KnE Life Sciences最新文献_第5页

Improving Vegetative Growth of Sweet Corn Through Filter Cake and Potassium Application 滤饼和施钾对甜玉米营养生长的促进作用

KnE Life Sciences Pub Date : 2022-12-27 DOI: 10.18502/kls.v7i5.12539

I. S. W. Atmaja, D. Nurmanah, A. Faqih, A. Jaenudin

引用次数: 0

Formulation and Antibacterial Activity of Transparent Solid Soap Combination of Secang Ethanolic Extract and Clove Bud Oil Against Skin Disease Bacteria 塞沧醇提物与丁香芽油复合透明固体皂的配方及对皮肤病细菌的抗菌活性

KnE Life Sciences Pub Date : 2022-12-27 DOI: 10.18502/kls.v7i5.12506

R. Aryani, Y. Lukmayani, S. Hazar

{"title":"Formulation and Antibacterial Activity of Transparent Solid Soap Combination of Secang Ethanolic Extract and Clove Bud Oil Against Skin Disease Bacteria","authors":"R. Aryani, Y. Lukmayani, S. Hazar","doi":"10.18502/kls.v7i5.12506","DOIUrl":"https://doi.org/10.18502/kls.v7i5.12506","url":null,"abstract":"Secang wood ethanolic extract and clove bud oil have antibacterial properties against Staphylococcus aureus, Propionibacterium acnes, and Pseudomonas aeruginosa. The formulation of both in transparent bath soap is additional protection for the body. This study formulated soaps and determined their antibacterial activity against Staphylococcus aureus, Propionibacterium acnes, and Pseudomonas aeruginosa. Soap was made using the hot process and the antibacterial activity was tested using the agar diffusion. The soap formulas F0 (as the base), F1 (3% clove bud oil), and F2 (a combination of 3% clove bud oil and 0.5% sappan wood ethanolic extract) have good appearance and quality including pH, foam stability, free alkali, unsaponifiable fat, and mineral oil content. The water content in the soap is >15%. The inhibitory diameter values of the soap (F0, F1, and F2) against S. aureus, P. acnes, and P. aeruginosa were in the moderate to strong category. Based on the contact time test of 90 seconds, F0 cannot kill bacteria; F1 can kill Staphylococcus aureus Propionibacterium acnes, and Pseudomonas aeruginosa; F2 killed Staphylococcus aureus in 90 seconds and Propionibacterium acnes, and Pseudomonas aeruginosa in 60 seconds. \u0000Keywords: soap, clove bud oil, secang, antibacterial","PeriodicalId":17898,"journal":{"name":"KnE Life Sciences","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81312010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Exploring Anticancer Potential in Bajakah Tampala by In Silico Virtual Screening 利用计算机虚拟筛选技术探索坦帕拉市的抗癌潜力

KnE Life Sciences Pub Date : 2022-12-27 DOI: 10.18502/kls.v7i5.12517

M. Tejasari, T. Respati, L. Yuniarti

引用次数: 0

Training Programs on the Uses and Benefits of Herbal Feminine Hygiene 草药女性卫生的使用和益处培训项目

KnE Life Sciences Pub Date : 2022-12-27 DOI: 10.18502/kls.v7i5.12502

L. Mulqie, F. Darusman, Uci Ary Lantika, S. Sunendiari

引用次数: 0

In-Silico Investigation of Beta-Cyclodextrin as a Stabilizer for Pineapple Peel Extract Mediated Silver Nanoparticles -环糊精作为菠萝皮萃取物介导的纳米银稳定剂的硅晶研究

KnE Life Sciences Pub Date : 2022-12-27 DOI: 10.18502/kls.v7i5.12534

H. A. Wisnuwardhani, Y. Lukmayani, K. M. Yuliawati, Y. Permanasari

{"title":"In-Silico Investigation of Beta-Cyclodextrin as a Stabilizer for Pineapple Peel Extract Mediated Silver Nanoparticles","authors":"H. A. Wisnuwardhani, Y. Lukmayani, K. M. Yuliawati, Y. Permanasari","doi":"10.18502/kls.v7i5.12534","DOIUrl":"https://doi.org/10.18502/kls.v7i5.12534","url":null,"abstract":"Pineapple peel waste was used in this study as a source of ferulic acid that has antioxidant and antibacterial properties. Pineapple peel extract can be used as a bioreductor in the synthesis of silver nanoparticles (AgNPs). Beta cyclodextrins are often added as stabilizers in the synthesis of AgNPs to increase their stability. This study aimed to investigate through in silico study the efficacy of beta cyclodextrin as a stabilizer in the synthesis of AgNPs. It also investigated whether ferulic acid plays the role of a bioreductor in the stabilization mechanism of the AgNPs. Molecular docking simulation was used to investigate the efficacy of beta cyclodextrin as a stabilizer in AgNPs synthesis using MGLTools 1.5.6 with AutodockTools 4.2. The visualization of each complex was observed using BIOVIA Discovery Studio Visualizer 2020. The results of this study showed that beta cyclodextrin had better affinity by stabilizing six AgNPs atoms, which was indicated by a free binding energy value of -5.15 kJ/mol. The presence of ferulic acid in the extract which was used as a bioreductor in the synthesis of AgNPs also had a better affinity for the six AgNPs atoms which was indicated by free binding energy of -2.51 kJ/mol. It can be concluded that beta cyclodextrins play the role of being a stabilizer in AgNPs synthesis. \u0000Keywords: in silico, beta-cyclodextrin, silver nanoparticles","PeriodicalId":17898,"journal":{"name":"KnE Life Sciences","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85677697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developing Open-Air Sports Facilities to Enhance Socio- Family Relations 发展露天体育设施，增进社会家庭关系

KnE Life Sciences Pub Date : 2022-12-27 DOI: 10.18502/kls.v7i5.12525

V. Susanto, A. S. Ekomadyo

引用次数: 1

Radiological Features in Deceased COVID-19 Patients at a Hospital in Bandung 万隆某医院COVID-19死亡患者的放射学特征

KnE Life Sciences Pub Date : 2022-12-27 DOI: 10.18502/kls.v7i5.12510

D. Setiapriagung, C. Tresnasari, T. Widiyanto, F. A. Yulianto, T. Respati, L. Yuniarti

{"title":"Radiological Features in Deceased COVID-19 Patients at a Hospital in Bandung","authors":"D. Setiapriagung, C. Tresnasari, T. Widiyanto, F. A. Yulianto, T. Respati, L. Yuniarti","doi":"10.18502/kls.v7i5.12510","DOIUrl":"https://doi.org/10.18502/kls.v7i5.12510","url":null,"abstract":"COVID-19 attacks the respiratory system, especially the lung. Therefore, it is necessary to examine the lung radiology of COVID-19 patients to plan the best treatment. This study aimed to describe radiological features in deceased patients at a hospital in Bandung, Indonesia. This study uses secondary data from the medical records of deceased COVID-19 patients from December 2020 to February 2021. Amongst the 129 patients who died whilst hospitalized, their chest X-ray showed pneumonia consisting of ground glass opacities (GGO) and consolidated lesions. The mean distribution of lesions was unilateral in 3 (2.33%) and bilateral in 126 (97.67%). In comparison, peripheral lesions were found in 80 (62.02%), and peripheral-medial lesions were found in 49 (37.98%). The mean of the lesions affecting the upper lung fields were 2.63 (DS 1.19), the middle lung fields were 4.39 (DS 1.82), and the lower lung fields were 4.88 (DS 1.53). When admitted to the isolation ward, the average Brixia score on a chest X-ray was 11.9 (95% CI 12.74; 11.16). In conclusion, the radiological features of COVID-19 patients who died under treatment showed ground glass opacities and consolidated lesions. The predominant distribution was on bilateral, peripheral, and lower lesions with a high Brixia score. \u0000Keywords: COVID-19, mortality, the brixia score.","PeriodicalId":17898,"journal":{"name":"KnE Life Sciences","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75763293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of Feminine Area Cleansers with Anti-fungal Properties Using Apple Rose Leaves as an Active Ingredient 以苹果玫瑰叶为有效成分的抗真菌女性部位洁面乳的研制

KnE Life Sciences Pub Date : 2022-12-27 DOI: 10.18502/kls.v7i5.12529

S. Suwendar, L. Wahidah, Y. Krisnamurti, M. L. Ridwan, W. Lestari, D. Mardliyani, N. Fitriani

{"title":"Development of Feminine Area Cleansers with Anti-fungal Properties Using Apple Rose Leaves as an Active Ingredient","authors":"S. Suwendar, L. Wahidah, Y. Krisnamurti, M. L. Ridwan, W. Lestari, D. Mardliyani, N. Fitriani","doi":"10.18502/kls.v7i5.12529","DOIUrl":"https://doi.org/10.18502/kls.v7i5.12529","url":null,"abstract":"Fungal infection has a high prevalence rate in the feminine area. The use of natural anti-fungal, natural feminine cleansers can be a solution to this problem. Apple rose leaves are thought to be an alternative active ingredient to be developed into a natural feminine area cleanser. In this study, in vitro antifungal activity of guava leaves was observed on Candidia albicans and their development into a feminine area cleanser. The results based on the ethanol extract, n-hexane fraction, ethyl acetate fraction and water fraction showed that there were high anti-fungal properties. The highest anti-fungal effect was shown by the n-hexane fraction. A feminine area cleanser was developed with the n-hexane fraction of apple rose leaves as the active ingredient. Pharmaceutic evaluation showed that the formulation obtained was milky white, odorless, homogeneous, produced foam with a height of 0.5 cm and had a pH of 4.5. Based on the results of the study, it can be concluded that apple rose leaves have the potential to be developed into a feminine area cleanser. \u0000Keywords: apple rose leaves, leukorrhea, natural anti-leukorrhea, feminine area cleansing preparation","PeriodicalId":17898,"journal":{"name":"KnE Life Sciences","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87076041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Development of a Natural, Antiseptic Liquid Bath Soap from Apple Rose Leaves 从苹果玫瑰叶中提取天然、防腐液体沐浴皂的研制

KnE Life Sciences Pub Date : 2022-12-27 DOI: 10.18502/kls.v7i5.12530

S. Suwendar, Y. Krisnamurti, W. Lestari, D. Mardliyani, N. Fitriani

引用次数: 0

The Inhibition of Angiotensin-Converting Enzyme 2 Receptors of SARS-CoV-2 Through Mucroporin Derived from Scorpion Venom 蝎毒微孔蛋白对SARS-CoV-2血管紧张素转换酶2受体的抑制作用

KnE Life Sciences Pub Date : 2022-12-27 DOI: 10.18502/kls.v7i5.12514

Taufik Muhammad Fakih, Mentari Luthfika Dewi, Eky Syahroni

{"title":"The Inhibition of Angiotensin-Converting Enzyme 2 Receptors of SARS-CoV-2 Through Mucroporin Derived from Scorpion Venom","authors":"Taufik Muhammad Fakih, Mentari Luthfika Dewi, Eky Syahroni","doi":"10.18502/kls.v7i5.12514","DOIUrl":"https://doi.org/10.18502/kls.v7i5.12514","url":null,"abstract":"The SARS-CoV-2 virus that causes COVID-19 has a spike glycoprotein that can bind to a host cell receptor, angiotensin-converting enzyme 2 (ACE-2). This plays an important role in the entry of viral cells. Therefore, targeting of the ACE- 2 receptor holds promise as a potential target for anti-viral interventions to prevent and inhibit COVID-19. This study aims to focus on in silico studies to screen alternative drugs that can block ACE-2 receptor properties as a receptor for SARS- CoV-2. It is a potential therapeutic target for COVID-19 using the bioactive peptide Mucroporin which is derived from scorpion venom. There were four sequences of Mucroporin peptides modeled using the PEP-FOLD 3.5 server. The protein- peptide-based molecular docking simulations were used to identify and evaluate the actions of Mucroporin against ACE-2 receptors using PatchDock. The best response is then further observed using BIOVIA Discovery Studio 2020. This study revealed that Mucroporin and Mucroporin-S1 gave the best docking scores compared to Mucroporin-M1 and Mucroporin-S2, with the binding free energy values of −943.53 kJ/mol, −162.42 kJ/mol, 867.80 kJ/mol and 43.14 kJ/mol respectively. This study reveals for the first time that Mucroporin and Mucroporin-S1 are functional inhibitors of ACE-2 and as such, that components of scorpion venom can be used as potential inhibitors to the ACE-2 receptor of SARS-CoV-2. \u0000Keywords: SARS-CoV-2; COVID-19; Angiotensin-Converting Enzyme 2 (ACE-2); Mucroporin; In Silico Study","PeriodicalId":17898,"journal":{"name":"KnE Life Sciences","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74052942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0