Journal of Zhejiang University SCIENCE B最新文献

Small fish making a big difference: beloved star of environmental toxicology research in the current era. 小鱼产生巨大影响：当今时代环境毒理学研究的宠儿。

IF 4.9 3区生物学

Journal of Zhejiang University SCIENCE B Pub Date : 2025-07-15 DOI: 10.1631/jzus.B2500166

Yang Jiang, Zhen Su, Jing Zheng, Chih-Hung Hsu, Ye Chen

引用次数: 0

Epigenetic factors associated with peri-implantitis: a review. 与种植体周围炎相关的表观遗传因素：综述。

IF 4.9 3区生物学

Journal of Zhejiang University SCIENCE B Pub Date : 2025-07-04 DOI: 10.1631/jzus.B2400032

Qianhui Li, Hongye Lu, Mengyuan Zhang, Yuting Ye, Qianming Chen, Ping Sun

{"title":"Epigenetic factors associated with peri-implantitis: a review.","authors":"Qianhui Li, Hongye Lu, Mengyuan Zhang, Yuting Ye, Qianming Chen, Ping Sun","doi":"10.1631/jzus.B2400032","DOIUrl":"10.1631/jzus.B2400032","url":null,"abstract":"Peri-implant diseases are characterized by the resorption of hard tissue and the inflammation of soft tissue. Epigenetics refers to alterations in the expression of genes that are not encoded in the DNA sequence, influencing diverse physiological activities, including immune response, inflammation, and bone metabolism. Epigenetic modifications can lead to tissue-specific gene expression variations among individuals and may initiate or exacerbate inflammation and disease predisposition. However, the impact of these factors on peri-implantitis remains inconclusive. To address this gap, we conducted a comprehensive review to investigate the associations between epigenetic mechanisms and peri-implantitis, specifically focusing on DNA methylation and microRNAs (miRNAs or miRs). We searched for relevant literature on PubMed, Web of Science, Scopus, and Google Scholar with keywords including \"epigenetics,\" \"peri-implantitis,\" \"DNA methylation,\" and \"microRNA.\" DNA methylation and miRNAs present a dynamic epigenetic mechanism operating around implants. Epigenetic modifications of genes related to inflammation and osteogenesis provide a new perspective for understanding how local and environmental factors influence the pathogenesis of peri-implantitis. In addition, we assessed the potential application of DNA methylation and miRNAs in the prevention, diagnosis, and treatment of peri-implantitis, aiming to provide a foundation for future studies to explore potential therapeutic targets and develop more effective management strategies for this condition. These findings also have broader implications for understanding the pathogenesis of other inflammation-related oral diseases like periodontitis.","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"26 7","pages":"657-674"},"PeriodicalIF":4.9,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12303790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EGCG as a therapeutic agent: a systematic review of recent advances and challenges in nanocarrier strategies. EGCG作为一种治疗剂：纳米载体策略的最新进展和挑战的系统综述。

IF 4.9 3区生物学

Journal of Zhejiang University SCIENCE B Pub Date : 2025-06-30 DOI: 10.1631/jzus.B2400040

Chee Ning Wong, Yang Mooi Lim, Kai Bin Liew, Yik-Ling Chew, Ang-Lim Chua, Siew-Keah Lee

{"title":"EGCG as a therapeutic agent: a systematic review of recent advances and challenges in nanocarrier strategies.","authors":"Chee Ning Wong, Yang Mooi Lim, Kai Bin Liew, Yik-Ling Chew, Ang-Lim Chua, Siew-Keah Lee","doi":"10.1631/jzus.B2400040","DOIUrl":"10.1631/jzus.B2400040","url":null,"abstract":"Epigallocatechin-3-gallate (EGCG), a bioactive polyphenol abundant in green tea, has garnered significant attention for its diverse therapeutic applications, ranging from antioxidant and anti-inflammatory effects to potential anticancer properties. Despite its immense promise, the practical utilization of EGCG in therapeutic settings as a medication has been hampered by inherent limitations of this drug, including poor bioavailability, instability, and rapid degradation. This review comprehensively explores the current challenges associated with the application of EGCG and evaluates the potential of nanoparticle-based formulations in addressing these limitations. Nanoparticles, with their unique physicochemical properties, offer a platform for the enhanced stability, bioavailability, and targeted delivery of EGCG. Various nanoparticle strategies, including polymeric nanoparticle, micelle, lipid-based nanocarrier, metal nanoparticle, and silica nanoparticle, are currently employed to enhance EGCG stability and pharmacological activity. This review concludes that the particle sizes of most of these formulated nanocarriers fall within 300 nm and their encapsulation efficiency ranges from 51% to 97%. Notably, the pharmacological activities of EGCG-loaded nanoparticles, such as antioxidative, anti-inflammatory, anticancer, and antimicrobial effects, are significantly enhanced compared to those of free EGCG. By critically analyzing the existing literature and highlighting recent advancements, this article provides valuable insights into the promising prospects of nanoparticle-mediated EGCG formulations, paving the way for the development of more effective and clinically viable therapeutic strategies.","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"26 7","pages":"633-656"},"PeriodicalIF":4.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12303791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of cardiac arrest and spontaneous renal hemorrhage in a male patient with persistent eosinophilia: highlighting the importance of early diagnosis of eosinophilic granulomatosis with polyangiitis. 持续嗜酸性粒细胞增多症男性患者心脏骤停并自发性肾出血1例：强调嗜酸性粒细胞肉芽肿病合并多血管炎早期诊断的重要性。

IF 4.9 3区生物学

Journal of Zhejiang University SCIENCE B Pub Date : 2025-06-24 DOI: 10.1631/jzus.B2300940

Jinya Lin, Rending Wang, Yuanyuan Zhu, Weijia Huang, Jie Sun

引用次数: 0

Competitive roles of slow/delta oscillation-nesting-mediated sleep disruption under acute methamphetamine exposure in monkeys. 急性甲基苯丙胺暴露下猴子慢振荡/ δ振荡筑巢介导的睡眠中断的竞争作用。

IF 4.9 3区生物学

Journal of Zhejiang University SCIENCE B Pub Date : 2025-06-23 DOI: 10.1631/jzus.B2400048

Xin Lv, Jie Liu, Shuo Ma, Yuhan Wang, Yixin Pan, Xian Qiu, Yu Cao, Bomin Sun, Shikun Zhan

{"title":"Competitive roles of slow/delta oscillation-nesting-mediated sleep disruption under acute methamphetamine exposure in monkeys.","authors":"Xin Lv, Jie Liu, Shuo Ma, Yuhan Wang, Yixin Pan, Xian Qiu, Yu Cao, Bomin Sun, Shikun Zhan","doi":"10.1631/jzus.B2400048","DOIUrl":"10.1631/jzus.B2400048","url":null,"abstract":"Abuse of amphetamine-based stimulants is a primary public health concern. Recent studies have underscored a troubling escalation in the inappropriate use of prescription amphetamine-based stimulants. However, the neurophysiological mechanisms underlying the impact of acute methamphetamine exposure (AME) on sleep homeostasis remain to be explored. This study employed non-human primates and electroencephalogram (EEG) sleep staging to evaluate the influence of AME on neural oscillations. The primary focus was on alterations in spindles, delta oscillations, and slow oscillations (SOs) and their interactions as conduits through which AME influences sleep stability. AME predominantly diminishes sleep-spindle waves in the non-rapid eye movement 2 (NREM2) stage, and impacts SOs and delta waves differentially. Furthermore, the competitive relationships between SO/delta waves nesting with sleep spindles were selectively strengthened by methamphetamine. Complexity analysis also revealed that the SO-nested spindles had lost their ability to maintain sleep depth and stability. In summary, this finding could be one of the intrinsic electrophysiological mechanisms by which AME disrupted sleep homeostasis.","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"26 7","pages":"694-707"},"PeriodicalIF":4.9,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12303792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pig meniscus single-cell sequencing reveals highly active red zone chondrocyte populations involved in stemness maintenance and vascularization development. 猪半月板单细胞测序显示高度活跃的红区软骨细胞群参与干性维持和血管化发育。

IF 4.9 3区生物学

Journal of Zhejiang University SCIENCE B Pub Date : 2025-06-18 DOI: 10.1631/jzus.B2400388

Monika Mankowska, Monika Stefanska, Anna Maria Mleczko, Katarzyna Sarad, Witold Kot, Lukasz Krych, Julia Anna Semba, Eric Lars-Helge Lindberg, Jakub Dalibor Rybka

{"title":"Pig meniscus single-cell sequencing reveals highly active red zone chondrocyte populations involved in stemness maintenance and vascularization development.","authors":"Monika Mankowska, Monika Stefanska, Anna Maria Mleczko, Katarzyna Sarad, Witold Kot, Lukasz Krych, Julia Anna Semba, Eric Lars-Helge Lindberg, Jakub Dalibor Rybka","doi":"10.1631/jzus.B2400388","DOIUrl":"10.1631/jzus.B2400388","url":null,"abstract":"Meniscus injuries are widespread and the available treatments do not offer enough healing potential. Here, we provide critical support for using pigs as a biological model for meniscal degeneration and the development of cutting-edge therapies in orthopedics. We present a single-cell transcriptome atlas of the meniscus, consisting of cell clusters corresponding to four major cell types: chondrocytes, endothelial cells, smooth muscle cells, and immune cells. Five distinct chondrocyte subclusters (CH0‒CH4) were annotated, of which only one was widespread in both the red and white zones, indicating a major difference in the cellular makeup of the zones. Subclusters distinct to the white zone appear responsible for cartilage-specific matrix deposition and protection against adverse microenvironmental factors, while those in the red zone exhibit characteristics of mesenchymal stem cells and are more likely to proliferate and migrate. Additionally, they induce remodeling actions in other chondrocyte subclusters and promote the proliferation and maturation of endothelial cells, inducing healing and vascularization processes. Considering that they have substantial remodeling capabilities, these subclusters should be of great interest for tissue engineering studies. We also show that the cellular makeup of the pig meniscus is comparable to that of humans, which supports the use of pigs as a model in orthopedic therapy development.","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"26 7","pages":"675-693"},"PeriodicalIF":4.9,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12303794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-cell transcriptome analysis reveals abnormal angiogenesis and placentation by loss of imprinted glutaminyl-peptide cyclotransferase. 单细胞转录组分析显示，由于谷氨酰胺肽环转移酶印迹的缺失，血管生成和胎盘异常。

IF 4.7 3区生物学

Journal of Zhejiang University SCIENCE B Pub Date : 2025-06-15 DOI: 10.1631/jzus.B2400099

Jing Guo, Jihong Zheng, Ruixia Li, Jindong Yao, He Zhang, Xu Wang, Chao Zhang

{"title":"Single-cell transcriptome analysis reveals abnormal angiogenesis and placentation by loss of imprinted glutaminyl-peptide cyclotransferase.","authors":"Jing Guo, Jihong Zheng, Ruixia Li, Jindong Yao, He Zhang, Xu Wang, Chao Zhang","doi":"10.1631/jzus.B2400099","DOIUrl":"10.1631/jzus.B2400099","url":null,"abstract":"Imprinted genes play a key role in regulating mammalian placental and embryonic development. Here, we generated glutaminyl-peptide cyclotransferase-knockout (Qpct-/-) mice utilizing the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) platform and identified Qpct as a novel anti-angiogenic factor in regulating mouse placentation. Compared with Qpct+/+ mice, placentae and embryos (Qpct-/+ and Qpct-/-) showed significant overgrowth at embryonic Day 12.5 (E12.5), E15.5, and E18.5. Using single-cell transcriptome analysis of 32 309 cells from Qpct+/+ and Qpct-/- mouse placentae, we identified 13 cell clusters via single-nucleus RNA sequencing (snRNA-seq) (8880 Qpct+/+ and 13 577 Qpct-/- cells) and 20 cell clusters via single-cell RNA sequencing (scRNA-seq) (6567 Qpct+/+ and 3285 Qpct-/- cells). Furthermore, we observed a global up-regulation of pro-angiogenic genes in the Qpct-/- background. Immunohistochemistry assays revealed a notable increase in the number of blood vessels in the decidual and labyrinthine layers of E15.5 Qpct-/+ and Qpct-/- mice. Moreover, the elevation of multiple pairs of ligand-receptor interactions was observed in decidual cells, endothelial cells, and macrophages, promoting angiogenesis and inflammatory response. Our findings indicate that loss of maternal Qpct leads to altered phenotypic characteristics of placentae and embryos and promotes angiogenesis in murine placentae.","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"26 6","pages":"589-608"},"PeriodicalIF":4.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12219499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144506066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seeing the macro in the micro: a diffusion model-based approach for style transfer in cellular images. 从微观看宏观：基于扩散模型的细胞图像风格转移方法。

IF 4.7 3区生物学

Journal of Zhejiang University SCIENCE B Pub Date : 2025-06-11 DOI: 10.1631/jzus.B2500012

Jiayi Cai, Yong He, Feng Liu, Byung-Ho Kang, Xuping Feng

{"title":"Seeing the macro in the micro: a diffusion model-based approach for style transfer in cellular images.","authors":"Jiayi Cai, Yong He, Feng Liu, Byung-Ho Kang, Xuping Feng","doi":"10.1631/jzus.B2500012","DOIUrl":"10.1631/jzus.B2500012","url":null,"abstract":"The internal structures of cells as the basic units of life are a major wonder of the microscopic world. Cellular images provide an intriguing window to help explore and understand the composition and function of these structures. Scientific imagery combined with artistic expression can further expand the potential of imaging in educational dissemination and interdisciplinary applications. This study presents an innovative diffusion model-based approach for style transfer in cellular images, combining scientific rigor with artistic expression. By leveraging training-free large-scale pre-trained diffusion models, the proposed method integrates the intricate morphological and textural features of cellular images with diverse artistic styles. Key techniques such as the inversion of denoising diffusion implicit models (DDIMs), adaptive instance normalization (AdaIN), self-attention style injection, and attention temperature scaling ensure the preservation of cellular structures while enhancing visual expressiveness. The results showcase the potential of this strategy for interdisciplinary applications, enriching both the visualization and educational dissemination of cellular imagery through compelling storytelling and aesthetic appeal.","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"26 6","pages":"609-612"},"PeriodicalIF":4.7,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12219496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144506065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Applications of bioactive peptides in cosmeceuticals: a review. 生物活性肽在药妆中的应用综述。

IF 4.7 3区生物学

Journal of Zhejiang University SCIENCE B Pub Date : 2025-06-11 DOI: 10.1631/jzus.B2400029

Tolulope Joshua Ashaolu

引用次数: 0

Fibroblast growth factors and endometrial decidualization: models, mechanisms, and related pathologies. 成纤维细胞生长因子与子宫内膜去个体化：模型、机制和相关病理。

IF 4.7 3区生物学

Journal of Zhejiang University SCIENCE B Pub Date : 2025-06-02 DOI: 10.1631/jzus.B2300830

Xueni Zhang, Yidi Mo, Chunbin Lu, Zhijian Su, Xiaokun Li

{"title":"Fibroblast growth factors and endometrial decidualization: models, mechanisms, and related pathologies.","authors":"Xueni Zhang, Yidi Mo, Chunbin Lu, Zhijian Su, Xiaokun Li","doi":"10.1631/jzus.B2300830","DOIUrl":"10.1631/jzus.B2300830","url":null,"abstract":"The onset of pregnancy is marked by the formation of a zygote, while the culmination of gestation is manifested by the delivery of a fetus. Meanwhile, a successful pregnancy entails a meticulously coordinated sequence of events from embryo implantation to sustained decidualization of the uterus to placental development and childbirth. The decidual reaction, a pivotal process occurring within the endometrium during pregnancy, is finely regulated by sex steroids and cytokines. Notably, fibroblast growth factors (FGFs), particularly FGF2, play a critical role in this physiological cascade. Dysregulated FGF expression may trigger inadequate decidualization, precipitating a spectrum of adverse pregnancy outcomes, including preeclampsia, recurrent implantation failure, and miscarriage. Furthermore, the human decidua, distinct from most mammalian species and similar to great apes, undergoes regular cycles of formation and shedding, independent of the presence of the embryo in the endometrium. This process is also tightly controlled by various FGFs. In this review, we comprehensively compare diverse research decidualization models, delineate the trend of endometrial FGFs during the menstrual cycle, and provide a synopsis of endometrial diseases triggered by FGF dysregulation.","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"26 6","pages":"573-588"},"PeriodicalIF":4.7,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12219500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144506148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0