Korean Circulation Journal最新文献

{"title":"The Quest for Longevity in Pulmonary Valve Replacement: Translating Experimental Insights Into Surgical Excellence.","authors":"Han Ki Park","doi":"10.4070/kcj.2026.0061","DOIUrl":"10.4070/kcj.2026.0061","url":null,"abstract":"","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"630-632"},"PeriodicalIF":3.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13368455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148295549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Korean Society of Interventional Cardiology Expert Consensus for the Management of Chronic Coronary Syndrome: Part 1.","authors":"Joo Myung Lee, Yisik Kim, Sang Yoon Lee, Woochan Kwon, Doyeon Hwang, Min Ku Chon, Hyun Sung Joh, Seung Hun Lee, Kwan Yong Lee, Young-Hoon Seo, Seonghyeon Bu, Sang-Don Park, Namkyun Kim, Jung-Sun Kim, Pil-Ki Min, Chang-Wook Nam, Cheol Whan Lee, Young Joon Hong, Hyeon-Cheol Gwon, Joo-Yong Hahn, Youngkeun Ahn","doi":"10.4070/kcj.2026.0191","DOIUrl":"10.4070/kcj.2026.0191","url":null,"abstract":"<p><p>Coronary artery disease is one of the leading causes of death worldwide and represents a major health burden in Korea. Chronic coronary syndrome (CCS) encompasses the long-term and heterogeneous clinical manifestations of ischemic heart disease, ranging from obstructive epicardial disease to non-obstructive and microvascular disease. This pathophysiological heterogeneity necessitates individualized diagnostic and therapeutic strategies to prevent progression from CCS to acute coronary syndrome. Since the publication of recent CCS guidelines, new evidence has emerged regarding optimal diagnostic strategies, physiological and intravascular imaging-based assessments, and medical therapy. In addition, contemporary CCS management increasingly emphasizes multidisciplinary integration, including cardiovascular prevention, non-invasive imaging-guided decision-making, and patient-centered revascularization strategies. However, the implementation of these principles in real-world Korean clinical practice remains unclear, highlighting the need for localized, evidence-based guidance for Korean patients with CCS. This expert consensus provides a comprehensive, stepwise framework for the diagnosis, treatment, and long-term management of CCS by integrating the latest international evidence with Korean clinical data and practice patterns.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":"56 7","pages":"531-561"},"PeriodicalIF":3.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13368462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148430773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rescue Chimney Stenting via Direct Carotid Access for Inadvertent Left Common Carotid Artery Coverage During Zone 2 Thoracic Endovascular Aortic Repair.","authors":"Adelin Dhivi Kemalasari, Jun-Chang Jeong, In Tae Jin, Sun-Oh Kim, Young-Guk Ko","doi":"10.4070/kcj.2025.0504","DOIUrl":"10.4070/kcj.2025.0504","url":null,"abstract":"","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"649-654"},"PeriodicalIF":3.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13368456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147963881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of the Implantation Angle on the Durability of a Bio-Prosthetic Pulmonary Valve in the Tetralogy of Fallot.","authors":"Yujin Kwak, Jae Gun Kwak, Sungkyu Cho, Woong-Han Kim","doi":"10.4070/kcj.2025.0250","DOIUrl":"10.4070/kcj.2025.0250","url":null,"abstract":"<p><strong>Background and objectives: </strong>Tetralogy of Fallot (TOF) patients require pulmonary valve replacement (PVR) after total correction to prevent the late complications associated with pulmonary valve dysfunction. This study aimed to evaluate factors affecting the durability of bio-prosthetic pulmonary valves, with an emphasis on the angle of implantation as well as age, size or materials of prosthetic valve.</p><p><strong>Methods: </strong>Of the 50 consecutive patients with TOF who underwent redo-PVR due to prosthetic valvular failure (PVF) between January 2001 and May 2020, 36 had good images for measuring implantation angle on computed tomography, magnetic resonance imaging, or angiography. We defined the angle of implantation as the angle between an imaginary axial line from the center of the prosthetic valve and an imaginary parallel line from the point where the line meets the anterior wall of main pulmonary artery on sagittal planes.</p><p><strong>Results: </strong>The median age at total repair of TOF was 13.4 months (interquartile range [IQR], 8.4-22.3 months) and the median age at initial PVR was 10.1 years (IQR, 8.4-12.2 years). The mean interval from initial PVR to redo-PVR was 10.1±3.6 years and follow-up duration was 15.6±2.5 years after initial PVR. The implantation angle (<30° or ≥45°) was significantly related with early (<10 years after PVR) PVF.</p><p><strong>Conclusions: </strong>The risk for early PVF was relatively lower when the implantation angle was between 30° and 45°. We should be careful to implant a prosthetic valve with an adequate angle to maintain a laminar flow in the pulmonary position for better durability.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"618-629"},"PeriodicalIF":3.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13368459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146227398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knockdown of ARID1A Protects H9c2 Cells Against Hypoxia/Reoxygenation (H/R)-Induced Injury by Targeting SOX9.","authors":"Pingfeng Wang, Xiaoyu Chen, Yimin Shu, Xuesi Chen","doi":"10.4070/kcj.2025.0296","DOIUrl":"10.4070/kcj.2025.0296","url":null,"abstract":"<p><strong>Background and objectives: </strong>Hypoxia/reoxygenation (H/R) injury is a major contributor to cardiac damage. The role of AT-rich interaction domain 1A (ARID1A) in cardiomyocyte H/R injury and its underlying mechanisms remain unclear.</p><p><strong>Methods: </strong>An H/R injury model was established using H9c2 cardiomyoblasts. Key assessments included cell viability (cell counting kit-8), apoptosis (Terminal deoxynucleotidyl transferase dUTP Nick End Labeling), DNA fragmentation, inflammatory cytokine levels (interleukin [IL]-1β, IL-6, IL-18), cardiac injury markers (creatine kinase-MB [CK-MB], cardiac troponin-I [cTn-I]), oxidative stress markers (lactate dehydrogenase [LDH] release, reactive oxygen species [ROS], glutathione peroxidase [GSH-Px], superoxide dismutase [SOD] activity), pyroptosis marker expression (NLR family pyrin domain containing 3 [NLRP3], caspase-1, gasdermin D [GSDMD]; Western blot), and ARID1A-SOX9 interaction (co-immunoprecipitation).</p><p><strong>Results: </strong>H/R significantly upregulated ARID1A and SOX9 expression in H9c2 cells. ARID1A knockdown effectively attenuated H/R-induced damage, including improved cell viability, reduced apoptosis and DNA fragmentation, suppressed pro-inflammatory cytokine release (IL-1β, IL-6, IL-18), lowered CK-MB and cTn-I levels, decreased LDH release and ROS generation, enhanced antioxidant enzyme activity (GSH-Px, SOD), and reduced expression of pyroptosis markers (NLRP3, caspase-1, GSDMD). Mechanistically, ARID1A physically bound to SOX9 and promoted its expression. Crucially, the protective effects of si-ARID1A against H/R injury (apoptosis, inflammation, oxidative stress, pyroptosis) were consistently reversed by SOX9 overexpression.</p><p><strong>Conclusions: </strong>ARID1A is upregulated during H/R injury and exacerbates cardiomyocyte damage by promoting apoptosis, inflammation, oxidative stress, and pyroptosis. ARID1A exerts its effects by binding to and positively regulating the expression of SOX9. Targeting the ARID1A/SOX9 axis represents a potential therapeutic strategy for mitigating H/R-induced cardiac injury.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"633-645"},"PeriodicalIF":3.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13368457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147499419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One Versus Two Months Anticoagulation After Catheter Ablation for Atrial Fibrillation in Patients Who Were Not Indicated for Long-Term OAC: A Pilot Randomized Controlled Trial (The REDUCIBLE Trial).","authors":"Nilar Aung, Soyoon Park, Soohyun Kim, Young Choi, Yong-Seog Oh, Seunghee Baek, Sung-Hwan Kim","doi":"10.4070/kcj.2025.0351","DOIUrl":"10.4070/kcj.2025.0351","url":null,"abstract":"<p><strong>Background and objectives: </strong>Even low-risk atrial fibrillation (AF) patients usually continue anticoagulant therapy for several months after the procedure. However, there is no solid evidence supporting this practice. The REDUCIBLE trial is designed to compare the outcomes of conventional 2- versus 1-month oral anticoagulant (OAC) therapy following successful catheter ablation (CA) in men with a CHA₂DS₂-VASc score of ≤1 and women with ≤2, where long-term OAC is not recommended.</p><p><strong>Methods: </strong>In this pilot study, patients undergoing CA for drug-refractory paroxysmal AF were randomly divided into 2 groups. One group received OAC for 1 month, whereas the other received it for 2 months. The primary outcome was the incidence of stroke and systemic embolism within 1 year after ablation.</p><p><strong>Results: </strong>A total of 220 patients were enrolled and randomly assigned to 2 groups. Baseline characteristics were similar between the groups. The AF recurrence-free survival (RFS) rate was similar (76.9% vs. 77.7%, p=0.98). During the blanking period, AF RFS was also similar (92.5% vs. 92.9%, p=0.98). No ischemic stroke or systemic embolism occurred in either group during 1-year follow-up. One patient in the 1-month group experienced a minor bleeding event when anticoagulants were not taken (7 months after ablation).</p><p><strong>Conclusions: </strong>This study found that a single month of OAC post-ablation did not significantly elevate the risk of stroke or systemic embolism in low-risk patients. Nonetheless, a larger sample size would be necessary to achieve the statistical power for definitive conclusions. Future larger prospective clinical trials are needed to address this question comprehensively.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT03573037.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"606-614"},"PeriodicalIF":3.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13368458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147499414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Implications and Evolution of Significant Tricuspid Regurgitation in Patients Undergoing Left Ventricular Assist Device Implantation.","authors":"Heayoung Shin, Darae Kim, David Hong, Ji Hyun Cha, Yang Hyun Cho, Jeong Hoon Yang, Jin-Oh Choi","doi":"10.4070/kcj.2025.0260","DOIUrl":"10.4070/kcj.2025.0260","url":null,"abstract":"<p><strong>Background and objectives: </strong>Tricuspid regurgitation (TR) is common in advanced heart failure patients undergoing left ventricular assist device (LVAD) implantation, yet its independent prognostic value and post-LVAD trajectory remain uncertain.</p><p><strong>Methods: </strong>This retrospective single-center study included 178 patients who underwent LVAD implantation without concomitant tricuspid valve intervention (TVI) between 2012 and 2024. Patients were stratified based on preoperative echocardiography into non-significant TR (n=141) and significant (≥ moderate) TR (n=37). Primary outcomes were early right ventricular (RV) failure, all-cause mortality and heart failure hospitalization.</p><p><strong>Results: </strong>Significant baseline TR independently predicted early RV failure (odds ratio, 2.38; 95% confidence interval, 1.04 to 5.70; p=0.041), but was not associated with long-term outcomes, including all-cause mortality or heart failure hospitalization. During follow-up, TR severity improved in 60% of patients and most patients achieved hemodynamic optimization regardless of baseline TR severity. Functional recovery was observed in both groups, with a greater tendency of 6-minute walk improvement in patients with significant TR (p=0.057).</p><p><strong>Conclusions: </strong>Baseline moderate-to-severe TR predicts early RV failure but not long-term adverse outcomes following LVAD implantation. Most patients experience spontaneous TR improvement and achieve similar hemodynamic optimization regardless of baseline TR severity. These findings suggest LVAD support alone promotes RV reverse remodeling without requiring routine concomitant TVI.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":"587-601"},"PeriodicalIF":3.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13368460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147499367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bleeding Requiring Re-Exploration After Heart Transplantation: More Than a Complication-A Cause and Marker of Poor Outcome.","authors":"Mi-Na Kim","doi":"10.4070/kcj.2026.0227","DOIUrl":"https://doi.org/10.4070/kcj.2026.0227","url":null,"abstract":"","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148669563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One in Five Coronary Arteries May Not Be Where You Expect: Lessons From a Korean Cadaveric Study.","authors":"SungA Bae","doi":"10.4070/kcj.2026.0163","DOIUrl":"https://doi.org/10.4070/kcj.2026.0163","url":null,"abstract":"","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148669786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stress Hormones and Variant Angina: From Episodic Vasospasm to Neuroendocrine Vulnerability.","authors":"Jun Hwan Cho","doi":"10.4070/kcj.2026.0225","DOIUrl":"https://doi.org/10.4070/kcj.2026.0225","url":null,"abstract":"","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148669902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}