Jurnal Ilmiah Farmasi Farmasyifa最新文献

{"title":"PERBANDINGAN EKSTRAK BENALU TEH (Scurrula atropurpurea (Bl.) Dans.) DENGAN EKSTRAK TEMULAWAK (Curcuma xanthorrhiza) SEBAGAI HEPATOPROTEKTOR PADA TIKUS WISTAR","authors":"Fetri Lestari, Mochamad Tanto Kuswanto, L. Mulqie","doi":"10.29313/jiff.v6i1.10816","DOIUrl":"https://doi.org/10.29313/jiff.v6i1.10816","url":null,"abstract":"","PeriodicalId":17775,"journal":{"name":"Jurnal Ilmiah Farmasi Farmasyifa","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84660511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"UJI TOKSISITAS AKUT EKSTRAK ETANOL 70% BUNGA TELANG (Clitoria ternatea L.) TERHADAP TIKUS BETINA GALUR WISTAR DENGAN METODE OECD 425","authors":"Sartika Dewi, K. Astuti, Esty Restiana Rusida","doi":"10.29313/jiff.v6i1.10420","DOIUrl":"https://doi.org/10.29313/jiff.v6i1.10420","url":null,"abstract":"","PeriodicalId":17775,"journal":{"name":"Jurnal Ilmiah Farmasi Farmasyifa","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85763217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AKTIVITAS ANTIJAMUR EKSTRAK ETANOL PALA (Myristica fragrans HOUTT.) TERHADAP Malassezia furfur DAN Tricophyton mentagrophytes","authors":"Muhamamad Fakhrur Rajih, Nur Asma Somadayo","doi":"10.29313/jiff.v6i1.10063","DOIUrl":"https://doi.org/10.29313/jiff.v6i1.10063","url":null,"abstract":"","PeriodicalId":17775,"journal":{"name":"Jurnal Ilmiah Farmasi Farmasyifa","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87927323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"STUDI IN SILICO PENGIKATAN MIR-142 DENGAN GEN SITOKIN INFLAMASI BERDASARKAN NILAI ∆G DAN LOGISTIC PROBABILITY SEBAGAI AGEN TERAPI INFEKSI MRSA","authors":"I. Ismail, Reny Syahruni, Jane Stefany","doi":"10.29313/jiff.v6i1.10423","DOIUrl":"https://doi.org/10.29313/jiff.v6i1.10423","url":null,"abstract":"","PeriodicalId":17775,"journal":{"name":"Jurnal Ilmiah Farmasi Farmasyifa","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83702870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AKTIVITAS ANTIAKTERI EKSTRAK ETANOL BIJI DAN BUAH KUPA (Syzygium polichepalum (miq.) Merr.& perry) TERADAP BAKTERI PENYEBAB JERAWAT","authors":"Ratih Aryani, Siti Hazar, Dieni Mardliyani","doi":"10.29313/jiff.v6i1.10708","DOIUrl":"https://doi.org/10.29313/jiff.v6i1.10708","url":null,"abstract":"","PeriodicalId":17775,"journal":{"name":"Jurnal Ilmiah Farmasi Farmasyifa","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88276015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FORMULASI DAN KARAKTERISASI SEDIAAN ORALLY DISSOLVING FILM TAMSULOSIN HIDROKLORIDA","authors":"Fitrianti Darusman, Muhammad Sultan Ramadhan, Uci Ary Lantika","doi":"10.29313/jiff.v6i1.10717","DOIUrl":"https://doi.org/10.29313/jiff.v6i1.10717","url":null,"abstract":"","PeriodicalId":17775,"journal":{"name":"Jurnal Ilmiah Farmasi Farmasyifa","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77917960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"POTENSI KRIM ANTIOKSIDAN GETAH JARAK TINTIR (Jatropha mulfida L.) DALAM MENGHAMBAT ENZIM TIROSINASE SECARA IN SILICO SEBAGAI ALTERNATIF AGEN PEMUTIH","authors":"Farah Salsabilla Saidah Azhar, Sheila Nur Hasanah, Renata Ananda Marthasedana, Meyra Pratami Dewilestari, Sri Restu Andriyani, Wulan Anggraeni, D. Suryasaputra, Akhirul Kahfi Syam, Hestiary Ratih","doi":"10.29313/jiff.v6i1.10700","DOIUrl":"https://doi.org/10.29313/jiff.v6i1.10700","url":null,"abstract":"Getah Jarak Tintir (Jatropha multifida Linn.) yang berasal dari famili Euphorbiaceae diketahui memiliki kandungan fenolik dan flavonoid yang berpotensi sebagai antioksidan alami. Penelitian ini bertujuan untuk mengetahui kandungan metabolit sebagai antioksidan, interaksi senyawa metabolit sekunder dalam getah jarak tintir dengan enzim tirosinase, dan mengaplikasikannya dalam bentuk sediaan. Metode pengujian antioksidan dilakukan dengan metode DPPH dan pengujian aktivitas inhibitor enzim tirosinase dilakukan dengan in silico metode molekular docking. Formulasi hand and body cream getah jarak tintir dibuat dalam tiga formula yaitu F0 (basis krim sebagai kontrol), F1 (basis krim dengan 100×IC50 serbuk getah jarak tintir), F2 (basis krim dengan 200×IC50 serbuk getah jarak tintir). Hasil penelitian menunjukkan bahwa senyawa yang mempunyai afinitas kuat dalam menghambat enzim tirosinase yaitu Multifidol dengan nilai ∆G sebesar -6,01 kkal/mol dan KI sebesar 39,37 nM. Hasil pengujian antioksidan dari hasil freeze drying serbuk getah jarak tintir menunjukkan nilai IC50 sebesar 8,33 µg/mL yang termasuk kategori sangat kuat. Persen inhibisi pada krim F1 (konsentrasi zat aktif 8,33 µg/mL) dan F2 (konsentrasi zat aktif 16,4 µg/mL) berturut-turut adalah 25,08% dan 50,57% yang termasuk kategori sangat kuat dan berpotensi sebagai alternatif krim pemutih. Kata kunci: Getah jarak tintir, molecular docking, krim, antioksidan, DPPH  The sap of Jarak Tintir (Jatropha multifida Linn.) from the family Euphorbiaceae was known to contain phenolic and flavonoid compounds that have the potential as natural antioxidants. This study aimed to determine the content of metabolites as antioxidants, the interaction of secondary metabolites in Jatropha sap with tyrosinase enzymes, and to apply them in a dosage form. The antioxidant test method was carried out using the DPPH method and the tyrosinase enzyme inhibitory activity was tested using the molecular docking in silico method. The hand and body cream formulation of the sap was made in three formulas, namely F0 (cream base as control), F1 (cream base + 100×IC50 of the sap powder), F2 (cream base + 200×IC50 of the sap powder). The results showed that the compound that has a strong affinity to inhibit the tyrosinase enzyme is Multifidol with a ∆G value of -6.01 kcal/mol and a KI of 39.37 nM. The freeze-drying of the sap powder had the potential as an antioxidant with an IC50 value of 8.32 g/mL which was categorized as very strong activity. The percentage of inhibition in F1 cream (active substance concentration 8.32 g/mL) and F2 (active substance concentration 16.4 g/mL) were 25.08% and 50.57%, respectively, included in the very strong category and have potential to be alternative whitening cream. Keywords:  the sap of Jarak tintir, molecular docking, cream, antioxidant, DPPH","PeriodicalId":17775,"journal":{"name":"Jurnal Ilmiah Farmasi Farmasyifa","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74609293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"KAJIAN PENGARUH PENGEMBANGAN SISTEM FITOSOM TERHADAP AKTIVITAS AGEN SITOTOKSIK HERBAL","authors":"Sani Ega Priani","doi":"10.29313/jiff.v6i1.10891","DOIUrl":"https://doi.org/10.29313/jiff.v6i1.10891","url":null,"abstract":"Prevalensi dan morbiditas penyakit kanker terus meningkat. Pencarian agen sitotoksik baru terus dilakukan termasuk yang berasal dari bahan alam. Pengembangan sistem penghantaran untuk meningkatkan aktivitas sitotoksik banyak dilakukan seperti dengan pembentukan  fitosom,  salah satu sistem nanovesikular. Tujuan dari penelitian ini adalah untuk mengkaji pengembangan bahan-banan herbal dengan sistem penghantaran fitosom dan juga mengetahui pengaruhnya terhadap aktivitas sitoksik dari senyawa bahan alam tersebut. Penelitian dilakukan dengan melakukan kajian literatur dari artikel yang berasal dari database bereputasi yang memenuhi kriteria inklusi dan eksklusi sesuai tujuan penelitian. Dari hasil kajian  diketahui bahwa sistem fitosom sudah banyak dikembangkan untuk penghantaran agen sitoksik herbal seperti pada ekstrak aloe vera, celastrol, curcumin, curcuminoid, diosgenin, icariin, genistein, lycopene, mytomicin, propolis, silibinin, sinigrin, dan thymoquinone. Fitosom diformulasikan dengan menggunakan fosfatidilkolin pada perbandingan fitokonstituen: fosfolipid yakni 1:(1-3), dengan atau tanpa penambahan kolesterol. Pengembangan sediaan fitosom terbukti mampu meningkatkan aktivitas sitotoksik bahan herbal baik berdasarkan pengujian in-vitro atau in-vivo. Pada pengujian in-vitro peningkatan aktivitas ditandai dengan penurunan nilai IC50 dengan tingkat penurunan yang bervariasi dalam rentang 1,7-11 kalinya. Ukuran partikel yang lebih kecil dengan struktur fosfolipid bilayer diketahui menjadi penyebab utama terjadinya peningkatan aktivitas tersebut. Dari hasil kajian disimpulkan bahwa sistem fitosom potensial untuk mampu meningkatkan aktivitas sitotoksik senyawa herbal.","PeriodicalId":17775,"journal":{"name":"Jurnal Ilmiah Farmasi Farmasyifa","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81407985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AKTIVITAS ANTI OKSIDAN DAN EVALUASI SEDIAAN MASKER PEEL-OFF EKSTRAK ETANOL RIMPANG KUNYIT PUTIH (Curcuma zedoaria Roscoe","authors":"H. Faisal, Adek Chan, Hanafis Sastra Winata, V. Diana, Widyastuti Atika","doi":"10.29313/jiff.v6i1.9085","DOIUrl":"https://doi.org/10.29313/jiff.v6i1.9085","url":null,"abstract":"","PeriodicalId":17775,"journal":{"name":"Jurnal Ilmiah Farmasi Farmasyifa","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88601166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SKRINING FITOKIMIA DAN POTENSI DAYA HAMBAT EKSTRAK METANOL KULIT BATANG MERBAU PANTAI (Intsia bijuga) TERHADAP ENZIM α-GLUKOSIDASE","authors":"E. Wilujeng, Ayik R. Puspaningtyas, Indah Purnama Sary","doi":"10.29313/jiff.v6i1.10133","DOIUrl":"https://doi.org/10.29313/jiff.v6i1.10133","url":null,"abstract":"","PeriodicalId":17775,"journal":{"name":"Jurnal Ilmiah Farmasi Farmasyifa","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89601625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}