{"title":"FORMULASI DAN EVALUASI MUTU FISIK SERUM NANOFITOSOM MYRICETIN","authors":"Yuli Edy Saputra, Nurleli Purnamasari, Galuh Octaviani Palupi","doi":"10.29313/jiff.v6i1.10253","DOIUrl":"https://doi.org/10.29313/jiff.v6i1.10253","url":null,"abstract":"Serum adalah sediaan dengan zat aktif yang mempunyai konsentrasi tinggi dan viskositas rendah, sehingga mudah diabsorbsi di permukaan kulit. Zat aktif alami yang dapat digunakan dalam formulasi serum yaitu Myricetin. Myricetin merupakan suatu flavonoid alami yang memiliki potensi sebagai antioksidan. Kekurangan dari suatu bahan obat yang berasal dari bahan alam salah satunya adalah biovailabilitas yang rendah. Nanofitosom merupakan suatu sistem yang dapat meningkatkan permeabilitas sehingga dapat menembus membrane lipid sehingga bioavailabilitas obat dapat tercapai. Penelitian ini bertujuan untuk mengetahui apakah myricetin dapat dibuat nanofitosom dan dapat diformulasikan menjadi sediaan serum dengan mutu fisik yang baik. Myricetin dibuat nanofitosom dengan metode hidrasi lapis tipis-sonikasi dengan perbandingan myricetin (1): lipid fosfatidilkolin (2): kolesterol (0,4). Formula serum dibuat menjadi 3 formula dengan perbedaan konsentrasi xanthan gum yaitu FI (0,15%); FII (0,25%); FIII (0,35%). Formula serum yang telah dibuat dilakukan pengujian mutu fisik serum meliputi uji organoleptis,, homogenitas, pH dan viskositas. Data yang diperoleh dianalisis dan dibandingkan dengan literatur yang ada. Hasil penelitian bahwa myricetin dapat dibuat nanofitosom dan diformulasikan menjadi sediaan serum dengan mutu fisik yang baik. Sediaan serum myricetin formula I, formula II, formula III berwarna kuning kecoklatan dan homogen. Ketiga formula memiliki pH 6,5 dan sesuai dengan pH normal kulit. Hasil uji viskositas formula I 165 dPas, formula II 175 dPas, dan formula III 190 dPas.Kata kunci: serum, myricetin, nanofitosom, mutu fisik sediaan ","PeriodicalId":17775,"journal":{"name":"Jurnal Ilmiah Farmasi Farmasyifa","volume":"8 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89981722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fadila Nur Annisa, Ganis Fitria Fauziyyah, I. A. Wicaksono, Keri Lestari
{"title":"REVIEW ARTIKEL : POTENSI TANAMAN HERBAL DI INDONESIA DALAM MENINGKATKAN KEBUGARAN TUBUH","authors":"Fadila Nur Annisa, Ganis Fitria Fauziyyah, I. A. Wicaksono, Keri Lestari","doi":"10.29313/jiff.v5i2.8841","DOIUrl":"https://doi.org/10.29313/jiff.v5i2.8841","url":null,"abstract":"Body fitness needs to be achieved and maintained in order to avoid excessive fatigue when doing any physical activity. There are many herbal plants that are empirically used by the community to help improve body fitness. Proof of stimulant activity can be done by testing the tonic effects on each herbal plant, which is carried out preclinically on test animals using the natatory exhaustion method. The purpose of this article is to provide information about what plants have the potential to improve fitness through journaling literature searches on an electronic database in the form of Google Scholar. Some of the herbal plants in Indonesia are obtained such as ceguk, gula aren, ilalang,","PeriodicalId":17775,"journal":{"name":"Jurnal Ilmiah Farmasi Farmasyifa","volume":"75 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86880849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"FORMULASI DAN UJI AKTIVITAS GEL ANTIINFLAMASI EKSTRAK ETANOL DAUN PEPAYA (Carica papaya L.) PADA MENCIT JANTAN PUTIH (Mus musculus)","authors":"Suhrah Febrina Karim","doi":"10.29313/jiff.v5i2.8970","DOIUrl":"https://doi.org/10.29313/jiff.v5i2.8970","url":null,"abstract":"","PeriodicalId":17775,"journal":{"name":"Jurnal Ilmiah Farmasi Farmasyifa","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83008620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"PENGARUH METODE EKSTRAKSI TERHADAP AKTIVITAS ANTIOKSIDAN EKSTRAK DAUN KARAMUNTING (Rhodomyrtus Tomentosa (Aiton) Hassk) DENGAN METODE DPPH","authors":"Nursamsiar Nursamsiar","doi":"10.29313/jiff.v5i2.9053","DOIUrl":"https://doi.org/10.29313/jiff.v5i2.9053","url":null,"abstract":"Karamunting (Rhodomyrtus tomentosa (Aiton) Hassk) merupakan tanaman yang telah banyak dimanfaatkan masyarakat dalam pengobatan berbagai penyakit. Daun karamunting diketahui memiliki kandungan senyawa kimia fenolik, flavonoid, tanin, saponin dan terpenoid. Penelitian ini bertujuan untuk mengetahui pengaruh metode ekstraksi terhadap aktivitas antioksidan daun karamunting dalam meredam radikal DPPH. Daun karamunting diektraksi dengan metode dingin (maserasi dan sonikasi) dan metode panas (refluks) menggunakan pelarut etanol 70% dan pengujian aktivitas antioksidan dengan spektrofotometri Uv-Vis pada panjang gelombang 515 nm. Hasil ekstraksi diperoleh rendemen metode maserasi, sonikasi dan refluks berturut-turut 15,6%; 3,4% dan 6,4%. Pengujian aktivitas antioksidan diperoleh nilai IC50 sebesar 15,33 µg/mL;6,1815 µg/mL dan 6,9720 µg/mL. Metode ekstraksi mempengaruhi aktivitas antioksidan dari daun karamunting dalam meredam radikal bebas DPPH.","PeriodicalId":17775,"journal":{"name":"Jurnal Ilmiah Farmasi Farmasyifa","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81541702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"TINGKAT PENGETAHUAN, PERSEPSI, DAN SIKAP MASYARAKAT TERHADAP KEHALALAN OBAT DI JAWA TIMUR","authors":"Isnaini Khoirun Nur Amin","doi":"10.29313/jiff.v5i2.9608","DOIUrl":"https://doi.org/10.29313/jiff.v5i2.9608","url":null,"abstract":"","PeriodicalId":17775,"journal":{"name":"Jurnal Ilmiah Farmasi Farmasyifa","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90095110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"EVALUASI INVITRO AKTIVITAS ANTIOKSIDAN DAN TABIR SURYA DARI EKSTRAK DAUN DAN AKAR TUMBUHAN Elephantopus mollis Kunth","authors":"Verawati Verawati, Miftahur Rahmi, Intan Suci Mayasari","doi":"10.29313/jiff.v5i2.8361","DOIUrl":"https://doi.org/10.29313/jiff.v5i2.8361","url":null,"abstract":"","PeriodicalId":17775,"journal":{"name":"Jurnal Ilmiah Farmasi Farmasyifa","volume":"146 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77729357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"PENELUSURAN PUSTAKA: POTENSI KELOMPOK SENYAWA BIOKIMIA BUAH LEUNCA (Solanum nigrum L.) SERTA MEKANISMENYA PADA TERAPI KANKER","authors":"Andri Ryandi","doi":"10.29313/jiff.v5i2.9759","DOIUrl":"https://doi.org/10.29313/jiff.v5i2.9759","url":null,"abstract":"Kanker adalah suatu kondisi pertumbuhan sel yang tidak normal di dalam tubuh. Terapi kanker dapat dilakukan melalui pembedahan yang disertai dengan kemoterapi dan/atau radioterapi. Diantara ketiganya, kemoterapi merupakan pilihan yang terbilang lebih mudah dijalani pasien, karena diberikan dalam bentuk sediaan yang tidak memerlukan tekhnik khusus dalam pengaplikasiannya. Meskipun begitu, efektifitas pengobatan dengan kemoterapi masih tergolong rendah, sehingga upaya pembuatan atau penemuan senyawa dengan efektifitas yang tinggi masih terus dilakukan. Mayoritas obat kemoterapi merupakan senyawa kimia sintetis, dan sampai tulisan ini dibuat, hanya ada empat kelompok senyawa biokimia antikanker yang paling efektif dan telah banyak digunakan, yaitu alkaloid vinca, epipodophyllotoxins, taxane, dan derivat camptothecin. Karenanya, penelitian terkait senyawa biokimia antikanker masih harus dikembangkan. Salah satu upaya untuk mengembangkan senyawa antikanker adalah dengan melakukan penelitian terhadap tumbuhan terkait kandungan senyawa biokimianya. Penelitian terhadap tumbuhan juga mampu memberikan nilai tambah terkait pemanfaatannya, terutama jika tumbuhan tersebut telah digunakan oleh masyarakat secara luas. Salah satu tumbuhan dengan potensi aktivitas antikanker adalah leunca (Solanum nigrum L.). Leunca telah banyak diteliti terkait aktivitasnya sebagai antikanker dan menunjukan hasil yang cukup baik. Buah leunca memiliki potensi sebagai antikanker karena kandungan kelompok senyawa khas didalamnya, meliputi kelompok senyawa alkaloid steroid, glikosida steroid, dan glikoalkaloid steroid. Mekanisme kerjanya berlangsung melalui beberapa cara, yaitu sebagai antiproliperatif, menginduksi apoptosis, antineoplastik, meningkatkan radiosensitivitas terapi kanker dan antimetastasis. Penelitian terkait buah leunca yang merupakan bahan pangan khas yang dikonsumsi secara tradisional dapat menjadi faktor pendukung bagi masyarakat dalam mengonsumsi panganan tradisional, karena selain didorong oleh budaya, lingkungan, atau kebiasaan, tapi juga secara ilmiah.","PeriodicalId":17775,"journal":{"name":"Jurnal Ilmiah Farmasi Farmasyifa","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79349160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"KAJIAN PENGEMBANGAN SISTEM MIKROENKAPSULASI UNTUK PENINGKATAN STABILITAS VITAMIN C","authors":"Raisha Az Zahra","doi":"10.29313/jiff.v5i2.9878","DOIUrl":"https://doi.org/10.29313/jiff.v5i2.9878","url":null,"abstract":"","PeriodicalId":17775,"journal":{"name":"Jurnal Ilmiah Farmasi Farmasyifa","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82551880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}