":"328 1","pages":"438-455"},"PeriodicalIF":7.5,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imr.13400","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142370416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Using IMGT unique numbering for IG allotypes and Fc-engineered variants of effector properties and half-life of therapeutic antibodies 使用 IMGT 对 IG 所有类型和 Fc 工程变体的效应特性和治疗性抗体的半衰期进行独特编号。

IF 7.5 2区医学

Immunological Reviews Pub Date : 2024-10-04 DOI: 10.1111/imr.13399

Marie-Paule Lefranc, Gérard Lefranc

{"title":"Using IMGT unique numbering for IG allotypes and Fc-engineered variants of effector properties and half-life of therapeutic antibodies","authors":"Marie-Paule Lefranc, Gérard Lefranc","doi":"10.1111/imr.13399","DOIUrl":"10.1111/imr.13399","url":null,"abstract":"Therapeutic monoclonal antibodies (mAb) are usually of the IgG1, IgG2, and IgG4 classes, and their heavy chains may be modified by amino acid (aa) changes involved in antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), complement-dependent cytotoxicity (CDC), and/or half-life. Allotypes and Fc-engineered variants are classified using IMGT/HGNC gene nomenclature (e.g., Homo sapiens IGHG1). Allotype names follow the WHO/IMGT nomenclature. IMGT-engineered variant names use the IMGT nomenclature (e.g., Homsap G1v1), which comprises species and gene name (both abbreviated) followed by the letter v (for variant) and a number. Both allotypes and engineered variants are defined by their aa changes and positions, based on the IMGT unique numbering for C domain, identified in sequence motifs, referred to as IMGT topological motifs, as their limits and length are standardized and correspond to a structural feature (e.g., strand or loop). One hundred twenty-six variants are displayed with their type, IMGT numbering, Eu-IMGT positions, motifs before and after changes, and their property and function (effector and half-life). Three motifs characterize effector variants, CH2 1.6–3, 23-BC-41, and the FG loop, whereas three different motifs characterize half-life variants, two on CH2 13-AB-18 and 89–96 with H93, and one on CH3 the FG loop with H115.","PeriodicalId":178,"journal":{"name":"Immunological Reviews","volume":"328 1","pages":"473-506"},"PeriodicalIF":7.5,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imr.13399","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142374751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The importance of IgG glycosylation—What did we learn after analyzing over 100,000 individuals IgG 糖基化的重要性--在分析了十多万人之后，我们学到了什么？

IF 7.5 2区医学

Immunological Reviews Pub Date : 2024-10-04 DOI: 10.1111/imr.13407

Jasminka Krištić, Gordan Lauc

{"title":"The importance of IgG glycosylation—What did we learn after analyzing over 100,000 individuals","authors":"Jasminka Krištić, Gordan Lauc","doi":"10.1111/imr.13407","DOIUrl":"10.1111/imr.13407","url":null,"abstract":"All four subclasses of immunoglobulin G (IgG) antibodies have glycan structures attached to the protein part of the IgG molecules. Glycans linked to the Fc portion of IgG are found in all IgG antibodies, while about one-fifth of IgG antibodies in plasma also have glycans attached to the Fab portion of IgG. The IgG3 subclass is characterized by more complex glycosylation compared to other IgG subclasses. In this review, we discuss the significant influence that glycans exert on the structural and functional properties of IgG. We provide a comprehensive overview of how the composition of these glycans can affect IgG's effector functions by modulating its interactions with Fcγ receptors and other molecules such as the C1q component of complement, which in turn influence various immune responses triggered by IgG, including antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). In addition, the importance of glycans for the efficacy of therapeutics like monoclonal antibodies and intravenous immunoglobulin (IVIg) therapy is discussed. Moreover, we offer insights into IgG glycosylation characteristics and roles derived from general population, disease-specific, and interventional studies. These studies indicate that IgG glycans are important biomarkers and functional effectors in health and disease.","PeriodicalId":178,"journal":{"name":"Immunological Reviews","volume":"328 1","pages":"143-170"},"PeriodicalIF":7.5,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imr.13407","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142370417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibodies in neurological diseases: Established, emerging, explorative 神经系统疾病中的抗体：已有的、新出现的、探索性的。

IF 7.5 2区医学

Immunological Reviews Pub Date : 2024-10-01 DOI: 10.1111/imr.13405

Lucie Y. Li, Amelya Keles, Marie A. Homeyer, Harald Prüss

{"title":"Antibodies in neurological diseases: Established, emerging, explorative","authors":"Lucie Y. Li, Amelya Keles, Marie A. Homeyer, Harald Prüss","doi":"10.1111/imr.13405","DOIUrl":"10.1111/imr.13405","url":null,"abstract":"Within a few years, autoantibodies targeting the nervous system resulted in a novel disease classification. For several of them, which we termed ‘established’, direct pathogenicity has been proven and now guides diagnostic pathways and early immunotherapy. For a rapidly growing number of further anti-neuronal autoantibodies, the role in disease is less clear. Increasing evidence suggests that they could contribute to disease, by playing a modulating role on brain function. We therefore suggest a three-level classification of neurological autoantibodies according to the degree of experimentally proven pathogenicity and strength of clinical association: established, emerging, explorative. This may facilitate focusing on clinical constellations in which autoantibody-mediated mechanisms have not been assumed previously, including autoimmune psychosis and dementia, cognitive impairment in cancer, and neurodegenerative diseases. Based on recent data reviewed here, humoral autoimmunity may represent an additional “super-system” for brain health. The “brain antibody-ome”, that is, the composition of thousands of anti-neuronal autoantibodies, may shape neuronal function not only in disease, but even in healthy aging. Towards this novel concept, extensive research will have to elucidate pathogenicity from the atomic to the clinical level, autoantibody by autoantibody. Such profiling can uncover novel biomarkers, enhance our understanding of underlying mechanisms, and identify selective therapies.","PeriodicalId":178,"journal":{"name":"Immunological Reviews","volume":"328 1","pages":"283-299"},"PeriodicalIF":7.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imr.13405","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142337941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular mechanisms of emerging inflammasome complexes and their activation and signaling in inflammation and pyroptosis 新出现的炎症小体复合物及其在炎症和脓毒症中的激活和信号传导的分子机制。

IF 7.5 2区医学

Immunological Reviews Pub Date : 2024-10-01 DOI: 10.1111/imr.13406

Abhimanu Pandey, Zheyi Li, Manjul Gautam, Aritra Ghosh, Si Ming Man

{"title":"Molecular mechanisms of emerging inflammasome complexes and their activation and signaling in inflammation and pyroptosis","authors":"Abhimanu Pandey, Zheyi Li, Manjul Gautam, Aritra Ghosh, Si Ming Man","doi":"10.1111/imr.13406","DOIUrl":"10.1111/imr.13406","url":null,"abstract":"Inflammasomes are multi-protein complexes that assemble within the cytoplasm of mammalian cells in response to pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs), driving the secretion of the pro-inflammatory cytokines IL-1β and IL-18, and pyroptosis. The best-characterized inflammasome complexes are the NLRP3, NAIP-NLRC4, NLRP1, AIM2, and Pyrin canonical caspase-1-containing inflammasomes, and the caspase-11 non-canonical inflammasome. Newer inflammasome sensor proteins have been identified, including NLRP6, NLRP7, NLRP9, NLRP10, NLRP11, NLRP12, CARD8, and MxA. These inflammasome sensors can sense PAMPs from bacteria, viruses and protozoa, or DAMPs in the form of mitochondrial damage, ROS, stress and heme. The mechanisms of action, physiological relevance, consequences in human diseases, and avenues for therapeutic intervention for these novel inflammasomes are beginning to be realized. Here, we discuss these emerging inflammasome complexes and their putative activation mechanisms, molecular and signaling pathways, and physiological roles in health and disease.","PeriodicalId":178,"journal":{"name":"Immunological Reviews","volume":"329 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11742652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142337945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fc gamma receptors: Their evolution, genomic architecture, genetic variation, and impact on human disease Fc γ 受体：它们的进化、基因组结构、遗传变异以及对人类疾病的影响。

IF 7.5 2区医学

Immunological Reviews Pub Date : 2024-09-30 DOI: 10.1111/imr.13401

Sarah Frampton, Rosanna Smith, Lili Ferson, Jane Gibson, Edward J. Hollox, Mark S. Cragg, Jonathan C. Strefford

{"title":"Fc gamma receptors: Their evolution, genomic architecture, genetic variation, and impact on human disease","authors":"Sarah Frampton, Rosanna Smith, Lili Ferson, Jane Gibson, Edward J. Hollox, Mark S. Cragg, Jonathan C. Strefford","doi":"10.1111/imr.13401","DOIUrl":"10.1111/imr.13401","url":null,"abstract":"Fc gamma receptors (FcγRs) are a family of receptors that bind IgG antibodies and interface at the junction of humoral and innate immunity. Precise regulation of receptor expression provides the necessary balance to achieve healthy immune homeostasis by establishing an appropriate immune threshold to limit autoimmunity but respond effectively to infection. The underlying genetics of the FCGR gene family are central to achieving this immune threshold by regulating affinity for IgG, signaling efficacy, and receptor expression. The FCGR gene locus was duplicated during evolution, retaining very high homology and resulting in a genomic region that is technically difficult to study. Here, we review the recent evolution of the gene family in mammals, its complexity and variation through copy number variation and single-nucleotide polymorphism, and impact of these on disease incidence, resolution, and therapeutic antibody efficacy. We also discuss the progress and limitations of current approaches to study the region and emphasize how new genomics technologies will likely resolve much of the current confusion in the field. This will lead to definitive conclusions on the impact of genetic variation within the FCGR gene locus on immune function and disease.","PeriodicalId":178,"journal":{"name":"Immunological Reviews","volume":"328 1","pages":"65-97"},"PeriodicalIF":7.5,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imr.13401","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142337942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0