{"title":"PROFIL KOMPONEN SENYAWA HERBA PEGAGAN (Centella asiatica L.) DARI BEBERAPA TEMPAT TUMBUH DI DAERAH SULAWESI SELATAN DENGAN ANALISIS SIDIK JARI MENGGUNAKAN FTIR","authors":"Asril Burhan","doi":"10.29313/jiff.v5i2.9716","DOIUrl":"https://doi.org/10.29313/jiff.v5i2.9716","url":null,"abstract":"Centella asiatica L. is the plant most widely used as a folk remedy traditional medicine to cure various diseases. The efficacy and quality of a natural medicine depend on the chemical composition contained in it. One of the factors that underlie the difference in chemical composition in a plant is the place where it is grown. The purpose of this study was to compare the compounds component profile of herb pegagan from several growing areas in South Sulawesi with fingerprint analysis using FTIR. The Samples used were from 9 regions of South Sulawesi, namely Toraja (Karua, Tondon, Sadan), Luwu (Batusitanduk, Lamasi, Walenrang), Makassar (Mangga 3, Tamalanrea, Moncongloe). Based on the results obtained were relatively the same spectrum results from 9 types of samples and infrared spectroscopy measurements combined with chemometric, group 1 (Karua, Mangga 3, Batusitanduk, Walenrang) and variable areas of group 2 (Tondon, Tamalanrea, Lamasi, Moncongloe) have 95.83% similarities. While the similarity of the regional variable profile of groups 1 and 2 when compared with the regional variable of group 3 (Sadan) has a similarity of 85.42%. The results of this study concluded that there were differences in the profile of the compound components in the herb pegagan which was taken from the nine growing sites in South Sulawesi.","PeriodicalId":17775,"journal":{"name":"Jurnal Ilmiah Farmasi Farmasyifa","volume":"123 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72840695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"PENGARUH PENGEMBANGAN SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM TERHADAP DISOLUSI, BIOAVAILABILITAS, DAN AKTIVITAS AGEN ANTIHIPERLIPIDEMIA","authors":"Sani Ega Priani","doi":"10.29313/jiff.v5i1.8967","DOIUrl":"https://doi.org/10.29313/jiff.v5i1.8967","url":null,"abstract":"Hiperlipidemia adalah suatu kondisi peningkatkan kadar lipid plasma yang dapat menjadi faktor resiko berbagai penyakit kardiovaskular. Diketahui beberapa agen antihiperlipidemia bersifat sukar larut dalam air sehingga dapat berpengaruh pada disolusi, bioavailabilitas, dan efek farmakologi yang dihasilkan. Self-nanoemulsifying Drug Delivery System (SNEDDS) merupakan salah satu sistem penghantaran obat yang diketahui mampu memperbaiki kelarutan zat sukar larut air. Kajian ini bertujuan untuk mengetahui pengaruh formulasi SNEDDS terhadap disolusi, bioavailabilitas, dan efektivitas dari agen antihiperlipidemia. Kajian berbasis systematic literature review dengan melakukan pengkajian artikel yang diperoleh dari database bereputasi yang memenuhi kriteria inklusi dan eksklusi yang telah ditetapkan. Hasil kajian menunjukkan formulasi SNEDDS terhadap agen antihiperlipidemia dapat menyebabkan peningkatan % disolusi zat sukar larut air hingga mencapai >80%. Formulasi SNEDDS mampu meningkatkan bioavailabilitas zat, yang ditandai dengan peningkatan signifikan dari nilai Cmax dan AUC (area under curve) dibandingkan dengan bentuk murni/suspensi. Formulasi SNEDDS juga mampu meningkatkan efektivitas antihiperlipidemia, yang ditandai dengan penurunan kadar kolesterol total, trigliserida, dan LDL yang lebih baik dibandingkan dengan zat murni/sediaan di pasaran. Dari hasil kajian dapat disimpulkan bahwa pengembangan sediaan SNEDDS potensial untuk meningkatkan disolusi, bioavaibilitas, dan efektivitas terapi dari agen antihiperlipidemia.","PeriodicalId":17775,"journal":{"name":"Jurnal Ilmiah Farmasi Farmasyifa","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79765186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluasi Kualitas Hidup Pasien Diabetes Melitus Tipe 2 Dengan Antidiabetik Oral Di Rumah Sakit Harapan dan Do’a Kota Bengkulu","authors":"D. Handayani, Dwi Dominica, Reza Pertiwi, Feby Aristia Putri, Tya Chalifatul, Dhea Ananda","doi":"10.29313/jiff.v5i1.7983","DOIUrl":"https://doi.org/10.29313/jiff.v5i1.7983","url":null,"abstract":"Diabetes mellitus termasuk kelainan metabolik heterogen dimana ditunjukkan dengan adanya hiperglikemia. Sebuah kunci untuk berhasilnya terapi DM yaitu melalui peningkatan kualitas hidup pasien yang bisa diukur memanfaatkan kuesioner DQLCTQ (Diabetes Quality of Life Clinical Trial Quessionnaire). Penelitan ini memiliki tujuan guna mengetahui kualitas hidup pasien diabetes melitus tipe 2 dengan antidiabetik oral di Rumah Sakit Harapan dan Do’a Kota Bengkulu berdasar faktor pola terapi yang diterima pasien, jenis obat yang digunakan, dan karakteristik responden. Penelitian ini merupakan penelitian observasional analitik dengan desain Cross Sectional dengan pengambilan data pasien secara concurrent. Penelitian dilakukan di Rumah Sakit Harapan dan Do’a Kota Bengkulu. Sampel penelitian ini sejumlah 98 pasien DM tipe 2 yang melakukan kontrol ke rumah sakit ketika penelitian berlangsung dan memperoleh obat antidiabetik oral dan bersedia mengisi kuesioner DQLCTQ. Hasil penelitian menunjukkan bahwa tidak terdapat pengaruh antara faktor karakterisktik responden terhadap kualitas hidup. Skor kualitas hidup pasien yang mendapatkan akarbose, metformin, dan sulfonilurea, masing-masing adalah 61,0;61,3 dan 61,4. Hasil uji statistik dengan ANOVA menunjukkan bahwa tidak terdapat perbedaan yang signifikan antara ketiga kelompok pasien tersebut (p=0,812). Pasien dengan pengobatan ADO tunggal skor kualitas hidupnya 64,0 sedangkan pasien dengan pengobatan ADO kombinasi skor kualitas hidupnya 62,3. Perbedaan ini berdasarkan uji Independent sample t-test, perbedaannya tidak berbeda signifikan (p=0,134).","PeriodicalId":17775,"journal":{"name":"Jurnal Ilmiah Farmasi Farmasyifa","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77506037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"PROFIL PENGGUNAAN ANTIRETROVIRAL DAN NILAI CD4 PASIEN HIV/AIDS SETELAH DIBERIKAN ANTIRETROVIRAL","authors":"Ratna Sari Dewi","doi":"10.29313/jiff.v5i1.7732","DOIUrl":"https://doi.org/10.29313/jiff.v5i1.7732","url":null,"abstract":"","PeriodicalId":17775,"journal":{"name":"Jurnal Ilmiah Farmasi Farmasyifa","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76657015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"AKTIVITAS ANTIKONVULSAN EKSTRAK RIMPANG TEMU IRENG (Curcuma aeruginosa Roxb.) PADA TIKUS PUTIH JANTAN MENGGUNAKAN ELEKTROKONVULSIOMETER","authors":"Agustin Yumita, Dwitiyanti Dwitiyanti, Putri Ermawati","doi":"10.29313/jiff.v5i1.8829","DOIUrl":"https://doi.org/10.29313/jiff.v5i1.8829","url":null,"abstract":"Submitted : Rimpang temu ireng (Curcuma aeruginosa Roxb.) diketahui memiliki kandungan metabolit sekunder yang dapat berkhasiat sebagai antikonvulsan. Penelitian ini bertujuan untuk mengetahui aktivitas antikonvulsan ekstrak etanol 70% rimpang temu ireng pada tikus putih jantan. Ekstraksi yang digunakan dalam metode ini adalah maserasi. Hewan uji diberi ekstrak etanol 70% rimpang temu ireng (100 mg/kgBB, 200 mg/kgBB, dan 400 mg/kgBB), pembanding standar asam valproate. Pengujian antikonvulsan menggunakan alat digital elektrokonvulsiometer dengan parameter yang diamati adalah onset HLE dan durasi HLE. Ekstrak etanol 70% rimpang temu ireng dosis 400 mg/kgBB memiliki aktivitas yang paling baik sebagai antikonvulsan dengan memperpanjang onset HLE dan mempersingkat durasi HLE sebanding dengan pembanding standar. Temu ireng memiliki potensi untuk dikembangkan sebagai antikonvulsan yang cukup baik. Kata kunci: Antikonvulsan, Asam valproate, Curcuma aeruginosa 5 November 2021","PeriodicalId":17775,"journal":{"name":"Jurnal Ilmiah Farmasi Farmasyifa","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88146681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Mulqie, S. Suwendar, Muhammad Fakhrur Rajih, D. Mardliyani, Imas Yumniati, Widiasari Widiasari, Zakiyyah Nurrosyidah
{"title":"AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN JAMBU AIR [Eugenia aqueum (Burm. F) Alston] DENGAN MIKRODILUSI AGAR","authors":"L. Mulqie, S. Suwendar, Muhammad Fakhrur Rajih, D. Mardliyani, Imas Yumniati, Widiasari Widiasari, Zakiyyah Nurrosyidah","doi":"10.29313/jiff.v5i1.7849","DOIUrl":"https://doi.org/10.29313/jiff.v5i1.7849","url":null,"abstract":"Submitted : Sumber daya alam yang dimiliki Indonesia cukup berlimpah. Tanaman merupakan sumber daya alam yang banyak dimanfaatkan sebagai obat. Salah satu tanaman obat yang dapat digunakan sebagai obat tradisional adalah jambu air. Tujuan penelitian ini yaitu untuk melihat aktivitas antibakteri ekstrak etanol daun jambu air terhadap S. aureus, dan E.coli dan penetapan nilai Konsentrasi Hambat Minimum (KHM), serta pengujian Konsentrasi Bunuh Minimum (KBM). Ekstraksi dilakukan secara maserasi dengan etanol 96%. Pengujian aktivitas antibakteri dan penetapan KHM dilakukan dengan metode mikrodilusi agar. Penetapan KBM dilakukan dengan menentukan bagian media agar yang menunjukkan tidak adanya pertumbuhan bakteri dengan hasil visual yang jernih. Nilai KHM dan KBM ekstrak etanol daun jambu air terhadap S. aureus, dan E.coli yaitu 20.000 μg/mL dan 40.000 μg/mL. Kata kunci: ekstrak etanol, jambu air, mikrodilusi agar 21 April 2021","PeriodicalId":17775,"journal":{"name":"Jurnal Ilmiah Farmasi Farmasyifa","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74881312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"PENGGUNAAN METODE RESPON PERMUKAAN DALAM OPTIMASI METODE EKSTRASKI KARBOHIDRAT DARI KULIT NANAS (Ananas commusus)","authors":"Kiki Mulkiya Yuliawati","doi":"10.29313/jiff.v5i1.8325","DOIUrl":"https://doi.org/10.29313/jiff.v5i1.8325","url":null,"abstract":"","PeriodicalId":17775,"journal":{"name":"Jurnal Ilmiah Farmasi Farmasyifa","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86146554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"AKTIVITAS ANTIBAKTERI EKSTRAK KAYU SECANG (Caesalpinia sappan L.) DAN MINYAK BUNGA CENGKEH (Syzygium aromaticum L.) SERTA KOMBINASINYA TERHADAP BAKTERI PENYEBAB PENYAKIT KULIT","authors":"Yani Lukmayani","doi":"10.29313/jiff.v5i1.8300","DOIUrl":"https://doi.org/10.29313/jiff.v5i1.8300","url":null,"abstract":"","PeriodicalId":17775,"journal":{"name":"Jurnal Ilmiah Farmasi Farmasyifa","volume":"77 5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89237387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}