Kidney international最新文献

{"title":"Pseudo-clubbing: Acro-osteolysis in Long-standing Renal Hyperparathyroidism","authors":"Barbara Majdowska,Satish Jayawardene,Claire Kennedy,Susan McAnallen","doi":"10.1016/j.kint.2026.09.008","DOIUrl":"https://doi.org/10.1016/j.kint.2026.09.008","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"13 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149020239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel human neutralizing monoclonal antibodies against Pregnancy-Associated Plasma Protein A for the treatment of Autosomal Dominant Polycystic Kidney Disease","authors":"Erding Hu,Matthew J. Gardener,Xiaofang Wang,Guizhen Luo,Chuck Kotzer,Li Jiang,Emily Mallick,Arun Srinivasan,Larissa Ouro-Gnao,Helena Firczuk,Shane Chandler,Chun-wa Chung,Panchali Goswami,Saaussan Madi,Stephen Lenhard,Hasan Alsaid,Minh Doan,Kavini Nanayakkara,Daniel I. Swerdlow,Juliet Roberts,Vicente E. Torres","doi":"10.1016/j.kint.2026.08.020","DOIUrl":"https://doi.org/10.1016/j.kint.2026.08.020","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"54 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149020235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pigtail calculus mimicking retained double-J stent tip","authors":"Gu Qianbiao,Hu Haipeng,Guo Yong","doi":"10.1016/j.kint.2026.09.009","DOIUrl":"https://doi.org/10.1016/j.kint.2026.09.009","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"11 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149022197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recommendations for the Management of Anemia in Patients with Cancer and Chronic Kidney Disease: A Position Statement from the American Society of Onco-Nephrology (ASON)","authors":"Verônica T. Costa e Silva,Swetha R. Kanduri,Layla Van Doren,Alfred I. Lee,Shuchi Anand,Pooja Amarapurkar,Stefanie W. Benoit,Nattawat Klomjit,Elena-Bianca Barbir,Anushree C. Shirali,Claude Bassil,Sandra M. Herrmann,Abhijat Kitchlu,Shveta S. Motwani","doi":"10.1016/j.kint.2026.09.007","DOIUrl":"https://doi.org/10.1016/j.kint.2026.09.007","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"5 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149049025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive proteomic and transcriptomic mapping study found porcine and human kidneys exhibit a profoundly altered biological profile during warm ex vivo perfusion","authors":"Veerle A. Lantinga,You Zuo,Chris L. Jaynes,Tim L. Hamelink,Elizabeth Orozco-García,Baran Ogurlu,Jan-Luuk Hillebrands,Benedikt M. Kessler,Roman Fischer,Maik Pietzner,L. Leonie van Leeuwen,Yonglun Luo,Henri G.D. Leuvenink,Lin Lin,Anna K. Keller,Cyril Moers","doi":"10.1016/j.kint.2026.08.017","DOIUrl":"https://doi.org/10.1016/j.kint.2026.08.017","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"19 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149020237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral renal vascular multiplicity precluding kidney donation","authors":"Grzegorz Wróbel,Waldemar Białek,Ryszard Maciejewski","doi":"10.1016/j.kint.2026.09.011","DOIUrl":"https://doi.org/10.1016/j.kint.2026.09.011","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"89 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149020241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Donor and recipient immune programs underlying delayed graft function in kidney transplantation revealed by temporal single-cell profiling","authors":"Martin L. Mak,Julia M. Murphy,Jessica A. Mathews,Shenghui Su,Ana Konvalinka,Slava Epelman,Sarah Q. Crome","doi":"10.1016/j.kint.2026.07.035","DOIUrl":"https://doi.org/10.1016/j.kint.2026.07.035","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"5 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149022198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large-scale organoid-derived cyst cultures as a drug discovery platform for polycystic kidney disease","authors":"Thitinee Vanichapol,Ruby Wangford,Shyla Mishra,Misao Takemoto,Motonari Uesugi,Alan J. Davidson,Veronika Sander","doi":"10.1016/j.kint.2026.07.034","DOIUrl":"https://doi.org/10.1016/j.kint.2026.07.034","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"22 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149020236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asia-Pacific summit on the implementation of clinical practice guidelines on diabetes and blood pressure management in chronic kidney disease: a Kidney Disease: Improving Global Outcomes (KDIGO) summit report.","authors":"Angela Yee-Moon Wang, Sinee Disthabanchong, Kei Fukami, Tazeen H Jafar, Hyeong Cheon Park, Sunita Bavanandan","doi":"10.1016/j.kint.2026.07.027","DOIUrl":"10.1016/j.kint.2026.07.027","url":null,"abstract":"<p><strong>Kidney disease: </strong>Improving Global Outcomes (KDIGO) has published the clinical practice guidelines (CPGs) on managing diabetes in CKD in 2022 and the CPGs on managing blood pressure in chronic kidney disease in 2020. KDIGO organized a guideline implementation summit targeting the Asia-Pacific region in Kuala Lumpur in 2024, with the aim to understand existing barriers and challenges in the implementation of the 2 CPGs and to propose possible solutions, tailored to the country or region's income level to bridge existing gaps in guideline implementation. The implementation summit discussion covered 4 key themes: (i) lifestyle interventions; (ii) adoption of comprehensive team-based integrated care model; (iii) achievement of various treatment targets, albuminuria screening, and kidney disease monitoring; and (iv) implementation of guideline-directed medical therapies. The summit was attended by co-chairs of the KDIGO CPGs on diabetes and blood pressure management in chronic kidney disease, with nephrologists, endocrinologists, primary care physicians, dietitians, a health economist, and patient partners from 13 Asia-Pacific countries or regions. This conference report summarizes the key challenges in the CPG implementation for diabetes and hypertension in people with chronic kidney disease in the Asia-Pacific region and provides a strategic framework of actions to overcome these barriers.</p>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":" ","pages":""},"PeriodicalIF":21.8,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148840511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving the histologic classification of advanced diabetic nephropathy based on the Transformative Research in Diabetic Nephropathy (TRIDENT) findings.","authors":"Samer Mohandes, Cynthia C Nast, Amy Mottl, Julia Scialla, Salem Almaani, Randy Luciano, Tamara Isakova, Carla Ellis, Shweta Bansal, Christos Argyropoulos, J Charles Jennette, Adil Gasim, Isaac E Stillman, Kirk N Campbell, Amin Abedini, Gaia Coppock, Katalin Susztak, Matthew B Palmer","doi":"10.1016/j.kint.2026.07.028","DOIUrl":"10.1016/j.kint.2026.07.028","url":null,"abstract":"<p><strong>Introduction: </strong>Diabetic nephropathy (DN) remains the leading cause of kidney failure worldwide. Histopathologic assessment is the diagnostic standard, and the Renal Pathology Society (RPS) classification system is widely used in clinical practice and research. However, its prognostic performance is limited, particularly in advanced disease.</p><p><strong>Methods: </strong>To examine this, we used TRIDENT, a multicenter, prospective observational cohort of patients with diabetes undergoing clinically indicated kidney biopsy (176 individuals). Light microscopy features were scored and analyzed by unsupervised k-means clustering to derive the RPS-TRIDENT modification (RPS-TM) classification. Associations between RPS-TM classes and kidney outcomes, death, dialysis initiation, or 40% or more decline in estimated glomerular filtration rate, were evaluated with Kaplan-Meier curves and Cox proportional hazards models. Clinical utility was assessed by decision-curve analysis. An external cohort of 101 individuals was used for validation.</p><p><strong>Results: </strong>The RPS classification showed only modest prognostic discrimination, with no significant survival difference between classes 3 and 4. The RPS-TM classification introduced an additional high-risk category (Class 5) defined by visceral epithelial hyperplasia, which more clearly separated risk groups, modestly improved prediction at one year (area under the curve 0.68 vs. 0.65) and two years (0.75 vs. 0.71), and demonstrated higher net benefit in decision curve analysis. RPS-TM Class 5 had the most rapid progression to kidney failure.</p><p><strong>Conclusions: </strong>The RPS-TM classification enhances prognostication in DN by identifying a morphologic subgroup characterized by visceral epithelial hyperplasia with aggressive clinical course. This framework offers more precise risk stratification and could guide targeted management and trial design in DN.</p>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":" ","pages":""},"PeriodicalIF":21.8,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148829772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}