Kidney international最新文献

{"title":"Kidney transplantation and hyperbaric oxygen treatment for calciphylaxis","authors":"Espen Nordheim , Markus Hovd , Dag Olav Dahle","doi":"10.1016/j.kint.2025.03.003","DOIUrl":"10.1016/j.kint.2025.03.003","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 6","pages":"Page 1113"},"PeriodicalIF":14.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144089272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Conclusions from a KDIGO Controversies Conference” and CKD-MBD–associated osteoporosis","authors":"Michael Pazianas , Paul D. Miller","doi":"10.1016/j.kint.2025.02.015","DOIUrl":"10.1016/j.kint.2025.02.015","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 6","pages":"Page 1114"},"PeriodicalIF":14.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144089274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Executive summary for the China Kidney Disease Network (CK-NET) 2017–2018 Annual Data Report","authors":"Chao Yang ,&nbsp;Bixia Gao ,&nbsp;Fang Wang ,&nbsp;Hong Chu ,&nbsp;Jinwei Wang ,&nbsp;Xiaoyu Sun ,&nbsp;Ping Zhang ,&nbsp;Hui Xu ,&nbsp;Huijuan Mao ,&nbsp;Changying Xing ,&nbsp;Menghua Chen ,&nbsp;Li Zuo ,&nbsp;Yue Wang ,&nbsp;Feng Yu ,&nbsp;Hong Zhang ,&nbsp;Haibo Wang ,&nbsp;Jianghua Chen ,&nbsp;Luxia Zhang ,&nbsp;Ming-Hui Zhao ,&nbsp;China Kidney Disease Network Work Group","doi":"10.1016/j.kint.2024.12.017","DOIUrl":"10.1016/j.kint.2024.12.017","url":null,"abstract":"<div><div>Chronic kidney disease (CKD) has become a public health issue. Rapid urbanization in China has been intimately linked to shifts in the spectrum of CKD, particularly as regards CKD related to diabetes mellitus. By amalgamating diverse data streams and harnessing cutting-edge technologies, the China Kidney Disease Network aspires to evolve into a comprehensive surveillance framework for kidney diseases in China. The China Kidney Disease Network 2017–2018 Annual Data Report is the fourth nationwide report produced by the China Kidney Disease Network team. Through the analysis of data from 3 large national databases and 4 provincial dialysis quality control centers, this report seeks to provide a robust foundation for understanding the current state of kidney disease in China. Specifically, in addition to providing epidemiological and economic data on CKD and dialysis from 2017 to 2018, hot topics such as environmental pollution and CKD, as well as digital intelligence in nephrology, have been addressed. This report could serve as a valuable resource for researchers, policymakers, and health care professionals alike, inspiring new ideas, fostering collaborations, and ultimately leading to improved outcomes for those affected by kidney diseases.</div></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 6","pages":"Pages 980-984"},"PeriodicalIF":14.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144089980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Standardized Outcomes in Nephrology (SONG) initiative: a decade of harmonizing patient voices and research in kidney disease","authors":"Colm O’Reilly ,&nbsp;Jonathan C. Craig ,&nbsp;Younghee Cho ,&nbsp;Sally Crowe ,&nbsp;John S. Gill ,&nbsp;Brenda Hemmelgarn ,&nbsp;Martin Howell ,&nbsp;Anastasia Hughes ,&nbsp;Angela Ju ,&nbsp;Karine Manera ,&nbsp;Braden Manns ,&nbsp;Roberto Pecoits-Filho ,&nbsp;Benedicte Sautenet ,&nbsp;Nicole Scholes-Robertson ,&nbsp;Armando Teixeira-Pinto ,&nbsp;Peter Tugwell ,&nbsp;Wim Van Biesen ,&nbsp;Andrea K. Viecelli ,&nbsp;Angela Yee-Moon Wang ,&nbsp;Wolfgang C. Winkelmayer ,&nbsp;Allison Jaure","doi":"10.1016/j.kint.2025.02.016","DOIUrl":"10.1016/j.kint.2025.02.016","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 6","pages":"Pages 955-958"},"PeriodicalIF":14.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144090066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How frequent is frequent? Rethinking monitoring intervals in glomerular disease","authors":"Mohamed E. Elrggal","doi":"10.1016/j.kint.2025.02.007","DOIUrl":"10.1016/j.kint.2025.02.007","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 6","pages":"Pages 1111-1112"},"PeriodicalIF":14.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144089987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Mayo MGRS Prediction Tool calculates the risk of finding monoclonal gammopathy of renal significance in a kidney biopsy in patients with monoclonal gammopathy.","authors":"Nattawat Klomjit,Michael D Evans,Maria Vargas,Nicholas Marka,Fernando Fervenza,Sanjeev Sethi,Ladan Zand","doi":"10.1016/j.kint.2025.04.018","DOIUrl":"https://doi.org/10.1016/j.kint.2025.04.018","url":null,"abstract":"INTRODUCTIONMonoclonal gammopathy of renal significance (MGRS) is increasingly recognized as an important causes of kidney failure. A kidney biopsy remains an important diagnostic measure. However, a kidney biopsy is not without risks. Here, we devised the Mayo MGRS Prediction Tool to assess the probability of finding MGRS in patients with chronic kidney disease with monoclonal gammopathy (MG).METHODSWe included patients from 2013 to October 2023 who underwent a kidney biopsy at the Mayo Clinic excluding those whose hematological condition required specific treatment due to tumor burden such as multiple myeloma.RESULTSOf 280 patients, 92 (32.9%) had MGRS lesions with amyloid light chain or primary amyloidosis being the most common lesion in 38 patients (41.3%). We performed multivariable logistic regression with forward variable selection to fit the model. The final model included eight predictors: diabetes, affected/unaffected free light chain ratio, urinary protein (g/24 hours), positive urine protein electrophoresis or immunofixation electrophoresis, serum creatinine, C3 level (mg/dL), hematuria, and systolic blood pressure. The calculated and optimism corrected area under the curve was 0.896 and 0.836 respectively. The decision curve analysis showed that the model provided net benefit across all thresholds. A threshold probability of 0.10 was 98.9% sensitive and 50.5% specific and threshold probability of 0.25 was 88.0% sensitive and 70.2% specific. The model was validated using an external cohort of 109 patients from the University of Minnesota with good performance.CONCLUSIONSOur Mayo MGRS Prediction Tool is useful assisting clinicians in predicting the probability of finding an MGRS lesion in a kidney biopsy.","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"137 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144122024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The authors reply","authors":"Smeeta Sinha ,&nbsp;Rachel M. Holden ,&nbsp;Rosa M.A. Moysés ,&nbsp;Markus Ketteler ,&nbsp;coauthors","doi":"10.1016/j.kint.2025.03.005","DOIUrl":"10.1016/j.kint.2025.03.005","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 6","pages":"Pages 1113-1114"},"PeriodicalIF":14.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144089273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osmotic nephropathy induced by SGLT2 inhibitor overdose","authors":"Yoshihiro Kawata ,&nbsp;Makoto Araki ,&nbsp;Yasuhiro Onodera ,&nbsp;Yayoi Ogawa ,&nbsp;Mitsuru Yanai","doi":"10.1016/j.kint.2024.10.035","DOIUrl":"10.1016/j.kint.2024.10.035","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 6","pages":"Page 1116"},"PeriodicalIF":14.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144090523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The metabolite alpha-ketoglutarate inhibits vascular calcification partially through modulation of TET2/NLRP3 inflammasome signaling pathway.","authors":"Mingwei Fu,Zirong Lan,Yuanzhi Ye,Yuan Gong,Qingchun Liang,Mingxi Li,Liyun Feng,An Chen,Qianqian Dong,Yining Li,Siyi Wang,Xiaoyu Liu,Xiuli Zhang,Jing-Song Ou,Lihe Lu,Jianyun Yan","doi":"10.1016/j.kint.2025.04.016","DOIUrl":"https://doi.org/10.1016/j.kint.2025.04.016","url":null,"abstract":"INTRODUCTIONVascular calcification is prevalent in chronic kidney disease (CKD), but existing medical treatments fail to achieve satisfactory therapeutic effects. Vascular calcification is now recognized as an active multifactorial process involving diverse mechanisms. Alpha-ketoglutarate (AKG), an intermediate in tricarboxylic acid cycle, has been demonstrated to extend lifespan and ameliorate age-related osteoporosis. However, whether AKG inhibits vascular calcification remains unknown.METHODSHere, mineral deposition was studied with AKG treatment in rodent and human vascular smooth muscle cells (VSMCs) under osteogenic conditions in vivo and in vitro.RESULTSAKG treatment remarkably ameliorated calcification of rat and human arterial rings ex vivo and aortic calcification in CKD rats and mice. Mechanistically, AKG treatment upregulated DNA demethylase ten-eleven translocation 2 (TET2) expression during vascular calcification. Knockdown of TET2 by siRNA and pharmacological inhibition of TET2 by Bobcat339 promoted vascular calcification in rat VSMCs. Bobcat339 also enhanced rat aortic ring calcification. Conversely, TET2 overexpression ameliorated vascular calcification in rat VSMCs, rat aortic rings and CKD rats. Furthermore, VSMC-specific TET2 deficiency promoted aortic calcification in CKD mice. Both TET2 siRNA and Bobcat339 independently counteracted the inhibitory effect of AKG on vascular calcification of rat VSMCs. Inhibitory effect of AKG administration on vascular calcification was reduced in TET2 knockout mice. TET2 overexpression reduced the levels of the NLRP3 inflammasome pathway, cleaved Caspase-1 and IL-1β protein expression in VSMCs and NLRP3 agonist Nigericin-induced cell calcification.CONCLUSIONSOur study demonstrate that AKG attenuates vascular calcification partially via upregulation of TET2 and inhibition of NLRP3 inflammasome, indicating the critical role of epigenetic modifier in vascular calcification. Modulation of TET2 may become a promising strategy for the treatment of vascular calcification.","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"42 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding the spectrum of genetic causes of DNA-specific exonucleaseTREX1 variants in thrombotic microangiopathy.","authors":"Jing-Yi Li,Ji-Cheng Lv,Hong Zhang,Xu-Jie Zhou","doi":"10.1016/j.kint.2025.04.014","DOIUrl":"https://doi.org/10.1016/j.kint.2025.04.014","url":null,"abstract":"INTRODUCTIONThrombotic microangiopathy (TMA) is a complex condition involving endothelial damage and microvascular thrombi. The International Society of Nephrology's HUS International Forum identified genetic variants as crucial for tailored therapies like plasma exchange and anti-complement therapy. Recent studies suggested that new pathogenic genes beyond complement, and coagulation pathways contribute to TMA including TREX1 variants. The protein TREX1, a DNA-specific exonuclease, maintains genome integrity and regulates immune responses by degrading damaged cytosolic DNA. Variants disrupting TREX1's endoplasmic reticulum anchoring can lead to vasculopathy.METHODSWe conducted retrospective in silico studies involving 53 patients with TMA, 94 with IgA nephropathy with microangiopathic lesions, 25 with C3G glomerulopathy and 20 with ANCA-associated vasculitis.RESULTSPathogenic variants of TREX1 were found in 5.7% of patients with TMA and 3.2% of patients with IgA nephropathy with microangiopathic lesions, but none in C3 glomerulopathy or ANCA-associated vasculitis.CONCLUSIONSOur study highlights the importance of TREX1 variants in microvascular diseases, particularly in thrombotic microangiopathy and IgA nephropathy. TREX1's critical role in genome integrity and immune regulation may offer new therapeutic avenues for treatment.","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"5 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}