Kidney & blood pressure research最新文献

{"title":"Elevated Serum Nardilysin Is Inversely Associated with Cardiovascular Disease in Kidney Transplant Recipients.","authors":"Anna Sączek, Krzysztof Batko, Małgorzata Banaszkiewicz, Jolanta Małyszko, Ewa Koc-Żórawska, Marcin Żórawski, Karolina Niezabitowska, Katarzyna Sobczyńska, Przemysław Miarka, Alina Bętkowska-Prokop, Katarzyna Krzanowska, Marcin Krzanowski","doi":"10.1159/000552202","DOIUrl":"10.1159/000552202","url":null,"abstract":"<p><strong>Background: </strong>Kidney transplant recipients (KTRs) suffer from enhanced cardiovascular (CV) and metabolic burden due to interplay between pro-inflammatory and metabolic risk factors. Nardilysin (NRDc) and mitochondrial open reading frame of 12S rRNA-c (MOTS-c) are circulating peptides that represent candidate markers of cardiometabolic pathobiology, though their relevance in KTRs is unknown.</p><p><strong>Methods: </strong>We measured serum NRDc and MOTS-c concentrations in an observational cohort of 150 patients (118 KTRs and aged-matched controls - 32 patients) using commercial ELISA kits. KTRs were followed for a median of 29.2 (25.3-31.9) months. Relationships with CV and metabolic parameters were assessed using Pearson's correlation and penalized logistic regression. Renal allograft loss with all-cause mortality as competing event was examined using Fine-Gray regression.</p><p><strong>Results: </strong>Median serum NRDc (1.91 vs. 0.42 ng/mL, p < 0.001) and MOTS-c (178 vs. 142 ng/mL, p = 0.014) were significantly higher in KTRs, as compared with controls. NRDc showed a weak positive linear relationship with BMI (r = 0.21, p = 0.02). After adjusting for age and sex, higher standardized ln-NRDc was independently associated with lower odds of prevalent CV disease (OR 0.59, 95% CI: 0.34-0.97, p = 0.04). This CV disease association was stable after further adjustment for hsIL-6. We did not observe significant associations for MOTS-c and cardiometabolic features. In competing risk analysis, MOTS-c showed a consistent but nonsignificant trend toward lower risk of allograft loss (adj. sHR 0.50, 95% CI: 0.22-1.10, p = 0.08), while NRDc was not associated with allograft loss. Both serum NRDc and MOTS-c markers were not associated with all-cause mortality or follow-up eGFR decline.</p><p><strong>Conclusions: </strong>Elevated circulating serum NRDc and MOTS-c levels in KTRs may reflect altered metabolic and inflammatory pathways. The inverse association between NRDc and prevalent CV disease warrants further investigation in longitudinal studies with incident CV events.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"518-529"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13395389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147988091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Estimated Glomerular Filtration Rate Slopes with Cardiorenal Outcomes in Patients with Chronic Kidney Disease before and after Multidisciplinary Education.","authors":"Masaru Matsui, Maiko Kokubu, Masatoshi Nishimoto, Takaaki Kosugi, Masahiro Eriguchi, Ken-Ichi Samejima, Kazuhiko Tsuruya","doi":"10.1159/000550676","DOIUrl":"10.1159/000550676","url":null,"abstract":"<p><strong>Introduction: </strong>Multidisciplinary education has been shown to slow the progression of chronic kidney disease (CKD) and reduce cardiovascular (CV) risk, although its effects depend partly on patient characteristics. The aim of this study was to assess how patients categorized on the basis of estimated glomerular filtration rate (eGFR) responded to multidisciplinary education in terms of cardiorenal outcomes.</p><p><strong>Methods: </strong>In this retrospective cohort study, we included 447 CKD patients who received multidisciplinary education between January 1, 2013, and December 31, 2020, at Nara Prefecture General Medical Center. Exposure was four categories according to eGFR slopes before and after multidisciplinary education. The primary outcomes were renal events defined as the composite of dialysis initiation, transplantation, and 30% eGFR decline, and CV events defined as the composite of heart failure requiring hospitalization, coronary or leg revascularization, cardiac sudden death, and stroke.</p><p><strong>Results: </strong>Multidisciplinary education decreased the median eGFR slope from -5.00 to -0.65 mL/min/1.73 m2/year. In fully adjusted models, the hazard ratios (95% confidence intervals) for total renal events relative to slow-slow eGFR decline were 1.02 (0.50-2.06) for fast-slow decline, 5.30 (2.82-9.97) for slow-fast decline, and 7.53 (4.02-14.1) for fast-fast decline. Only fast-fast eGFR decline was associated with a high risk of CV events. Subgroup analyses showed similar trends. Fast decline after education was independently associated with increased proteinuria and decreased hemoglobin levels.</p><p><strong>Conclusions: </strong>Fast eGFR decline after but not before multidisciplinary education was significantly associated with renal and CV events in CKD patients. Attention should be paid to CKD patients with limited benefit from multidisciplinary education.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"141-150"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146063980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2025 KDIGO Executive Summary: Diagnosis and Management of Pediatric Autosomal Dominant Polycystic Kidney Disease.","authors":"Sanat Subhash, Amir Safadi, Ruhaan Bajpai, Rupesh Raina","doi":"10.1159/000550103","DOIUrl":"10.1159/000550103","url":null,"abstract":"<p><p>Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disorder, affecting 1 in 400 to 1,000 people worldwide. These significant care requirements reflect the importance of early diagnosis and prevention for affected patients and the need for evidence-based guidelines for treatment protocols and best practice measures. The 2025 KDIGO guidelines build on earlier frameworks such as the 2019 International consensus statement on the diagnosis and management of ADPKD in children and young people to improve screening, monitoring, and treatment methodology for pediatric ADPKD patients. Young and adolescent patients face unique challenges to care from detection of asymptomatic disease progression to early-onset hypertension, alongside stress faced by caregivers and families. This executive summary synthesizes the updated 2025 KDIGO recommendations and supporting evidence to outline new advancements and provide a practical approach for pediatric nephrologists to support improved treatment and transition into adulthood.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"101-106"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12948374/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146030269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Integrated, Evidence-Guided Framework for Chronic Kidney Disease Self-Management: Behavioral Mechanisms, Implementation Strategies, and Real-World Application.","authors":"Janet Diaz-Martinez, Staci Leon Morris, Iván Delgado-Enciso, Gustavo A Hernández-Fuentes, Osiris G Delgado-Enciso, Gilda Stanco, Laura Kallus, Aydeivis Jean-Pierre, Carlos Duran, Yoel Madruga-Reyes, Brenda Lopez, Jessica Mancilla, Lazaro Parra-Vidal, Michelle Hospital","doi":"10.1159/000552085","DOIUrl":"10.1159/000552085","url":null,"abstract":"<p><strong>Background: </strong>Chronic kidney disease (CKD) affects over 850 million people worldwide and contributes substantially to cardiovascular complications, reduced quality of life, and high healthcare utilization. Self-management support can improve patient activation, self-management behaviors, and quality of life, yet application in routine CKD care remains inconsistent. Many existing programs lack explicit specification of behavioral mechanisms and implementation-relevant delivery approaches, limiting reproducibility and real-world scale-up.</p><p><strong>Summary: </strong>We conducted a structured narrative review with framework development. A structured database search (PubMed, Embase, CINAHL, Scopus) identified English-language quantitative, qualitative, mixed-methods, and review studies published from January 2010 to March 2025 addressing CKD self-management behaviors, behavioral mechanisms, delivery approaches, and evaluation measures. Findings were extracted into a structured evidence matrix and synthesized using a combined deductive-inductive approach to develop a practice-oriented framework. We synthesized 144 included records into an integrated framework linking domain-specific barriers, strategies/delivery supports, and evaluation measures. Seven priority CKD self-management domains were identified: (1) patient activation; (2) medication adherence; (3) dietary and fluid management; (4) clinical and home monitoring; (5) lifestyle modification; (6) emotional, psychological, and symptom burden; and (7) preparation for kidney failure treatment pathways (dialysis, transplant, or conservative kidney management). Cross-domain strategy clusters were mapped to behavioral mechanisms (e.g., self-efficacy strengthened through mastery experiences, observational learning, motivational communication, and management of emotional/physiological feedback). Implementation guidance was organized into a six-step, adaptable process: (1) identify and prioritize behaviors; (2) select and apply relevant behavioral theories; (3) conduct participatory co-design and contextual adaptation; (4) implement multimodal delivery (clinic, digital, and community reinforcement) with structured follow-up; (5) evaluate and refine using behavioral, clinical, patient-reported, utilization, and implementation outcomes; and (6) plan for scalability, sustainability, and policy integration.</p><p><strong>Key messages: </strong>This structured narrative synthesis integrates behavioral mechanisms with implementation-relevant strategies to provide a practice-oriented framework for designing, implementing, and evaluating CKD self-management support across clinical and community settings.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"429-451"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13331468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147729414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Inflammatory Milieu Exacerbates Anemia of Chronic Kidney Disease: From the Gut-Kidney Axis to Bone Marrow Hematopoiesis Inhibition.","authors":"Na Zhang, Jiaming Han, Xuan Li, Huiying Xu, Xiangming Wang, Baihai Jiao","doi":"10.1159/000553297","DOIUrl":"10.1159/000553297","url":null,"abstract":"<p><strong>Background: </strong>Traditionally, erythropoietin (EPO) deficiency has been known as a central component of the pathophysiology of anemia in chronic kidney disease (CKD). Although renal injury is the primary factor causing EPO deficiency, notably, the efficacy of hypoxia-inducible factor prolyl hydroxylase inhibitors highlights that the EPO production potential in residual renal tissue and other sites, such as the liver, remains pharmacologically mobilizable. Nevertheless, in CKD patients, this potential appears unable to be effectively activated by endogenous hypoxia signaling. This phenomenon suggests other factors, such as chronic inflammation, may contribute to the decreased hypoxia sensitivity.</p><p><strong>Summary: </strong>As inflammatory cytokines are known to impair erythropoiesis, we reasonably speculate that they also suppress the upstream hypoxic signaling that governs EPO production and play a key role in the blunted endogenous response in CKD. Therefore, this review focuses on how persistent, low-grade chronic inflammation in CKD patients suppresses EPO expression and EPO downstream signaling, disrupts iron metabolism, and impairs hematopoiesis in the bone marrow. Moreover, the gut-kidney axis is an underestimated source of inflammation, with dysfunction resulting from gut flora imbalance, the accumulation of uric toxins, and the activation of inflammatory factors.</p><p><strong>Key message: </strong>Herein, we discuss the underlying mechanism of action of chronic inflammation in anemia of CKD, while highlighting that anti-inflammatory therapy is one of the highly effective adjuvant therapies for the future.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"669-684"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13461126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148376159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lifestyle and Environment Aspects Challenging Kidney Health.","authors":"Adamasco Cupisti, Claudia D'Alessandro, Antonello Di Paolo, Pietro Manuel Ferraro, Edoardo La Porta, Annalisa Noce, Vincenzo Panichi, Attilio Parisi, Piergiorgio Messa","doi":"10.1159/000552770","DOIUrl":"10.1159/000552770","url":null,"abstract":"<p><strong>Background: </strong>Both acute kidney injury and chronic kidney disease (AKI, CKD) are increasingly frequently reported conditions. This translates into a progressive increase in the number of patients reaching advanced stages of kidney failure, which, in addition to being associated with increased cardiovascular morbidity and mortality, leads to an increase in patients requiring renal replacement therapy, with a significant clinical and economic impact. Evidence has accumulated that unhealthy dietary habits and lifestyles are associated with a higher incidence of both AKI and CKD. This is driving the medical community to take action to raise awareness among the general population and policymakers of the need to implement programs aimed at correcting unhealthy dietary habits and lifestyles in order to maximize preventive effectiveness in maintaining kidney and cardiovascular health for as long as possible.</p><p><strong>Summary: </strong>This is a narrative review focusing on some of the main behavioral patterns related to dietary and/or lifestyle habits, some of which are known to potentially impact kidney health (e.g., food quality; water intake; alcohol consumption; smoking; physical activity; etc.) but also focusing on less recognized emerging issues indirectly related to environmental changes (air pollution; micro-/nanoplastics, food supplements; herbal products; etc.), which may also play a detrimental role in kidney and general health.</p><p><strong>Key messages: </strong>(1) CKD is one of the most common chronic noncommunicable diseases. (2) It is urgent to implement organizational plans aimed at preventing and intercepting CKD in its early stages. (3) Among preventive actions, dietary behavior patterns and a healthy lifestyle play a fundamental role. (4) Awareness needs to be raised that the use of over-the-counter medications without clear need could lead to potential renal toxicity. (5) There is still limited recognition and awareness of the possible inadvertent intake of substances present in foods, resulting from uncontrolled food preparation chains or environmental alterations.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"500-517"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13395402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148150247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monkeypox Infection in Kidney Transplant Recipients.","authors":"Ai-Qin Sheng, Zhi-Qiang Zhao, Fei Liu, Jing-Jing Wang, Jian-Hua Mao, Hai-Dong Fu","doi":"10.1159/000550870","DOIUrl":"10.1159/000550870","url":null,"abstract":"<p><strong>Background: </strong>The monkeypox virus is currently circulating in Africa and has been declared a public health emergency of international concern. Due to lifelong immunosuppressive therapy, kidney transplant recipients are susceptible to infections and at high risk for developing serious complications.</p><p><strong>Summary: </strong>We summarized the clinical data of 11 patients from the database. A total of 10 cases occurred in males, with age ranging from 25 to 62 years old. Common clinical features include rashes, anorectal pain, fever, pharyngitis, diarrhea, dyspnea and abdominal pain. Median duration of symptoms at presentation was 54 days (range, 21-120 days). Once diagnosed, immunosuppressive agents were adjusted among seven patients (7/11). A total of 10 cases received antiviral medication including tecovirimat, cidofovir and brincidofovir. The median time to initiate treatment was 16.5 days (range, 4-35 days). The majority (10/11) had a good prognosis, with one monkeypox-related death in the cohort.</p><p><strong>Key messages: </strong>Monkeypox infection is spreading fast over the world and presents a major concern to kidney transplant recipients. In this immunocompromised group, we should focus more on effective preventative and treatment techniques. Further research is needed to standardize management algorithms.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"200-208"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13082762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147317303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Preservation to Regeneration: Stem Cell-Derived Therapies in Machine-Perfused Kidney Transplants - A Systematic Review and Meta-Analysis.","authors":"Margaux Navez, Elisa Dos Santos Barata, Nathalie Maes, Elena Levtchenko, Fanny Oliveira Arcolino, Perrine Burdeyron, Clara Steichen, Olivier Detry, Nicholas Gilbo, François Jouret","doi":"10.1159/000552604","DOIUrl":"10.1159/000552604","url":null,"abstract":"<p><strong>Introduction: </strong>Ischemia-reperfusion injury remains a critical determinant of graft outcomes in kidney transplantation, contributing to delayed graft function and reduced long-term survival. Machine perfusion has emerged as a dynamic preservation strategy offering a therapeutic window to condition organs prior to implantation. The integration of stem cells and extracellular vesicles (EVs), known for their immunomodulatory and cytoprotective properties, into perfusion protocols represents a novel and potentially synergistic approach. However, the evidence base remains limited and heterogeneous.</p><p><strong>Methods: </strong>This systematic review and meta-analysis evaluated the therapeutic potential of stem cell-based interventions during machine perfusion, following PRISMA guidelines. PubMed, Embase, and Scopus were searched for experimental studies using stem cells or EVs during hypothermic or normothermic machine perfusion in animal or discarded human kidneys. Outcomes included renal function, injury biomarkers, inflammation, and histology.</p><p><strong>Results: </strong>Nine studies were included, seven in meta-analysis. Several reported reductions in inflammatory cytokines (IL-6, IL-1β) and biomarkers (NGAL) following stem cell or EV administration. However, meta-analysis showed no significant effects on creatinine clearance (SMD: 0.00; 95% CI: -0.54 to 0.55), urine output (SMD: 0.54; 95% CI: -0.46 to 1.55), or NGAL (SMD: -1.68; 95% CI: -5.60 to 2.25). Stem cell retention was limited, mechanisms of action remain incompletely understood, and only one study assessed post-transplant function.</p><p><strong>Conclusion: </strong>Despite potential immunomodulatory and cytoprotective effects, consistent functional benefits were not demonstrated. Standardized studies incorporating transplant models and long-term outcomes are needed to clarify therapeutic potential and optimize delivery strategies.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"589-605"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13427320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148176341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperuricaemia-Induced Hypertension in Rats by Regulating the RhoA/ROCK Pathway.","authors":"Yan Zhang, Zhongchao Wang, Yinli Xu, Nan Wang, Zihua Xu, Tianshu Ren, Qingchun Zhao, Weihong Meng","doi":"10.1159/000552806","DOIUrl":"10.1159/000552806","url":null,"abstract":"<p><strong>Introduction: </strong>Hyperuricaemia (HUA) is associated with hypertension, but the mechanisms remain unclear. This study investigated whether the RhoA/ROCK pathway mediates HUA-induced vascular remodelling and hypertension.</p><p><strong>Methods: </strong>Thirty male Sprague-Dawley rats were divided into control, HUA, and fasudil (ROCK inhibitor) groups. Serum uric acid, creatinine, and blood pressure were measured biweekly. Histopathology, qPCR, and Western blotting assessed thoracic aortic changes and RhoA/ROCK pathway activation. Rat vascular smooth muscle cells (VSMCs) were treated with uric acid, with or without RhoA/ROCK inhibitors, to evaluate nitric oxide (NO) levels and protein expression.</p><p><strong>Results: </strong>HUA significantly increased systolic blood pressure, aortic media thickness, smooth muscle cell proliferation, and expression of RhoA, ROCK 1/2, and MLC1, with elevated phosphorylation of MLC and MYPT-1. Fasudil reduced blood pressure and ameliorated vascular remodelling but did not lower uric acid levels. In VSMCs, HUA decreased NO content, enhanced RhoA membrane translocation, and increased ROCK 2 expression, effects reversed by RhoA or ROCK inhibitors.</p><p><strong>Conclusion: </strong>HUA promotes hypertension by activating the RhoA/ROCK pathway, leading to vascular remodelling and dysfunction. Inhibition of this pathway attenuates HUA-induced hypertension, highlighting the mechanistic relevance of the RhoA/ROCK pathway.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"766-780"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13498314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148422175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Phenome-Wide Association and Mendelian Randomization Study of Genetically Predicted Membranous Nephropathy with Multiple Diseases.","authors":"Alida Wenghaerbai, Akehu Alemasi, Lijiang Gu, Jianjun Deng, Yilun Zhou","doi":"10.1159/000551046","DOIUrl":"10.1159/000551046","url":null,"abstract":"<p><strong>Introduction: </strong>Membranous nephropathy constitutes a significant proportion of cases leading to end-stage renal disease. In such instances, the accurate distinction between primary and secondary forms is crucial for proper treatment. Consequently, we systematically examined the link between genetically predicted membranous nephropathy and various diseases.</p><p><strong>Methods: </strong>The phenome-wide association approach assessed the links between genetically predicted membranous nephropathy and 2,408 diseases. Two-sample Mendelian randomization was then employed to explore causal relationships using methods like inverse variance weighting, MR-Egger, weighted median, and others. A replication analysis was conducted to confirm these associations. Gene enrichment analysis was conducted using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses to explore potential pathogenic mechanisms.</p><p><strong>Results: </strong>A statistically significant association was noted between genetically predicted Graves' disease, thyrotoxicosis, and thyrotoxicosis with diffuse goiter and an elevated risk of membranous nephropathy. Subsequent replication analysis for Graves' disease demonstrated consistent results. Functional analysis suggests that Graves' disease may affect membranous nephropathy by influencing pathophysiological mechanisms and pathways related to the proliferation and differentiation of lymphocytes and leukocytes, adhesion between leukocytes and cells, differentiation of CD4+ αβ T cells, and differentiation of Th1 and Th2 cells.</p><p><strong>Conclusion: </strong>Our study indicates that genetically predicted thyrotoxicosis, thyrotoxicosis with diffuse goiter, and Graves' disease are correlated with an increased likelihood of membranous nephropathy. Graves' disease may affect membranous nephropathy development by influencing leukocyte proliferation and differentiation. Additional research is warranted to validate these findings and ascertain their relevance in clinical management.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"167-177"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13048723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147307465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}