Kidney & blood pressure research最新文献

{"title":"Perirenal Fat and Chronic Kidney Disease: A Systematic Review and Meta-Analysis.","authors":"Pengfei Kang, Boju Sun, Jing Hao, Conghui Wang, Xiangmei Chen","doi":"10.1159/000543989","DOIUrl":"10.1159/000543989","url":null,"abstract":"<p><strong>Introduction: </strong>Although previous studies have investigated the impact of perirenal fat on chronic kidney disease (CKD), there are yet no systematic reviews and meta-analyses to investigate the association between perirenal fat and CKD.</p><p><strong>Methods: </strong>We searched six English electronic databases including PubMed, Scopus, Web of Science, Ovid, Embase, and the Cochrane Library to select clinical studies that reported the relationship between perirenal fat and CKD, and the search period ranged from the establishment of the database to September 10, 2024. Two researchers independently screened the studies and ultimately compared the literature. Stata (version 16 SE; College Station, TX, USA) software was used for statistical analysis.</p><p><strong>Results: </strong>A total of eight articles that included 2,576 patients were included in this meta-analysis. The results showed a significant association between perirenal fat and CKD (95% CI: 0.48-0.65, p = 0.00), and no heterogeneity was detected between these two groups (I2 = 31.06%, p = 0.18). Subgroup analysis revealed that whether it is diabetic nephropathy, nephropathy caused by abnormal cardiac function, or primary CKD, perirenal fat is closely related to them.</p><p><strong>Conclusion: </strong>The results of this systematic review and meta-analysis showed that perirenal fat thickness is closely related to CKD. Clinicians should pay attention to relevant indicators when diagnosing and treating patients with CKD.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"240-248"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"End-Stage Chronic Kidney Disease Affects Serum Nostrin Turnover.","authors":"Vivien Latuske, Stefan Erfurt, Daniel Patschan, Meike Hoffmeister","doi":"10.1159/000545521","DOIUrl":"10.1159/000545521","url":null,"abstract":"<p><strong>Introduction: </strong>Serum Nostrin was recently identified as novel predictor of important clinical outcomes in acute kidney injury (AKI) and has also emerged as a predictor of recovery of kidney function (ROKF) in AKI patients. ROKF is a critical factor for the transition of AKI into chronic kidney disease (CKD). Therefore the aim of the present study was to evaluate serum Nostrin levels in CKD patients.</p><p><strong>Methods: </strong>Blood samples were collected from CKD patients before and after dialysis, and serum Nostrin levels were determined using ELISAs.</p><p><strong>Results: </strong>Serum Nostrin levels were previously shown to be significantly increased in AKI patients in comparison with healthy controls. In CKD patients, the levels of serum Nostrin were further increased without significant differences of Nostrin concentrations before and after dialysis.</p><p><strong>Conclusion: </strong>The further elevation of serum Nostrin concentrations in CKD in comparison with AKI indicates a significant impairment of Nostrin turnover and supports the possible suitability of Nostrin as potential diagnostic value in both AKI and CKD.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"321-324"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Roles of Serum NLRP3 Inflammasome and Associated Cytokines in Gout-Induced Kidney Injury.","authors":"Xiaoqing Xu, Juanjuan Zhang, Yanqun Wu","doi":"10.1159/000545492","DOIUrl":"10.1159/000545492","url":null,"abstract":"<p><strong>Introduction: </strong>Gout, characterized by hyperuricemia and urate crystal deposition, is associated with systemic inflammatory complications, including kidney injury. This study aimed to investigate the role of serum nucleotide-binding oligomerization domain-like receptor 3 (NLRP3) inflammasome and associated cytokines (IL-1β and IL-18) in gout-related kidney injury (GRI).</p><p><strong>Methods: </strong>A total of 279 gout patients (96 with renal injury and 183 without renal injury) and 100 healthy controls were included. Serum NLRP3, IL-1β, and IL-18 were measured and compared using an enzyme-linked immunosorbent assay. Receiver operating characteristic (ROC) analysis was carried out to evaluate the diagnostic values of individual or combinational biomarkers. Spearman's correlation analysis was employed to analyze correlations between NLRP3, IL-1β, and IL-18 and renal function indicators or serum uric acid.</p><p><strong>Results: </strong>Serum levels of NLRP3, IL-1β, and IL-18 were significantly higher in gout patients compared to healthy controls (p < 0.001, gout group with kidney injury [GKI]: n = 96, gout group without kidney injury [GNKI]: n = 183, controls: n = 100), with elevated levels observed in GKI patients compared to GNKI (p < 0.001). Correlations between these markers were confirmed among all gout patients (n = 279), including serum NLRP3 with IL-1β (r = 0.34, p < 0.001) and NLRP3 with IL-18 (r = 0.47, p < 0.001). ROC analysis revealed that the combined model of NLRP3, IL-1β, and IL-18 showed improved diagnostic accuracy for GRI, with an AUC of 0.85 (95% CI: 0.81-0.89, p < 0.001). In GKI patients (n = 96), serum NLRP3, IL-1β, and IL-18 were inversely correlated with eGFR (NLRP3: r = -0.43, p < 0.01). Additionally, serum IL-18 positively correlated with serum uric acid levels (r = 0.27, p = 0.009).</p><p><strong>Conclusion: </strong>These findings highlight the potential of serum NLRP3, IL-1β, and IL-18 as diagnostic markers and therapeutic targets in GRI, providing insights into early intervention and improved clinical outcomes in gout patients with renal complications.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"341-350"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Spatial Distribution of Interstitial Cells in Kidney Tissue.","authors":"Jingyun Ou, Huiyi Zeng, Yu Shangguan, Shaodong Luan, Hongwei Wu, Haitao Li, Wenyu Gong, Donge Tang, Xiaojun Tan, Lianghong Yin, Yong Dai","doi":"10.1159/000542501","DOIUrl":"10.1159/000542501","url":null,"abstract":"<p><strong>Introduction: </strong>Interstitial cells are crucial to the development of kidney structure and function, although the mechanism underlying their role in it remains unclear to date. Our previous study identified cell clusters in human fetal kidney tissue, and we further analyzed the interstitial cell cluster within this context.</p><p><strong>Methods: </strong>We extracted the barcoded cDNA from tissue samples and prepared spatial transcriptome libraries. Sequencing data were quality-checked, normalized, and clusters were identified using Seurat. Single-cell and spatial data were integrated using multimodal intersection analysis, and cell types were deconvoluted. DEGs in interstitial cells were identified and functionally annotated using DAVID. CellPhoneDB was used to predict ligand-receptor interactions between cell types.</p><p><strong>Results: </strong>The results of the present study revealed that this cluster of interstitial cells appeared to be scattered in the junction between the cortical and medullary regions. The subsequent Kyoto Encyclopedia of Genes and Genome pathway analysis revealed that the differentially expressed genes (DEGs) in this cluster of interstitial cells were involved in the WNT signaling pathway. The Gene Ontology (GO) analysis revealed that these DEGs were involved in multiple pathways associated with kidney development, with six of the genes (NKD2, TCF21, WNT5A, WNT4, MDK, and SFRP1) associated with kidney development exhibiting significant upregulation. Accordingly, it was inferred that these interstitial cells might be involved in regulating epithelial cell differentiation, ureteral bud development, and morphogenesis. The subsequent cell-cell communication analysis revealed that the cellular crosstalk was primarily regulated mainly by ligand-receptor pairs. Additionally, 17 genes reported to be associated with kidney disease were focused on, and these genes were found to be predominantly expressed in a single-cell type.</p><p><strong>Conclusion: </strong>In summary, the present study revealed the characteristics of a previously identified cluster of interstitial cells in the kidney tissue, thereby providing fresh insights into the process of kidney development.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"1-13"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142623216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atheroembolic Kidney Disease and Atypical Hemolytic Uremic Syndrome: Two Sides of the Same Coin?","authors":"Antonio Pisani, Pasquale Buonanno, Maria Amicone, Eleonora Riccio, Ivana Capuano","doi":"10.1159/000542788","DOIUrl":"10.1159/000542788","url":null,"abstract":"<p><strong>Introduction: </strong>Atheroembolic kidney disease (AEKD) is an under-recognized cause of kidney failure, secondary to the obstruction of the renal artery and/or its branches due to the rupture of an unstable atherosclerotic plaque in patients treated with surgical and invasive cardiovascular procedures. The embolization of cholesterol crystals in the renal artery activates the complement and triggers an inflammatory reaction. Atypical hemolytic uremic syndrome (aHUS) is a thrombotic microangiopathy caused by the hyperactivation of the alternative complement pathway, leading to a prothrombotic and proinflammatory state on the endothelial surface. AEKD and aHUS could share the involvement of the complement in their pathophysiological mechanism and the former could lead to the latter.</p><p><strong>Case presentation: </strong>A 72-year-old man was referred to our clinic because of a rapid worsening of renal function after 9 months from an endovascular aortic repair (EVAR). After 4 months from the intervention, his renal function worsened, he developed hypereosinophilia and skin lesions; the renal ultrasound showed increased resistance indexes, strongly suggestive of atheroembolic kidney disease. Successively, we observed thrombocytopenia, anemia, increased LDH, low plasmatic haptoglobin, schistocytes in blood smear, and normal ADAMTS13. We promptly diagnosed an atypical hemolytic uremic syndrome and started ravulizumab.</p><p><strong>Conclusion: </strong>To our knowledge, this is the first case of aHUS secondary to a subacute AEKD. Further studies are necessary to fill the gap in the knowledge of the precise mechanism leading to aHUS secondary to AEKD and to confirm that they are two sides of the same coin.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"171-175"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tandem Upregulation of Ion Transporters in Thick Ascending Limb of Henle's Loop of Young Milan Hypertensive Strain of Rats.","authors":"Abbas Shams, Laura Di Donato, Laura Zucaro, Anna Iervolino, Giovanna Capolongo, Mariadelina Simeoni, Yoko Suzumoto, Giovambattista Capasso","doi":"10.1159/000542827","DOIUrl":"10.1159/000542827","url":null,"abstract":"<p><strong>Introduction: </strong>Milan hypertensive strain (MHS) of rat represents as one of the ideal rat models to study the genetic form of hypertension associated with aberrant renal salt reabsorption. In contrast to Milan normotensive strain (MNS), MHS rats possess missense mutations in three adducin genes and develop hypertension at 3 months old due to upregulation of sodium-chloride cotransporter (NCC). At prehypertensive stage (23-25 days old), MHS rats show enhanced protein abundance of Na+-K+-2Cl- cotransporter (NKCC2) but retain blood pressure comparable to MNS probably through enhanced GFR and reduced NCC and α-subunit of epithelial sodium channel (ENaC) expressed in distal convoluted tubule (DCT) and collecting duct (CD).</p><p><strong>Methods: </strong>In the present study, mRNA and protein expressions of ion transporters in thick ascending limb of Henle's loop (TAL) of young MHS rats were investigated.</p><p><strong>Results: </strong>Protein abundance of core-glycosylated form of renal outer medullary potassium (ROMK) channel in inner stripe of outer medulla (ISOM) is remarkably increased in MHS rats at prehypertensive stage. Furthermore, basolaterally expressed Na+-K+-ATPase and Barttin were upregulated.</p><p><strong>Discussion/conclusion: </strong>These results may indicate that in TAL of MHS rats at this age, both total NKCC2 and core-glycosylated ROMK are upregulated in tandem potentially to balance the luminal potassium concentration. On the basolateral side, upregulation of Na+-K+-ATPase and CLC-Ka/b may energize the excretion of sodium and chloride out from the cells. These data may suggest the interplay of apical and basolateral ion transporters in TAL for the modulation of TAL function in favor of enhancing the transepithelial sodium reabsorption, although this seems compensated by NCC and ENaC expressed at the downstream nephron segments in young MHS rats.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"97-104"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Perspective on Gas Chromatography-Mass Spectrometry Urinary Metabolomic Analysis and Efficient Risk Assessment of Urolithiasis: Morning Urine Organic Acid Profiles.","authors":"Jiangtao Yang, Dongfang Zhang, Yan Lu, Haixing Mai, Song Wu, Qin Yang, Hanxiong Zheng, Ruqin Yu, Hongmin Luo, Panpan Jiang, Liping Wu, Caili Zhong, Chenqing Zheng, Yanling Yang, Jiaxiang Cui, Qifang Lei, Zhaohui He","doi":"10.1159/000542263","DOIUrl":"10.1159/000542263","url":null,"abstract":"<p><strong>Introduction: </strong>Urolithiasis is characterized by a high morbidity and recurrence rate, primarily attributed to metabolic disorders. The identification of more metabolic biomarkers would provide valuable insights into the etiology of stone formation and the assessment of disease risk. The present study aimed to seek potential organic acid (OA) biomarkers from morning urine samples and explore new methods based on machine learning (ML) for metabolic risk prediction of urolithiasis.</p><p><strong>Methods: </strong>Morning urine samples were collected from 117 healthy controls and 156 urolithiasis patients. Gas chromatography-mass spectrometry was used to obtain metabolic profiles. Principal component analysis and ML were carried out to screen robust markers and establish a prediction evaluation model.</p><p><strong>Results: </strong>There were 25 differential metabolites identified, such as palmitic acid, <sc>l</sc>-pyroglutamic acid, glyoxylate, and ketoglutarate, mainly involving arginine and proline metabolism, fatty acid degradation, glycine, serine, and threonine metabolism, glyoxylate and dicarboxylic acid metabolism. The urinary OA markers significantly improved the performance of the ML model. The sensitivity and specificity were up to 87.50% and 84.38%, respectively. The area under the receiver operating characteristic curve (AUC) was significantly improved (AUC = 0.9248).</p><p><strong>Conclusion: </strong>The results suggest that OA profiles in morning urine can improve the accuracy of predicting urolithiasis risk and possibly help understand the involvement of metabolic perturbations in metabolic pathways of stone formation and to provide new insights.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"83-96"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liver Blood Stagnation: An Overlooked but Significant Factor in Intradialytic Hypotension.","authors":"Takahito Ito, Takahiro Shinzato","doi":"10.1159/000545113","DOIUrl":"10.1159/000545113","url":null,"abstract":"<p><strong>Background: </strong>Intradialytic hypotension (IDH) occurs suddenly and without warning, although it is generally reversible. While ultrafiltration rate, cardiac function, and vascular resistance have been widely studied, more attention should be given to venous blood return to the heart in relation to blood stagnation. Both existing literature and clinical observations suggest that as a hemodialysis session progresses, the vascular bed of the liver expands, reducing venous return to the heart. This decrease in cardiac output may further increase hepatic blood volume, potentially playing a central role in the development of IDH.</p><p><strong>Summary: </strong>This review explores the role of reduced venous return to the heart, caused by liver blood stagnation, as a key contributor to IDH.</p><p><strong>Key messages: </strong>We tentatively name this pathophysiological mechanism \"liver circulation jam.\" The clinical significance of this concept requires validation through future research.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"259-266"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Usefulness of Radiomics and Kidney Volume Based on Non-Enhanced Computed Tomography in Chronic Kidney Disease: Initial Report.","authors":"Piotr Białek, Adam Dobek, Krzysztof Falenta, Ilona Kurnatowska, Ludomir Stefańczyk","doi":"10.1159/000543305","DOIUrl":"10.1159/000543305","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic kidney disease (CKD) is classified according to the estimated glomerular filtration rate (eGFR), but kidney volume (KV) can also provide meaningful information. Very few radiomics (RDX) studies on CKD have utilized computed tomography (CT). This study aimed to determine whether non-enhanced computed tomography (NECT)-based RDX can be useful in evaluation of patients with CKD and to compare it with KV.</p><p><strong>Methods: </strong>The NECT scans of 64 subjects with impaired kidney function (defined as <60 mL/min/1.73 m2) and 60 controls with normal kidney function were retrospectively analyzed. Kidney segmentations, volume measurements, and RDX features extraction were performed. Machine-learning models using RDX were constructed to classify the kidneys as having structural markers of impaired or normal function.</p><p><strong>Results: </strong>The median KV in the impaired kidney function group was 114.83 mL vs. 159.43 mL (p < 0.001) in the control group. There was a statistically significant strong positive correlation between KV and eGFR (rs = 0.579, p < 0.001) and a strong negative correlation between KV and serum creatinine level (rs = -0.514, p < 0.001). The KV-based models achieved the best area under the curve (AUC) of 0.746, whereas the RDX-based models achieved the best AUC of 0.878.</p><p><strong>Conclusions: </strong>RDX can be useful in identifying patients with impaired kidney function on NECT. RDX-based models outperformed KV-based models. RDX has the potential to identify patients with a higher risk of CKD based on imaging, which, as we believe, can indirectly support clinical decision-making.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"161-170"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nephrologists' Insights on Exercise in Renal Health.","authors":"Yuri Battaglia, Federica Baciga, Alda Storari, Maria Teresa Zicarelli, Nicola Lamberti, Fabio Manfredini, Alessandro Capitanini","doi":"10.1159/000543285","DOIUrl":"10.1159/000543285","url":null,"abstract":"","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"147-150"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}