Kidney & blood pressure research最新文献

{"title":"Epidemiology and Multimorbidity in Hemodialysis Patients at a Tertiary Care Center in Northern Mexico: Implications for Hospital-Based Adverse Outcomes.","authors":"Mara Cecilia Olivo-Gutiérrez, Gerardo Mendoza-Lara, Irma Isabel Flores-Ponzio, Tanya Paola Rodriguez-Cerda, Allina Primavera Flores-Mendoza, Sofía López-Guzmán","doi":"10.1159/000552998","DOIUrl":"10.1159/000552998","url":null,"abstract":"<p><strong>Introduction: </strong>Patients with chronic kidney disease (CKD) in maintenance hemodialysis are vulnerable to adverse hospital-based outcomes. The present study aimed to describe the association between clinical variables and hospital admission and mortality in patients ascribed to an outpatient hemodialysis unit in northeastern Mexico.</p><p><strong>Methods: </strong>We conducted a retrospective analytical study with data recorded during the period of January to June 2025. Two hundred fifteen adult patients with maintenance hemodialysis were included. Associations between clinical data and hospitalizations, readmissions, and in-hospital mortality were analyzed.</p><p><strong>Results: </strong>In the present study, 32.8% of patients had CKD related to diabetes mellitus and hypertension. Totally, 53% of patients received two hemodialysis sessions per week. The median number of comorbidities was two and hypertension was the most frequent comorbidity. In total, 37% of patients required at least one hospital admission; the most common cause of hospitalization was volume overload followed by infections. In total, 12% of hospitalized patients died. Hospital admission was associated with cancer, erythropoietin use, fewer hemodialysis sessions and uncontrolled hypertension. Mortality was associated with peripheral artery disease, erythropoietin use and male gender. In multivariable analyses, no independent predictors of in-hospital mortality were identified. We observed a tendency towards an association between diuretic use and hospital readmissions.</p><p><strong>Conclusion: </strong>Comorbidity burden, pharmacologic treatment and hemodialysis prescription should be taken into account in patients with maintenance hemodialysis to lower hospital-based adverse outcomes. Diagnostic and therapeutic strategies aimed at diminishing volume overload may have a significant impact reducing hospitalizations in outpatient hemodialysis patients.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"781-789"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13533477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148376145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LncRNA RAD51-AS1 Alleviates Oxidative Stress and Inflammation in Diabetic Nephropathy by Adsorbing miR-154-5p.","authors":"Mengmeng Pu, Yijun Chen, Dewei Ouyang","doi":"10.1159/000552931","DOIUrl":"10.1159/000552931","url":null,"abstract":"<p><strong>Introduction: </strong>Diabetic nephropathy (DN) is one of the severe complications of diabetes. The specific roles and mechanisms of lncRNAs in DN remain to be further elucidated. This study aimed to investigate whether lncRNA RAD51-AS1 participates in oxidative stress and inflammatory responses in DN by regulating the miR-154-5p/MPC2 axis, and to elucidate its potential molecular mechanisms.</p><p><strong>Methods: </strong>This study included 74 patients with DN, 104 patients with type 2 diabetes alone, and 80 healthy controls, assessing their clinical indexes and gene expression. DN models were established using HK-2 cells treated with high-glucose (HG). Cell proliferation and apoptosis were assessed using CCK-8 assay and flow cytometry. Oxidative stress indicators and inflammatory factors were measured by ELISA. The targeting relationship was validated using dual-luciferase reporter assay.</p><p><strong>Results: </strong>Clinical studies indicated that serum RAD51-AS1 levels were downregulated in DN patients, and it was positively correlated with estimated glomerular filtration rate while negatively correlated with blood urea nitrogen, serum creatinine, and urinary albumin-to-creatinine ratio. Overexpression of RAD51-AS1 significantly inhibited HG-induced oxidative stress and inflammatory responses in HK-2 cells, manifested as enhanced cell proliferation, suppressed apoptosis, reduced levels of MDA, IL-6, IL-1β, and TNF-α, and increased SOD activity. Furthermore, overexpression of miR-154-5p reversed protective effect of RAD51-AS1 on cell injury. In addition, as an endogenous competitive RNA, RAD51-AS1 adsorbed miR-154-5p, thereby releasing its suppression of the target gene MPC2.</p><p><strong>Conclusion: </strong>RAD51-AS1 is downregulated in DN, and it regulates MPC2 by adsorbing miR-154-5p, thereby participating in oxidative stress and inflammatory responses in DN. This study elucidated a novel mechanism of RAD51-AS1/miR-154-5p/MPC2 axis in DN pathogenesis, providing potential theoretical basis and new targets for therapy of DN.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"737-748"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13493087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148317884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Betaine Supplementation Increases Creatinine Clearance and Upregulates MAS and AT2 Receptor Expression in Spontaneously Hypertensive Rat Kidneys.","authors":"Mateusz Koper, Kinga Jaworska, Wojciech Kopacz, Emilia Samborowska, Marcin Ufnal","doi":"10.1159/000552883","DOIUrl":"10.1159/000552883","url":null,"abstract":"<p><strong>Introduction: </strong>Hypertension contributes to renal dysfunction, partly through dysregulation of the renin-angiotensin system (RAS). Betaine, an osmolyte that helps maintain medullary osmotic gradients, has demonstrated renoprotective effects in models of nephrotoxicity. Previously, we showed that acute betaine administration increases diuresis - more pronounced in spontaneously hypertensive rats (SHRs) than in normotensive Wistar-Kyoto rats - without affecting blood pressure. In this study, we investigated the effects of chronic betaine supplementation on SHR renal function.</p><p><strong>Methods: </strong>Six-week-old male SHRs received either 0.5% betaine in drinking water or tap water for 16 weeks. Hemodynamics, serum and urine biochemistry, and renal mRNA expression of RAS components and betaine transporters (SLC6A12, SLC6A20) were assessed.</p><p><strong>Results: </strong>Betaine-treated SHRs demonstrated higher creatinine clearance without significant changes in arterial blood pressure. Renal expression of angiotensinogen and AT1B receptor was reduced, while MAS and AT2 receptor expression increased. Transporter expression showed region-specific regulation: cortical SLC6A20 and medullary SLC6A12 were lower in betaine-treated rats, whereas medullary SLC6A20 was higher.</p><p><strong>Conclusion: </strong>Chronic betaine supplementation was associated with increased creatinine clearance and a renal RAS mRNA profile shifted toward MAS and AT2 receptor predominance. These findings support further investigation of betaine as a potential strategy for early prevention of hypertensive kidney injury. However, direct evidence of improved glomerular filtration and functional activation of protective RAS pathways is still needed.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"648-657"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13450977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148330604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Pre-Dialysis Fluid Overload, Intradialytic Relative Blood Volume Levels, and Cumulative Ultrafiltration Volume on Pulse Wave-Derived Features during Hemodialysis: Results from a Longitudinal Cohort Study.","authors":"Simon Krenn, Leszek Pstras, Sebastian Mussnig, Amelie Kurnikowski, Siegfried Wassertheurer, Manfred Hecking, Christopher Clemens Mayer","doi":"10.1159/000552495","DOIUrl":"10.1159/000552495","url":null,"abstract":"<p><strong>Introduction: </strong>Arterial pulse wave-derived features (PWFs) reflect hemodynamic changes during hemodialysis, and while their use is not currently recommended by clinical practice guidelines, many PWFs are associated with patient outcomes beyond classical blood pressure measurements. Pre-dialysis fluid overload (FO), intradialytic relative blood volume (RBV), and cumulative ultrafiltration volume (cUFV) may influence PWFs, but these relationships remain incompletely characterized. We aimed to explore associations between FO, RBV, cUFV, and PWFs during hemodialysis.</p><p><strong>Methods: </strong>We analyzed 79 hemodialysis sessions in 24 patients over 5 weeks. Each session included pre-dialysis bioimpedance spectroscopy, cuff-based pulse wave measurements every 15 min, and continuous RBV/cUFV monitoring. Associations between RBV or cUFV and 28 PWFs (including blood pressure measures, parameters of cardiac function, and various arterial wave features derived from pulse wave analysis) were assessed using confounder-adjusted generalized estimating equations. Repeated-measures correlation analysis evaluated within-patient associations between pre-dialysis FO and both initial PWF levels (median from the first 45 min) and their intradialytic changes (late minus early 45-min median).</p><p><strong>Results: </strong>We analyzed 817 pulse wave measurements from 24 patients (21 men; median age 66 years). Overall, RBV was associated with 18/28 PWFs (64%) and cUFV with 10/28 (36%), with distinct patterns: independently of each other, RBV was associated mainly with stroke volume, cardiac output, heart rate, systolic and reflected intensity peaks, and excess pressure; cUFV mainly with diastolic blood pressure, peripheral resistance, reservoir pressure, and the ratio of forward intensity peaks. Significant early-to-late intradialytic changes in PWFs included a decrease in stroke volume, reflection coefficient, and cardiac output, as well as an increase in pulse pressure amplification and reflected intensity peak. Among initial PWF levels, only the excess pressure integral correlated with pre-dialysis FO; however, FO correlated positively with intradialytic changes in systolic and mean blood pressure, pulse wave velocity, and reservoir pressure, indicating attenuated decreases in these parameters when baseline fluid excess was higher.</p><p><strong>Conclusion: </strong>In the studied cohort, RBV and cUFV showed distinct association profiles with PWFs during hemodialysis. These relationships warrant consideration in studies assessing or intervening on PWFs in dialysis patients.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"378-393"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13286474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147930884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kidney Dysfunction-Associated Intracerebral Haemorrhage: Global Trends and Regional Disparities (1990-2021).","authors":"Lili Tang, Hu Jiang, Hongtao Zhang, Weiwei Wan, Lingting Zang, Xiaoyue Li, Qiang Wu","doi":"10.1159/000552469","DOIUrl":"10.1159/000552469","url":null,"abstract":"<p><strong>Introduction: </strong>Kidney dysfunction is an increasingly recognized risk factor of intracerebral haemorrhage (ICH), but its global burden remains underexplored. This study systematically evaluated the burden, trends, health disparities, and future projections related to kidney dysfunction-associated ICH (KD-ICH) from 1990 to 2021.</p><p><strong>Methods: </strong>Data were extracted from the Global Burden of Disease Study 2021. We estimated deaths, disability-adjusted life years (DALYs), and age-standardized mortality (ASMR) and DALY rates (ASDR) across sex, age, region, and sociodemographic index (SDI) strata. Temporal trends were analysed using the estimated annual percentage change. Health inequality was assessed using the Slope Index of Inequality (SII) and concentration index. Future projections to 2040 were generated using ARIMA models.</p><p><strong>Results: </strong>Between 1990 and 2021, the absolute burden of KD-ICH increased significantly, with deaths rising from 241,229 to 329,737 and DALYs increasing from 6.23 million to 8.05 million, despite a decline in global ASMR and ASDR. Older adults, especially those aged 60-79 years, and males were disproportionately affected. Nearly 75% of the global burden was concentrated in low-, middle-low-, and middle-SDI regions, which also experienced slower declines in ASR burden. The SDI and the KD-ICH burden were strongly negatively correlated, and healthy inequality metrics confirmed persistent and widening global disparities. The ARIMA model projected a continued decline in age-standardized burden through 2040.</p><p><strong>Conclusion: </strong>The growing absolute burden and pronounced health inequities of KD-ICH highlight the need for context-specific prevention strategies, improved chronic disease management, greater health system investment, and equitable allocation of resources to address disparities and mitigate the future burden of KD-ICH.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"614-636"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13427322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148042574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clarifying Molecular Mechanisms and Novel Strategies for Intervention of Uremia and Cognitive Decline.","authors":"Yang Liang, Lingyan Ren, Misbah Ullah Khan, Yu Deng","doi":"10.1159/000550688","DOIUrl":"10.1159/000550688","url":null,"abstract":"<p><strong>Background: </strong>Uremia is now considered to be one of the most relevant causes of dementia, but at that time, it was defined as a sign of the failure of the kidney. The condition of CKD patients is cognitive impairment, which sometimes progresses to dementia; that condition was mentioned very often in cases on dialysis. However, it is still uncertain whether uremia is directly connected with cognitive dysfunction.</p><p><strong>Summary: </strong>More recent studies indicate that factors associated with uremic toxicity are affected by changes in protein and metabolic waste products in plasma along with inflammatory cytokines. The presence of these toxins, inflammation, oxidation damage, and alteration in vascular properties of the brain could at least affect the quality of neuronal integrity in the affected cerebral system. This review provides an overview of molecular aspects contributing to neuro-cognition in uremia about the brain's vulnerability to exposure to toxins. Emerging treatment strategies include prevention by way of biomarker identification and early intervention in addition to the help of innovative imaging approaches as well as precision medicine strategies. Certainly, regarding the problem of cognitive impairment, one can discuss the creation of new therapeutic approaches, which include the queries of neuroprotective drugs and the improvement of the methods of hemodialysis and renal transplantation.</p><p><strong>Key messages: </strong>This study calls for a multifaceted approach to both the understanding and treatment process of cognitive decline in uremic patients, bridging nephrology with neurology and proposing future directions for research and practice.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"245-263"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13175540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147690914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Statement.","authors":"","doi":"10.1159/000552330","DOIUrl":"https://doi.org/10.1159/000552330","url":null,"abstract":"<p><p>The article \"Impact of Renal Artery Stenosis on Renovascular Hypertension and the Therapeutic Role of Renal Artery Stenting: A Comprehensive Review\" [Kidney Blood Press Res. 2025; https://doi.org/10.1159/000545135] by Changgang Shao, Guoqing Chi, Fang Li, Hongcheng Ren, Liyan Zhang, Jinming Yang, Bin Wang and Mingchao Ding has been retracted by the Publisher and the Editor.After peer review, the accepted, unedited manuscript was published online as Early View. The authors did not respond to our requests and communication regarding the production process of their article despite extensive attempts at contact. As the article has not been approved by the authors for publication, we cannot publish the final version. To avoid confusion for readers we are retracting the Early View accepted, unedited manuscript.The authors did not respond to correspondence about the retraction.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":"51 1","pages":"364"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148265231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simplified Subjective Global Assessment at Hemodialysis Initiation and Its Association with 2-Year Mortality and Hospitalization.","authors":"Kotaro Doi, Kana Suzuki, Mikie Imafuku, Yohei Komaru, Teruhiko Yoshida, Ryo Matsuura, Masaomi Nangaku, Yoshifumi Hamasaki","doi":"10.1159/000553346","DOIUrl":"10.1159/000553346","url":null,"abstract":"<p><strong>Introduction: </strong>Nutritional risk assessment, which is necessary for initiating appropriate nutritional therapy to improve prognosis, should be as simple as possible to perform, particularly when direct patient contact is limited. We examined whether simplified Subjective Global Assessment (SGA), a modified SGA method omitting physical examination components, is associated with prognosis in patients with kidney failure starting hemodialysis (HD).</p><p><strong>Methods: </strong>Retrospectively, we reviewed the medical records of patients who initiated HD between 2016 and 2018. Based on these records, two dialysis nurses independently assessed each patient's nutritional status using simplified SGA and categorized them as well-nourished (W) or malnourished (M). Patients were classified into 3 groups (W-W, W-M, and M-M) according to the combination of the 2 assessments. The primary composite outcome was death or hospitalization within 2 years.</p><p><strong>Results: </strong>A total of 138 patients starting HD (mean age 66.8 years; 70% male) were examined. According to simplified SGA, 97 (70%), 25 (18%), and 16 (12%) patients were categorized respectively as W-W, W-M, and M-M. Kaplan-Meier analysis showed significantly lower survival and hospitalization-free rates in the M-M group (p < 0.001 and = 0.024, respectively). Cox proportional hazards analysis demonstrated significant association between the M-M category and the primary outcome (hazard ratio 3.34, 95% confidence interval 1.52-7.36).</p><p><strong>Conclusion: </strong>Simplified SGA scores might be associated with 2-year adverse outcomes in patients starting HD.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"685-694"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13461122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148339003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Anticomplement Drugs in Nephrology: Mechanism and Indication.","authors":"Lucia Macciò, Elisa Russo, Francesca Costigliolo, Yuri Battaglia, Francesca Viazzi, Pasquale Esposito","doi":"10.1159/000551965","DOIUrl":"10.1159/000551965","url":null,"abstract":"<p><strong>Background: </strong>The complement system is a key component of innate immunity, critical for pathogen defense, inflammation, and immune regulation. Dysregulation or overactivation of complement pathways contributes to the pathogenesis of numerous kidney diseases, including atypical hemolytic uremic syndrome, C3 glomerulopathy, membranous nephropathy, systemic lupus erythematosus, antiphospholipid antibody syndrome, ANCA-associated vasculitis, diabetic nephropathy, and focal segmental glomerulosclerosis. In these conditions, uncontrolled complement activation drives renal inflammation, microvascular injury, and fibrosis.</p><p><strong>Summary: </strong>Recent advances in complement biology have enabled the development of targeted anticomplement therapies. These include C5 inhibitors (eculizumab, ravulizumab, crovalimab, nomacopan), C3 inhibitors (pegcetacoplan), factor B and D inhibitors (iptacopan, danicopan, vemircopan), C5a receptor antagonists (avacopan), and MASP-2 inhibitors (narsoplimab). This review outlines their mechanisms of action, current clinical indications, and evidence from clinical trials and real-world experience. It also addresses challenges such as safety, cost, and optimization of treatment strategies, while considering future directions in biomarker-driven, personalized approaches.</p><p><strong>Key messages: </strong>Anticomplement therapies represent a transformative advance in nephrology, offering targeted interventions that can improve outcomes for patients with complement-mediated kidney diseases. Their strategic use may reduce disease progression, manage inflammation, and mitigate organ damage, highlighting the potential of personalized treatment approaches in complement-driven renal disorders.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"365-377"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13271687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147654399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measurement of Skinfold Thickness in Subscapular Area to Monitor Hydration Status in Chronic Hemodialysis Patients.","authors":"Katarzyna Pęczek-Bartyzel, Piotr Pęczek, Aleksandra Marczyk, Laura Lis, Bruno Łubiński, Aleksandra Turek, Michał Nowicki","doi":"10.1159/000548108","DOIUrl":"10.1159/000548108","url":null,"abstract":"<p><strong>Introduction: </strong>Maintaining fluid balance is one of the major challenges of the dialysis therapy. It includes, in particular, the management of \"dry body mass.\" We postulated that simple measurement of subscapular skinfold thickness before and after hemodialysis could help monitor hydration status in chronic dialysis patients. The aim of the study was to compare the conventional methods of monitoring hydration status during hemodialysis with an assessment of skinfold thickness.</p><p><strong>Methods: </strong>A total of 50 participants (21 F, 29 M; age 60 ± 15 years) were enrolled. Directly before the hemodialysis session, the following parameters were measured: body composition with bioimpedance spectroscopy, skinfold thickness in subscapular area with standardized caliper and blood tests - blood count, urea, n-terminal pro-B-type natriuretic peptide (nt-proBNP), and pro-adrenomedullin. The procedures were repeated at the end of three consecutive hemodialysis sessions.</p><p><strong>Results: </strong>The mean change of skinfold thickness in subscapular area before and after hemodialysis session was -2.2 ± 1.6 mm. A significant correlation was found between the change of extracellular water volume and skinfold thickness before and after hemodialysis (r = 0.33; p = 0.02) and between the change of total water volume and body mass before and after hemodialysis (r = 0.49; p < 0.01). There was also a positive correlation between the change of skinfold thickness and systolic blood pressure before and after a hemodialysis session (R = 0.36; p = 0.01). Dialysis vintage correlated significantly with the changes of plasma nt-proBNP level during hemodialysis (r = 0.40; p = 0.02). Multivariate analysis revealed that baseline body mass, BMI, changes of systolic blood pressure determined the variability of skinfold thickness during hemodialysis. Receiver operating curve analysis revealed that BIA spectrometry was more sensitive and specific than the skinfold thickness assessment for the assessment of hydration condition.</p><p><strong>Conclusion: </strong>The simple measurements of skinfold in subscapular area may approximate changes of hydration status but are inferior to BIA spectroscopy. Further research is needed to confirm the utility of this method in monitoring blood pressure control in dialysis patients.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"1-9"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12757109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145648826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}