Journal of Zhejiang University SCIENCE B最新文献

{"title":"Advances in biomarkers for Parkinson's disease: from molecular pathology to precision diagnostics.","authors":"Xiang Li, Honglin Chen, Xu Wang, Yuhe Hu, Zhaofei Yang, Min Wei","doi":"10.1631/jzus.B2500789","DOIUrl":"10.1631/jzus.B2500789","url":null,"abstract":"<p><p>Parkinson's disease (PD) is the second most common neurodegenerative disorder, and continues to present significant challenges in early diagnosis, precise subtyping, and prognosis assessment. In recent years, the field of biomarker research has undergone a profound paradigm shift from static concentration measurements to functional activity detection. The most revolutionary breakthrough is the α-synuclein seed amplification assay (α-Syn-SAA), which enables ultrasensitive and specific detection of pathological α-Syn in both clinical and prodromal stages, thus providing an unprecedented window for early intervention. Substantial progress has also been made in the development of biomarkers such as neurofilament light chain (NfL), Alzheimer's disease-related biomarkers, and genetic biomarkers, as well as in detection technologies based on peripheral samples. The integrated application of cutting-edge technologies, such as real-time quaking-induced conversion (RT-QuIC), high-resolution mass spectrometry, and high-field magnetic resonance imaging (MRI), is advancing the field into a new stage characterized by a focus on pathological activity, multi-omics integration, and non- or minimally invasive approaches. In this review, we explore recent advances in PD biomarkers, focusing on core pathophysiological markers. We examine the potential of multi-omics and artificial intelligence (AI) to enhance diagnostic, subtyping, and prognostic accuracy, while also outlining the pivotal role and future directions of biomarkers in advancing precision medicine for PD.</p>","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"27 7","pages":"736-760"},"PeriodicalIF":5.7,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13420509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148620659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-functional nanoplatform for simultaneous degradation of circRNA <i>CDR1as</i> and real-time monitoring of miR-7 in live cells.","authors":"Yan Huang, Jialin Ye, Lan Xu, Xingjie Hu, Nan Chen","doi":"10.1631/jzus.B2500787","DOIUrl":"10.1631/jzus.B2500787","url":null,"abstract":"<p><p>Circular RNAs (circRNAs) are key post-transcriptional regulators with critical roles in pathogenesis, yet existing tools for their precise manipulation and functional analysis in living cells remain to be developed. A compelling therapeutic target in this field is the circRNA cerebellar degeneration-related protein 1 antisense (<i>CDR1as</i>), functioning as an oncogenic sponge for microRNA-7 (miR-7). Herein, we report a novel multifunctional zeolitic imidazolate framework-8 (ZIF-8)-based nanoplatform for the simultaneous disruption and real-time monitoring of the <i>CDR1as</i>/miR-7 regulatory axis. This system, named DZ/MB@ZIF-8, co-encapsulates a designed set of DNAzymes (DZs) for the catalytic cleavage of <i>CDR1as</i> as well as a molecular beacon (MB) for reporting on miR-7 activity. Following cellular uptake and lysosomal trafficking, the acidic microenvironment triggers nanoplatform disassembly, concurrently releasing the therapeutic and sensing components along with essential Zn²⁺ cofactors for DZ activation. This system demonstrates efficient <i>CDR1as</i> degradation, which liberates miR-7 and inhibits the expression of its downstream oncogenic targets. Crucially, this therapeutic effect is directly correlated with a turn-on fluorescent signal from the MB, enabling the real-time, live-cell readout of circRNA regulation. This work establishes a versatile theranostic strategy that merges targeted gene regulation with intrinsic biosensing, offering a powerful platform for probing circRNA function and advancing RNA-based therapeutics.</p>","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"27 7","pages":"761-774"},"PeriodicalIF":5.7,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13420507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148620651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intelligent biosensing and point-of-care testing: from molecular recognition to decentralized precision care.","authors":"Jixi Zhang, Yi Zhang","doi":"10.1631/jzus.B2610002","DOIUrl":"10.1631/jzus.B2610002","url":null,"abstract":"<p><p>Point-of-care testing (POCT) is changing the way diagnostic information is generated, interpreted, and used. Its value extends well beyond shortening turnaround time. A meaningful POCT result should support a defined clinical or public-health action, such as early triage, treatment selection, disease surveillance, referral, or longitudinal follow-up. In this sense, POCT is best understood as a distributed extension of laboratory medicine rather than a simplified replacement for the central laboratory (Banfi et al., 2024; Plebani et al., 2025).</p>","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"27 7","pages":"671-676"},"PeriodicalIF":5.7,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13420515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148620587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural network approach for predicting outcomes of external cephalic version for breech presentation: a retrospective cohort study.","authors":"Yuting Xiang, Wenjian Yang, Haote Han, Haixia Lin, Wanhua Wu, Suran Huang, Hao Wang, Ning Hu, Zhongjun Li","doi":"10.1631/jzus.B2500259","DOIUrl":"10.1631/jzus.B2500259","url":null,"abstract":"<p><p>The procedure of external cephalic version (ECV) is an important option in the management of breech presentation. However, there is still a lack of effective methods to accurately predict the likelihood of ECV success on the basis of individual conditions. With the aim of better predicting the outcomes of ECV and subsequent delivery modes, this study developed neural network-based models. We conducted a retrospective cohort study of women with singleton pregnancies who underwent an ECV for breech presentation at a single, tertiary, university-affiliated hospital between January 2016 and September 2023. Data on the demographic characteristics, comprehensive preoperative ultrasound assessment, and conditions during the ECV procedure were extracted from the hospital's electronic record system. A neural network algorithm was implemented to establish prediction models for the success or failure of ECV, as well as subsequent delivery modes. The performance of the models was improved by increasing the number of iterations. A total of 378 patients were retrospectively included, including 279 successful and 99 failed cases, showing an overall success rate of 73.8%. Univariate analysis revealed that gravidity, parity, systolic blood pressure, presence of uterine fibroids, and amniotic fluid index (AFI) indicated by preoperative and intra-operative ultrasound were positively associated with ECV success, while thicker maternal abdominal walls and the use of anesthesia were correlated with failure. Multivariate analysis determined that parity, uterine fibroids, AFI, and the use of anesthesia were independent determinants of ECV outcomes. The samples were then divided into training and testing sets in a 1 ׃ 1 ratio. By increasing the number of iterations, the true positive rates for the successful and failed versions both reached 100%. The overall accuracy was 82.5% for predicting ECV outcomes. A total of 291 samples with delivery records were included for the prediction of delivery modes. The neural network-based model achieved a predictive accuracy of 78.8% after 2000 iterations, with the true positive rates for vaginal delivery and cesarean section both reaching 100%. These algorithms output exact predicted probabilities instead of providing the outcomes alone. An external validation set was also employed to further confirm the algorithm's performance. Collectively, prediction models formulated on the basis of neural network algorithms were developed to assess the ECV outcomes and subsequent delivery modes, with both models demonstrating favorable results and great performance. For women eligible for ECV, the application of these models can potentially assist in the crucial clinical decision-making process.</p>","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"27 9","pages":"996-1012"},"PeriodicalIF":5.7,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13621207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IL-15 aggravates cardiac ischemic injury via impairing macrophage efferocytosis and driving inflammation.","authors":"Lei Guo, Zhehui Yin, Ning Zhang, Han Chen, Zhuo Wang, Yuxue Huang, Jiniu Huang, Yayu You, Chenyun Zhang, Qinyi Bao, Shuxin Lei, Jun Jiang, Xiaojie Xie","doi":"10.1631/jzus.B2500477","DOIUrl":"https://doi.org/10.1631/jzus.B2500477","url":null,"abstract":"<p><p>Acute myocardial infarction (AMI) remains a major global health burden and is characterized by profound cardiac inflammation, apoptotic cell death, and impaired myocardial function. While interleukin-15 (IL-15) has been implicated in immune regulation, its precise role in the pathogenesis of AMI has not been clarified. Therefore, this study sought to delineate the functional role of IL-15 in the progression of AMI, with a particular focus on its influence on macrophage-driven inflammation, efferocytosis, and metabolic reprogramming. IL-15 levels were assessed in AMI patients and murine models. To evaluate the impact of IL-15 on cardiac inflammation, apoptosis, and functional outcomes following AMI, <i>IL-15</i> and IL-15 receptor α (<i>IL-15Rα</i>) knockout (KO) mouse models were employed. Mechanistic studies were conducted to investigate IL-15-mediated effects on macrophage efferocytosis, polarization, and metabolic remodeling, with an emphasis on nuclear factor-κB (NF-κB) signaling and glycolytic flux. Elevated IL-15 levels were detected in both the plasma of AMI patients and the cardiac tissues of murine AMI models, correlating with increased disease severity. The genetic deletion of <i>IL-15</i> or <i>IL-15Rα</i> significantly ameliorated cardiac injury by reducing inflammation and apoptosis while preserving myocardial function. Mechanistic analyses revealed that IL-15 impaired macrophage efferocytosis via Mer tyrosine kinase (MERTK) downregulation and promoted M1 polarization via NF-κB pathway activation. Furthermore, IL-15 reprogrammed macrophage metabolism by enhancing glycolytic activity. Ultimately, IL-15 restoration exacerbated cardiac ischemic injury following AMI, serving as a critical regulator of macrophage-mediated inflammation in AMI. These findings highlight the role of IL-15 as a potential therapeutic and prognostic target for mitigating cardiac inflammation and improving myocardial recovery in AMI.</p>","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"27 8","pages":"856-871"},"PeriodicalIF":5.7,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13474201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148761428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of workplace impairment and daily activity impairment in acute and chronic insomnia disorder: a study of Chinese adults.","authors":"Leqin Fang, Shixu DU, Hangyi Yang, Xue Luo, Shuqiong Zheng, Zhiting Huang, Yuhan Zhao, Shufei Zeng, Bin Zhang","doi":"10.1631/jzus.B2500586","DOIUrl":"10.1631/jzus.B2500586","url":null,"abstract":"<p><p><b>BACKGROUND</b>: Insomnia is a common condition that adversely affects work productivity, and a significant proportion of individuals with acute insomnia disorder (AID) eventually develop chronic insomnia disorder (CID). However, it remains unclear whether workplace impairment and daily activity impairment occur early in the course of insomnia. <b>METHODS</b>: This cross-sectional study included 295 AID and 305 CID participants. Multiple linear regression was used to assess associations between insomnia, workplace and daily activity impairment, and related factors (daytime sleepiness, depressive and anxiety symptoms). Restricted cubic spline (RCS) analysis was also conducted to explore nonlinear relationships. Mediation analysis was performed to assess the potential mediating effects of daytime sleepiness and depressive and anxiety symptoms between insomnia and workplace and daily activity impairment. <b>RESULTS</b>: No significant differences were found between the AID and CID groups in presenteeism or productivity-loss costs (<i>P</i>>0.05). Insomnia severity, daytime sleepiness, and depressive and anxiety symptoms were the correlated factors of workplace and daily activity impairment (<i>P</i><0.05). A nonlinear relationship between depressive symptoms and presenteeism, as well as between daytime sleepiness and daily activity impairment, was identified in both groups (<i>P</i>_overall<0.01, <i>P</i>_nonlinearity<0.05). Mediation analysis showed that in the AID group, depressive symptoms mediated the effects on absenteeism and daily activity impairment (mediation proportions: 37.02% and 28.61%, respectively). In the CID group, anxiety symptoms had a greater mediating effect on presenteeism and daily activity impairment (mediation proportions: 53.01% and 31.70%, respectively). <b>CONCLUSIONS</b>: Presenteeism and productivity-loss costs occur in AID and are comparable with those resulting from CID. Depressive and anxiety symptoms are also important mediators of workplace and daily activity impairment in AID. We recommend investing in portable and effective interventions to improve work productivity.</p>","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"27 9","pages":"1031-1040"},"PeriodicalIF":5.7,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13621206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149074834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IL-1β pathway-dependent regulation of glutamate receptor activity by gut microbiota in bipolar depression.","authors":"Anying Tang, Yi Chen, Kaijing Ding, Jinyu Zhang, Le Xu, Wenhao Chen, Shaohua Hu, Jianbo Lai","doi":"10.1631/jzus.B2500219","DOIUrl":"https://doi.org/10.1631/jzus.B2500219","url":null,"abstract":"<p><strong>Objectives: </strong>Neuroinflammation may disrupt neurotransmitter signaling. This study investigated whether gut microbiota-induced neuroinflammation can regulate glutamate pathways in bipolar disorder (BD).</p><p><strong>Methods: </strong>Fecal microbiota transplantation (FMT) was performed to observe behavioral changes in the antibiotic-treated C57BL/6J male mouse model of bipolar depression. Gut microbial structure, circulating, and prefrontal levels of inflammatory factors, microglial activation, and transcription levels of <i>N</i>-methyl- d-aspartate receptor (<i>NMDAR</i>) and α-amino-3-hydroxy-5-methyl-4 isoxazole receptor (<i>AMPAR</i>) genes were measured in the \"BD\" and control mice. Furthermore, the effects of interleukin-1 (IL-1) receptor antagonist (IL-1RA) on the glutamate pathways were assessed.</p><p><strong>Results: </strong>Compared with the control mice, \"BD\" mice displayed depression-like behaviors, with a lower diversity of gut bacteria and a decreased abundance of certain species. In addition, \"BD\" mice showed increased levels of inflammatory factors (e.g., IL-1β) in the serum and prefrontal cortex, microglial activation, and changes in the messenger RNA (mRNA) levels of <i>NMDAR</i> and <i>AMPAR</i>. Treatment with IL-1RA partially reversed the behavioral patterns, neuroinflammation, and transcription levels of glutamate receptors.</p><p><strong>Conclusions: </strong>The findings suggest that gut microbiota may influence glutamate receptor gene expression via an IL-1β-dependent pathway in a mouse model of BD, potentially contributing to neuroinflammatory mechanisms relevant to this disorder.</p>","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"27 8","pages":"888-905"},"PeriodicalIF":5.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13474199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148764913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nrf2 signaling pathway and its molecular regulatory mechanism.","authors":"Yunfei Pan, Xiaodong Zhang, Yimin Lu, Hao Qin, Rong Chen, Handong Fan","doi":"10.1631/jzus.B2500053","DOIUrl":"10.1631/jzus.B2500053","url":null,"abstract":"<p><p>Nuclear factor erythroid 2-related factor 2 (Nrf2) is a crucial transcription factor that orchestrates the expression of genes involved in antioxidant defense, detoxification, and the maintenance of cellular homeostasis. This review provides a comprehensive analysis of the dual regulatory role of Nrf2 in both normal physiological and pathological conditions, focusing on the molecular mechanisms by which it modulates mitochondrial function, oxidative stress, inflammation, and autophagy. The review summarizes the current knowledge on the effects of various synthetic and natural compounds, such as flavonoids and resveratrol, on Nrf2 activity. The review also explores the therapeutic potential of Nrf2 in neurodegenerative diseases, cancers, diabetes, and other disorders, laying a foundation for the development of Nrf2-targeted pharmacological interventions.</p>","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"27 9","pages":"978-995"},"PeriodicalIF":5.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13621205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotection of engineered <i>Clostridium butyricum</i>-pMTL007-GLP-1 in A53T α-synuclein (α-syn) mouse model via PI3K/AKT/GSK-3β.","authors":"Xin Fang, Yun Wang, Zhenli Long, Bin Liao, Bo Wang, Daojun Hong, Jie Luo, Tingtao Chen","doi":"10.1631/jzus.B2500237","DOIUrl":"https://doi.org/10.1631/jzus.B2500237","url":null,"abstract":"<p><p>Parkinson's disease (PD) is a prevalent neurodegenerative disorder with limited therapeutic options and no cure, underscoring the urgent need for novel treatment strategies. Our previous work demonstrated that an engineered strain of <i>Clostridium butyricum</i>-pMTL007-glucagon-like peptide-1 (<i>C. butyricum</i>-pMTL007-GLP-1) alleviated PD symptoms by enhancing mitophagy, though the exact molecular mechanisms remained incompletely understood. In this study, we further investigated the neuroprotective effects and underlying mechanisms of this engineered strain using an A53T α-synuclein (α-syn) transgenic mouse model of PD. Specifically, we evaluated its impact on motor function, gut α-syn expression, intestinal barrier function, gut microbial composition, and neuropathological changes, with a focus on the phosphoinositide-3-kinase (PI3K)/protein kinase B (AKT)/glycogen synthase kinase-3β (GSK-3β) signaling pathway. Our findings revealed that <i>C. butyricum</i>-pMTL007-GLP-1 ameliorated motor deficits in PD mice by reducing intestinal α-syn accumulation, restoring gut barrier function, and modulating microbial diversity-notably increasing the relative abundance of <i>Prevotella</i> at the genus level. Furthermore, the engineered strain attenuated neuropathological alterations by decreasing phosphorylated α-syn (p-α-syn) in the substantia nigra while upregulating tyrosine hydroxylase (TH), dopamine-transporter (DAT), and glucagon-like peptide-1-receptor (GLP-1R) expression. These neuroprotective effects were associated with suppressed proinflammatory responses and enhanced anti-inflammatory and anti-apoptotic signaling, likely mediated through PI3K/AKT/GSK-3β pathway activation. In conclusions, <i>C. butyricum</i>-pMTL007-GLP-1 exerts significant neuroprotective effects in PD mice by reshaping gut microbiota composition and activating the PI3K/AKT/GSK-3β pathway. These findings provide further theoretical support for the potential application of probiotic-based therapies in PD treatment.</p>","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"27 8","pages":"872-887"},"PeriodicalIF":5.7,"publicationDate":"2026-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13474202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148758562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Promoting skin regeneration: research progress on hydrogel wound dressings related to scarless healing.","authors":"Xian Hu, Fawei Xu, Minxia Zhang, Yiqing Chen, Jiaqin Cai, Jingjing Ma, Weiqiang Tan, Qingqing Fang","doi":"10.1631/jzus.B2500261","DOIUrl":"https://doi.org/10.1631/jzus.B2500261","url":null,"abstract":"<p><p>This review summarizes progress made in research on hydrogel wound dressings in promoting scarless skin healing. Wound healing is a complex biological process that involves four stages: hemostasis, inflammation, proliferation, and remodeling. Scar formation is a common issue during this process, especially pathological scars such as hypertrophic scars and keloids, which severely affect aesthetics and function. In recent years, hydrogel dressings have become a research hotspot for promoting scarless healing due to their unique physicochemical and biological properties. Hydrogels promote wound healing and reduce scar formation through multiple mechanisms, including providing a moist environment, antimicrobial activity, anti-inflammatory effects, promoting tissue regeneration, and regulating the wound microenvironment. This review details the concept and mechanisms of scarless healing and explores the application of hydrogel dressings loaded with anti-scarring drugs, stem cells, and extracellular vesicles (EVs) in scarless wound healing. Additionally, it summarizes progress in research on hydrogel dressings that regulate mechanical signals and innovative multifunctional hydrogel dressings, such as photo-responsive, organic biopolymer, and nanoparticle hydrogels. These hydrogel dressings show great potential for clinical application but still face challenges such as drug delivery efficiency, biocompatibility, and long-term safety. Future research needs to further optimize the composition and functionality of hydrogels and explore their potential applications in clinical settings.</p>","PeriodicalId":17797,"journal":{"name":"Journal of Zhejiang University SCIENCE B","volume":"27 8","pages":"832-855"},"PeriodicalIF":5.7,"publicationDate":"2026-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13474200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148764976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}