Kidney & blood pressure research最新文献

{"title":"Association of Renal Function Deterioration with Baseline Uricosuria.","authors":"Amnon Gil, Daniel Kushnir, Victor Frajewicki","doi":"10.1159/000548605","DOIUrl":"https://doi.org/10.1159/000548605","url":null,"abstract":"<p><p>Introduction Previous studies have found a relative risk of 1.6-2 for renal function deterioration with serum uric acid (UA) level increment. However, the association between the baseline urinary uric acid (UUA) level and renal function decline remains unclear, and we aimed to assess this association. Methods In this retrospective cohort-controlled study, we included patients who met the following inclusion criteria: age > 18 years, the presence of at least one UUA level in their electronic medical records (EMR), and two eGFR values. The exclusion criteria were chronic dialysis treatment before the baseline eGFR or any history of kidney transplantation. The EMR of the patients have been retrospectively screened between 31st December 2001 and 31st January 2022. The study group consisted of patients with UUA levels of ≥750 mg/day. In the control group, we included patients whose every UUA level was <750 mg/day. The primary endpoint was a composite of eGFR decline of ≥50%, eGFR <15 mL/min, dialysis initiation, or death. Secondary endpoints were as follows: eGFR decline of ≥50%, the latest eGFR <15 mL/min, or death. The endpoints were compared between the groups by Cox proportional hazards model analysis. Results We included 480 patients in the study group and 2,998 in the control group. The primary end point was observed in 30.95% and 16.25% of participants in the control and study groups, respectively; however, after it was compared between the two groups using the Cox model, there was no significant difference (HR 1.20, 95% CI: 0.96-1.51, p = 0.11). Similarly, no significant differences in the rates of secondary endpoints between the two groups were observed, except the difference between the eGFR declines >50% which was significant, as was observed by the Cox model (HR 2.22, 95% CI: 1.47-3.37, p < 0.001). Conclusion There was no significant difference in the rate of the composite endpoint between the study and control groups. Kidney function deterioration (as measured by eGFR decline of ≥50%) was significantly higher among patients with baseline hyperuricosuria (UUA ≥750 mg/day) than in those with normal uricosuria, as was observed by the Cox model. Further prospective studies are needed to clarify the role of uricosuria in renal function deterioration.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"1-13"},"PeriodicalIF":2.1,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Admission blood gas variables and electrolytes in predicting significant endpoints in ICU patients with emerging acute kidney injury.","authors":"Baschar Khader, Rebecca Lehmann, Benedikt Marahrens, Oliver Ritter, Daniel Patschan","doi":"10.1159/000548324","DOIUrl":"https://doi.org/10.1159/000548324","url":null,"abstract":"<p><p>Introduction Acute kidney injury (AKI) is a prevalent issue in intensive care units (ICUs). There is a paucity of data regarding the use of blood gas and electrolyte measurements in predicting the risk of significant endpoints (kidney replacement therapy, death) in emerging, yet undiagnosed AKI. Methods Retrospective, observational, single-center study. The study documented 4 admission electrolytes (serum sodium, potassium, ionized calcium, and phosphate) and 3 admission blood gas variables (arterial pH, actual bicarbonate, pCO2). The endpoints of the study were the need for kidney replacement therapy (KRT) and death in the ICU. Results A total of 213 patients were included in the study. The ICU mortality rate was 31%, and 22.5% of all subjects required at least one individual KRT session. There were significant differences in admission serum sodium and phosphate levels between survivors and non-survivors (both lower in survivors), and in arterial pH and actual bicarbonate levels (both higher in survivors). The majority of all tested variables were identified as independent predictors of either the need for KRT or ICU death. Conclusions Integrating admission electrolytes and blood gas variables may potentially aid in identifying subsets of acute kidney injury (AKI) patients at risk of death.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"1-17"},"PeriodicalIF":2.1,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High serum phosphate promotes cognitive impairment in uremia rats via mediating vascular calcification.","authors":"Damei Li, Kang Xun, Miao Jia, Shaobo Sun, Qian Wu, Weijiang Wu, Donghua Jin","doi":"10.1159/000548490","DOIUrl":"https://doi.org/10.1159/000548490","url":null,"abstract":"<p><strong>Introduction: </strong>Cognitive impairment (CI) is common in patients with end-stage renal disease (ESRD), but the mechanism of uremia-associated CI is poorly recognized.</p><p><strong>Methods: </strong>In this study, we constructed uremia rat models, treated with high level phosphate (Pi) and vascular calcification inhibitor sodium thiosulphate (STP). Assessed the spatial learning and memory by Morris Water Maze (MWM), detected the vascular calcification (VC) by histological staining and monitored the osteogenic factors ALP and Runx2 expressions in Uremia + Pi and Uremia + Pi + STP rats through qPCR, Western blotting analysis and Immunohistochemistry analysis. Moreover, we examined the calcium content, and the ALP and Runx2 expressions in VSMCs treated with Pi and STP.</p><p><strong>Results: </strong>The results showed that both the learning and memory abilities and the spatial exploration ability of the rats in Uremia + Pi group were significantly decreased with enhanced expressions of ALP and Runx2, calcium content and ALP activity, however, STP supplementation significantly alleviated the spatial learning and memory damage, reduced the ALP and Runx2 expressions, calcium content and ALP activity. Moreover, Pi treatment significantly increased the calcium and MDA content in VSMCs, and ALP and Runx2 expressions, STP addition reversed these changes, indicating high phosphate level induced VC development.</p><p><strong>Conclusion: </strong>Taking together, these results indicated that elevated serum phosphate might promote VC in uremic rats by activating the expressions of ALP and Runx2, thereby causing damages to the kidneys and complications of uremia such as CI. Therefore, this study improved understanding to possible pathogenic mechanisms of uremia-induced CI, and will be beneficial to optimize the prevention and treatment strategy for CI in uremia patients.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"1-24"},"PeriodicalIF":2.1,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality of patients with heart diseases and unplanned start of maintenance hemodialysis in the city of São Paulo, Brazil.","authors":"Farid Samaan, Luiz Minuzzo, Amanda Paz Loca, Amanda Souza Dias, Isabel Longo Oliveira Monteiro, Karla Lorena Campos Gonçalves, Larissa Moreira Rochel, Lina Ahamad Melhim, Veronica Paduam, Vitoria Falotico Ottoni Oliveira, Yara Lopes Souza Costa, Lucas Petri Damiani, Kleber Gomes Franchini, Fausto Feres, Gianna Mastroianni Kirsztajn, Ricardo Sesso","doi":"10.1159/000548462","DOIUrl":"https://doi.org/10.1159/000548462","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic kidney disease worsens the prognosis of cardiovascular disease (CVD) and vice versa. This study aimed to evaluate the mortality of patients with a high CVD burden and unplanned start of maintenance hemodialysis (HD).</p><p><strong>Methods: </strong>A retrospective study was performed at a tertiary cardiological hospital in São Paulo, Brazil. Hospitalized patients ≥18 years old were identified by the public chronic kidney replacement therapy (KRT) regulatory system between 01/01/2014 and 12/31/2018. In-hospital and post-discharge mortality, along with associated risk factors, were assessed. Death information up to December 31, 2022, was obtained from the state of São Paulo mortality database.</p><p><strong>Results: </strong>302 patients with unplanned start of HD were included. The mean age was 65±13 years old; 68% were male. The heart conditions were as follows: 60% chronic heart failure, 27% coronary artery disease, 13% arrhythmia, and 7% valve disease. Comorbidities included: 93% hypertension, 62% diabetes, 31% dyslipidemia, and 27% known CKD. The mortality rate (deaths per 100 patient-years) was 71.4 between 0 and 3 months, 23.0 between 3 and 12 months, and 39.5 over the entire 0-to-12-month period. The factors independently associated with in-hospital death were age, heart valve disease, chronic obstructive pulmonary disease, positive serology for hepatitis B, and need for HD catheter replacement. The factors associated with post-discharge death (mean±SD follow-up: 6.4±1.4 years) were age, presence of two or more heart diseases, and HD catheter-related infection.</p><p><strong>Conclusion: </strong>Patients with a high burden of cardiovascular morbidity and an unplanned start of HD exhibit elevated mortality rates. Some factors independently related to poorer outcomes, such as HD catheter-related complications, could potentially be mitigated through adequate pre-dialysis care.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"1-23"},"PeriodicalIF":2.1,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between sleep duration trajectory and risk of chronic kidney disease: A 9-year follow-up survey in China.","authors":"Chunyan Qin, Zhenghua Li, Ting Jiang, Huan Feng, Jinhua Feng, Haijie Hu","doi":"10.1159/000548489","DOIUrl":"https://doi.org/10.1159/000548489","url":null,"abstract":"<p><strong>Background: </strong>Limited studies have explored the link between sleep duration and chronic kidney disease (CKD). However, the longitudinal alteration of sleep duration over time, known as sleep duration trajectories, have not been well explored. This gap results in an unclear understanding of the relationship between sleep duration trajectories and the risk of developing CKD, which is addressed in this study.</p><p><strong>Methods: </strong>Based on longitudinal data from the China Health and Retirement Longitudinal Study (2011, 2013 and 2015 waves), a group-based trajectory model was used to identify distinct patterns of sleep duration. Cox proportional hazards model was employed to assess the hazard ratios associated with each trajectory in relation to CKD onset (2018, and 2020 waves). Additionally, interaction analysis was conducted to examine potential individual-level modifiers of the relationship between sleep duration trajectories and CKD onset. Three different sensitivity analyses were performed to ensure the robustness of the findings.</p><p><strong>Results: </strong>A total of 11,059 individuals were included in this survey with three distinct sleep duration trajectories identified: Group 1 (Mean sleep duration: 3.56 ± 1.32), Group 2 (Mean sleep duration: 5.83 ± 1.36) and Group 3 (Mean sleep duration: 7.70 ± 1.17). Group 1 showed the highest risk of developing CKD, with an incidence of 10.54 cases per 1,000 person-years (95% confidence interval 8.77-12.68). Relative to group 1, group 3 was significantly associated with a reduced risk of CKD (hazard ratio 0.55, 95% confidence interval 0.44-0.70). A notable decrease in CKD risk was observed across all subgroups, and no significant interaction effects were found between covariates and the association between sleep duration trajectory and CKD.</p><p><strong>Conclusions: </strong>Among middle aged and elderly adults, persistent long sleep duration was associated with a lower risk of CKD. Maintaining adequate and stable sleep duration may be beneficial for CKD risk management in this population. However, further evidence is required to inform definitive public health recommendations.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"1-29"},"PeriodicalIF":2.1,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poor exercise capacity and elevated N-terminal prohormone of brain natriuretic peptide in the prediction of long-term cardiovascular events and mortality in advanced chronic kidney disease - The CADKID study.","authors":"Noora Manni, Markus Hakamäki, Niilo Liuhto, Roosa Lankinen, Jonna Virtanen, Tomi Toukola, Jussi P Pärkkä, Kaj Metsärinne, Mikko J Järvisalo, Tapio Hellman","doi":"10.1159/000548172","DOIUrl":"https://doi.org/10.1159/000548172","url":null,"abstract":"<p><p>Introduction Chronic kidney disease (CKD) is an important risk factor for cardiovascular disease and mortality. However, data on the prediction of long-term adverse outcomes in advanced predialysis CKD patients is lacking. Methods We studied the factors associated with mortality and major adverse cardiovascular and cerebrovascular events (MACCE, including cardiovascular death, myocardial infarction, stroke and coronary revascularization) in a cohort of 210 patients with non-dialysis CKD stage 4-5 during a five-year follow-up. The participants underwent stress ergometry testing to study maximal exercise capacity (Wmax%), a plain lateral abdominal radiograph to study abdominal aortic calcification score (AAC) and laboratory tests including cardiac troponin T (TnT) and N-terminal pro-B-type natriuretic peptide (ProBNP). Furthermore, a dichotomous composite covariate was created and explored by combining ProBNP and Wmax% using the cut-offs determined with the Youden index. The associations between covariates of interest and study outcomes were explored using multivariable Cox proportional hazards models adjusted with age, sex, coronary artery disease (CAD) and incident kidney transplantation (KTx). Results Median age at baseline was 65 (52-73) years and eGFR 12 (10-15) ml/min/1.73 m2, 34.8 % were female and 44.8 % had diabetes. Altogether 67 (31.9 %) patients died during follow-up and 65 (31.0%) were observed with a MACCE. In separate multivariable Cox proportional hazards models adjusted for age, gender, CAD and KTx, Wmax% (HR 0.983 [95 % CI: 0.968-0.999], p=0.019), TnT (HR 1.004 [95 % CI: 1.002-1.005], p<0.001 and) and ProBNP (HR 1.036 per 1000 ng/l [95 % CI: 1.014-1.059], p=0.002 were independently associated with mortality. In similarly adjusted multivariable Cox models Wmax% (HR 0.977 [95 % CI: 0.962-0.992], p=0.003), TnT (HR 1.004 [95 % CI: 1.002-1.005], p<0.001) and ProBNP (HR 1.034 per 1000 ng/l [95 % CI: 1.010-1.058], p=0.006) were independently associated with the occurrence of MACCE during follow-up. AAC was associated with the risk of an incident MACCE (HR 1.080 [95% CI 1.028-1.135], p=0.002) but, surprisingly, not with mortality (HR 1.046 [95% CI 0.994-1.101], p=0.083). Finally, in participants with Wmax ≤50 % and ProBNP ≥1270 ng/l the risk of mortality (HR 8.760 [95 % CI: 4.730-16.222], p<0.001) and MACCE (HR 3.293 [95 % CI: 1.850-5.862], p<0.001) was significantly greater than those with Wmax>50% and/or ProBNP <1270 ng/L. Conclusion Wmax% and ProBNP separately and together as a composite risk factor may serve as important predictors of long-term all-cause mortality and MACCE in patients with CKD stage 4-5 not undergoing dialysis at baseline.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"1-25"},"PeriodicalIF":2.1,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcium‒Phosphorus Metabolism in Chronic Kidney Disease and Its Relationship with Vascular Calcification.","authors":"Lei Ran, Xiaoxi Wu, Li Guo, Yapu Zhang, Lei Wang, Tingting Cai, Youlan Gong","doi":"10.1159/000548408","DOIUrl":"https://doi.org/10.1159/000548408","url":null,"abstract":"<p><strong>Objective: </strong>To explore bone metabolism in chronic kidney disease (CKD) and its correlation with nutritional indicators and to identify risk factors for abdominal aortic calcification (AAC).</p><p><strong>Methods: </strong>This cross-sectional study enrolled 148 adults (>18 years) with CKD stages 3-5 (stage 3: n=13, stage 4: n=15, stage 5: n=120 including dialysis and non-dialysis patients) between May 2018 and May 2021. Participants met strict criteria: confirmed CKD diagnosis per Kidney Disease Outcomes Quality Initiative guidelines, stable nutritional status without malabsorption disorders and no vitamin K antagonist use. Exclusion criteria included acute kidney injury, transplant recipients, malignancies and thyroid/parathyroid disorders. Using convenience sampling, we assessed correlations between nutritional/mineral markers via Pearson's analysis and identified intima-media thickness (IMT)/AAC risk factors through binary logistic regression.</p><p><strong>Results: </strong>Positive correlations were observed between serum calcium and 25-hydroxyvitamin D (25-[OH]D), haemoglobin, albumin (Alb), prealbumin (PAlb) and serum magnesium. Negative correlations were found with blood urea nitrogen (BUN), serum creatinine (SCr), the estimated glomerular filtration rate (eGFR), serum phosphorus and intact parathyroid hormone (iPTH). Serum phosphorus was positively correlated with BUN, SCr, uric acid, cystatin C (CysC), calcium-phosphate product (Ca×P), iPTH, PAlb and serum magnesium and negatively correlated with eGFR and 25-(OH)D. Parathyroid hormone levels were positively correlated with BUN, SCr, CysC, Ca×P, Alb and PAlb and negatively correlated with eGFR and 25-(OH)D. Logistic regression identified age, sex, and diabetes as independent risk factors for IMT, and age, dialysis vintage and low Alb as risk factors for AAC. Significant differences in AAC were found for sex, dialysis vintage, cholesterol, high-density lipoprotein and serum calcium levels.</p><p><strong>Conclusion: </strong>Calcium‒phosphorus metabolism plays a role in vascular calcification in CKD, with age, diabetes, dialysis vintage, lipid levels, and low Alb levels contributing to this process.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"1-20"},"PeriodicalIF":2.1,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimated dietary Na+/K+ -ratio and cardiovascular disease: a systematic review and meta-analysis.","authors":"Charlotte L Zwager, Malik I Esseghir, Anne Myrthe C van Vliet, Joost G Daams, Liffert Vogt, Rik H G Olde Engberink","doi":"10.1159/000548424","DOIUrl":"https://doi.org/10.1159/000548424","url":null,"abstract":"<p><p>Introduction High sodium and low potassium intake are associated with cardiovascular disease. This meta-analysis investigates the combined effect of dietary sodium and potassium intake (Na/K-ratio), on cardiovascular outcome. Methods We systematically searched MEDLINE and EMBASE databases (1946 - 2024) for randomized controlled trials and cohort studies reporting the association between estimated dietary Na/K-ratio and cardiovascular events or mortality in adults. Two authors independently screened articles, extracted data, and assessed risk of bias (ROBINS-E tool). We pooled results using random-effects models and compared outcomes across the general population, patients with chronic kidney disease, and those with a history of cardiovascular disease. The study was registered in PROSPERO (ID: CRD42024450279). Results Twenty-four studies were included. Participants were 59±11 years old, 49±22% were men and the estimated dietary Na/K-ratio was 2.0±0.6 mmol/mmol. The risk of bias was low in 9% of the studies, high in 39% of the studies and 52% of the studies were appraised as some concerns. Higher estimated dietary Na/K-ratio was associated with a higher risk for cardiovascular events and mortality (HR 1.10 [95% CI: 1.06-1.16]), which was apparent in the general population and subjects with a history of cardiovascular disease. In patients with chronic kidney disease, only limited data was available. Conclusion Higher estimated dietary Na/K-ratio is associated with an increased incidence of cardiovascular events and mortality in the general population and patients with a cardiovascular disease history.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"1-18"},"PeriodicalIF":2.1,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the correlation between serum lipid levels and disease activity in patients with systemic lupus erythematosus.","authors":"Lu Li, Lin-Lin Li, Yang Dong, Hui-Xia Cao, Lei Yan","doi":"10.1159/000548039","DOIUrl":"https://doi.org/10.1159/000548039","url":null,"abstract":"<p><p>Abstract： Background The pathogenesis of systemic lupus erythematosus (SLE) remains complex, and studies have found that abnormal lipid metabolism may be involved in the disease. Therefore, we aim to investigate the dyslipidemia in SLE patients and analyze the relationship between lipid metabolism and the disease activity. Methods 174 patients diagnosed with SLE were enrolled in Henan Provincial People's Hospital from December 2016 to September 2022. Clinical data and laboratory indicators were collected, and SLE patients were grouped according to the levels of serum lipid. SPSS 26.0 statistical software was used for comparative analysis of SLE patients. Results The prevalence of dyslipidemia was about 92.53% (161/174), mainly with decreased HDL (125/174, 77.64%) and increased TG (86/174, 53.42%). The lipids were positively correlated with inflammatory indexes, such as WBC, NEC, SII, NLR, LMR and so on. Furthermore, the blood lipid levels were significantly correlated with SLEDAI-2K, ESR, C3, C4, BUN, Scr and 24-hour urine protein(P<0.05). With the increasing types of dyslipidemia, the value of inflammatory indicators such as WBC and SII were higher, as well as the rate of kidney involvement. This is manifested by the elevation of renal function parameters such as BUN, Scr, eGFR and 24-hour urine protein levels, while the levels of IgG, total protein and albumin decrease accordingly. The area under the curve (AUC) values of TC, TG and LDL predicting LN were 0.759, 0.713 and 0.729, which provided 69.6%, 81.4% and 63.7% sensitivity, and 76.4%, 56.9% and 73.6% specificity, respectively. With an AUC of 0.771, the combined detection of TC, TG, HDL, and LDL exhibited a greater potential for discrimination than any separate measurements. Conclusions Dyslipidemia is prevalent among SLE patients, and the levels of lipid can be informative in predicting renal involvement in SLE. It is crucial to monitor lipid levels and inflammation indexes and take lipid-lowering therapy along the discourse of SLE. Keywords：systemic lupus erythematosus, dyslipidemia, albuminuria, inflammation.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"1-14"},"PeriodicalIF":2.1,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of GALNT14 as a Key Regulator of Ferroptosis in Cisplatin-Induced Acute Kidney Injury: A Potential Target for Kidney Injury Treatment.","authors":"Cheng Yuan, Yulu Ye, Yinjie Zhou, Lu Xu, Tingzhuang Yi, Lihua Ni","doi":"10.1159/000548252","DOIUrl":"https://doi.org/10.1159/000548252","url":null,"abstract":"<p><strong>Objective: </strong>Cisplatin-induced acute kidney injury (Cis-AKI) is a significant cause of renal damage, characterized by tubular injury, ferroptosis, and oxidative stress. While therapeutic options for Cis-AKI remain limited, identifying novel targets to prevent kidney injury is critical. This study focuses on GALNT14, a gene associated with ferroptosis, and its potential role in mitigating Cis-AKI.</p><p><strong>Methods: </strong>Differentially expressed genes (DEGs) between saline and cisplatin group were analyzed using Limma package. The weighted correlation network analysis (WGCNA) was performed to identify the co-expressed modules and hub genes associated with Cis-AKI. The hub genes were then put into String database to create a network of protein-protein interactions (PPI). The ferroptosis-related genes (FRGs) were obtained from the FerrDb database, which screening for ferroptosis associated with CiS-AKI. The role of GALNT14 was examined in vitro using HK-2 renal tubular cells and in vivo in a Cis-AKI murine model.</p><p><strong>Results: </strong>Totally, 1201 DEGs in intravenous (iv) administration group were retrieved. The 806 genes were obtained from intersection WGCNA and DEGs. Ultimately, we identified 4 genes (ALOX5, CD44, GALNT14 and ASNS) that may play important roles in the regulation of ferroptosis in CiS-AKI. Among them, the mRNA expression level of GALNT14 showed the most significant difference between Cis-AKI and the control group. In vitro, GALNT14 overexpression in HK-2 cells reduced renal injury and ferroptosis markers, including KIM1, NGAL, and FSP1, while increasing GPX4 expression. Conversely, silencing GALNT14 exacerbated Cis-AKI-induced injury. In vivo, GALNT14 overexpression in Cis-AKI mice attenuated kidney injury, reduced ferroptosis markers, and reversed pathological alterations such as tubular dilatation and loss of brush border.</p><p><strong>Conclusion: </strong>GALNT14 inhibits Cis-AKI by regulating tubular ferroptosis, demonstrating its potential as a therapeutic target for kidney injury. Our findings suggest that GALNT14 could be an effective strategy for preventing Cis-AKI and improving renal function in kidney injury-related diseases.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"1-23"},"PeriodicalIF":2.1,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}