Journal of Zhejiang University SCIENCE B最新文献

Advancements in molecular imaging probes for precision diagnosis and treatment of prostate cancer. 分子成像探针在前列腺癌精确诊断和治疗中的应用进展。

IF 4.7 3区生物学

Journal of Zhejiang University SCIENCE B Pub Date : 2025-01-16 DOI: 10.1631/jzus.B2300614

Jiajie Fang, Ahmad Alhaskawi, Yanzhao Dong, Cheng Cheng, Zhijie Xu, Junjie Tian, Sahar Ahmed Abdalbary, Hui Lu

{"title":"Advancements in molecular imaging probes for precision diagnosis and treatment of prostate cancer.","authors":"Jiajie Fang, Ahmad Alhaskawi, Yanzhao Dong, Cheng Cheng, Zhijie Xu, Junjie Tian, Sahar Ahmed Abdalbary, Hui Lu","doi":"10.1631/jzus.B2300614","DOIUrl":"https://doi.org/10.1631/jzus.B2300614","url":null,"abstract":"Prostate cancer is the second most common cancer in men, accounting for 14.1% of new cancer cases in 2020. The aggressiveness of prostate cancer is highly variable, depending on its grade and stage at the time of diagnosis. Despite recent advances in prostate cancer treatment, some patients still experience recurrence or even progression after undergoing radical treatment. Accurate initial staging and monitoring for recurrence determine patient management, which in turn affect patient prognosis and survival. Classical imaging has limitations in the diagnosis and treatment of prostate cancer, but the use of novel molecular probes has improved the detection rate, specificity, and accuracy of prostate cancer detection. Molecular probe-based imaging modalities allow the visualization and quantitative measurement of biological processes at the molecular and cellular levels in living systems. An increased understanding of tumor biology of prostate cancer and the discovery of new tumor biomarkers have allowed the exploration of additional molecular probe targets. The development of novel ligands and advances in nano-based delivery technologies have accelerated the research and development of molecular probes. Here, we summarize the use of molecular probes in positron emission tomography (PET), single-photon emission computed tomography (SPECT), magnetic resonance imaging (MRI), optical imaging, and ultrasound imaging, and provide a brief overview of important target molecules in prostate cancer.","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":" ","pages":"1-21"},"PeriodicalIF":4.7,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thirteen serum biochemical indexes and five whole blood coagulation indices in a point-of-care testing analyzer: ideal protocol for evaluating pulmonary and critical care medicine. 13项血清生化指标和5项全血凝血指标的即时检测分析仪：评估肺部和重症监护医学的理想方案。

IF 4.7 3区生物学

Journal of Zhejiang University SCIENCE B Pub Date : 2025-01-16 DOI: 10.1631/jzus.B2300433

Mingtao Liu, Li Liu, Jiaxi Chen, Zhifeng Huang, Huiqing Zhu, Shengxuan Lin, Weitian Qi, Zhangkai J Cheng, Ning Li, Baoqing Sun

{"title":"Thirteen serum biochemical indexes and five whole blood coagulation indices in a point-of-care testing analyzer: ideal protocol for evaluating pulmonary and critical care medicine.","authors":"Mingtao Liu, Li Liu, Jiaxi Chen, Zhifeng Huang, Huiqing Zhu, Shengxuan Lin, Weitian Qi, Zhangkai J Cheng, Ning Li, Baoqing Sun","doi":"10.1631/jzus.B2300433","DOIUrl":"https://doi.org/10.1631/jzus.B2300433","url":null,"abstract":"The accurate and timely detection of biochemical coagulation indicators is pivotal in pulmonary and critical care medicine. Despite their reliability, traditional laboratories often lag in terms of rapid diagnosis. Point-of-care testing (POCT) has emerged as a promising alternative, which is awaiting rigorous validation. We assessed 226 samples from patients at the First Affiliated Hospital of Guangzhou Medical University using a Beckman Coulter AU5821 and a PUSHKANG POCT Biochemistry Analyzer MS100. Furthermore, 350 samples were evaluated with a Stago coagulation analyzer STAR MAX and a PUSHKANG POCT Coagulation Analyzer MC100. Metrics included thirteen biochemical indexes, such as albumin, and five coagulation indices, such as prothrombin time. Comparisons were drawn against the PUSHKANG POCT analyzer. Bland-Altman plots (MS100: 0.8206‒0.9995; MC100: 0.8318‒0.9911) evinced significant consistency between methodologies. Spearman correlation pinpointed a potent linear association between conventional devices and the PUSHKANG POCT analyzer, further underscored by a robust correlation coefficient (MS100: 0.713‒0.949; MC100: 0.593‒0.950). The PUSHKANG POCT was validated as a dependable tool for serum and whole blood biochemical and coagulation diagnostics. This emphasizes its prospective clinical efficacy, offering clinicians a swift diagnostic tool and heralding a new era of enhanced patient care outcomes.","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":" ","pages":"1-14"},"PeriodicalIF":4.7,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New perspectives on microbiome-dependent gut-brain pathways for the treatment of depression with gastrointestinal symptoms: from bench to bedside. 治疗伴有胃肠道症状的抑郁症的微生物依赖性肠脑通路的新视角：从工作台到床边。

IF 4.7 3区生物学

Journal of Zhejiang University SCIENCE B Pub Date : 2025-01-15 Epub Date: 2024-09-27 DOI: 10.1631/jzus.B2300343

Menglin Liu, Genhao Fan, Lingkai Meng, Kuo Yang, Huayi Liu

{"title":"New perspectives on microbiome-dependent gut-brain pathways for the treatment of depression with gastrointestinal symptoms: from bench to bedside.","authors":"Menglin Liu, Genhao Fan, Lingkai Meng, Kuo Yang, Huayi Liu","doi":"10.1631/jzus.B2300343","DOIUrl":"10.1631/jzus.B2300343","url":null,"abstract":"Patients with depression are more likely to have chronic gastrointestinal (GI) symptoms than the general population, but such symptoms are considered only somatic symptoms of depression and lack special attention. There is a chronic lack of appropriate diagnosis and effective treatment for patients with depression accompanied by GI symptoms, and studying the association between depression and GI disorders (GIDs) is extremely important for clinical management. There is growing evidence that depression is closely related to the microbiota present in the GI tract, and the microbiota-gut-brain axis (MGBA) is creating a new perspective on the association between depression and GIDs. Identifying and treating GIDs would provide a key opportunity to prevent episodes of depression and may also improve the outcome of refractory depression. Current studies on depression and the microbially related gut-brain axis (GBA) lack a focus on GI function. In this review, we combine preclinical and clinical evidence to summarize the roles of the microbially regulated GBA in emotions and GI function, and summarize potential therapeutic strategies to provide a reference for the study of the pathomechanism and treatment of depression in combination with GI symptoms.","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":" ","pages":"1-25"},"PeriodicalIF":4.7,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11735910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical efficacy and safety of vortioxetine as an adjuvant drug for patients with bipolar depression. 沃替西汀辅助治疗双相抑郁症的临床疗效和安全性。

IF 4.7 3区生物学

Journal of Zhejiang University SCIENCE B Pub Date : 2025-01-15 DOI: 10.1631/jzus.B2400470

Chunxiao Dai, Yaoyang Fu, Xuanwei Li, Meihua Lin, Yinbo Li, Xiao Li, Keke Huang, Chengcheng Zhou, Jian Xie, Qingwei Zhao, Shaohua Hu

{"title":"Clinical efficacy and safety of vortioxetine as an adjuvant drug for patients with bipolar depression.","authors":"Chunxiao Dai, Yaoyang Fu, Xuanwei Li, Meihua Lin, Yinbo Li, Xiao Li, Keke Huang, Chengcheng Zhou, Jian Xie, Qingwei Zhao, Shaohua Hu","doi":"10.1631/jzus.B2400470","DOIUrl":"10.1631/jzus.B2400470","url":null,"abstract":"Objectives: Whether vortioxetine has a utility as an adjuvant drug in the treatment of bipolar depression remains controversial. This study aimed to validate the efficacy and safety of vortioxetine in bipolar depression.Methods: Patients with bipolar Ⅱ depression were enrolled in this prospective, two-center, randomized, 12-week pilot trial. The main indicator for assessing treatment effectiveness was a Montgomery-Asberg Depression Rating Scale (MADRS) of ≥50%. All eligible patients initially received four weeks of lurasidone monotherapy. Patients who responded well continued to receive this kind of monotherapy. However, no-response patients were randomly assigned to either valproate or vortioxetine treatment for eight weeks. By comprehensively comparing the results of MADRS over a period of 4‍‒‍12 weeks, a systematic analysis was conducted to determine whether vortioxetine could be used as an adjuvant drug for treating bipolar depression.Results: Thirty-seven patients responded to lurasidone monotherapy, and 60 patients were randomly assigned to the valproate or vortioxetine group for eight weeks. After two weeks of combined valproate or vortioxetine treatment, the MADRS score in the vortioxetine group was significantly lower than that in the valproate group. There was no difference in the MADRS scores between the two groups at 8 and 12 weeks. The incidence of side effects did not significantly differ between the valproate and vortioxetine groups. Importantly, three patients in the vortioxetine group appeared to switch to mania or hypomania.Conclusions: This study suggested that lurasidone combination with vortioxetine might have potential benefits to bipolar II depression in the early stage, while disease progression should be monitored closely for the risk of switching to mania.","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"26 1","pages":"26-38"},"PeriodicalIF":4.7,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11735911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Residual hyperglycemia after successful treatment of a patient with severe copper sulfate poisoning. 1例严重硫酸铜中毒患者成功治疗后残余高血糖。

IF 4.7 3区生物学

Journal of Zhejiang University SCIENCE B Pub Date : 2024-12-18 DOI: 10.1631/jzus.B2400305

Ting Li, Yuan-Qiang Lu

{"title":"Residual hyperglycemia after successful treatment of a patient with severe copper sulfate poisoning.","authors":"Ting Li, Yuan-Qiang Lu","doi":"10.1631/jzus.B2400305","DOIUrl":"10.1631/jzus.B2400305","url":null,"abstract":"Copper sulfate is a frequently used copper compound in laboratory settings, with instances of poisoning being uncommon. A study conducted by the American Association of Poison Control Centers' National Poison Data System found that only 140 individuals were exposed to copper compounds over the course of a year, with five cases being intentional (Gummin et al., 2023). Severe poisoning from copper sulfate can result in isolated gastrointestinal injury (Galust et al., 2023), intravascular hemolysis (Adline et al., 2024), rhabdomyolysis (Richards et al., 2020), and other symptoms documented in the literature. However, there have been no reports of long-term uncontrolled hyperglycemia in patients with copper sulfate poisoning. This case study documents the treatment approach for a patient with unexplained, long-term, uncontrolled hyperglycemia, alongside multiple organ dysfunction resulting from intentional ingestion of a large dose of copper sulfate. This case report details the long-term complications in a patient's recovery from acute copper sulfate, highlighting the significance of ongoing monitoring and intervention.","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"25 12","pages":"1120-1124"},"PeriodicalIF":4.7,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11693388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficient genome editing in medaka (Oryzias latipes) using a codon-optimized SaCas9 system. 利用密码子优化的SaCas9系统对稻科植物进行高效基因组编辑。

IF 4.7 3区生物学

Journal of Zhejiang University SCIENCE B Pub Date : 2024-12-15 DOI: 10.1631/jzus.B2300899

Yuewen Jiang, Qihua Pan, Zhi Wang, Ke Lu, Bilin Xia, Tiansheng Chen

{"title":"Efficient genome editing in medaka (Oryzias latipes) using a codon-optimized SaCas9 system.","authors":"Yuewen Jiang, Qihua Pan, Zhi Wang, Ke Lu, Bilin Xia, Tiansheng Chen","doi":"10.1631/jzus.B2300899","DOIUrl":"10.1631/jzus.B2300899","url":null,"abstract":"The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) system, belonging to the type II CRISPR/Cas system, is an effective gene-editing tool widely used in different organisms, but the size of Streptococcus pyogenes Cas9 (SpCas9) is quite large (4.3 kb), which is not convenient for vector delivery. In this study, we used a codon-optimized Staphylococcus aureus Cas9 (SaCas9) system to edit the tyrosinase (tyr), oculocutaneous albinism II (oca2), and paired box 6.1 (pax6.1) genes in the fish model medaka(Oryzias latipes), in which the size of SaCas9 (3.3 kb) is much smaller and the necessary protospacer-adjacent motif (PAM) sequence is 5'-NNGRRT-3'. We also used a transfer RNA (tRNA)‍-single-guide RNA (sgRNA) system to express the functional sgRNA by transcription eitherin vivo or in vitro, and the combination of SaCas9 and tRNA-sgRNA was used to edit the tyr gene in the medaka genome. The SaCas9/sgRNA and SaCas9/tRNA-sgRNA systems were shown to edit the medaka genome effectively, while the PAM sequence is an essential part for the efficiency of editing. Besides, tRNA can improve the flexibility of the system by enabling the sgRNA to be controlled by a common promoter such as cytomegalovirus. Moreover, the all-in-one cassette cytomegalovirus (CMV)‍-SaCas9-tRNA-sgRNA-tRNA is functional in medaka gene editing. Taken together, the codon-optimized SaCas9 system provides an alternative and smaller tool to edit the medaka genome and potentially other fish genomes.","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"25 12","pages":"1083-1096"},"PeriodicalIF":4.7,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11693391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Co-culture of natural killer cells and tumor spheroids on a heterogeneous multilayer paper stack. 自然杀伤细胞与肿瘤球体在异质多层纸堆上的共培养。

IF 4.7 3区生物学

Journal of Zhejiang University SCIENCE B Pub Date : 2024-12-15 DOI: 10.1631/jzus.B2300617

Yuanyuan Xie, Xiaoyan Yang, Rong Pan, Lixia Gao, Ling Yu

{"title":"Co-culture of natural killer cells and tumor spheroids on a heterogeneous multilayer paper stack.","authors":"Yuanyuan Xie, Xiaoyan Yang, Rong Pan, Lixia Gao, Ling Yu","doi":"10.1631/jzus.B2300617","DOIUrl":"10.1631/jzus.B2300617","url":null,"abstract":"Multilayer paper-based cell culture, as an in vitro three-dimensional (3D) cell culture method, has been frequently used to research drug bioavailability, therapeutic efficacy, and dose-limiting toxicity in malignant tumors. This paper proposes a heterogenous multilayer paper stacking co-culture system to establish a model of natural killer (NK) cells moving through the endothelium layer and attacking tumor spheroids. This system consists of three layers: a bottom tumor-spheroid layer, a middle invasion layer, and a top endothelium layer. NK-92 cells were placed in the supernatant on top of the three layers. After two days of co-culture, the attack of tumor spheroids by NK cells was observed. We additionally examined the infiltration of NK-92 cells within the tumor spheroids at different Z-axis depths using a confocal microscope, and the results suggested that the system successfully realizes NK cells traveling cross the endothelium layer to form tumor-infiltrating NK cells (TINKs). The potential application of multilayer paper for co-culture models involving cancer cells and immune cells holds great promise for exploring the interaction dynamics of these two cell types.","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"25 12","pages":"1097-1107"},"PeriodicalIF":4.7,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11693390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deciphering odontogenic myxoma: the role of copy number variations as diagnostic signatures. 解读牙源性黏液瘤：拷贝数变化作为诊断特征的作用。

IF 4.7 3区生物学

Journal of Zhejiang University SCIENCE B Pub Date : 2024-12-15 DOI: 10.1631/jzus.B2400081

Aobo Zhang, Jianyun Zhang, Xuefen Li, Xia Zhou, Yanrui Feng, Lijing Zhu, Heyu Zhang, Lisha Sun, Tiejun Li

{"title":"Deciphering odontogenic myxoma: the role of copy number variations as diagnostic signatures.","authors":"Aobo Zhang, Jianyun Zhang, Xuefen Li, Xia Zhou, Yanrui Feng, Lijing Zhu, Heyu Zhang, Lisha Sun, Tiejun Li","doi":"10.1631/jzus.B2400081","DOIUrl":"10.1631/jzus.B2400081","url":null,"abstract":"In light of the lack of reliable molecular markers for odontogenic myxoma (OM), the detection of copy number variation (CNV) may present a more objective method for assessing ambiguous cases. In this study, we employed multiregional microdissection sequencing to integrate morphological features with genomic profiling. This allowed us to reveal the CNV profiles of OM and compare them with dental papilla (DP), dental follicle (DF), and odontogenic fibroma (OF) tissues. We identified a distinct and robustly consistent CNV pattern in 93.75% (30/32) of OM cases, characterized by CNV gain events in chromosomes 4, 5, 8, 10, 12, 16, 17, 20, and 21. This pattern significantly differed from the CNV patterns observed in DP, DF, and OF. The Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis indicated potential links between this CNV patterns and the calcium signaling pathway and salivary secretion, while Gene Ontology (GO) term analysis implicated CNV patterns in tumor adhesion, tooth development, and cell proliferation. Comprehensive CNV analysis accurately identified a case that was initially disputable between OF and OM as OM. Our findings provide a reliable diagnostic clue and fresh insights into the molecular biological mechanism underlying OM.","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"25 12","pages":"1071-1082"},"PeriodicalIF":4.7,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11693393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aberrant network topological structure of sensorimotor superficial white-matter system in major depressive disorder. 重性抑郁症感觉运动浅白质系统的网络拓扑结构异常。

IF 4.7 3区生物学

Journal of Zhejiang University SCIENCE B Pub Date : 2024-12-06 DOI: 10.1631/jzus.B2300880

Peng Wang, Yanling Bai, Yang Xiao, Yuhong Zheng, Li Sun, The Direct Consortium, Jinhui Wang, Shaowei Xue

{"title":"Aberrant network topological structure of sensorimotor superficial white-matter system in major depressive disorder.","authors":"Peng Wang, Yanling Bai, Yang Xiao, Yuhong Zheng, Li Sun, The Direct Consortium, Jinhui Wang, Shaowei Xue","doi":"10.1631/jzus.B2300880","DOIUrl":"10.1631/jzus.B2300880","url":null,"abstract":"White-matter tracts play a pivotal role in transmitting sensory and motor information, facilitating interhemispheric communication and integrating different brain regions. Meanwhile, sensorimotor disturbance is a common symptom in patients with major depressive disorder (MDD). However, the role of aberrant sensorimotor white-matter system in MDD remains largely unknown. Herein, we investigated the topological structure alterations of white-matter morphological brain networks in 233 MDD patients versus 257 matched healthy controls (HCs) from the DIRECT consortium. White-matter networks were derived from magnetic resonance imaging (MRI) data by combining voxel-based morphometry (VBM) and three-dimensional discrete wavelet transform (3D-DWT) approaches. Support vector machine (SVM) analysis was performed to discriminate MDD patients from HCs. The results indicated that the network topological changes in node degree, node efficiency, and node betweenness were mainly located in the sensorimotor superficial white-matter system in MDD. Using network nodal topological properties as classification features, the SVM model could effectively distinguish MDD patients from HCs. These findings provide new evidence to highlight the importance of the sensorimotor system in brain mechanisms underlying MDD from a new perspective of white-matter morphological network.","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"26 1","pages":"39-51"},"PeriodicalIF":4.7,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11735912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aberrant network topological structure of sensorimotor superficial white-matter system in major depressive disorder. 重性抑郁症感觉运动浅白质系统的网络拓扑结构异常。

IF 4.7 3区生物学

Journal of Zhejiang University SCIENCE B Pub Date : 2024-12-03 DOI: 10.1631/jzus.B2300880

Peng Wang, Yanling Bai, Yang Xiao, Yuhong Zheng, Li Sun, The Direct Consortium, Jinhui Wang, Shaowei Xue

{"title":"Aberrant network topological structure of sensorimotor superficial white-matter system in major depressive disorder.","authors":"Peng Wang, Yanling Bai, Yang Xiao, Yuhong Zheng, Li Sun, The Direct Consortium, Jinhui Wang, Shaowei Xue","doi":"10.1631/jzus.B2300880","DOIUrl":"10.1631/jzus.B2300880","url":null,"abstract":"White-matter tracts play a pivotal role in transmitting sensory and motor information, facilitating interhemispheric communication and integrating different brain regions. Meanwhile, sensorimotor disturbance is a common symptom in patients with major depressive disorder (MDD). However, the role of aberrant sensorimotor white-matter system in MDD remains largely unknown. Herein, we investigated the topological structure alterations of white-matter morphological brain networks in 233 MDD patients versus 257 matched healthy controls (HCs) from the DIRECT consortium. White-matter networks were derived from magnetic resonance imaging (MRI) data by combining voxel-based morphometry (VBM) and three-dimensional discrete wavelet transform (3D-DWT) approaches. Support vector machine (SVM) analysis was performed to discriminate MDD patients from HCs. The results indicated that the network topological changes in node degree, node efficiency, and node betweenness were mainly located in the sensorimotor superficial white-matter system in MDD. Using network nodal topological properties as classification features, the SVM model could effectively distinguish MDD patients from HCs. These findings provide new evidence to highlight the importance of the sensorimotor system in brain mechanisms underlying MDD from a new perspective of white-matter morphological network.","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":" ","pages":"1-13"},"PeriodicalIF":4.7,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0