Development of Feminine Area Cleansers with Anti-fungal Properties Using Apple Rose Leaves as an Active Ingredient

Abstract

Fungal infection has a high prevalence rate in the feminine area. The use of natural anti-fungal, natural feminine cleansers can be a solution to this problem. Apple rose leaves are thought to be an alternative active ingredient to be developed into a natural feminine area cleanser. In this study, in vitro antifungal activity of guava leaves was observed on Candidia albicans and their development into a feminine area cleanser. The results based on the ethanol extract, n-hexane fraction, ethyl acetate fraction and water fraction showed that there were high anti-fungal properties. The highest anti-fungal effect was shown by the n-hexane fraction. A feminine area cleanser was developed with the n-hexane fraction of apple rose leaves as the active ingredient. Pharmaceutic evaluation showed that the formulation obtained was milky white, odorless, homogeneous, produced foam with a height of 0.5 cm and had a pH of 4.5. Based on the results of the study, it can be concluded that apple rose leaves have the potential to be developed into a feminine area cleanser. Keywords: apple rose leaves, leukorrhea, natural anti-leukorrhea, feminine area cleansing preparation