Immunological Reviews最新文献_第3页

Emerging Concepts in Cytokine Regulation of Airway Remodeling in Asthma 哮喘气道重塑中细胞因子调控的新概念。

IF 7.5 2区医学

Immunological Reviews Pub Date : 2025-03-21 DOI: 10.1111/imr.70020

Jana Latayan, Santhoshi V. Akkenapally, Satish K. Madala

{"title":"Emerging Concepts in Cytokine Regulation of Airway Remodeling in Asthma","authors":"Jana Latayan, Santhoshi V. Akkenapally, Satish K. Madala","doi":"10.1111/imr.70020","DOIUrl":"10.1111/imr.70020","url":null,"abstract":"Asthma, a chronic respiratory condition that has seen a dramatic rise in prevalence over the past few decades, now affects more than 300 million people globally and imposes a significant burden on healthcare systems. The key pathological features of asthma include inflammation, airway hyperresponsiveness, mucus cell metaplasia, smooth muscle hypertrophy, and subepithelial fibrosis. Cytokines released by lung epithelial cells, stromal cells, and immune cells during asthma are critical to pathological tissue remodeling in asthma. Over the past few decades, researchers have made great strides in understanding key cells involved in asthma and the cytokines that they produce. Epithelial cells as well as many adaptive and innate immune cells are activated by environmental signals to produce cytokines, namely, type 2 cytokines (IL-4, IL-5, IL-13), IFN-γ, IL-17, TGF-β, and multiple IL-6 family members. However, the precise mechanisms through which these cytokines contribute to airway remodeling remain elusive. Additionally, multiple cell types can produce the same cytokines, making it challenging to decipher how specific cell types and cytokines uniquely contribute to asthma pathogenesis. This review highlights recent advances and provides a comprehensive overview of the key cells involved in the production of cytokines and how these cytokines modulate airway remodeling in asthma.","PeriodicalId":178,"journal":{"name":"Immunological Reviews","volume":"330 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early-Life Host–Microbial Interactions and Asthma Development: A Lifelong Impact? 早期宿主-微生物相互作用和哮喘发展：终身影响？

IF 7.5 2区医学

Immunological Reviews Pub Date : 2025-03-18 DOI: 10.1111/imr.70019

Céline Pattaroni, Benjamin J. Marsland, Nicola L. Harris

{"title":"Early-Life Host–Microbial Interactions and Asthma Development: A Lifelong Impact?","authors":"Céline Pattaroni, Benjamin J. Marsland, Nicola L. Harris","doi":"10.1111/imr.70019","DOIUrl":"https://doi.org/10.1111/imr.70019","url":null,"abstract":"Childhood is a multifactorial disease, and recent research highlights the influence of early-life microbial communities in shaping disease risk. This review explores the roles of the gut and respiratory microbiota in asthma development, emphasizing the importance of early microbial exposure. The gut microbiota has been particularly well studied, with certain taxa like Faecalibacterium and Bifidobacterium linked to asthma protection, whereas short-chain fatty acids produced by gut microbes support immune tolerance through the gut–lung axis. In contrast, the respiratory microbiota, though low in biomass, shows consistent associations between early bacterial colonization by Streptococcus, Moraxella, and Haemophilus and increased asthma risk. The review also addresses the emerging roles of the skin microbiota and environmental fungi in asthma, though findings remain inconsistent. Timing is a critical factor, with early-life disruptions, such as antibiotic use, potentially leading to increased asthma risk. Despite significant advances, there are still unresolved questions about the long-term consequences of early microbial perturbations, particularly regarding whether microbial dysbiosis is a cause or consequence of asthma. This review integrates current findings, highlighting the need for deeper investigation into cross-organ interactions and early microbial exposures to understand childhood asthma pathophysiology.","PeriodicalId":178,"journal":{"name":"Immunological Reviews","volume":"330 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imr.70019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143638771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innate Immunity and Asthma Exacerbations: Insights From Human Models 先天免疫和哮喘恶化：从人体模型的见解

IF 7.5 2区医学

Immunological Reviews Pub Date : 2025-03-14 DOI: 10.1111/imr.70016

Jehan Alladina, Benjamin D. Medoff, Josalyn L. Cho

{"title":"Innate Immunity and Asthma Exacerbations: Insights From Human Models","authors":"Jehan Alladina, Benjamin D. Medoff, Josalyn L. Cho","doi":"10.1111/imr.70016","DOIUrl":"https://doi.org/10.1111/imr.70016","url":null,"abstract":"<div>\u0000 \u0000 Asthma is a common chronic respiratory disease characterized by the presence of airway inflammation, airway hyperresponsiveness, and mucus hypersecretion. Repeated asthma exacerbations can lead to progressive airway remodeling and irreversible airflow obstruction. Thus, understanding and preventing asthma exacerbations are of paramount importance. Although multiple endotypes exist, asthma is most often driven by type 2 airway inflammation. New therapies that target specific type 2 mediators have been shown to reduce the frequency of asthma exacerbations but are incompletely effective in a significant number of asthmatics. Furthermore, it remains unknown whether current treatments lead to sustained changes in the airway or if targeting additional pathways may be necessary to achieve asthma remission. Activation of innate immunity is the initial event in the inflammatory sequence that occurs during an asthma exacerbation. However, there continue to be critical gaps in our understanding of the innate immune response to asthma exacerbating factors. In this review, we summarize the current understanding of the role of innate immunity in asthma exacerbations and the methods used to study them. We also identify potential novel therapeutic targets for asthma and future areas for investigation.\u0000 </div>","PeriodicalId":178,"journal":{"name":"Immunological Reviews","volume":"330 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Soluble Factors and Mechanisms Regulated by Sialylated IgG Signaling 唾液化IgG信号调节的可溶性因子和机制

IF 7.5 2区医学

Immunological Reviews Pub Date : 2025-03-14 DOI: 10.1111/imr.70021

Desmond L. Edwards, Min Huang, Taia T. Wang

{"title":"Soluble Factors and Mechanisms Regulated by Sialylated IgG Signaling","authors":"Desmond L. Edwards, Min Huang, Taia T. Wang","doi":"10.1111/imr.70021","DOIUrl":"https://doi.org/10.1111/imr.70021","url":null,"abstract":"<div>\u0000 \u0000 Inflammation is a complex biological response that can be both induced and actively suppressed by IgG-Fc gamma receptor (FcγR) interactions. This review explores the role of IgG sialylation in reducing or blocking inflammatory responses. We first revisit foundational studies that established the anti-inflammatory properties of sialylated IgG1 Fc. These early investigations revealed that the sialylated fraction is crucial for intravenous immunoglobulin's (IVIg's) ability to reduce inflammation in many autoinflammatory diseases and defined a paracrine signaling mechanism underlying this activity. Next, we discuss a recently identified mechanism whereby sialylated IgG directly induces RE1-Silencing Transcription Factor (REST) which functions as a transcriptional repressor of NF-κB1. This mechanism suggests a very broad role for sialylated IgG signaling in inflammation control since NF-κB is a central mediator of responses downstream of diverse activating receptors on both adaptive and innate immune cells. Finally, we review a set of soluble factors that are suppressed by sialylated IgG signaling in the murine airway and in purified human macrophages, providing additional insight into mechanisms by which sialylated IgG contributes to broad inflammatory control.\u0000 </div>","PeriodicalId":178,"journal":{"name":"Immunological Reviews","volume":"330 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143622452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Microbiome in Asthma Heterogeneity: The Role of Multi-Omic Investigations 微生物组在哮喘异质性中的作用：多组学研究

IF 7.5 2区医学

Immunological Reviews Pub Date : 2025-03-12 DOI: 10.1111/imr.70015

Yvonne J. Huang

{"title":"The Microbiome in Asthma Heterogeneity: The Role of Multi-Omic Investigations","authors":"Yvonne J. Huang","doi":"10.1111/imr.70015","DOIUrl":"https://doi.org/10.1111/imr.70015","url":null,"abstract":"Asthma is one of the most prevalent and extensively studied chronic respiratory conditions, yet the heterogeneity of asthma remains biologically puzzling. Established factors like exogenous exposures and treatment adherence contribute to variability in asthma risk and clinical outcomes. It is also clear that the endogenous factors of genetics and immune system response patterns play key roles in asthma. Despite significant existing knowledge in the above, divergent clinical trajectories and outcomes are still observed, even among individuals with similar risk profiles, biomarkers, and optimal medical management. This suggests uncaptured biological interactions that contribute to asthma's heterogeneity, for which the role of host microbiota has lately attracted much research attention. This review will highlight recent evidence in this area, focusing on bedside-to-bench investigations that have leveraged omic technologies to uncover microbiome links to asthma outcomes and immunobiology. Studies centered on the respiratory system and the use of multi-omics are noted in particular. These represent a new generation of reverse-translational investigations revealing potential functional crosstalk in host microbiomes that may drive phenotypic heterogeneity in chronic diseases like asthma. Multi-omic data offer a wide lens into ecosystem interactions within a host. This informs new hypotheses and experimental work to elucidate mechanistic pathways for unresolved asthma endotypes. Further incorporation of multi-omics into patient-centered investigations can yield new insights that hopefully lead to even more precise, microbiome-informed strategies to reduce asthma burden.","PeriodicalId":178,"journal":{"name":"Immunological Reviews","volume":"330 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imr.70015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to “The β Common Cytokine Receptor Family Reveals New Functional Paradigms From Structural Complexities” 更正“β共同细胞因子受体家族揭示了结构复杂性的新功能范式”

IF 7.5 2区医学

Immunological Reviews Pub Date : 2025-03-11 DOI: 10.1111/imr.70017

引用次数: 0

Harnessing the Farm Effect: Microbial Products for the Treatment and Prevention of Asthma Throughout Life 利用农场效应：用于治疗和预防哮喘的微生物产品

IF 7.5 2区医学

Immunological Reviews Pub Date : 2025-03-04 DOI: 10.1111/imr.70012

Maile K. Hollinger, Emily M. Grayson, Caroline M. Ferreira, Anne I. Sperling

引用次数: 0

Chronic Inflammation in Asthma: Looking Beyond the Th2 Cell 哮喘中的慢性炎症：超越Th2细胞

IF 7.5 2区医学

Immunological Reviews Pub Date : 2025-02-27 DOI: 10.1111/imr.70010

Simone E. M. Olsthoorn, Anneloes van Krimpen, Rudi W. Hendriks, Ralph Stadhouders

{"title":"Chronic Inflammation in Asthma: Looking Beyond the Th2 Cell","authors":"Simone E. M. Olsthoorn, Anneloes van Krimpen, Rudi W. Hendriks, Ralph Stadhouders","doi":"10.1111/imr.70010","DOIUrl":"https://doi.org/10.1111/imr.70010","url":null,"abstract":"Asthma is a common chronic inflammatory disease of the airways. A substantial number of patients present with severe and therapy-resistant asthma, for which the underlying biological mechanisms remain poorly understood. In most asthma patients, airway inflammation is characterized by chronic activation of type 2 immunity. CD4+ T helper 2 (Th2) cells are the canonical producers of the cytokines that fuel type 2 inflammation: interleukin (IL)-4, IL-5, IL-9, and IL-13. However, more recent findings have shown that other lymphocyte subsets, in particular group 2 innate lymphoid cells (ILC2s) and type 2 CD8+ cytotoxic T (Tc2) cells, can also produce large amounts of type 2 cytokines. Importantly, a substantial number of severe therapy-resistant asthma patients present with chronic type 2 inflammation, despite the high sensitivity of Th2 cells for suppression by corticosteroids—the mainstay drugs for asthma. Emerging evidence indicates that ILC2s and Tc2 cells are more abundant in severe asthma patients and can adopt corticosteroid-resistance states. Moreover, many severe asthma patients do not present with overt type 2 airway inflammation, implicating non-type 2 immunity as a driver of disease. In this review, we will discuss asthma pathophysiology and focus on the roles played by ILC2s, Tc2 cells, and non-type 2 lymphocytes, placing special emphasis on severe disease forms.","PeriodicalId":178,"journal":{"name":"Immunological Reviews","volume":"330 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imr.70010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Location, Location, Location: Spatial Immune-Stroma Crosstalk Drives Pathogenesis in Asthma 位置，位置，位置：空间免疫-间质串扰驱动哮喘发病机制

IF 7.5 2区医学

Immunological Reviews Pub Date : 2025-02-24 DOI: 10.1111/imr.70013

Régis Joulia, Clare M. Lloyd

{"title":"Location, Location, Location: Spatial Immune-Stroma Crosstalk Drives Pathogenesis in Asthma","authors":"Régis Joulia, Clare M. Lloyd","doi":"10.1111/imr.70013","DOIUrl":"https://doi.org/10.1111/imr.70013","url":null,"abstract":"Chronic lung diseases including asthma are characterized by an abnormal immune response and active tissue remodeling. These changes in the architecture of the tissue are a fundamental part of the pathology across the life course of patients suffering from asthma. Current treatments aim at dampening the immune system hyperactivation, but effective drugs targeting stromal or acellular structures are still lacking. This is mainly due to the lack of a detailed understanding of the composition of the large airways and the cellular interactions taking place in this niche. We and others have revealed multiple aspects of the spatial architecture of the airway wall in response to airborne insults. In this review, we discuss four elements that we believe should be the focus of future asthma research across the life course, to increase understanding and improve therapies: (i) specialized lung niches, (ii) the 3D architecture of the epithelium, (iii) the extracellular matrix, and (iv) the vasculature. These components comprise the main stromal structures at the airway wall, each playing a key role in the development of asthma and directing the immune response. We summarize promising future directions that will enhance lung research, ultimately benefiting patients with asthma.","PeriodicalId":178,"journal":{"name":"Immunological Reviews","volume":"330 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imr.70013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

T1-T2 Interplay in the Complex Immune Landscape of Severe Asthma T1-T2在严重哮喘复杂免疫景观中的相互作用

IF 7.5 2区医学

Immunological Reviews Pub Date : 2025-02-24 DOI: 10.1111/imr.70011

Marc Gauthier, Sagar L. Kale, Anuradha Ray

{"title":"T1-T2 Interplay in the Complex Immune Landscape of Severe Asthma","authors":"Marc Gauthier, Sagar L. Kale, Anuradha Ray","doi":"10.1111/imr.70011","DOIUrl":"https://doi.org/10.1111/imr.70011","url":null,"abstract":"Asthma is orchestrated by an aberrant immune response involving a complex interplay between multiple inflammatory cell types. An increase in Th2 cells in the asthmatic airway is a hallmark of asthma, and biologics blocking their effector functions have been life-changing for many severe asthma patients who poorly respond to immunosuppression by corticosteroids. However, studies in the past decade have highlighted not only other cell types that also produce Th2 cytokines boosting the Type 2/T2 phenotype but also a heightened IFN-γ response, primarily from T cells, referred to as a Type 1/T1 immune response. Data derived from studies of immune cells in the airways and mouse models of severe asthma suggest a role of IFN-γ in corticosteroid resistance, airway hyperreactivity, and also airway remodeling via effects on other cell types including mast cells, eosinophils, airway epithelial cells, and airway smooth muscle cells. The simultaneous presence of T1 and T2 immune responses is detectable in the sickest of asthma patients in whom corticosteroids suppress the T2 but not the T1 response. This article has reviewed our current understanding of the complex T1–T2 interplay in severe asthma highlighting mediators that impact both arms which may be targeted alone or in combination for disease alleviation.","PeriodicalId":178,"journal":{"name":"Immunological Reviews","volume":"330 1","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imr.70011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0