Journal of Zhejiang University SCIENCE B最新文献_第10页

Micropeptides: origins, identification, and potential role in metabolism-related diseases. 微肽:起源、鉴定及其在代谢相关疾病中的潜在作用

IF 5.1 3区生物学

Journal of Zhejiang University SCIENCE B Pub Date : 2023-12-15 DOI: 10.1631/jzus.B2300128

Yirui Lu, Yutong Ran, Hong Li, Jiao Wen, Xiaodong Cui, Xiaoyun Zhang, Xiumei Guan, Min Cheng

引用次数: 0

Abscisic acid-mediated cytosolic Ca²⁺ modulates triterpenoid accumulation of Ganoderma lucidum. 脱落酸介导的胞质Ca2+调节灵芝三萜积累。

IF 5.1 3区生物学

Journal of Zhejiang University SCIENCE B Pub Date : 2023-12-15 DOI: 10.1631/jzus.B2300279

Meilin Cui, Yitao Zhao, Xiuhong Zhang, Wei Zhao

{"title":"Abscisic acid-mediated cytosolic Ca2+ modulates triterpenoid accumulation of Ganoderma lucidum.","authors":"Meilin Cui, Yitao Zhao, Xiuhong Zhang, Wei Zhao","doi":"10.1631/jzus.B2300279","DOIUrl":"10.1631/jzus.B2300279","url":null,"abstract":"Ganoderma lucidum is a mushroom widely used for its edible and medicinal properties. Primary bioactive constituents of G. lucidum are ganoderic triterpenoids (GTs), which exhibit important pharmacological activity. Abscisic acid (ABA), a plant hormone, is associated with plant growth, development, and stress responses. ABA can also affect the growth, metabolism, and physiological activities of different fungi and participates in the regulation of the tetracyclic triterpenes of some plants. Our findings indicated that ABA treatment promoted GT accumulation by regulating the gene expression levels (squalene synthase (sqs), 3-hydroxy-3-methylglutaryl-CoA reductase (hmgr), and lanosterol synthase (ls)), and also activated cytosolic Ca2+ channels. Furthermore, under ABA mediation, exogenous Ca2+ donors and inhibitors directly affected the cytosolic Ca2+ concentration and related gene expression in Ca2+ signaling. Our study also revealed that ABA-mediated cytosolic Ca2+ played a crucial regulatory role in GT biosynthesis, accompanied by antioxidant defense modulation with increasing superoxide dismutase (SOD) activity and ascorbate peroxidase (APX) activity, and the resistance ability of O2•- and glutathione (GSH) contents.","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"24 12","pages":"1174-1179"},"PeriodicalIF":5.1,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10710909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138498740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Luteolin suppresses oral carcinoma 3 (OC3) cell growth and migration via modulating polo-like kinase 1 (PLK1) expression and cellular energy metabolism. 木犀草素通过调节polo样激酶1 (PLK1)表达和细胞能量代谢抑制口腔癌3 (OC3)细胞生长和迁移。

IF 5.1 3区生物学

Journal of Zhejiang University SCIENCE B Pub Date : 2023-12-15 DOI: 10.1631/jzus.B2300200

Pengfei Gao, Wentao Zhang, Yujie Lin, Ruijie Lu, Zijian Lou, Gang Lu, Ruolang Pan, Yunfang Chen

{"title":"Luteolin suppresses oral carcinoma 3 (OC3) cell growth and migration via modulating polo-like kinase 1 (PLK1) expression and cellular energy metabolism.","authors":"Pengfei Gao, Wentao Zhang, Yujie Lin, Ruijie Lu, Zijian Lou, Gang Lu, Ruolang Pan, Yunfang Chen","doi":"10.1631/jzus.B2300200","DOIUrl":"10.1631/jzus.B2300200","url":null,"abstract":"Oral squamous cell carcinoma (OSCC) is a prevalent malignant tumor affecting the head and neck region (Leemans et al., 2018). It is often diagnosed at a later stage, leading to a poor prognosis (Muzaffar et al., 2021; Li et al., 2023). Despite advances in OSCC treatment, the overall 5-year survival rate of OSCC patients remains alarmingly low, falling below 50% (Jehn et al., 2019; Johnson et al., 2020). According to statistics, only 50% of patients with oral cancer can be treated with surgery. Once discovered, it is more frequently at an advanced stage. In addition, owing to the aggressively invasive and metastatic characteristics of OSCC, most patients die within one year of diagnosis. Hence, the pursuit of novel therapeutic drugs and treatments to improve the response of oral cancer to medication, along with a deeper understanding of their effects, remains crucial objectives in oral cancer research (Johnson et al., 2020; Bhat et al., 2021; Chen et al., 2023; Ruffin et al., 2023).","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"24 12","pages":"1151-1158"},"PeriodicalIF":5.1,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10710912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138498744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proapoptotic protein Bim regulates the suppressive function of Treg cells. 促凋亡蛋白Bim调节Treg细胞的抑制功能。

IF 5.1 3区生物学

Journal of Zhejiang University SCIENCE B Pub Date : 2023-12-15 DOI: 10.1631/jzus.B2300288

Di Wu

引用次数: 0

Typical hemophagocytic syndrome associated with cytomegalovirus infection in an immunocompetent patient: a case report and literature review. 免疫功能正常患者巨细胞病毒感染伴典型噬血细胞综合征1例报告及文献复习。

IF 5.1 3区生物学

Journal of Zhejiang University SCIENCE B Pub Date : 2023-12-15 DOI: 10.1631/jzus.B2300232

Fangfang Geng, Meifang Yang, Xuan Zhang, Hong Zhao, De Zhou, Jianhua Hu

引用次数: 0

A case of vitiligo after COVID-19 vaccination: a possible role of thymic dysfunction. COVID-19疫苗接种后白癜风1例:胸腺功能障碍的可能作用

IF 5.1 3区生物学

Journal of Zhejiang University SCIENCE B Pub Date : 2023-12-15 DOI: 10.1631/jzus.B2300025

Denis Kuznetsov, Oleg Kalyuzhin, Andrey Mironov, Valery Neschisliaev, Anastasiia Kuznetsova

引用次数: 0

Fibrillarin promotes homologous recombination repair by facilitating the recruitment of recombinase RAD51 to DNA damage sites. 纤维蛋白通过促进重组酶RAD51在DNA损伤位点的募集来促进同源重组修复。

IF 5.1 3区生物学

Journal of Zhejiang University SCIENCE B Pub Date : 2023-12-15 DOI: 10.1631/jzus.B2300518

Yanhua Mu, Jinhua Han, Mingjie Wu, Zongfang Li, Ke DU, Yameng Wei, Mengjie Wu, Jun Huang

{"title":"Fibrillarin promotes homologous recombination repair by facilitating the recruitment of recombinase RAD51 to DNA damage sites.","authors":"Yanhua Mu, Jinhua Han, Mingjie Wu, Zongfang Li, Ke DU, Yameng Wei, Mengjie Wu, Jun Huang","doi":"10.1631/jzus.B2300518","DOIUrl":"10.1631/jzus.B2300518","url":null,"abstract":"Eukaryotic organisms constantly face a wide range of internal and external factors that cause damage to their DNA. Failure to accurately and efficiently repair these DNA lesions can result in genomic instability and the development of tumors (Canela et al., 2017). Among the various forms of DNA damage, DNA double-strand breaks (DSBs) are particularly harmful. Two major pathways, non-homologous end joining (NHEJ) and homologous recombination (HR), are primarily responsible for repairing DSBs (Katsuki et al., 2020; Li and Yuan, 2021; Zhang and Gong, 2021; Xiang et al., 2023). NHEJ is an error-prone repair mechanism that simply joins the broken ends together (Blunt et al., 1995; Hartley et al., 1995). In contrast, HR is a precise repair process. It involves multiple proteins in eukaryotic cells, with the RAD51 recombinase being the key player, which is analogous to bacterial recombinase A (RecA) (Shinohara et al., 1992). The central event in HR is the formation of RAD51-single-stranded DNA (ssDNA) nucleoprotein filaments that facilitate homology search and DNA strand invasion, ultimately leading to the initiation of repair synthesis (Miné et al., 2007; Hilario et al., 2009; Ma et al., 2017).","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"24 12","pages":"1165-1173"},"PeriodicalIF":5.1,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10710916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138498742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial expression of the nonsense-mediated mRNA decay factors UPF3A and UPF3B among mouse tissues. 无义介导的mRNA衰变因子UPF3A和UPF3B在小鼠组织中的空间表达。

IF 4.7 3区生物学

Journal of Zhejiang University SCIENCE B Pub Date : 2023-11-15 DOI: 10.1631/jzus.B2300126

Xin Ma, Yan Li, Chen Chengyan, Yanmin Shen, Hua Wang, Tangliang Li

引用次数: 0

HPCAL1 is a novel driver of autophagy-dependent ferroptosis. HPCAL1是一种新的自噬依赖性铁下垂驱动因子。

IF 4.7 3区生物学

Journal of Zhejiang University SCIENCE B Pub Date : 2023-11-15 DOI: 10.1631/jzus.B2300241

Liwen Wang, Qin Li, Huimei Liu, Lanfang Li

引用次数: 0

Advantages of contrast-enhanced ultrasound in the localization and diagnostics of sentinel lymph nodes in breast cancer. 超声造影在乳腺癌前哨淋巴结定位和诊断中的优势。

IF 5.1 3区生物学

Journal of Zhejiang University SCIENCE B Pub Date : 2023-11-15 DOI: 10.1631/jzus.B2300019

Qiuhui Yang, Yeqin Fu, Jiaxuan Wang, Hongjian Yang, Xiping Zhang

{"title":"Advantages of contrast-enhanced ultrasound in the localization and diagnostics of sentinel lymph nodes in breast cancer.","authors":"Qiuhui Yang, Yeqin Fu, Jiaxuan Wang, Hongjian Yang, Xiping Zhang","doi":"10.1631/jzus.B2300019","DOIUrl":"10.1631/jzus.B2300019","url":null,"abstract":"Sentinel lymph nodes (SLNs) are the first station of lymph nodes that extend from the breast tumor to the axillary lymphatic drainage. The pathological status of these LNs can predict that of the entire axillary lymph node. Therefore, the accurate identification of SLNs is necessary for sentinel lymph node biopsy (SLNB) to replace axillary lymph node dissection (ALND). The quality of life and prognosis of breast cancer patients are related to proper surgical treatment after the precise identification of SLNs. Some of the SLN tracers that have been identified include radioisotope, nano-carbon, indocyanine green (ICG), and methylene blue (MB). However, these tracers have certain limitations, such as pigmentation, radiation dangers, and the requirement for costly detection equipment. Ultrasound contrast agents (UCAs) have good specificity and sensitivity, and thus can compensate for some shortcomings of the mentioned tracers. This technique is also being applied to SLNB in patients with breast cancer, and can even provide an initial judgment on SLN status. Contrast-enhanced ultrasound (CEUS) has the advantages of high distinguishability, simple operation, no radiation harm, low cost, and accurate localization; therefore, it is expected to replace the traditional biopsy methods. In addition, it can significantly enhance the accuracy of SLN localization and shorten the operation time.","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"24 11","pages":"985-997"},"PeriodicalIF":5.1,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92154875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0