Kidney International Reports最新文献

{"title":"Acute Tubular Injury and Fanconi Syndrome Associated With Red Yeast Rice Supplement","authors":"Mayu Shimokawa , Yuki Kajio , Keishu Kawanishi , Kunio Kawanishi , Mika Shiomi , Tomoki Morikawa , Fumihiko Sasai , Masaki Baba , Dedong Kang , Takashi Takaki , Taihei Suzuki , Fumihiko Koiwa , Kazuho Honda , Hirokazu Honda","doi":"10.1016/j.ekir.2024.12.016","DOIUrl":"10.1016/j.ekir.2024.12.016","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 3","pages":"Pages 956-959"},"PeriodicalIF":5.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemophagocytic Lymphohistiocytosis in Solid Organ Transplants","authors":"Priyamvada Singh , Mohankumar Doraiswamy , Alka Tyagi , Deepali Pandey , Navdeep Singh , Todd E. Pesavento","doi":"10.1016/j.ekir.2024.12.003","DOIUrl":"10.1016/j.ekir.2024.12.003","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 3","pages":"Pages 960-963"},"PeriodicalIF":5.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"World Kidney Day: Case Finding for Kidney Disease in Children – From Neonates to Adolescents","authors":"Thomas A. Forbes , David T. Selewski","doi":"10.1016/j.ekir.2024.12.024","DOIUrl":"10.1016/j.ekir.2024.12.024","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 3","pages":"Pages 641-644"},"PeriodicalIF":5.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Winter Bluesky: Is There a Mass Migration of Nephrology Social Media?","authors":"Cristina Popa , Jade Teakell , Alexander Woywodt","doi":"10.1016/j.ekir.2025.01.006","DOIUrl":"10.1016/j.ekir.2025.01.006","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 3","pages":"Pages 650-653"},"PeriodicalIF":5.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to “The Urgent Need for Hemodialysis and Ultrafiltration Devices Specifically Designed for Neonates”","authors":"Giovanni Ceschia , Denise C. Hasson , Stuart L. Goldstein","doi":"10.1016/j.ekir.2025.01.018","DOIUrl":"10.1016/j.ekir.2025.01.018","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 3","pages":"Page 976"},"PeriodicalIF":5.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Similar Efficacy in Belatacept-Converted Kidney Transplant Recipients With Steroid-Avoiding Regimen","authors":"Nathalie Chavarot ,&nbsp;Lara Cabezas ,&nbsp;Hannah Kaminski ,&nbsp;Helene Lazareth ,&nbsp;Mélanie Try ,&nbsp;Juliette Leon ,&nbsp;Anne Scemla ,&nbsp;Thomas Jouve ,&nbsp;Eric Thervet ,&nbsp;Dany Anglicheau ,&nbsp;Lionel Couzi ,&nbsp;Rebecca Sberro-Soussan ,&nbsp;Johan Noble","doi":"10.1016/j.ekir.2024.12.019","DOIUrl":"10.1016/j.ekir.2024.12.019","url":null,"abstract":"<div><h3>Introduction</h3><div>Belatacept offers a valuable alternative to calcineurin inhibitors (CNIs) for reducing toxicity in kidney transplant recipients (KTRs). No study has evaluated the efficacy and safety of late-conversion belatacept with steroid avoidance in KTRs.</div></div><div><h3>Methods</h3><div>This retrospective multicentric study evaluated the efficacy and safety of a belatacept-based steroid-avoiding therapy, in comparison with concomitant steroid use. The study included KTRs from 4-French transplant centers who were converted to belatacept at least 6 months posttransplantation.</div></div><div><h3>Results</h3><div>Overall, 512 KTRs were converted to belatacept in a median time of 38 (15.7–83.2) months after kidney transplantation (KT), including 199 patients without steroids after conversion (BelaS−). Median follow-up time was 78.9 (50.3–129.4) months. Compared with the 313 KTRs who had concomitant steroid use (BelaS+), BelaS− patients had a similar acute rejection (AR) rate (19 [6.1%] and 12 [6.0%] patients, <em>P</em> = 0.126, including 13 [68.4%] and 5 [41.7%] T cell–mediated rejection in BelaS+ and BelaS− patients, respectively), and a similar graft survival (graft loss occurred in respectively 23 [7.3%] and 9 [4.5%] patients in BelaS+ and BelaS− groups [<em>P</em> = 0.198]). However, patient mortality was higher among BelaS+ patients (16.6% vs. 3%, <em>P</em> &lt; 0.001). Steroid use was an independent risk factor of mortality (<em>P</em> = 0.009) along with age (<em>P</em> = 0.0001) and diabetes (<em>P</em> = 0.001) at switch and the occurrence of severe infections with belatacept use (<em>P</em> = 0.0005). In addition, BelaS+ patients experienced a higher incidence of severe infections (cumulative incidence of 13.7 vs. 6.7 events/100-person-year), cytomegalovirus (CMV) disease (<em>P</em> &lt; 0.001), infection by norovirus (<em>P</em> &lt; 0.001), and hospitalization with COVID-19 (<em>P</em> &lt; 0.001). BelaS+ patients were significantly more sensitized at conversion (donor-specific antibodies [DSA] in 21.8% vs. 6.6% in BelaS− patients, <em>P</em> &lt; 0.001). DSA incidence remained stable after conversion. BelaS+ patients developed significantly more <em>de novo</em> DSA (14 [4.9%] vs. 2 [1.0%], <em>P</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Avoiding steroids in KTRs who are late–converted to belatacept is associated with a similar efficacy along with lower mortality and reduced incidence of severe infections in selected low-sensitized patients.</div></div>","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 3","pages":"Pages 803-815"},"PeriodicalIF":5.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Early Versus Late Diagnosis on Disease Progression in Cystinosis","authors":"Mark R. Benfield","doi":"10.1016/j.ekir.2024.10.037","DOIUrl":"10.1016/j.ekir.2024.10.037","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 3","pages":"Pages S779-S783"},"PeriodicalIF":5.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"World Kidney Day: Detecting Kidney Disease in Low- and Middle-Income Countries","authors":"Eranga Wijewickrama ,&nbsp;Robert Kalyesubula","doi":"10.1016/j.ekir.2025.01.016","DOIUrl":"10.1016/j.ekir.2025.01.016","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 3","pages":"Pages 637-640"},"PeriodicalIF":5.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy as a Window to Current and Future Kidney Health–An Opportunity","authors":"Shilpanjali Jesudason ,&nbsp;Liz Lightstone","doi":"10.1016/j.ekir.2025.01.015","DOIUrl":"10.1016/j.ekir.2025.01.015","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 3","pages":"Pages 645-649"},"PeriodicalIF":5.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Individual- and Area-Level Social Determinants of Health on Likelihood of Living Versus Deceased Donor Kidney Transplantation","authors":"Tatenda G. Mupfudze ,&nbsp;Dzhuliyana Handarova ,&nbsp;Samantha M. Noreen ,&nbsp;Darren E. Stewart ,&nbsp;Sumit Mohan ,&nbsp;Jesse D. Schold","doi":"10.1016/j.ekir.2024.12.011","DOIUrl":"10.1016/j.ekir.2024.12.011","url":null,"abstract":"<div><h3>Introduction</h3><div>Social determinants of health (SDOH) are associated with disparities in access to living donor kidney transplantation (LDKT). However, the separate and joint impact of individual- and area-level SDOH on the likelihood of LDKT versus deceased donor kidney transplantation (DDKT) is unclear.</div></div><div><h3>Methods</h3><div>This retrospective cohort study analyzed adult, kidney-alone recipients transplanted in 2020 or 2022, using data from the organ procurement and transplantation network (OPTN). Individual-level SDOH and patient address were obtained from LexisNexis; area-level SDOH were obtained from the American Community Survey and County Health Rankings. We fit 3 logistic regression models to estimate the effects of the following: (i) individual-level SDOH, (ii) area-level SDOH, and (iii) both individual- and area-level SDOH on the likelihood of LDKT, adjusting for clinical and demographic factors.</div></div><div><h3>Results</h3><div>This study included 38,964 adult kidney recipients; <em>n</em> = 9664 (25%) received a LDKT. In multilevel, multivariable analysis, adjusting for both individual- and area-level SDOH, higher individual income quartiles were associated with higher odds of LDKT (odds ratio[OR] [95% confidence interval, CI]: 1.35[1.23–1.47]; 1.48[1.35–1.63]; 2.07 [1.87–2.30], for quartiles Q2–Q4, respectively, compared with the Q1 [lowest income]). Although attenuated, the association between neighborhood median household income and likelihood of LDKT persisted after adjusting for individual-level income. The impact of insurance, education level, and county-level SDOH on likelihood of LDKT persisted in models adjusting for both individual- and area-level SDOH.</div></div><div><h3>Conclusion</h3><div>Our findings suggest that individual- and area-level SDOH play overlapping but distinct roles contributing to disparities in LDKT. Addressing individual- and area-level SDOH is crucial, considering the accentuated effect of income at the individual- rather than area-level.</div></div>","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 3","pages":"Pages 791-802"},"PeriodicalIF":5.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}