Korean Journal of Radiology最新文献

{"title":"State-of-the-Art Imaging in Antibody-Drug Conjugate Treatment for Advanced Bladder Cancer.","authors":"Sarah Eid, Abdullah S Al-Yousef, Kyung Won Kim, Shinkyo Yoon, Rashad Nawfal, Joaquim Bellmunt, Toni K Choueiri, Katherine M Krajewski","doi":"10.3348/kjr.2025.0416","DOIUrl":"10.3348/kjr.2025.0416","url":null,"abstract":"<p><p>Antibody-drug conjugates (ADCs) have revolutionized the treatment landscape for advanced bladder cancer, particularly enfortumab vedotin and trastuzumab deruxtecan, which target Nectin-4 and human epidermal growth factor receptor 2 (HER 2), respectively. These ADCs have shown substantial efficacy, improving survival in patients who have progressed after chemotherapy and immunotherapy. Imaging plays a pivotal role in ADC-based therapy, extending beyond diagnosis and staging to assessing treatment response, detecting recurrence, and evaluating toxicity. Computed tomography (CT), multiparametric magnetic resonance imaging (MRI), and fluorodeoxyglucose positron emission tomography (FDG-PET) are widely used for these purposes. Despite the efficacy of ADCs, resistance mechanisms such as antigen loss and payload resistance continue to pose challenges, necessitating the development of next-generation ADCs. Response assessment largely relies on Response Evaluation Criteria in Solid Tumors (RECIST) 1.1, with growing interest in multiparametric MRI for evaluating complete response in bladder lesions. Additionally, imaging helps identify ADC-related toxicities, including pneumonitis and gastrointestinal complications. Radiologists must be aware of these evolving therapeutic and imaging paradigms to optimize patient management. The integration of imaging with ADC-based treatment requires a multidisciplinary approach to improve outcomes. This review highlights the critical role of imaging in ADC therapy and underscores the need for radiologists to adapt to these advancements in bladder cancer treatment.</p>","PeriodicalId":17881,"journal":{"name":"Korean Journal of Radiology","volume":"26 10","pages":"959-972"},"PeriodicalIF":5.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-of-Flight MRI Transition From 2D to 3D Fused Sequences: Noninvasive Technique for Angiographically Evaluating Pelvic Arteries in Placenta Accreta Spectrum Cases.","authors":"Pedro Teixeira Castro, Ana Paula Pinho Matos, Gerson Ribeiro, Marcio Silva, Jorge Lopes, Edward Araujo Júnior, Heron Werner","doi":"10.3348/kjr.2025.0327","DOIUrl":"https://doi.org/10.3348/kjr.2025.0327","url":null,"abstract":"","PeriodicalId":17881,"journal":{"name":"Korean Journal of Radiology","volume":"26 9","pages":"893-895"},"PeriodicalIF":5.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12394818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Updates on Cardiac MRI and PET Imaging for the Diagnosis and Monitoring of Cardiac Sarcoidosis.","authors":"Noriko Oyama-Manabe, Osamu Manabe, Tadao Aikawa, Yoshitaka Sobue, Ryosuke Asakura","doi":"10.3348/kjr.2025.0148","DOIUrl":"https://doi.org/10.3348/kjr.2025.0148","url":null,"abstract":"<p><p>Cardiac sarcoidosis (CS) poses significant diagnostic and therapeutic challenges due to its heterogeneous clinical manifestations and the limitations of conventional diagnostic approaches. Advances in imaging modalities, particularly cardiac magnetic resonance imaging (CMR) and ¹⁸F-fluorodeoxyglucose positron emission tomography (FDG-PET), have revolutionized the evaluation and management of this complex condition. CMR, with its superior spatial resolution and advanced techniques such as late gadolinium enhancement, T1/T2 mapping, and extracellular volume quantification, offers unparalleled insights into myocardial structure and fibrosis. These techniques not only enhance diagnostic accuracy but also provide critical information on disease activity and treatment response. Among these, T2 mapping has emerged as a valuable marker for active inflammation, with high values reliably indicating acute disease states. FDG-PET serves as a complementary modality by detecting active granulomatous inflammation and guiding immunosuppressive therapy. The synergistic integration of CMR and FDG-PET provides a comprehensive approach to diagnosing and monitoring CS, enabling the identification of subclinical disease and the optimization of therapeutic strategies. Furthermore, the incorporation of quantitative biomarkers, such as strain metrics and T2 values, promises to refine disease assessment and management. These advancements have the potential to transform the paradigm of CS care, ultimately improving patient outcomes.</p>","PeriodicalId":17881,"journal":{"name":"Korean Journal of Radiology","volume":"26 9","pages":"804-816"},"PeriodicalIF":5.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12394825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncover This Tech Term: Agentic Artificial Intelligence in Radiology.","authors":"Shahriar Faghani, Mana Moassefi, Pouria Rouzrokh, Bardia Khosravi, Bradley J Erickson","doi":"10.3348/kjr.2025.0370","DOIUrl":"https://doi.org/10.3348/kjr.2025.0370","url":null,"abstract":"","PeriodicalId":17881,"journal":{"name":"Korean Journal of Radiology","volume":"26 9","pages":"888-892"},"PeriodicalIF":5.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12394819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence Analysis of Chest Radiographs for Predicting Major Adverse Events in Patients Visiting the Emergency Department With Acute Cardiopulmonary Symptoms.","authors":"Chanyoung Rhee, Ki Jeong Hong, Ki Hong Kim, Jin Mo Goo, Eui Jin Hwang","doi":"10.3348/kjr.2025.0237","DOIUrl":"https://doi.org/10.3348/kjr.2025.0237","url":null,"abstract":"<p><strong>Objective: </strong>In this study, we investigated whether artificial intelligence (AI) analysis of chest radiographs (CXRs) can predict major adverse clinical events in patients visiting the emergency department (ED) with acute cardiopulmonary symptoms.</p><p><strong>Materials and methods: </strong>This secondary analysis of a previous clinical trial included patients who visited the ED with symptoms suggestive of acute cardiopulmonary disease and underwent chest radiography between June 2020 and December 2021. All patients underwent triage upon arrival at ED according to the Korean Triage and Acuity Scale (KTAS). The CXRs were retrospectively analyzed using a commercial AI (Lunit INSIGHT CXR, version 3.1.4.1) capable of detecting seven abnormalities on a single frontal CXR. The predictive performance of the AI analysis for major adverse cardiopulmonary events (any among hospitalization, ED revisits, and death in the ED due to acute cardiopulmonary disease) was compared with that of the KTAS using the area under the receiver operating characteristic curve (AUC). Multivariable (the AI analysis result and KTAS level) logistic regression analysis was conducted to investigate whether the AI analysis result was an independent predictor of the events and whether the combination of the AI analysis and KTAS has additional merit.</p><p><strong>Results: </strong>Among 3576 patients (1966 males; mean age, 64 years), 1148 (32.1%) experienced major adverse cardiopulmonary events. AI analysis of CXRs outperformed the KTAS in predicting these events (AUC, 0.795 vs. 0.610; <i>P</i> < 0.001). The AI analysis result was an independent predictor of these events after adjusting for the KTAS level (adjusted odd ratios of 1.032 and 6.913 for every 1% increase and ≥15%, respectively, in the AI probability score; <i>P</i> < 0.001). The combination of the AI analysis and KTAS showed an AUC that was higher than that of the KTAS alone (0.799; <i>P</i> < 0.001) and in-par with that of the AI analysis only (<i>P</i> = 0.187).</p><p><strong>Conclusion: </strong>AI analysis of CXRs showed greater accuracy than the KTAS did in predicting major adverse cardiopulmonary events in patients visiting the ED with acute cardiopulmonary symptoms. AI analysis may enhance the efficacy of patient triage in the ED.</p>","PeriodicalId":17881,"journal":{"name":"Korean Journal of Radiology","volume":"26 9","pages":"877-887"},"PeriodicalIF":5.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12394822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiparametric MRI Features of Plasmacytoid Urothelial Carcinoma of the Urinary Bladder.","authors":"Yeo Eun Han, Deuk Jae Sung, Hyun Yee Cho, Kyung Sook Yang, Jae Wook Park, Ki Choon Sim, Na Yeon Han, Beom Jin Park, Min Ju Kim","doi":"10.3348/kjr.2025.0419","DOIUrl":"https://doi.org/10.3348/kjr.2025.0419","url":null,"abstract":"<p><strong>Objective: </strong>Plasmacytoid urothelial carcinoma (PUC) is a rare aggressive bladder cancer subtype with limited imaging data owing to its low incidence. This study aimed to report the characteristic features of PUC on multiparametric MRI (mpMRI).</p><p><strong>Materials and methods: </strong>We retrospectively analyzed 13 patients with histologically confirmed PUC who underwent preoperative mpMRI between January 2019 and August 2024. Two blinded radiologists independently assessed tumor size, morphology, signal intensity, apparent diffusion coefficient (ADC) values, dynamic contrast enhancement patterns, contrast enhancement features, and invasive characteristics. Vesical imaging-reporting and data system (VI-RADS) scores were recorded. Interobserver agreement was evaluated using the kappa statistic.</p><p><strong>Results: </strong>PUC predominantly exhibited diffuse (6/13, 46.2%) or localized (5/13, 38.5%) bladder wall thickening. Diffuse thickening was often associated with a linitis plastica-like appearance. On high b-value diffusion-weighted imaging (DWI), eight and seven cases depending on readers (61.5% and 53.8%, respectively) showed mild hyperintensity or isointensity, with a mean ADC value of 1.1 × 10⁻³ mm²/s. Dynamic contrast-enhanced MRI revealed progressive and prolonged enhancement in 10 cases (76.9%). VI-RADS scores ≥ 4 were observed in 11 cases (84.6%). Histopathological analysis showed that tumors with progressive and prolonged enhancement contained myxoid stroma and some fibrous tissue. Interobserver agreement was excellent for most imaging features, except for good agreement on DWI signal intensity.</p><p><strong>Conclusion: </strong>PUC demonstrates notable mpMRI features, including localized or diffuse wall thickening (often with a linitis plastica-like appearance), muscle-invasive and advanced disease, progressive and prolonged enhancement patterns, and mild hyperintensity or isointensity on high b-value DWI. These features, which are potentially linked to the myxoid stromal composition of the tumor, suggest that mpMRI may serve as a noninvasive diagnostic tool for this aggressive malignancy. However, further studies with larger cohorts are required to confirm these findings.</p>","PeriodicalId":17881,"journal":{"name":"Korean Journal of Radiology","volume":"26 9","pages":"832-840"},"PeriodicalIF":5.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12394820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large Language Models for CAD-RADS 2.0 Extraction From Semi-Structured Coronary CT Angiography Reports: A Multi-Institutional Study.","authors":"Dabin Min, Kwang Nam Jin, SangHeum Bang, Moon Young Kim, Hack-Lyoung Kim, Won Gi Jeong, Hye-Jeong Lee, Kyongmin Sarah Beck, Sung Ho Hwang, Eun Young Kim, Chang Min Park","doi":"10.3348/kjr.2025.0293","DOIUrl":"10.3348/kjr.2025.0293","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the accuracy of large language models (LLMs) in extracting Coronary Artery Disease-Reporting and Data System (CAD-RADS) 2.0 components from coronary CT angiography (CCTA) reports, and assess the impact of prompting strategies.</p><p><strong>Materials and methods: </strong>In this multi-institutional study, we collected 319 synthetic, semi-structured CCTA reports from six institutions to protect patient privacy while maintaining clinical relevance. The dataset included 150 reports from a primary institution (100 for instruction development and 50 for internal testing) and 169 reports from five external institutions for external testing. Board-certified radiologists established reference standards following the CAD-RADS 2.0 guidelines for all three components: stenosis severity, plaque burden, and modifiers. Six LLMs (GPT-4, GPT-4o, Claude-3.5-Sonnet, o1-mini, Gemini-1.5-Pro, and DeepSeek-R1-Distill-Qwen-14B) were evaluated using an optimized instruction with prompting strategies, including zero-shot or few-shot with or without chain-of-thought (CoT) prompting. The accuracy was assessed and compared using McNemar's test.</p><p><strong>Results: </strong>LLMs demonstrated robust accuracy across all CAD-RADS 2.0 components. Peak stenosis severity accuracies reached 0.980 (48/49, Claude-3.5-Sonnet and o1-mini) in internal testing and 0.946 (158/167, GPT-4o and o1-mini) in external testing. Plaque burden extraction showed exceptional accuracy, with multiple models achieving perfect accuracy (43/43) in internal testing and 0.993 (137/138, GPT-4o, and o1-mini) in external testing. Modifier detection demonstrated consistently high accuracy (≥0.990) across most models. One open-source model, DeepSeek-R1-Distill-Qwen-14B, showed a relatively low accuracy for stenosis severity: 0.898 (44/49, internal) and 0.820 (137/167, external). CoT prompting significantly enhanced the accuracy of several models, with GPT-4 showing the most substantial improvements: stenosis severity accuracy increased by 0.192 (<i>P</i> < 0.001) and plaque burden accuracy by 0.152 (<i>P</i> < 0.001) in external testing.</p><p><strong>Conclusion: </strong>LLMs demonstrated high accuracy in automated extraction of CAD-RADS 2.0 components from semi-structured CCTA reports, particularly when used with CoT prompting.</p>","PeriodicalId":17881,"journal":{"name":"Korean Journal of Radiology","volume":"26 9","pages":"817-831"},"PeriodicalIF":5.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12394816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Academic Journal Podcast and Generative Artificial Intelligence: Introducing KJR SummaryCast.","authors":"Jeong Hyun Lee, Hye Young Jang, Seong Ho Park","doi":"10.3348/kjr.2025.0845","DOIUrl":"https://doi.org/10.3348/kjr.2025.0845","url":null,"abstract":"","PeriodicalId":17881,"journal":{"name":"Korean Journal of Radiology","volume":"26 9","pages":"801-803"},"PeriodicalIF":5.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12394817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of Large Language Models in Detecting Cases Requiring Immediate Reporting in Pediatric Radiology: A Feasibility Study Using Publicly Available Clinical Vignettes.","authors":"Jun Sung Park, Jisun Hwang, Pyeong Hwa Kim, Woo Hyun Shim, Min Jeong Seo, Dahyun Kim, Jeong In Shin, In Hwa Kim, Hwon Heo, Chong Hyun Suh","doi":"10.3348/kjr.2025.0240","DOIUrl":"https://doi.org/10.3348/kjr.2025.0240","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the accuracy of multimodal large language models (LLMs) in detecting cases requiring immediate radiology reporting in pediatric radiology.</p><p><strong>Materials and methods: </strong>Seventy-one publicly available, paraphrased pediatric clinical vignettes with images-sourced from the <i>New England Journal of Medicine</i>, <i>The Lancet</i>, <i>Archives of Pediatrics & Adolescent Medicine</i>, and <i>Radiology</i>-were assessed by seven vision-capable LLMs (temperature levels 0 and 1; t0 and t1) and four human readers (an expert pediatric radiologist, a trainee radiologist, an expert pediatrician, and a trainee pediatrician). Cases were classified as requiring immediate reporting (n = 33) if they corresponded to Korean Triage and Acuity Scale (KTAS) levels 1-2 (n = 24) or met the criteria for a critical value report (CVR) (n = 11). The most accurate LLM was compared with each human reader, with significance set at <i>P</i> < 0.013.</p><p><strong>Results: </strong>LLMs demonstrated 60.6%-83.1% accuracy in detecting cases requiring immediate radiology reporting: 57.7%-81.7% and 53.5%-87.3% for KTAS levels 1-2 and CVR cases, respectively. Gemini-Flash with t1 showed the highest accuracy among the LLMs: 83.1% (95% confidence interval [CI]: 74.6%-91.5%), 81.7% (95% CI: 71.8%-90.1%), and 87.3% (95% CI: 78.9%-94.4%) for identifying cases requiring immediate reporting, KTAS level 1-2 cases, and CVR cases, respectively, despite its low sensitivity for CVR detection (3/11, 27.3%). Human readers demonstrated 62.0%-84.5% accuracy for immediate radiology reporting, 73.2%-84.5% for KTAS levels 1-2, and 39.4%-94.4% for CVR cases. The accuracy of Gemini-Flash t1 in identifying cases requiring immediate radiology reporting was comparable to that of the most accurate human reader (vs. expert pediatrician: 84.5% [95% CI: 76.1%-93.0%]; <i>P</i> < 0.99).</p><p><strong>Conclusion: </strong>Multimodal LLMs may achieve overall accuracy comparable to or exceeding that of human readers in identifying cases requiring immediate radiology reporting, supporting their potential use for pediatric radiology worklist prioritization. However, the models' sensitivity in detecting such cases was not reliable.</p>","PeriodicalId":17881,"journal":{"name":"Korean Journal of Radiology","volume":"26 9","pages":"855-866"},"PeriodicalIF":5.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12394824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CT and MRI in Advanced Ovarian Cancer: Advances in Imaging Techniques.","authors":"Selina Chiu, Yvonne Tsitsiou, Andrea Da Silva, Cathy Qin, Christina Fotopoulou, Andrea Rockall","doi":"10.3348/kjr.2025.0357","DOIUrl":"https://doi.org/10.3348/kjr.2025.0357","url":null,"abstract":"<p><p>Ovarian cancer (OC) remains one of the leading causes of gynecologic cancer-related mortality, with most patients presenting with disseminated disease, particularly within the peritoneal cavity. Standard treatment includes cytoreductive surgery, platinum-based chemotherapy, and targeted maintenance approaches depending on the patient's and tumor's genetic profile. Despite treatment advancements, approximately 25% of high-grade serous OC cases relapse within a year despite optimal primary treatment with complete tumor clearance at cytoreduction. Advances in contrast-enhanced CT (CE-CT) and MRI have revolutionized the evaluation and treatment planning of advanced OC. CT remains the gold standard for staging and assessing tumor extent, effectively identifying peritoneal, lymphatic, and distant metastases. However, it is less effective in detecting small-volume peritoneal dissemination. MRI, with superior soft-tissue contrast, complements CT by providing a detailed assessment of peritoneal disease, characterizing sonographically indeterminate adnexal masses. Diffusion-weighted imaging and gadolinium-enhanced MRI have improved the diagnostic sensitivity for peritoneal disease but are unable to predict treatment response, recurrence risk, and prognosis. Radiomics, which extracts quantitative tumor features from imaging data, holds promise for personalizing treatment and identifying patients at risk for early recurrence despite optimal therapy. The integration of CT, MRI, and radiomics could enhance surgical planning and improve long-term survival outcomes in patients with advanced OC.</p>","PeriodicalId":17881,"journal":{"name":"Korean Journal of Radiology","volume":"26 9","pages":"841-854"},"PeriodicalIF":5.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12394823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}