Korean Circulation Journal最新文献

{"title":"Implications and Application Prospects of LncRNA in Acute Myocardial Infarction.","authors":"Maosheng Yang","doi":"10.4070/kcj.2026.0212","DOIUrl":"https://doi.org/10.4070/kcj.2026.0212","url":null,"abstract":"","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148669745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethinking Initial Coronary Evaluation in Type 2 Diabetes: Is CCTA Ready for First-Line Use?","authors":"Sanghoon Shin","doi":"10.4070/kcj.2026.0173","DOIUrl":"10.4070/kcj.2026.0173","url":null,"abstract":"","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148722678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Modified Anastomosis Sequence on Warm Ischemic Time and Clinical Outcomes in Orthotopic Heart Transplantation.","authors":"Joon Young Kim, EunJi Kim, Hong Rae Kim, Sung-Ho Jung, Jae-Joong Kim, Jae Won Lee","doi":"10.4070/kcj.2025.0532","DOIUrl":"https://doi.org/10.4070/kcj.2025.0532","url":null,"abstract":"<p><strong>Background and objectives: </strong>Prolonged ischemic time adversely affects outcomes after orthotopic heart transplantation (OHT). We implemented a modified anastomosis sequence to reduce warm ischemic time (WIT) and evaluated its impact on myocardial preservation and clinical outcomes.</p><p><strong>Methods: </strong>We retrospectively analyzed 273 OHT recipients who underwent either a conventional (n=101) or modified (n=172) sequence between March 2009 and December 2020. In the modified group, the left atrial and aortic anastomoses were completed under aortic cross-clamping (ACC), followed by reperfusion and completion of the remaining anastomoses on a beating heart. Baseline imbalances were addressed using inverse probability of treatment weighting based on propensity scores, with additional adjustment for covariates that remained imbalanced after weighting.</p><p><strong>Results: </strong>After adjustment, the modified anastomosis sequence was associated with shorter WIT (43.3±2.8 vs. 61.1±3.2 minutes; p<0.001) and lower postoperative myocardial injury markers, including creatine kinase-myocardial band and troponin-I. The modified sequence was also associated with lower odds of low cardiac output syndrome requiring extracorporeal membrane oxygenation support (odds ratio [OR], 0.07; 95% confidence interval [CI], 0.01-0.59; p=0.016) and left ventricular primary graft dysfunction (OR, 0.05; 95% CI, 0.00-0.53; p=0.014). Early mortality showed no statistically significant association with the anastomosis sequence. Findings were consistent in prespecified sensitivity analyses addressing transplant era.</p><p><strong>Conclusions: </strong>The modified anastomosis sequence was associated with shorter WIT, lower myocardial injury markers, and a lower risk of early graft dysfunction. As a structured approach intended to reduce WIT through earlier ACC release, the modified sequence may be associated with more favorable early myocardial preservation and graft function after transplantation.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148669653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Initial Antiplatelet Strategy and 1-Year Outcomes in East Asian Patients With Acute Myocardial Infarction and Renal Dysfunction.","authors":"Seok Oh, Kyung Hoon Cho, Min Chul Kim, Doo Sun Sim, Young Joon Hong, Ju Han Kim, Jang Hoon Lee, Chang-Hwan Yoon, Weon Kim, Jin-Yong Hwang, Myung Ho Jeong, Youngkeun Ahn","doi":"10.4070/kcj.2025.0522","DOIUrl":"10.4070/kcj.2025.0522","url":null,"abstract":"<p><strong>Background and objectives: </strong>The optimal P2Y12 inhibitor for patients with acute myocardial infarction and renal impairment (AMI-RI) remains unclear, particularly in East Asian populations. This study compared the real-world effectiveness and safety of initial ticagrelor versus clopidogrel therapy in Korean patients with AMI-RI.</p><p><strong>Methods: </strong>We analyzed 7,590 patients with AMI-RI (estimated glomerular filtration rate [eGFR] <90 mL/min/1.73 m²) from a nationwide multicenter registry. Of these, 3,793 received ticagrelor and 3,797 received clopidogrel as initial P2Y12 therapy. The primary efficacy endpoint was major adverse cardiac and cerebrovascular events (MACCEs), and the primary safety endpoint was clinically significant bleeding. Propensity score matching (PSM) was performed to adjust for baseline differences.</p><p><strong>Results: </strong>At 1 year, after PSM (n=1,869 per group), no significant differences were observed between ticagrelor and clopidogrel in the primary efficacy endpoint (MACCE; hazard ratio [HR], 0.810; p=0.212) or clinically significant bleeding (HR, 1.056; p=0.795). Renal function-stratified analyses showed consistent outcomes across eGFR categories, with no significant differences in MACCE after adjustment. During follow-up, a substantial proportion of patients initially treated with ticagrelor switched to clopidogrel, whereas most patients in the clopidogrel group maintained their initial therapy.</p><p><strong>Conclusions: </strong>Among Korean patients with AMI-RI, most clopidogrel users continued therapy, whereas many ticagrelor users switched during the 1-year follow-up. After propensity score adjustment, no statistically significant differences in ischemic or clinically significant bleeding outcomes were observed between the initial ticagrelor and clopidogrel strategies. These findings should be interpreted as inconclusive rather than indicative of equivalence.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148726251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilizing Lead aVR QRS Morphology to Localize Abnormal Substrates in Arrhythmogenic Right Ventricular Cardiomyopathy.","authors":"Chiao-Chin Lee, Chin-Yu Lin, Fa-Po Chung, Yenn-Jiang Lin, Shih-Lin Chang, Li-Wei Lo, Yu-Feng Hu, Ta-Chuan Tuan, Tze-Fan Chao, Jo-Nan Liao, Ling Kuo, Ting-Yung Chang, Chih-Min Liu, Cheng-I Wu, Shin-Huei Liu, Ming-Jen Kuo, Guan-Yi Li, Yu-Shan Huang, Wen-Po Fan, Lo-Chieh Ling, Shih-Ann Chen","doi":"10.4070/kcj.2025.0547","DOIUrl":"https://doi.org/10.4070/kcj.2025.0547","url":null,"abstract":"<p><strong>Background and objectives: </strong>The electrocardiography (ECG) morphology of lead aVR has been associated with arrhythmic risk in Brugada syndrome, but its role in arrhythmogenic right ventricular cardiomyopathy (ARVC) remains unclear. To evaluate the clinical significance of aVR morphology in ARVC patients.</p><p><strong>Methods: </strong>A total of 45 subjects diagnosed with ARVC who underwent epicardial-endocardial mapping were enrolled in the study. The patients were divided into two groups based on the presence of an epicardial right ventricular outflow tract (RVOT) scar: the n-RVOT group (scar area <50%, n=10) and the p-RVOT group (scar area ≥50%, n=35). The aVR morphology was classified into QR pattern, R pattern (including R wave, rS or Rs), and QS pattern. The baseline characteristics and procedural parameters were analyzed.</p><p><strong>Results: </strong>A higher incidence of inferior axis ventricular arrhythmia (VA) was observed in the p-RVOT group (64.2% vs. 33.3%, p=0.050). An R wave and QS pattern in aVR were associated with epicardial RVOT scar involvement. Among patients with QR pattern, an R/Q ratio<0.582 discriminated epicardial RVOT scar involvement (area under the receiver operating characteristic curve=0.88), with a sensitivity of 93.3% and specificity 80.0%. An R pattern was associated with reduced right ventricular ejection fraction (p=0.033) and a higher incidence of clinical or inducible ventricular fibrillation (p=0.021). There was no significant difference in post-ablation VA recurrence based on the presence of RVOT scar and aVR morphology.</p><p><strong>Conclusions: </strong>In patients with ARVC, the ECG morphology of lead aVR was associated with scar distribution and right ventricular dysfunction.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148430794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contemporary CTO Management in Korea: Insights from the K-CTO Registry 2.0.","authors":"Eun-Seok Shin","doi":"10.4070/kcj.2026.0200","DOIUrl":"https://doi.org/10.4070/kcj.2026.0200","url":null,"abstract":"","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148430748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LncRNA NRIR Promotes Myocardial Injury Through the miR-515-5p/SLC40A1 Axis: Diagnostic and Prognostic Implications in Acute Myocardial Infarction.","authors":"Peng Wang, Yuling Ma, Peirong Zhang, Lijun Xu, Yanwei Cheng, Tai Dou","doi":"10.4070/kcj.2025.0472","DOIUrl":"https://doi.org/10.4070/kcj.2025.0472","url":null,"abstract":"<p><strong>Background and objectives: </strong>Acute myocardial infarction (AMI) remains an important driver of cardiovascular mortality. Long non-coding RNA negative regulator of interferon response (NRIR) has been implicated in oxidative stress and apoptotic pathways, but its role in AMI is not yet clear. This study aimed to explore the diagnostic and prognostic significance of NRIR and its potential molecular mechanism in AMI.</p><p><strong>Methods: </strong>Two hundred twenty-six participants were enrolled, including 102 stable angina pectoris and 124 AMI patients. NRIR expression was quantified, and the diagnostic value was evaluated using receiver operating characteristic. Logistic regression was used to identify risk factors for major adverse cardiovascular events (MACE). H9c2 cardiomyocytes were subjected to oxygen-glucose deprivation (OGD). Cell viability, apoptosis, oxidative stress (ROS, MDA), and mitochondrial function (ATP, NADPH/NADP⁺) were assessed. The interactions between NRIR, miR-515-5p, and SLC40A1 were verified by dual-luciferase assays and functional rescue experiments.</p><p><strong>Results: </strong>NRIR was upregulated in AMI case and showed good diagnostic performance. Elevated NRIR levels were independently associated with poor MACE. OGD increased NRIR expression and induced cell injury, whereas NRIR knockdown alleviated apoptosis, oxidative stress, and mitochondrial dysfunction. NRIR is directly bound to miR-515-5p, which targets SLC40A1. Inhibition of miR-515-5p counteracted the effects of NRIR knockdown. Overexpression of SLC40A1 reversed the effects of miR-515-5p mimic. The NRIR/miR-515-5p/SLC40A1 axis modulated OGD-induced cardiomyocyte injury.</p><p><strong>Conclusions: </strong>NRIR is elevated in AMI, correlates with cardiac injury, and promotes cardiomyocyte damage via the miR-515-5p/SLC40A1 axis; further large-scale studies are needed to confirm its diagnostic and prognostic value.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148430785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Future Application of Virtual Reality Exercise to Various Types of Congenital Heart Disease.","authors":"Lucy Youngmin Eun","doi":"10.4070/kcj.2026.0081","DOIUrl":"10.4070/kcj.2026.0081","url":null,"abstract":"","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"492-494"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13320574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147964169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stability or Latent Risk? Interpreting MRA Withdrawal in Recovered Heart Failure.","authors":"Abdülmelik Birgün, Mehmet Mustafa Yılmaz, Macit Kalçık","doi":"10.4070/kcj.2026.0083","DOIUrl":"10.4070/kcj.2026.0083","url":null,"abstract":"","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"525-526"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13320572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147963911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative Reverse Remodeling in Aortic Regurgitation: What One-Year Left Ventricular Mass Regression Tells Us.","authors":"Jieun Lee, Jin Oh Na","doi":"10.4070/kcj.2026.0004","DOIUrl":"10.4070/kcj.2026.0004","url":null,"abstract":"","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"523-524"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13320569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148042598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}