Korean Circulation Journal最新文献_第7页

Malnutrition in Heart Failure With Preserved Ejection Fraction: Still a Neglected Risk Factor? 有保留射血分数的心力衰竭患者营养不良：仍是一个被忽视的危险因素？

IF 3.1 3区医学

Korean Circulation Journal Pub Date : 2025-06-24 DOI: 10.4070/kcj.2025.0182

Minjae Yoon, Jin Joo Park

引用次数: 0

Clinical Characteristics of Women With Chest Pain: Men From Mars, Women From Venus. 女性胸痛的临床特征：男性来自火星，女性来自金星。

IF 3.1 3区医学

Korean Circulation Journal Pub Date : 2025-06-23 DOI: 10.4070/kcj.2025.0185

Wang-Soo Lee

引用次数: 0

Quantifying Hemodynamic Instability in Fulminant Myocarditis: Clinical Implications for Decision-Making. 量化暴发性心肌炎的血流动力学不稳定性：决策的临床意义。

IF 3.1 3区医学

Korean Circulation Journal Pub Date : 2025-06-23 DOI: 10.4070/kcj.2025.0192

Hyue Mee Kim

引用次数: 0

LV Diastolic Dysfunction and Inappropriate LV Filling Pressure Escalation: The Core of Exercise Intolerance in Heart Failure. 左室舒张功能障碍和不适当的左室充盈压力升高：心力衰竭运动不耐受的核心。

IF 3.1 3区医学

Korean Circulation Journal Pub Date : 2025-06-17 DOI: 10.4070/kcj.2024.0369

Wei-Ming Huang, Chiao-Nan Chen, Hao-Chih Chang, Yen-Tung Liu, Yen-Tze Wu, Tzu-Ying Tseng, Hao-Min Cheng, Wen-Chung Yu, Chern-En Chiang, Chen-Huan Chen, Shih-Hsien Sung

{"title":"LV Diastolic Dysfunction and Inappropriate LV Filling Pressure Escalation: The Core of Exercise Intolerance in Heart Failure.","authors":"Wei-Ming Huang, Chiao-Nan Chen, Hao-Chih Chang, Yen-Tung Liu, Yen-Tze Wu, Tzu-Ying Tseng, Hao-Min Cheng, Wen-Chung Yu, Chern-En Chiang, Chen-Huan Chen, Shih-Hsien Sung","doi":"10.4070/kcj.2024.0369","DOIUrl":"https://doi.org/10.4070/kcj.2024.0369","url":null,"abstract":"Background and objectives: Exercise intolerance is the most common symptom of patients with heart failure (HF), regardless of the phenotypes. We aim to investigate the determinants of exercise capacity in chronic stable HF with reduced, mildly reduced, preserved, and recovered ejection fraction (EF).Methods: Ambulatory HF subjects were recruited for a combined cardiopulmonary exercise test and exercise stress echocardiography. Impaired exercise capacity was referred to a peak oxygen consumption of <14 mL/kg/min, and a relationship between minute ventilation and carbon dioxide production of >34 was defined as ventilatory inefficiency.Results: Among 66 participants, there were 16 HF with reduced EF, 18 HF with mildly reduced EF, 12 HF preserved EF, and 20 HF recovered EF. Diastolic dysfunction indices were independently predictive of impaired exercise capacity (odds ratio [OR], 3.847; 95% confidence interval [CI], 1.369-10.810). Global longitudinal strain (GLS) at rest was independently correlated with ventilatory inefficiency (OR, 1.404; 95% CI, 1.050-1.877). Among the exercise indices, the peak medial E/e' to cardiac output (CO) ratio was independently associated with impaired exercise capacity (OR, 3.478; 95% CI, 1.313-9.214) and peak GLS was best related to ventilatory inefficiency (OR, 1.403; 95% CI, 1.076-1.828).Conclusions: Among resting and exertional echocardiographic variables, the peak medial E/e' to CO ratio, a non-invasive assessment of exertional left ventricular filling pressure indexed to CO, was the major determinant of exercise capacity in patients with different HF phenotypes.","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Age-Dependent Role of Genetics and Renal Function for Atrial Fibrillation Development in Hypertrophic Cardiomyopathy. 肥厚性心肌病患者房颤发展中遗传和肾功能的年龄依赖性作用。

IF 3.1 3区医学

Korean Circulation Journal Pub Date : 2025-06-16 DOI: 10.4070/kcj.2025.0048

Hyemoon Chung, Yoonjung Kim, Jiwon Seo, In-Soo Kim, Sungsoo Cho, Chul-Hwan Park, Tae Hoon Kim, Se-Joong Rim, Kyung-A Lee, Eui-Young Choi

{"title":"Age-Dependent Role of Genetics and Renal Function for Atrial Fibrillation Development in Hypertrophic Cardiomyopathy.","authors":"Hyemoon Chung, Yoonjung Kim, Jiwon Seo, In-Soo Kim, Sungsoo Cho, Chul-Hwan Park, Tae Hoon Kim, Se-Joong Rim, Kyung-A Lee, Eui-Young Choi","doi":"10.4070/kcj.2025.0048","DOIUrl":"https://doi.org/10.4070/kcj.2025.0048","url":null,"abstract":"Background and objectives: The objective of this study was to investigate whether genetic, structural, and clinical factors were associated with atrial fibrillation (AF) in patients with hypertrophic cardiomyopathy (HCM).Methods: Of the 212 prospectively enrolled patients in the HCM genetic registry, 33 had initial AF, and the remaining 179 (126 males, 58±13 years) were followed up for the development of new-onset AF.Results: Patients with initial AF had older age, lower estimated glomerular filtration rate (eGFR), lower left ventricular (LV) global longitudinal strain, higher left atrial volume index (LAVI), and higher LV extracellular volume fraction. During a median follow-up period of 916 (400-1,327) days, AF occurred in 12 (6.7%) patients. In Cox regression analysis, lower eGFR (hazard ratio per 1 mL/min/1.73 m² increase, 0.93; p=0.007), LV ejection fraction (hazard ratio, 0.82; p=0.009), and higher LAVI (hazard ratio, 1.07; p=0.010) were associated with increased risk of future AF. The addition of eGFR to LAVI significantly increased the global χ² value (8.508 to 15.017; p=0.006). Among patients younger than 65 years (n=128), those with any sarcomere variants (pathogenic and variants of uncertain significance [VUS], n=77) had a higher prevalence of overall AF (initial and new-onset, 82.4% vs. 56.8%; p=0.045).Conclusions: In patients with HCM, decreased renal function provides an additive predictive value on LAVI for future AF. In patients younger than 65, the presence of sarcomere variants, including VUS, is related to a higher prevalence of AF.","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

When Compatibility Creates Inequality: Blood Type O and the Korean Heart Transplant System. 当相容性造成不平等：O型血和韩国心脏移植系统。

IF 3 3区医学

Korean Circulation Journal Pub Date : 2025-06-01 DOI: 10.4070/kcj.2025.0125

Soo Yong Lee

引用次数: 0

Osfit™, a Novel Stent Designed for the Treatment of Coronary Ostial Lesions: Initial Clinical Experience and Intravascular Ultrasound Evaluation. 用于治疗冠状动脉口病变的新型支架Osfit™：初步临床经验和血管内超声评估

IF 3 3区医学

Korean Circulation Journal Pub Date : 2025-06-01 Epub Date: 2025-02-03 DOI: 10.4070/kcj.2024.0256

Kyoung-Woo Seo, Seung-Jea Tahk, Hyoung-Mo Yang, Hong-Seok Lim, Myeong-Ho Yoon, So-Yeon Choi

{"title":"Osfit™, a Novel Stent Designed for the Treatment of Coronary Ostial Lesions: Initial Clinical Experience and Intravascular Ultrasound Evaluation.","authors":"Kyoung-Woo Seo, Seung-Jea Tahk, Hyoung-Mo Yang, Hong-Seok Lim, Myeong-Ho Yoon, So-Yeon Choi","doi":"10.4070/kcj.2024.0256","DOIUrl":"10.4070/kcj.2024.0256","url":null,"abstract":"Background and objectives: Stent implantation for coronary ostial lesions is challenging. This study evaluated the feasibility, safety, and immediate procedural results of the Osfit™, innovatively designed sirolimus drug-eluting stent delivery system for the treatment of coronary ostial lesions.Methods: The Osfit™ has a 5 mm long extended balloon proximal to the stent (bare balloon without mounted stent). When inflated at 1.5 atm, only bare balloon inflated and acts like a stopper. We evaluated the technical feasibility in 49 patients with a coronary ostial lesion (defined as stenosis within 3 mm from the origin of the vessel) who had received the Osfit™. Intravascular ultrasound (IVUS) analysis was done in 11 patients who consented to IVUS examination, and the depth from the proximal edge of the stent to the ostial plane (DSO) was measured.Results: In all 49 lesions, stents were successfully implanted in one single angiographic view without obvious stent protrusion or definite angiographic missing of the ostium. The proportions of aorto-ostial, and bifurcation lesions were 28.6% and 71.4%, respectively. The DSO was 0.2±0.69 mm, and the proximal stent edges were located within 1 mm of the ostial edge in all patients. No adverse events like death, myocardial infarction, target lesion revascularization, target vessel revascularization or stent thrombosis were reported during the in-hospital period or within 30 days.Conclusions: The implantation of the Osfit™ for coronary ostial lesions appears to be an accurate and safe procedure that may reduce multiple angiographic projections and advanced skills.","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"497-508"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exosome-Based Therapy in Cardiovascular Diseases: A New Frontier in Cardiovascular Disease Treatment. 基于外泌体的心血管疾病治疗：心血管疾病治疗的新前沿。

IF 3 3区医学

Korean Circulation Journal Pub Date : 2025-06-01 Epub Date: 2025-03-05 DOI: 10.4070/kcj.2025.0022

Cheong-Whan Chae, Gun Choi, Taehun Yoon, Yoo-Wook Kwon

{"title":"Exosome-Based Therapy in Cardiovascular Diseases: A New Frontier in Cardiovascular Disease Treatment.","authors":"Cheong-Whan Chae, Gun Choi, Taehun Yoon, Yoo-Wook Kwon","doi":"10.4070/kcj.2025.0022","DOIUrl":"10.4070/kcj.2025.0022","url":null,"abstract":"Exosomes, small extracellular vesicles ranging from 30 to 150 nanometers in diameter, have emerged as pivotal mediators of intercellular communication. These vesicles, originally perceived as cellular debris, are now recognized for their intricate roles in transporting bioactive molecules, including proteins, lipids, and nucleic acids, between cells. Exosomes have received considerable attention due to their roles in diverse physiological and pathological processes, especially in relation to cardiovascular diseases (CVDs). CVDs are intricately linked, sharing common risk factors and pathological mechanisms, such as inflammation, oxidative stress, and endothelial dysfunction. Exosomes have been implicated in either directly or indirectly influencing these phenomena. They are secreted by virtually all cell types, including endothelial cells, cardiomyocytes, and stem cells, play critical roles in maintaining vascular homeostasis and responding to pathological stimuli. Their capacity to traverse biological barriers, maintain stability in circulation, and effectively encapsulate and deliver a variety of molecular cargos makes them promising candidates for both biomarkers and therapeutic agents. This review aims to explore the multifaceted roles of exosomes in CVDs. And we will discuss the mechanisms of exosome biogenesis and release, their molecular composition, and the ways in which they contribute to disease pathophysiology. Additionally, we will emphasize the potential of exosomes as diagnostic biomarkers and their therapeutic uses, highlighting their significance in the advancement of innovative treatment strategies. This review explores recent findings and advancements in exosome research, emphasizing their significance in CVD and paving the way for future studies and clinical applications.","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"461-480"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultimately, the Problem Lies in the Arterial Diameter. 最终，问题出在动脉直径上。

IF 3 3区医学

Korean Circulation Journal Pub Date : 2025-06-01 Epub Date: 2025-02-19 DOI: 10.4070/kcj.2025.0030

Hyoung Woo Chang

引用次数: 0

Sex Differences in Patients With Cardiogenic Shock Receiving Venoarterial Extracorporeal Membrane Oxygenation. 心源性休克患者接受静脉体外膜氧合的性别差异。

IF 3 3区医学

Korean Circulation Journal Pub Date : 2025-06-01 Epub Date: 2025-02-10 DOI: 10.4070/kcj.2024.0330

Onyou Kim, David Hong, Ki Hong Choi, Joo Myung Lee, Taek Kyu Park, Young Bin Song, Joo-Yong Hahn, Seung-Hyuk Choi, Yang Hyun Cho, Hyeon-Cheol Gwon, Jeong Hoon Yang

{"title":"Sex Differences in Patients With Cardiogenic Shock Receiving Venoarterial Extracorporeal Membrane Oxygenation.","authors":"Onyou Kim, David Hong, Ki Hong Choi, Joo Myung Lee, Taek Kyu Park, Young Bin Song, Joo-Yong Hahn, Seung-Hyuk Choi, Yang Hyun Cho, Hyeon-Cheol Gwon, Jeong Hoon Yang","doi":"10.4070/kcj.2024.0330","DOIUrl":"10.4070/kcj.2024.0330","url":null,"abstract":"Background and objectives: Limited data are available on sex differences in clinical outcomes of patients with profound cardiogenic shock (CS) receiving venoarterial extracorporeal membrane oxygenation (VA-ECMO). Therefore, our study sought to compare clinical pictures and outcomes between male and female patients treated with VA-ECMO.Methods: A total of 1,328 patients receiving VA-ECMO were selected from either the Samsung Medical Center or a multicenter CS registry named the SMART RESCUE study. The study population was divided into men (n=903) and women (n=425). The primary outcome was in-hospital mortality, and the secondary outcome was procedure-related complications, which included limb ischemia, extracorporeal membrane oxygenation (ECMO) site bleeding and infection, and wound dehiscence.Results: There was no significant difference in in-hospital mortality (men vs. women, 46.4% vs. 45.6%; adjusted odds ratio [OR], 0.78; 95% confidence interval [CI], 0.58-1.05; p=0.106) based on multivariable analysis. Women showed higher rates of procedure-related complication than men (18.7% vs. 25.9%; adjusted OR, 1.82; 95% CI, 1.29-2.57; p=0.001) mainly driven by higher incidence of limb ischemia (7.1% vs. 12.9%; adjusted OR, 2.32; 95% CI, 1.42-3.78; p=0.001) On multivariable logistic regression analysis, female sex was an independent predictor of procedure-related complications (adjusted OR, 1.68; 95% CI, 1.13-2.49; p=0.009).Conclusions: Although no significant difference in either in-hospital or mid-term mortality was found between men and women, female sex is an independent factor for ECMO-related complications.Trial registration: ClinicalTrials.gov Identifier: NCT02985008.","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"541-551"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0