Journal of Zhejiang University SCIENCE B最新文献

{"title":"TAF1 aggravates ferroptosis by promoting the ubiquitin-mediated degradation of nuclear GPX4.","authors":"Kehong Ye, Meifu Gan, Liang Sun, Chaoyi Chen, Xuan Lai, Yinjun He, Ming Zhu, Weiqin Jiang, Honghe Zhang","doi":"10.1631/jzus.B2500567","DOIUrl":"https://doi.org/10.1631/jzus.B2500567","url":null,"abstract":"<p><p>Glutathione peroxidase 4 (GPX4) is a primary inhibitor of ferroptosis, a regulated form of cell death driven by the accumulation of lipid hydroperoxides. GPX4 exists in three isoforms localized in the cytosol, mitochondria, and nucleus; however, the regulatory mechanisms governing nuclear GPX4 (nGPX4) remain largely unclear. Herein, we identified TATA box-binding protein-associated factor 1 (TAF1) as a pivotal regulator of nGPX4. TAF1 phosphorylates nGPX4, leading to its lysine 11 (K11)-linked ubiquitination and proteasomal degradation, thereby promoting ferroptosis in tumor protein p53 (<i>TP53</i>)-mutant cells. Conversely, in <i>TP53</i>-wild-type (WT) cells, TAF1 phosphorylates TP53, facilitating murine double minute 2 (MDM2)-mediated TP53 degradation, which upregulates solute carrier family 7 member 11 (<i>SLC7A11</i>) expression and reduces cellular susceptibility to ferroptosis. Collectively, TAF1 plays dual and context-dependent roles in ferroptosis regulation, acting as both a promoter and an inhibitor depending on the <i>TP53</i> status.</p>","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"27 4","pages":"359-374"},"PeriodicalIF":4.9,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13121887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infra-slow body-surface potentials show a group-level association with thyroid cancer.","authors":"Bohan Deng, Ruili Zhang, Yuxuan Liu, Jinglao Lin, Shicong Gui, Xihao Wei, Yin Cheng, Li Zheng, Shaohua Hu, Pingping Lyu, Yubo Li, Huafen Wang","doi":"10.1631/jzus.B2600040","DOIUrl":"https://doi.org/10.1631/jzus.B2600040","url":null,"abstract":"<p><p>Thyroid cancer is a common malignancy with broad systemic endocrine and metabolic effects (Hammond et al., 2024). Regarding diagnostics, if infra-slow body-surface potential (BSP) features reflect a systemic state, then this type of cancer is a reasonable clinical test case. Prior electrodermal work has focused on faster transients above 0.5 Hz (Boucsein, 2012; Posada-Quintero and Chon, 2020), and task-state skin potential abnormalities have been shown to distinguish mood disorders from healthy controls (Lyu et al., 2024). We concentrated on an infra-slow band from 0.025 to 0.2 Hz, called Band 1 herein. We evaluated whether infra-slow features carry reproducible group-level information when artifacts are explicitly controlled, with one pre-specified primary endpoint. \"Separable\" here means a group-level statistical difference, not individual-level diagnosis. In a cohort of 321 cancer patients, Band 1 energy showed a clear group-level association with thyroid cancer, which persisted after automated quality control (QC) and under stricter artifact-removal settings.</p>","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"27 4","pages":"426-430"},"PeriodicalIF":4.9,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13121882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metagenomic sequencing reveals high reproducibility of human donor microbiota transplanted into germ-free mice via lower gut route.","authors":"Yapeng Yang, Xiang Tan, Zeyue Zhang, Lifeng Liang, Zhifeng Wu, Jinhui He, Yuqing Wang, Miaomiao Dong, Jixia Zheng, Hang Zhang, Shuaifei Feng, Wei Cheng, Bota Cui, Hong Wei, Qinjin Li","doi":"10.1631/jzus.B2400495","DOIUrl":"https://doi.org/10.1631/jzus.B2400495","url":null,"abstract":"<p><p>Human flora-associated (HFA) mice are often used to simulate the structure of human intestinal microbiota and to study the causal relationships between diseases and gut microbiota. However, several factors affect the colonization efficiency of human microbiota in germ-free (GF) mice, and the differential effects of gavage and lower gut transplantation on colonization are still unclear. In this study, we explored the reproducibility of the recipient-to-donor gut microbiota community structure and function under different transplantation routes and the differences in microbial colonization between recipients via gavage transplantation (GT_mice group) and lower gut transplantation (LGT_mice group). High-throughput sequencing of the metagenome was performed on the feces of each subject, and the composition of microbiome of each group was analyzed. As expected, the introduction of human fecal microbiota into GF mice via lower gut transplantation had a high transfer efficiency, which was evident from the similar species community structure to that of the donor (Adonis <i>R</i>²=0.713 960 for LGT_mice group‒donor group; Adonis <i>R</i>²=0.774 095 for GT_mice group‒donor group) and a higher bacterial colonization rate. The findings provide unique insights into improving the accuracy of constructing humanized microbiota transplantation models, aiding our understanding of the relationships between the human gut microbiota and disease.</p>","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"27 4","pages":"375-389"},"PeriodicalIF":4.9,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13121883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sporadic Alzheimer's disease with bipolar-like features: a case report and a brief review of the current research status.","authors":"Lingzhuo Kong, Yan Yang, Weihua Zhou, Shaohua Hu","doi":"10.1631/jzus.B2500307","DOIUrl":"https://doi.org/10.1631/jzus.B2500307","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is among the main causes of cognitive impairment, memory loss, and dementia, particularly in old adults. It has been listed as one of the most expensive, lethal, and burdening diseases of the 21st century and develops with the process of aging worldwide (Scheltens et al., 2021). Currently, it is widely acknowledged that the typical pathogenesis of AD involves the deposition of amyloid-β (Aβ) and Tau proteins in the cerebral parenchyma and vasculature, intraneuronal neurofibrillary tangles, and the gradual degeneration of synapses (Scheltens et al., 2016; Rostagno, 2022). According to several hypotheses, abnormalities and dysfunctions in vascular structure, mitochondrial metabolism, oxidative stress, glucose utilization, and neuroinflammation are considered fundamental for AD pathology (Scheltens et al., 2016).</p>","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"27 4","pages":"416-425"},"PeriodicalIF":4.9,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13121885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic structure and admixture of the Yi and Qiang in southwestern China.","authors":"Jun Liu, Li Jiang, Yongqiang Kong, Chunnian Wang, Shuo Feng, Xuanzhu Chen, Deqin Zhang, Chuanchao Wang, Caixia Li","doi":"10.1631/jzus.B2400576","DOIUrl":"https://doi.org/10.1631/jzus.B2400576","url":null,"abstract":"<p><p>The Tibetan-Yi Corridor in southwestern China is well-known for the origins, migration, and evolution of Sino-Tibetan populations. Previous genetic studies have primarily focused on Han and Tibetan populations, thereby leaving the significant genetic diversity within the Tibeto-Burman groups under-researched. In this study, to explore the genetic structure and admixture history of Tibeto-Burman populations in southwestern China, we sequenced the human genomes of 100 individuals from the Qiang and Yi ethnic groups in Sichuan Province. These populations were found to have the closest genetic affinity with nearby Tibeto-Burman-speaking Tujia and Tibetan populations. The Qiang share more allele sites with northern Altaic-speaking populations, while the Yi have closer genetic relationships with southern Hmong-Mien populations. The dominant ancestry of the Yi and Qiang derived from Neolithic millet agriculturalists in the Yellow River Basin, with a smaller proportion from Neolithic coastal populations in southern China, supporting the hypothesis of a northern origin of Sino-Tibetan populations. The Yi have more southern genetic components than the Qiang, reflecting the differential genetic influences of southeastern coastal populations on these groups. In summary, this study elucidates the fine-scale genetic structure of Tibeto-Burman populations and their genetic relationships with other Chinese populations, laying the foundation for forensic genetic research in East Asian populations.</p>","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"27 4","pages":"402-415"},"PeriodicalIF":4.9,"publicationDate":"2026-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13121884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early albumin infusion and mortality in elderly patients with sepsis based on analysis of the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database.","authors":"Jinmin Chen, Yuanqiang Lu","doi":"10.1631/jzus.B2400268","DOIUrl":"https://doi.org/10.1631/jzus.B2400268","url":null,"abstract":"<p><p>As the impact of early albumin infusion on the prognosis of elderly individuals diagnosed with sepsis remains uncertain, this study aimed to investigate this effect in elderly patients with sepsis in the intensive care unit (ICU). We identified the information of elderly patients with sepsis requiring ICU admission from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database. They were divided into hypoalbuminemia group and control group, and the primary outcome was 90-d mortality. A multivariate logistic regression model and a multivariate Cox proportional-hazards model were used to analyze the correlation between hypoalbuminemia and patient prognosis. Kaplan-Meier survival curve and log-rank test were performed to analyze the survival outcomes. Propensity score matching (PSM) was implemented to determine the precise effect of early albumin infusion on the prognosis of elderly ICU patients with sepsis, and subgroups of patients were identified to explore the factors influencing the relationship. Early hypoalbuminemia was strongly associated with an increased risk of adverse clinical outcomes in elderly patients with sepsis in the ICU. In-hospital mortality (28.6% vs. 19.1%, <i>P</i><0.001) and 90-d mortality (48.8% vs. 33.4%, <i>P</i><0.001) were both significantly higher in the early hypoalbuminemia group than in the control group. PSM analysis showed that early albumin infusion was associated with lower in-hospital mortality and 90-d mortality in elderly patients with sepsis combined with hypoalbuminemia in the ICU. Early infusion of albumin could improve patient prognosis and reduce in-hospital mortality and 90-d mortality.</p>","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"27 4","pages":"390-401"},"PeriodicalIF":4.9,"publicationDate":"2026-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13121881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting <i>WTAP</i> sensitizes hepatocellular carcinoma to sorafenib by inhibiting the ERK signaling pathway.","authors":"Yu Wu, Guomin Ju, Xueyu Zhou, Jian Wu, Shusen Zheng, Chuanhui Peng","doi":"10.1631/jzus.B2500191","DOIUrl":"10.1631/jzus.B2500191","url":null,"abstract":"<p><p>Hepatocellular carcinoma (HCC) often requires targeted therapy and immunotherapy due to frequent delayed diagnosis. Sorafenib, the first targeted drug applied to treat HCC, has demonstrated a remarkable therapeutic effect in the clinic. However, its clinical application has been limited by drug resistance and the insufficient understanding of the relevant mechanism. Wilms' tumor 1-associated protein (WTAP), associated with tumor progression, remains unstated in sorafenib resistance. In this study, <i>WTAP</i> expression patterns in HCC were systematically characterized through integrative analysis of The Cancer Genome Atlas (TCGA) datasets and spatial transcriptomic profiling. To delineate the potential mechanisms of <i>WTAP</i>-mediated sorafenib resistance in HCC, multimodal approaches integrating gene set enrichment analysis (GSEA), predictions from the \"oncoPredict\" package in vitro experiments, molecular docking simulations, and western blot validation were applied. To further investigate the role of <i>WTAP</i> in drug resistance, hydrodynamic tail vein injection (HTVi) mouse models and immunohistochemistry were utilized. Significant <i>WTAP</i> upregulation was identified in HCC tissues, showing strong associations with tumor progression and adverse clinical outcomes. The knockdown of <i>WTAP</i> sensitized HCC cells to sorafenib in vitro. GSEA, molecular docking analysis, and western blot analysis demonstrated that <i>WTAP</i> induces the activation of the extracellular signal-regulated kinase (ERK) signaling pathway, a critical link in chemoresistance mechanisms. In the HTVi HCC model, the combination of <i>WTAP</i> knockdown with sorafenib markedly suppressed tumor progression and boosted survival rates. These findings highlight that <i>WTAP</i> positively regulates the ERK pathway in HCC, promoting sorafenib resistance; therefore, targeting <i>WTAP</i> may represent a novel strategy to potentiate sorafenib responsiveness in HCC.</p>","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"27 3","pages":"310-320"},"PeriodicalIF":4.9,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12996864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147474388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ectopic expression of structurally similar major royal jelly proteins reveals their distinct functions in <i>Drosophila</i>.","authors":"Lingqi Yu, Danfeng Wang, Xuanhao Chen, Jiayu Xie, Dongjing Wen, Yi Zhang, Lirong Shen, Wenfeng Chen, Zhenxing Liu, Yufeng Yang","doi":"10.1631/jzus.B2400624","DOIUrl":"10.1631/jzus.B2400624","url":null,"abstract":"<p><p>Royal jelly (RJ), secreted by the hypopharyngeal and mandibular glands of young worker bees, is rich in proteins, 80%‒90% of which are major royal jelly proteins (MRJPs). While MRJPs from RJ have been shown to exhibit specific biological functions and are also expressed in neuronal cells, their roles in vivo remain poorly understood. The aim of this study was to elucidate the functional roles of individual MRJPs (MRJP1‒9) in vivo by ectopically expressing them in <i>Drosophila</i> neurons in a binary expression system using fluorescent proteins as controls. Transcriptome sequencing revealed that although MRJP1‒9 share similar tertiary structures, their overexpression affects distinct gene sets. MRJP1, MRJP2, MRJP3, MRJP5, and MRJP7 induced more differentially expressed genes (DEGs), while MRJP4, MRJP6, MRJP8, and MRJP9 induced fewer such genes. Weighted gene co-expression network analysis (WGCNA) and gene set enrichment analysis (GSEA) revealed that MRJP1, MRJP2, MRJP3, MRJP5, and MRJP7 regulated overlapping gene sets, including an estradiol-responsive set, and activated cell proliferation pathways. MRJP6 lacked any significant gene set enrichment, while MRJP8 and MRJP9 modulated similar sets. Notably, the neuron-specific overexpression of MRJP1, MRJP2, MRJP3, and MRJP5 in <i>Drosophila</i> showed activated cell proliferation-related pathways and increased body sizes, highlighting their functional diversity and context-dependent effects. These findings expand our understanding of the functional roles of MRJPs and provide a foundation for further exploring their biological significance in honeybees and beyond.</p>","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"27 3","pages":"295-309"},"PeriodicalIF":4.9,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12996861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147474374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microencapsulation and characterization of controlled-release intestinal drugs: a critical review.","authors":"Weiguang Su, Dawei Wang, Siegfried Yeboah, Jinshen Wang, Chonghai Xu, Li Wang","doi":"10.1631/jzus.B2400617","DOIUrl":"https://doi.org/10.1631/jzus.B2400617","url":null,"abstract":"<p><p>Oral administration is associated with high patient adherence, as it is not only the route for primary site absorption of nutrients and peptide drugs but also is important for treating intestinal diseases. However, traditional oral intestinal drugs are limited by drug degradation and inactivation, particularly for proteins and peptides, due to gastric acid and digestive enzymes, making it difficult to effectively deliver drugs to target sites. To address these challenges, controlled-release microencapsulated intestinal drugs (MeIDs) have been developed and have attracted attention for their ability to protect drugs from degradation by gastric acid and digestive enzymes. In this study, we systematically reviewed research articles on the preparation methods, release mechanisms, and evaluation strategies of MeIDs using Google Scholar, Web of Science, and Science Direct databases. Our findings show that the preparation of emulsions, microencapsulation methods, shell material selection, and drug properties need to be considered comprehensively for MeID development. In addition, we found that coating, micro/nanocarriers, and absorption enhancers can be combined to enhance microcapsule performance. Beyond focusing on drug loading efficiency and microcapsule morphology, we also found that cell models, animal models, and spectroscopic analysis techniques can be used to evaluate drug biocompatibility, stability, and efficacy. Finally, the literature has shown that optimizing the preparation process can regulate drug release kinetics. For future research, we suggest that studies should focus on low-cost methods for producing monodisperse microcapsules, developing dynamic responsive shell materials, and using organ-on-a-chip technology for precise evaluation, as part of the theoretical support towards the development of microencapsulated drugs and targeted drug delivery.</p>","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"27 4","pages":"321-342"},"PeriodicalIF":4.9,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13121888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroscientific therapies for subjective tinnitus.","authors":"Peng Liu, Xinmiao Xue, Zhixin Zhang, Hanwen Zhou, Cong Xu, Lijun Zhang, Zhen Li, Yongqing Zhou, Shanwei Song, Yameng Tian, Fangyuan Wang, Xiaoming Li, Shiming Yang","doi":"10.1631/jzus.B2400579","DOIUrl":"https://doi.org/10.1631/jzus.B2400579","url":null,"abstract":"<p><p>Tinnitus, a prevalent auditory symptom, can significantly impair quality of life, yet no definitive pharmacological interventions exist despite extensive ongoing research into its pathophysiology and treatments. The advent of biomedical engineering has introduced neuromodulation as a pivotal therapeutic approach alongside conventional strategies such as pharmacotherapy and surgery. Through the deployment of invasive and non-invasive techniques, using various modalities including magnetic, electronic, and optical means, neuromodulation aims to regulate neural functions. This has not only led to the refinement of fundamental theories but has also enhanced the optimization of clinical applications. As an emerging and promising intervention, neuromodulation enriches the toolkit available for basic neuroscience inquiry and broadens the spectrum of clinical therapies for conditions affecting the central nervous system, including tinnitus. In this paper, we succinctly review the current understanding of tinnitus mechanisms, discuss the features of diverse neuromodulation technologies, explore their application in tinnitus management, and contemplate prospects for their development in treating tinnitus.</p>","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"27 4","pages":"343-358"},"PeriodicalIF":4.9,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13121886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}