Journal of Zhejiang University SCIENCE B最新文献

{"title":"Sporadic Alzheimer's disease with bipolar-like features: a case report and a brief review of the current research status.","authors":"Lingzhuo Kong, Yan Yang, Weihua Zhou, Shaohua Hu","doi":"10.1631/jzus.B2500307","DOIUrl":"10.1631/jzus.B2500307","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is among the main causes of cognitive impairment, memory loss, and dementia, particularly in old adults. It has been listed as one of the most expensive, lethal, and burdening diseases of the 21st century and develops with the process of aging worldwide (Scheltens et al., 2021). Currently, it is widely acknowledged that the typical pathogenesis of AD involves the deposition of amyloid-β (Aβ) and Tau proteins in the cerebral parenchyma and vasculature, intraneuronal neurofibrillary tangles, and the gradual degeneration of synapses (Scheltens et al., 2016; Rostagno, 2022). According to several hypotheses, abnormalities and dysfunctions in vascular structure, mitochondrial metabolism, oxidative stress, glucose utilization, and neuroinflammation are considered fundamental for AD pathology (Scheltens et al., 2016).</p>","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"27 4","pages":"416-425"},"PeriodicalIF":5.7,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13121885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell proliferation and differentiation during epidermis renewal.","authors":"Kai Liu, Kaidi Ren, Dengwen Li, Yang Yang","doi":"10.1631/jzus.B2500085","DOIUrl":"10.1631/jzus.B2500085","url":null,"abstract":"<p><p>Residing at the outermost layer of the skin, the epidermis is composed of stratified squamous epithelial cells. Regular renewal of the epidermis is essential for maintaining its barrier function, which is dependent on the orchestrated proliferation and differentiation of stem cells located in the basal epidermis. This process necessitates precise dual regulation through the intrinsic control of cell division orientation and external microenvironmental influences. In this comprehensive review, we delve into the critical processes underlying epidermis renewal, emphasizing the balance between symmetric and asymmetric cell fate and the integration of differentiated cells into the suprabasal layer. Our paper highlights the pivotal roles of single-cell omics, live imaging, and artificial intelligence (AI)-driven modeling techniques in elucidating the molecular mechanisms governing cell proliferation and differentiation during epidermis renewal.</p>","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"27 6","pages":"603-614"},"PeriodicalIF":5.7,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13294290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148317775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic structure and admixture of the Yi and Qiang in southwestern China.","authors":"Jun Liu, Li Jiang, Yongqiang Kong, Chunnian Wang, Shuo Feng, Xuanzhu Chen, Deqin Zhang, Chuanchao Wang, Caixia Li","doi":"10.1631/jzus.B2400576","DOIUrl":"10.1631/jzus.B2400576","url":null,"abstract":"<p><p>The Tibetan-Yi Corridor in southwestern China is well-known for the origins, migration, and evolution of Sino-Tibetan populations. Previous genetic studies have primarily focused on Han and Tibetan populations, thereby leaving the significant genetic diversity within the Tibeto-Burman groups under-researched. In this study, to explore the genetic structure and admixture history of Tibeto-Burman populations in southwestern China, we sequenced the human genomes of 100 individuals from the Qiang and Yi ethnic groups in Sichuan Province. These populations were found to have the closest genetic affinity with nearby Tibeto-Burman-speaking Tujia and Tibetan populations. The Qiang share more allele sites with northern Altaic-speaking populations, while the Yi have closer genetic relationships with southern Hmong-Mien populations. The dominant ancestry of the Yi and Qiang derived from Neolithic millet agriculturalists in the Yellow River Basin, with a smaller proportion from Neolithic coastal populations in southern China, supporting the hypothesis of a northern origin of Sino-Tibetan populations. The Yi have more southern genetic components than the Qiang, reflecting the differential genetic influences of southeastern coastal populations on these groups. In summary, this study elucidates the fine-scale genetic structure of Tibeto-Burman populations and their genetic relationships with other Chinese populations, laying the foundation for forensic genetic research in East Asian populations.</p>","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"27 4","pages":"402-415"},"PeriodicalIF":5.7,"publicationDate":"2026-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13121884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early albumin infusion and mortality in elderly patients with sepsis based on analysis of the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database.","authors":"Jinmin Chen, Yuanqiang Lu","doi":"10.1631/jzus.B2400268","DOIUrl":"10.1631/jzus.B2400268","url":null,"abstract":"<p><p>As the impact of early albumin infusion on the prognosis of elderly individuals diagnosed with sepsis remains uncertain, this study aimed to investigate this effect in elderly patients with sepsis in the intensive care unit (ICU). We identified the information of elderly patients with sepsis requiring ICU admission from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database. They were divided into hypoalbuminemia group and control group, and the primary outcome was 90-d mortality. A multivariate logistic regression model and a multivariate Cox proportional-hazards model were used to analyze the correlation between hypoalbuminemia and patient prognosis. Kaplan-Meier survival curve and log-rank test were performed to analyze the survival outcomes. Propensity score matching (PSM) was implemented to determine the precise effect of early albumin infusion on the prognosis of elderly ICU patients with sepsis, and subgroups of patients were identified to explore the factors influencing the relationship. Early hypoalbuminemia was strongly associated with an increased risk of adverse clinical outcomes in elderly patients with sepsis in the ICU. In-hospital mortality (28.6% vs. 19.1%, <i>P</i><0.001) and 90-d mortality (48.8% vs. 33.4%, <i>P</i><0.001) were both significantly higher in the early hypoalbuminemia group than in the control group. PSM analysis showed that early albumin infusion was associated with lower in-hospital mortality and 90-d mortality in elderly patients with sepsis combined with hypoalbuminemia in the ICU. Early infusion of albumin could improve patient prognosis and reduce in-hospital mortality and 90-d mortality.</p>","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"27 4","pages":"390-401"},"PeriodicalIF":5.7,"publicationDate":"2026-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13121881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting <i>WTAP</i> sensitizes hepatocellular carcinoma to sorafenib by inhibiting the ERK signaling pathway.","authors":"Yu Wu, Guomin Ju, Xueyu Zhou, Jian Wu, Shusen Zheng, Chuanhui Peng","doi":"10.1631/jzus.B2500191","DOIUrl":"10.1631/jzus.B2500191","url":null,"abstract":"<p><p>Hepatocellular carcinoma (HCC) often requires targeted therapy and immunotherapy due to frequent delayed diagnosis. Sorafenib, the first targeted drug applied to treat HCC, has demonstrated a remarkable therapeutic effect in the clinic. However, its clinical application has been limited by drug resistance and the insufficient understanding of the relevant mechanism. Wilms' tumor 1-associated protein (WTAP), associated with tumor progression, remains unstated in sorafenib resistance. In this study, <i>WTAP</i> expression patterns in HCC were systematically characterized through integrative analysis of The Cancer Genome Atlas (TCGA) datasets and spatial transcriptomic profiling. To delineate the potential mechanisms of <i>WTAP</i>-mediated sorafenib resistance in HCC, multimodal approaches integrating gene set enrichment analysis (GSEA), predictions from the \"oncoPredict\" package in vitro experiments, molecular docking simulations, and western blot validation were applied. To further investigate the role of <i>WTAP</i> in drug resistance, hydrodynamic tail vein injection (HTVi) mouse models and immunohistochemistry were utilized. Significant <i>WTAP</i> upregulation was identified in HCC tissues, showing strong associations with tumor progression and adverse clinical outcomes. The knockdown of <i>WTAP</i> sensitized HCC cells to sorafenib in vitro. GSEA, molecular docking analysis, and western blot analysis demonstrated that <i>WTAP</i> induces the activation of the extracellular signal-regulated kinase (ERK) signaling pathway, a critical link in chemoresistance mechanisms. In the HTVi HCC model, the combination of <i>WTAP</i> knockdown with sorafenib markedly suppressed tumor progression and boosted survival rates. These findings highlight that <i>WTAP</i> positively regulates the ERK pathway in HCC, promoting sorafenib resistance; therefore, targeting <i>WTAP</i> may represent a novel strategy to potentiate sorafenib responsiveness in HCC.</p>","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"27 3","pages":"310-320"},"PeriodicalIF":5.7,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12996864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147474388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ectopic expression of structurally similar major royal jelly proteins reveals their distinct functions in <i>Drosophila</i>.","authors":"Lingqi Yu, Danfeng Wang, Xuanhao Chen, Jiayu Xie, Dongjing Wen, Yi Zhang, Lirong Shen, Wenfeng Chen, Zhenxing Liu, Yufeng Yang","doi":"10.1631/jzus.B2400624","DOIUrl":"10.1631/jzus.B2400624","url":null,"abstract":"<p><p>Royal jelly (RJ), secreted by the hypopharyngeal and mandibular glands of young worker bees, is rich in proteins, 80%‒90% of which are major royal jelly proteins (MRJPs). While MRJPs from RJ have been shown to exhibit specific biological functions and are also expressed in neuronal cells, their roles in vivo remain poorly understood. The aim of this study was to elucidate the functional roles of individual MRJPs (MRJP1‒9) in vivo by ectopically expressing them in <i>Drosophila</i> neurons in a binary expression system using fluorescent proteins as controls. Transcriptome sequencing revealed that although MRJP1‒9 share similar tertiary structures, their overexpression affects distinct gene sets. MRJP1, MRJP2, MRJP3, MRJP5, and MRJP7 induced more differentially expressed genes (DEGs), while MRJP4, MRJP6, MRJP8, and MRJP9 induced fewer such genes. Weighted gene co-expression network analysis (WGCNA) and gene set enrichment analysis (GSEA) revealed that MRJP1, MRJP2, MRJP3, MRJP5, and MRJP7 regulated overlapping gene sets, including an estradiol-responsive set, and activated cell proliferation pathways. MRJP6 lacked any significant gene set enrichment, while MRJP8 and MRJP9 modulated similar sets. Notably, the neuron-specific overexpression of MRJP1, MRJP2, MRJP3, and MRJP5 in <i>Drosophila</i> showed activated cell proliferation-related pathways and increased body sizes, highlighting their functional diversity and context-dependent effects. These findings expand our understanding of the functional roles of MRJPs and provide a foundation for further exploring their biological significance in honeybees and beyond.</p>","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"27 3","pages":"295-309"},"PeriodicalIF":5.7,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12996861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147474374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microencapsulation and characterization of controlled-release intestinal drugs: a critical review.","authors":"Weiguang Su, Dawei Wang, Siegfried Yeboah, Jinshen Wang, Chonghai Xu, Li Wang","doi":"10.1631/jzus.B2400617","DOIUrl":"10.1631/jzus.B2400617","url":null,"abstract":"<p><p>Oral administration is associated with high patient adherence, as it is not only the route for primary site absorption of nutrients and peptide drugs but also is important for treating intestinal diseases. However, traditional oral intestinal drugs are limited by drug degradation and inactivation, particularly for proteins and peptides, due to gastric acid and digestive enzymes, making it difficult to effectively deliver drugs to target sites. To address these challenges, controlled-release microencapsulated intestinal drugs (MeIDs) have been developed and have attracted attention for their ability to protect drugs from degradation by gastric acid and digestive enzymes. In this study, we systematically reviewed research articles on the preparation methods, release mechanisms, and evaluation strategies of MeIDs using Google Scholar, Web of Science, and Science Direct databases. Our findings show that the preparation of emulsions, microencapsulation methods, shell material selection, and drug properties need to be considered comprehensively for MeID development. In addition, we found that coating, micro/nanocarriers, and absorption enhancers can be combined to enhance microcapsule performance. Beyond focusing on drug loading efficiency and microcapsule morphology, we also found that cell models, animal models, and spectroscopic analysis techniques can be used to evaluate drug biocompatibility, stability, and efficacy. Finally, the literature has shown that optimizing the preparation process can regulate drug release kinetics. For future research, we suggest that studies should focus on low-cost methods for producing monodisperse microcapsules, developing dynamic responsive shell materials, and using organ-on-a-chip technology for precise evaluation, as part of the theoretical support towards the development of microencapsulated drugs and targeted drug delivery.</p>","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"27 4","pages":"321-342"},"PeriodicalIF":5.7,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13121888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroscientific therapies for subjective tinnitus.","authors":"Peng Liu, Xinmiao Xue, Zhixin Zhang, Hanwen Zhou, Cong Xu, Lijun Zhang, Zhen Li, Yongqing Zhou, Shanwei Song, Yameng Tian, Fangyuan Wang, Xiaoming Li, Shiming Yang","doi":"10.1631/jzus.B2400579","DOIUrl":"10.1631/jzus.B2400579","url":null,"abstract":"<p><p>Tinnitus, a prevalent auditory symptom, can significantly impair quality of life, yet no definitive pharmacological interventions exist despite extensive ongoing research into its pathophysiology and treatments. The advent of biomedical engineering has introduced neuromodulation as a pivotal therapeutic approach alongside conventional strategies such as pharmacotherapy and surgery. Through the deployment of invasive and non-invasive techniques, using various modalities including magnetic, electronic, and optical means, neuromodulation aims to regulate neural functions. This has not only led to the refinement of fundamental theories but has also enhanced the optimization of clinical applications. As an emerging and promising intervention, neuromodulation enriches the toolkit available for basic neuroscience inquiry and broadens the spectrum of clinical therapies for conditions affecting the central nervous system, including tinnitus. In this paper, we succinctly review the current understanding of tinnitus mechanisms, discuss the features of diverse neuromodulation technologies, explore their application in tinnitus management, and contemplate prospects for their development in treating tinnitus.</p>","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"27 4","pages":"343-358"},"PeriodicalIF":5.7,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13121886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Roles of Wnt signaling pathway in cementum formation, cementum regeneration, and cementocyte function.","authors":"Tiancheng Li, Xinyi Zeng, Shuxian Yang, Lynda Faye Bonewald, Peipei Duan","doi":"10.1631/jzus.B2400637","DOIUrl":"10.1631/jzus.B2400637","url":null,"abstract":"<p><p>Cementum, a mineralized connective tissue that covers the tooth root, is crucial in protecting the root from resorption, maintaining occlusal relationships, and supporting tooth function. Cementocytes are embedded within the cementum matrix and extend dendritic processes through the canaliculi. They are thought to be mechanosensitive, responding to changes in mechanical loading, and are physiologically responsive cells associated with the formation of cellular cementum in response to variations in functional demands on the tooth. The wingless and int (Wnt) signaling pathway, which controls cell fate and regulates growth, development, and homeostasis in the body, plays a pivotal regulatory role in normal biological development and disease progression. Currently, the mechanisms by which the Wnt signaling pathway influences cementogenesis and regeneration remain controversial. Research findings on the roles of Wnt/β-catenin signaling in cementoblast differentiation and function have been mixed. Some studies indicate that activating this pathway enhances cementoblast differentiation, while others suggest that Wnt signaling may inhibit it, favoring cell proliferation instead. This paper reviews the structure and physiological roles of cementum, focusing on how Wnt signaling influences the growth and differentiation of cementoblasts. We emphasize the pivotal role of the Wnt pathway in cementum formation and development, as well as in root resorption and repair, and hypothesize that maintaining low Wnt/β-catenin levels is crucial to achieving an optimal balance between cementoblast proliferation and differentiation. Finally, we propose periodontal regeneration treatment strategies based on the Wnt signaling pathway and suggest future research directions.</p>","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"27 3","pages":"207-224"},"PeriodicalIF":5.7,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12996863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147474425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type 2 inflammation accelerates CD4⁺ T-cell senescence in asthma.","authors":"Huan Liu, Zemin Li, Yongchang Sun, Abudureyimujiang Aili, Chun Chang","doi":"10.1631/jzus.B2500233","DOIUrl":"10.1631/jzus.B2500233","url":null,"abstract":"<p><p>Asthma is a complex and chronic inflammatory airway disease associated with the abnormal activation of immune cells. T-cell senescence is linked to immune dysfunction and persistent inflammation, but the relationship between asthma and T-cell senescence remains unexplored. This study reveals significantly higher percentages of cluster of differentiation 4-positive (CD4⁺) senescent T cells (Tsens) in asthma patients than in healthy controls, while CD8⁺ Tsen percentages do not appear to increase. CD4⁺ Tsen percentages in both the blood and sputum are positively correlated with fractional exhaled nitric oxide (FeNO) values, eosinophil abundance, and T helper type 2 (Th2) cell abundance in the blood. The clinical manifestations of asthma were recreated in a house dust mite (HDM)-induced mouse model. In HDM-exposed mice, CD4⁺ Tsen percentages were also elevated in the lungs. To counteract T-cell senescence, therapeutic interventions, including interleukin-4 (IL-4) antibodies and dexamethasone, were administered to the mice. IL-4 neutralization reduced CD4⁺ Tsen percentages and inhibited p38 mitogen-activated protein kinase (MAPK) activation. Adoptive transfer of CD4⁺ Tsens did not induce spontaneous asthma in phosphate-buffered saline (PBS)-treated mice but exacerbated type 2 inflammation in HDM-treated mice. Our study revealed a significant increase in CD4⁺ Tsen (CD57⁺CD28^-) abundance in asthma patients and suggested that type 2 inflammation drives CD4⁺ T-cell senescence in asthma. Furthermore, adoptive transfer of CD4⁺ Tsens appears to exacerbate type 2 inflammation.</p>","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"27 2","pages":"149-163"},"PeriodicalIF":5.7,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12885609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146142871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}