Nanocarrier-Based Drug Delivery Systems Targeting Kidney Diseases.

IF 2.3 4区医学 Q2 PERIPHERAL VASCULAR DISEASE

Kidney & blood pressure research Pub Date : 2024-10-15 DOI:10.1159/000541848

Laura Zucaro, Consiglia Longobardi, Antonio Miele, Antonio Villanova, Yoko Suzumoto

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引用次数: 0

Abstract

Background: The potential applications of nanotechnology in the medical field have become increasingly recognized in recent years. Nanocarriers have emerged as a versatile tool, offering a wide range of applications due to their unique properties. In addition to the targeted drugs delivery, nanocarriers have also proven to be extremely effective in imaging and diagnostics. Continuous advances in nanotechnology have paved the way for innovative solutions to complex challenges in human health, shaping the future of nanotechnology and its applications.

Summary: By exploring different types of nanoparticles, this review delves into the different characteristics that can be tailored to enhance their kidney access. Although the structural complexity of the kidney may prevent nanocarriers passage, optimization of nanocarrier characteristics such as shape, size, charge, and surface modifications may overcome these barriers, allowing for targeted delivery. By harnessing the potential of nanoparticles, researchers aim to develop targeted and efficient therapies that can address various kidney-related disorders.

Key messages: This review highlights the promising advancements in nanotechnology and their potential impact on improving the therapeutic outcomes for several kidney diseases.

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针对肾脏疾病的纳米载体给药系统。

背景：近年来，人们越来越认识到纳米技术在医疗领域的潜在应用。纳米载体是一种多功能工具，由于其独特的性质，可提供广泛的应用。除靶向给药外，纳米载体还被证明在成像和诊断方面极为有效。纳米技术的不断进步为人类健康面临的复杂挑战提供了创新解决方案，塑造了纳米技术及其应用的未来。摘要：通过探索不同类型的纳米颗粒，本综述深入探讨了可量身定制的不同特性，以增强其肾脏通路。虽然肾脏结构的复杂性可能会阻碍纳米载体的通过，但优化纳米载体的形状、大小、电荷和表面修饰等特性可以克服这些障碍，实现有针对性的递送。通过利用纳米颗粒的潜力，研究人员旨在开发出有针对性的高效疗法，以解决各种与肾脏有关的疾病：本综述重点介绍了纳米技术的发展前景及其对改善多种肾脏疾病治疗效果的潜在影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Kidney & blood pressure research 医学-泌尿学与肾脏学

CiteScore

4.80

自引率

3.60%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal comprises both clinical and basic studies at the interface of nephrology, hypertension and cardiovascular research. The topics to be covered include the structural organization and biochemistry of the normal and diseased kidney, the molecular biology of transporters, the physiology and pathophysiology of glomerular filtration and tubular transport, endothelial and vascular smooth muscle cell function and blood pressure control, as well as water, electrolyte and mineral metabolism. Also discussed are the (patho)physiology and (patho) biochemistry of renal hormones, the molecular biology, genetics and clinical course of renal disease and hypertension, the renal elimination, action and clinical use of drugs, as well as dialysis and transplantation. Featuring peer-reviewed original papers, editorials translating basic science into patient-oriented research and disease, in depth reviews, and regular special topic sections, ''Kidney & Blood Pressure Research'' is an important source of information for researchers in nephrology and cardiovascular medicine.