Kidney & blood pressure research最新文献

{"title":"Clinical Features and Genetic Diversity of Primary Hyperoxaluria: A Case Series Analysis of Chinese Patients.","authors":"Yuxuan Yuan, Lijuan Li, Xiaoyu Wang, Erzhi Gao, Feng Xu, Zhen Cheng, Dongrui Cheng, Xuefeng Ni, Kenan Xie, Zhuo Shi, Caihong Zeng, ShaoShan Liang","doi":"10.1159/kbr/adjag021","DOIUrl":"https://doi.org/10.1159/kbr/adjag021","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to characterize the clinical features, genetic profiles, and outcomes of primary hyperoxaluria (PH) in a Chinese cohort.</p><p><strong>Methods: </strong>We retrospectively reviewed patients diagnosed with PH between 2008 and 2025 at our institution. Diagnosis was established through genetic analysis or histopathological findings combined with clinical manifestations and positive family history. Clinical, laboratory, genetic, imaging, histopathological, treatment, and outcome data were collected.</p><p><strong>Results: </strong>Thirteen patients were included (PH1, n=7; PH2, n=3; PH3, n=2; unclassified, n=1). Median ages at symptom onset and diagnosis were 7 and 21 years, respectively. Renal involvement manifested as urolithiasis (92.3%) and nephrocalcinosis (30.8%). At diagnosis, the overall median serum creatinine was 335 µmol/L, and the median 24-hour urinary oxalate excretion was 0.8 mmol/1.73m² (n = 6). Systemic oxalate deposition was observed in 30.8% of patients, predominantly affecting bone and heart. Five previously unreported genetic variants were identified. Treatment consisted of supportive care, with vitamin B6 for PH1. Over a median follow‑up of 13.0 years, 100% of PH1 and 66.7% of PH2 patients progressed to end-stage renal disease, with two infantile-onset PH1 patients demonstrating rapid progression; conversely, PH3 patients preserved renal function (chronic kidney disease stage 1). Three PH1 patients developed recurrent oxalate nephropathy following isolated kidney transplantation. The overall mortality was 15.4%.</p><p><strong>Conclusions: </strong>PH commonly presents with non-specific symptoms of urolithiasis, frequently resulting in diagnostic delay. PH1 is associated with a more severe clinical course than other subtypes, particularly in infantile-onset cases. This study expands the known genetic variant spectrum and underscores the importance of early genetic diagnosis.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"1"},"PeriodicalIF":2.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149194860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Host-Shaped Microbial Metabolite Signaling in the AKI-to-CKDTransition: Mechanisms and Therapeutic Boundaries.","authors":"Zhixuan Xu, Weipeng Chen, Feng Lu","doi":"10.1159/kbr/adjag015","DOIUrl":"https://doi.org/10.1159/kbr/adjag015","url":null,"abstract":"<p><p>Acute kidney injury (AKI) increases the subsequent risk of chronic kidney disease (CKD), but the transition is shaped by the quality of tubular repair rather than nephron loss alone. We frame the gut-kidney axis as a bidirectional host-microbial system in which AKI-related inflammation, impaired solute clearance, altered tubular transport, intestinal barrier dysfunction, medications, diet, and intestinal transit may redirect microbial metabolic output during recovery. Repair-disrupting candidates, including trimethylamine N-oxide (TMAO), indoxyl sulfate (IS), p-cresyl sulfate (PCS), and broader aromatic solute burden, are evaluated alongside repair-permissive candidates such as short-chain fatty acids (SCFAs), selected indoles, and bile acids; polyamines are treated as bidirectional and stage-dependent. We connect these exposures to mitochondrial recovery, cell-cycle arrest, senescence, immune recruitment, endothelial stress, and fibroblast activation, while distinguishing microbial production from host transformation, renal clearance, and tubular uptake. Direct human AKI-to-CKD evidence remains limited, and antibiotic-depletion studies cannot isolate a single metabolite pathway. Translational studies should therefore combine longitudinal blood, urine, and fecal profiling with AKI etiology, treatment exposures, tubular injury markers, spatial kidney biology, and target-engagement endpoints.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"1"},"PeriodicalIF":2.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149194856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between Metabolic indicators and chronic kidney disease in adults--a cohort analysis.","authors":"Dakai Sun, Caie Hou, Haoyang He, Zhixing Tao, Yongneng Li, Bo Chen, Zhidong Liu, Yunqiang Shi","doi":"10.1159/kbr/adjag014","DOIUrl":"https://doi.org/10.1159/kbr/adjag014","url":null,"abstract":"<p><strong>Introduction: </strong>In recent years, the correlation between metabolic disorders and chronic kidney disease (CKD) has received increasing attention. However, the association between metabolic markers and CKD risk remains unclear. This study was conducted among middle-aged and elderly Chinese adults to investigate the relationship between metabolism-related indicators and CKD.</p><p><strong>Methods: </strong>Data were obtained from the 2011 and 2015 waves of the China Health and Retirement Longitudinal Study (CHARLS). Participants with hemoglobin glycation index (HGI), weight-adjusted-waist index (WWI), and CKD at baseline, as well as those with incomplete data, were excluded, leaving a cohort of 3,414 participants (aged ≥45 years) who completed follow-up and were included in the longitudinal study. Logistic regression models were used to investigate the longitudinal relationships between baseline HGI and WWI and CKD prevalence.</p><p><strong>Results: </strong>During the 4-year follow-up period (2012-2015), 303 participants (8.9%) developed new-onset CKD. Results demonstrated a significant association between the HGI and CKD incidence. This positive correlation remained stable after further adjusting for all covariates in Model 3 (OR = 1.27, 95% CI: 1.05-1.53). Subgroup analyses confirmed consistent, robust associations between HGI and CKD across subgroups. Threshold effect analysis indicated a stronger association between HGI and CKD risk when population HGI values were < 0.333. Furthermore, no significant association was found between WWI and CKD incidence in this study.</p><p><strong>Conclusions: </strong>The findings of this study indicate that HGI is significantly positively correlated with the risk of developing CKD. Effective management of HGI levels may help reduce the prevalence of CKD.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"1"},"PeriodicalIF":2.1,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149137379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"U-shaped association of time-averaged cumulative diastolic blood pressure slope with mortality in hemodialysis patients.","authors":"Kosaku Iwatsubo, Michikazu Nakai, Shouichi Fujimoto","doi":"10.1159/kbr/adjag019","DOIUrl":"https://doi.org/10.1159/kbr/adjag019","url":null,"abstract":"<p><strong>Background: </strong>Blood pressure (BP) is an important modifiable prognostic factor in maintenance hemodialysis patients. We previously introduced intradialytic time-averaged cumulative blood pressure (TAC-BP), calculated from all BP measurements obtained during each dialysis session using the trapezoidal rule. We hypothesized that the longitudinal slope of session-level TAC-BP values (TAC-BP Slope) is associated with all-cause mortality.</p><p><strong>Methods: </strong>This single-center retrospective cohort study included 209 maintenance hemodialysis patients followed from August 2018 to March 2025. Four longitudinal BP slope indicators were calculated: TAC-systolic BP (SBP) Slope, TAC-diastolic BP (DBP) Slope, Predialysis SBP Slope, and Predialysis DBP Slope. Multivariable Cox regression was performed. Non-linear associations were examined using tertile analysis. Incremental discrimination was assessed using bootstrap mean C-index comparison.</p><p><strong>Results: </strong>Over a mean follow-up of 2.8 years, 75 patients (35.9%) died. In linear Cox models, all four indicators were significantly associated with mortality, with TAC-DBP Slope showing the strongest linear association (HR 1.767, 95% CI 1.404-2.224). For TAC-DBP Slope, both declining (HR 4.21, 95% CI 2.28-7.75) and increasing (HR 2.81, 95% CI 1.44-5.50) tertiles showed significantly elevated mortality versus stable tertile, indicating a U-shaped association. In sensitivity analyses excluding measurements from the 6 months preceding death or censoring, the association in the declining tertile was attenuated and no longer significant (HR 1.44, 95% CI 0.73-2.84), whereas the increasing tertile remained significant (HR 2.07, 95% CI 1.06-4.06). C-index analysis demonstrated that TAC-DBP Slope deviation provided significantly improved internal discrimination beyond established and predialysis variables (ΔC = +0.048, p=0.010).</p><p><strong>Conclusions: </strong>Longitudinal TAC-DBP Slope shows a U-shaped association with all-cause mortality, but the two arms differ in origin: the declining arm largely reflects terminal decline preceding death, whereas the increasing arm persists after exclusion of terminal measurements. TAC-DBP Slope may therefore be useful for risk stratification rather than as a validated prediction tool.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"1"},"PeriodicalIF":2.1,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149128001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to letter \"Inflammatory Biomarkers in Long COVID: From Cross-Sectional Association to Claims of Prediction\".","authors":"Alessandra Perna, Margherita Borriello, Giuseppe Signoriello, Mariadelina Simeoni, Diego Ingrosso","doi":"10.1159/kbr/adjag018","DOIUrl":"https://doi.org/10.1159/kbr/adjag018","url":null,"abstract":"","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"1"},"PeriodicalIF":2.1,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149128023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is uric acid excretion a possible cause of kidney damage? A cross-sectional study of CHARLS and CHNS with Mendelian randomization verification.","authors":"Lin Zhuo, Zhiyuan Zhuang, Siyuan Gao, Xiuying Wang, Xueyao Han, Lingli Zhou","doi":"10.1159/kbr/adjag013","DOIUrl":"https://doi.org/10.1159/kbr/adjag013","url":null,"abstract":"<p><strong>Background and objectives: </strong>To explore whether uric acid excretion (UAE) causes kidney damage.</p><p><strong>Materials and methods: </strong>Cross-sectional analyses were conducted using the China Health and Retirement Longitudinal Study (CHARLS), with external validation in the China Health and Nutrition Survey (CHNS). The relationship between fractional excretion of uric acid (FEUA) and estimated glomerular filtration rate (eGFR) decline was assessed using univariate and multivariate logistic regression analysis. Six sets of TSMR analyses were performed for verification using FEUA, Urinary uric acid clearance (UACL), renal-under-excretive and renal-overload type gout, SLC2A9 increase, SLC22A11 decrease related single-nucleotide polymorphisms (SNPs). Cochran's Q test, MR-Egger intercept, power calculation, and sample overlap analysis were performed.</p><p><strong>Results: </strong>Logistic regression analysis revealed that FEUA was significantly, independently associated with eGFR decline adjusting for confounders (OR=1.218, 95%CI: 1.176∼1.262, P<0.001). FEUA decrease was causally associated with eGFR increase (Wald Ratio method: β = 0.003, 95% CI: 0.002∼0.004, P= 1.456E-8). UACL increase achieved a borderline causality with eGFR decline (IVW method: β = -0.545, 95% CI: -1.095∼0.005, P= 0.052). SLC2A9 increase was causally associated with eGFR decline (Wald Ratio method: β = -0.007, 95% CI: -0.008∼-0.006, P= 2.754E-4). SLC22A11 decrease was causally associated with eGFR increase (Wald Ratio method: β = 0.005, 95% CI: 0.004∼0.006, P= 0.018).</p><p><strong>Conclusions: </strong>This study demonstrated that FEUA is positively associated with eGFR decline and a greater UAE burden harms the kidney, whereas an increase in renal UA excretory ability protects it, underscoring the importance of early detection of FEUA or UACL or renal UA transporters capacity to benefit kidney protection in people prone to kidney damage.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"1"},"PeriodicalIF":2.1,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149111566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory Biomarkers in Long COVID: From Cross-Sectional Association to Claims of Prediction.","authors":"Charlotte Delrue, Marijn Speeckaert","doi":"10.1159/kbr/adjag017","DOIUrl":"https://doi.org/10.1159/kbr/adjag017","url":null,"abstract":"","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"1"},"PeriodicalIF":2.1,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149111530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ratio of red blood cell distribution width to albumin level and mortality outcomes in population with chronic kidney disease.","authors":"Kaixin Lei, Xinqi An, Ao Chen, Liping Lin, Baihai Su, Yupei Li","doi":"10.1159/kbr/adjag012","DOIUrl":"https://doi.org/10.1159/kbr/adjag012","url":null,"abstract":"<p><strong>Background: </strong>Chronic kidney disease (CKD) is one of the major public health issues worldwide. The red blood cell distribution width to albumin ratio (RAR) has emerged as a reliable and accessible marker to reflect inflammation and nutrition, suggesting underlying associations with prognosis in CKD population.</p><p><strong>Methods: </strong>Using data from the National Health and Nutrition Examination Survey 1999 to 2018 and the National Death Index, 3965 patients with CKD were enrolled in this study. Weighted Cox proportional hazards regression models were employed to investigate the associations of RAR with all-cause mortality, cardiovascular disease (CVD) mortality, and cancer mortality. Restricted cubic spline (RCS) analysis was used to detect non-linear relationships and threshold effects. Stratified analysis was conducted to evaluate interactions of potential variables.</p><p><strong>Results: </strong>Across the entire follow-up period, a total of 1163 fatal events occurred. Weighted Cox analysis revealed RAR was independently associated with all-cause mortality (HR, 1.81, 95%CI, 1.60 - 2.06, P < 0.001), CVD mortality (HR, 1.89, 95%CI, 1.59 - 2.26, P < 0.001), and cancer mortality (HR, 1,76, 95%CI, 1.46 - 2.11, P < 0.001). RCS analysis demonstrated non-linear relationships for all-cause mortality (P for non-linear < 0.001) and CVD mortality (P for non-linear < 0.001), while a linear relationship was observed for cancer mortality (P for non-linear = 0.113). Subgroup analysis identified age, gender, urine albumin-to-creatinine ratio and poverty income ratio as potential interactive factors.</p><p><strong>Conclusion: </strong>These findings suggested that RAR had robust associations with both all-cause and cause-specific mortality in CKD patients. Future clinical trials are required to elucidate the underlying processes.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"1"},"PeriodicalIF":2.1,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149062197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Uric Acid and Blood Urea Nitrogen as Primary Determinants of eGFR in 23,960 Chinese Adults: A Cross-Sectional Study with Machine Learning and Longitudinal Validation.","authors":"Shumin Bao, Wenyi Zhu, Guojuan Zhang","doi":"10.1159/kbr/adjag011","DOIUrl":"https://doi.org/10.1159/kbr/adjag011","url":null,"abstract":"<p><strong>Background: </strong>Chronic kidney disease (CKD) affects approximately 850 million individuals worldwide. Machine learning (ML) approaches offer potential advantages over traditional regression for identifying eGFR determinants, but prior studies frequently include serum creatinine or cystatin C in predictor sets, creating tautological prediction bias. We aimed to identify eGFR determinants using ML with methodological safeguards against data leakage in a large Chinese population.</p><p><strong>Methods: </strong>We conducted a population-based cross-sectional study of 23,960 unique adult participants (first visit per patient) recruited across five annual waves (2011-2015) in Eastern China, with a longitudinal validation subset of 14,309 patients with two visits. eGFR was calculated using the CKD-EPI 2021 race-free equation. LightGBM and traditional regression were applied to 35 clinical and laboratory predictors, explicitly excluding serum creatinine and cystatin C to prevent tautological prediction. Patient-level data splitting (70/15/15) ensured no individual appeared in both training and test sets.</p><p><strong>Results: </strong>CKD (eGFR <60 mL/min/1.73m²) was present in 2.3% (n=554) of participants; mean eGFR was 91.9±15.3 mL/min/1.73m². LightGBM achieved R²=0.461 (RMSE=11.63 mL/min/1.73m²) compared to linear regression R²=0.450. Feature importance analysis identified serum uric acid (SUA, 10.1%), blood urea nitrogen (BUN, 9.6%), and age (7.2%) as primary eGFR determinants. Multivariable regression confirmed age (β=-0.809 per year, 95% CI: -0.843 to -0.774) and SUA (β=-0.064 per µmol/L, 95% CI: -0.069 to -0.060) as independent predictors (both p<0.001). In the longitudinal subset, mean eGFR declined by 4.44±12.50 mL/min/1.73m² between visits. CKD prevalence increased from 2.5% (2011) to 3.6% (2015; p<0.001).</p><p><strong>Conclusions: </strong>Using a methodologically rigorous approach that excludes GFR-derived metabolites from predictor sets, SUA and BUN are identified as primary eGFR determinants in a large Chinese population. The modest ML advantage over traditional regression (ΔR²≈0.011) reflects capture of non-linear interactions. These findings support targeted screening of individuals with elevated uric acid and BUN for CKD prevention.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"1"},"PeriodicalIF":2.1,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149062163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of denosumab or romosozumab on vascular calcification in dialysis patients: a systematic review and meta-analysis.","authors":"Dueanchonnee Sribenjalak, Hyeonmok Kim, Peter R Ebeling, Alexander J Rodríguez","doi":"10.1159/kbr/adjag010","DOIUrl":"https://doi.org/10.1159/kbr/adjag010","url":null,"abstract":"<p><strong>Introduction: </strong>Patients on hemodialysis are at high risk of vascular calcification, which contributes to cardiovascular events and mortality. The impact of osteoporosis therapies, including denosumab and romosozumab, on vascular calcification in this population remains uncertain. This systematic review and meta-analysis aim to synthesize current evidence on their effects, addressing a critical knowledge gap in advanced chronic kidney disease (CKD) management.</p><p><strong>Methods: </strong>MEDLINE, Embase, and Web of Science were searched through November 2025 for studies evaluating either denosumab or romosozumab and vascular calcification in hemodialysis patients. Random-effects models were used to pool standardized mean differences (SMDs) with 95% confidence intervals, and leave-one-out sensitivity analyses assessed robustness.</p><p><strong>Results: </strong>Six studies on denosumab and one on romosozumab were included. Meta-analysis of denosumab (422 participants) showed a small, non-significant change in vascular calcification (SMD -0.20 95% CI -0.75 to 0.36; I² = 82.6%). Subgroup analysis of coronary artery calcification yielded similar non-significant results (SMD -0.22, 95% CI -0.67 to 0.23; I² = 41.5%). The single romosozumab study reported a significant increase in calcium score from baseline. All studies reported post-injection hypocalcemia.</p><p><strong>Conclusion: </strong>Current evidence indicates that denosumab does not significantly alter vascular calcification in dialysis patients, whereas limited data suggest romosozumab may increase vascular calcification. Serum calcium should be monitored in dialysis patients receiving these agents. Given the small number of studies and substantial heterogeneity, further well-designed prospective studies are required to clarify the cardiovascular safety of these agents in advanced CKD.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"1"},"PeriodicalIF":2.1,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149062180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}