Kidney International Reports最新文献_第8页

Association Between Albuminuria and Glomerular Filtration Rate With Incident Frailty

IF 5.7 2区医学

Kidney International Reports Pub Date : 2025-02-01 DOI: 10.1016/j.ekir.2024.11.017

Elisa K. Bongetti , Anna L. Wilkinson , James B. Wetmore , Anne M. Murray , Robyn L. Woods , Sara Espinoza , Michael E. Ernst , Michelle A. Fravel , Suzanne G. Orchard , Le Thi Phuong Thao , Joanne Ryan , Rory Wolfe , Kevan R. Polkinghorne

{"title":"Association Between Albuminuria and Glomerular Filtration Rate With Incident Frailty","authors":"Elisa K. Bongetti , Anna L. Wilkinson , James B. Wetmore , Anne M. Murray , Robyn L. Woods , Sara Espinoza , Michael E. Ernst , Michelle A. Fravel , Suzanne G. Orchard , Le Thi Phuong Thao , Joanne Ryan , Rory Wolfe , Kevan R. Polkinghorne","doi":"10.1016/j.ekir.2024.11.017","DOIUrl":"10.1016/j.ekir.2024.11.017","url":null,"abstract":"<div><h3>Introduction</h3><div>The association between estimated glomerular filtration rate (eGFR) and albuminuria with incident frailty in generally healthy older individuals is unclear. We investigated whether baseline eGFR or urine albumin-to-creatinine ratio (UACR) are associated with incident frailty and assessed them using 2 separate methods: a modified Fried frailty phenotype (FP), and a deficit accumulation frailty index (FI).</div></div><div><h3>Methods</h3><div>This was a secondary analysis of the ASPirin in Reducing Events in the Elderly (ASPREE) randomized trial cohort, which enrolled independent, healthy, older adults aged ≥65 years in Australia and the USA. Time to incident frailty was analyzed using discrete time survival analysis.</div></div><div><h3>Results</h3><div>In total, 16,965 participants were included using the FP, mean age was 75.0 ± 4.5 years, median baseline eGFR was 78.6 ml/min per 1.73 m<sup>2</sup> (interquartile range [IQR]: 67.6–89.5), and the median UACR was 0.80 mg/mmol (0.50–1.50). Data to generate the FI outcomes were available for 12,272 participants. The relationships between eGFR and both incident FP and FI were nonlinear, such that an eGFR < 30 or ≥ 95 ml/min per 1.73 m<sup>2</sup> was significantly associated with an increased risk of incident frailty. For every doubling of baseline UACR, risk of incident frailty increased by 4% using the FP (hazard ratio [HR]: 1.04, 95% CI: 1.02, 1.07) and the FI (HR: 1.04, 95% confidence interval [CI]: 1.01–1.07).</div></div><div><h3>Conclusion</h3><div>In older, generally healthy adults, both low and high eGFRs were associated with increased risk of incident frailty. Doubling of UACR, even at low levels, was independently associated with incident frailty.</div></div>","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 2","pages":"Pages 489-502"},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143161352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

WCN25-2391 Acid-Bace Balance of Renal Venous Blood in Patients with Secondary Hypertension

IF 5.7 2区医学

Kidney International Reports Pub Date : 2025-02-01 DOI: 10.1016/j.ekir.2024.11.080

Vladimir Voitovitch ∗

引用次数: 0

Concomitant Treatment With Lumasiran and Nedosiran in a Child With Primary Hyperoxaluria Type 1

IF 5.7 2区医学

Kidney International Reports Pub Date : 2025-02-01 DOI: 10.1016/j.ekir.2024.12.014

Eline Braekman , Ann Raes , Ruth De Bruyne , Patrick Verloo , Agnieszka Prytula

引用次数: 0

Response to Early Detection Matters: Bridging Evidence and Practice, a Call for Enhanced Cardiovascular Screening in ADPKD

IF 5.7 2区医学

Kidney International Reports Pub Date : 2025-02-01 DOI: 10.1016/j.ekir.2024.11.011

Priyanka S. Sagar , Gopala K. Rangan

引用次数: 0

WCN25-3855 ASSOCIATION BETWEEN REDUCED MIDTERM RENAL HYPERFILTRATION AND ADVERSE GESTATIONAL OUTCOMES- A PROSPECTIVE STUDY FROM A TERTIARY CARE CENTRE

IF 5.7 2区医学

Kidney International Reports Pub Date : 2025-02-01 DOI: 10.1016/j.ekir.2024.11.100

DEEPA KP ∗ , George Ashish , S. Gomathy

引用次数: 0

Corrigendum to “POS-074 SERUM NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN, EARLY BIOMARKER OF ACUTE KIDNEY INJURY IN ASPHYXIATED TERM NEONATES AT LAGOS STATE UNIVERSITY TEACHING HOSPITAL” [Kidney International Reports Volume 7, Issue 2, Supplement, February 2022, Page S31]

IF 5.7 2区医学

Kidney International Reports Pub Date : 2025-02-01 DOI: 10.1016/j.ekir.2024.12.010

Ogbuokiri E , Solarin A , Disu E , Njokanma F

引用次数: 0

Breastfeeding in the Dialysis Ward

IF 5.7 2区医学

Kidney International Reports Pub Date : 2025-02-01 DOI: 10.1016/j.ekir.2024.11.021

Alejandra Orozco , Giorgina Piccoli

引用次数: 0

A Targeted Release Capsule of Lanthanum Carbonate: a New Efficient Cheap Treatment for Primary Hyperoxalurias

IF 5.7 2区医学

Kidney International Reports Pub Date : 2025-02-01 DOI: 10.1016/j.ekir.2024.11.020

Marc E. De Broe , Marc P. Uytterhoeven , Jan De Causmaecker , Yannick De Brucker , Erik D. Snelders , Johan Van De Walle , Koen Van Hoeck , Dominique Trouet , Monique Elseviers

{"title":"A Targeted Release Capsule of Lanthanum Carbonate: a New Efficient Cheap Treatment for Primary Hyperoxalurias","authors":"Marc E. De Broe , Marc P. Uytterhoeven , Jan De Causmaecker , Yannick De Brucker , Erik D. Snelders , Johan Van De Walle , Koen Van Hoeck , Dominique Trouet , Monique Elseviers","doi":"10.1016/j.ekir.2024.11.020","DOIUrl":"10.1016/j.ekir.2024.11.020","url":null,"abstract":"<div><h3>Introduction</h3><div>Primary hyperoxaluria (PH) is a devastating disease in children and adults. Recently, a substantial progress in the treatment of this deadly disease has been made that consists of the introduction of the RNA inhibitors, lumasiran and nedosiran, which deplete the substrate for oxalate synthesis.</div></div><div><h3>Methods</h3><div>Lanthanum carbonate (Lanth.Carb., La<sup>2</sup>[CO<sub>3</sub>]<sup>3</sup>) is a powerful phosphate binder having a strong affinity to oxalate. Its use as such in PH is not relevant because patients with normal renal function develop a severe phosphate depletion without a clear effect on oxalate balance. Considering that the absorption of phosphate is in the early gastrointestinal (GI) tract and mainly in the distal part of the GI tract for oxalate, we developed a targeted release capsule (trc) containing 500 mg Lant.Carb. released in the distal part of the GI tract as proven by radiological investigations of the radiopaque trcLanth.Carb.</div></div><div><h3>Results</h3><div>Four patients with PH and estimated glomerular filtration rate > 60 ml/min per 1.73 m<sup>2</sup> were treated with trcLanth.Carb., which turned out to decrease the urinary oxalate concentrations clearly < 0.51 mmol/24 h per 1.73 m<sup>2</sup>,45 mg/24 h per 1.73 m<sup>2</sup> (considered as upper limit of normal), after 2.5 months of treatment in 3 patients and 18 months in 1 patient. Calciuria remained normal or decreased slightly. Phosphaturia and phosphatemia remained normal and stable in all 4 cases.</div></div><div><h3>Conclusion</h3><div>trcLanth.Carb. is a promising repurposed, efficient, nontoxic, and cheap drug, lacking serious side effects in the treatment of any type of PH in whatever place in the world. A randomized controlled trial supporting this proof-of-concept is the next step.</div></div>","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 2","pages":"Pages 503-515"},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143160855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

WCN25-547 HYPONATREMIA AND OTHER ELECTROLYTE DISORDERS IN PATIENTS OF CHRONIC KIDNEY DISEASE OF UNKNOWN ORIGIN (CKDu): WHY ARE THEY SO DIFFERENT?

IF 5.7 2区医学

Kidney International Reports Pub Date : 2025-02-01 DOI: 10.1016/j.ekir.2024.11.072

Jyoti Aggarwal ∗ , Vinay Rathore , Anish Kumar Saha , Suprava Patel , Varun Agrawal , Amritava Ghosh , Naman Mahesh Pathak , Rohit Paras Badge

引用次数: 0

WCN25-2250 Evaluation of nephrotoxic medication exposure and nephrotoxic medication induced Acute Kidney Injury in hospitalised non critically ill children – single centre study

IF 5.7 2区医学

Kidney International Reports Pub Date : 2025-02-01 DOI: 10.1016/j.ekir.2024.11.132

Keerthiga Narasimman ∗ , Dr. Edwin Fernando , Dr. Murugesan Vellaichamy , Dr. Srinivasa Prasad , Dr. P. Abirami , Dr. S. Thirumavalavan , Dr. Sujith Surendran , Dr. Poongodi Annadurai , Dr. M.A. Aravind

引用次数: 0