Kidney International Reports最新文献

{"title":"Corrigendum to “PREGNANCY AS A WINDOW TO CURRENT AND FUTURE KIDNEY HEALTH–AN OPPORTUNITY” [Volume 10, Issue 3, March 2025, Pages 645-649]","authors":"Shilpanjali Jesudason , Liz Lightstone","doi":"10.1016/j.ekir.2025.03.023","DOIUrl":"10.1016/j.ekir.2025.03.023","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 5","pages":"Page 1607"},"PeriodicalIF":5.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding Glomerular Disease: Baseline Profiles and Insights From the I-TANGIBLE Registry","authors":"Kavita Yadav , Raja Ramachandran , Vinod Kumar , Arun Prabhahar , Ashok K. Yadav , Natarajan Gopalakrishnan , Sourabh Sharma , Priyamvada P.S. , Arpita Lahiri , Manisha Sahay , Sree Bhushan Raju , M. Sreelatha , R. Manorajan , Pinaki Mukhopadhyay , Narayan Prasad , Vamsidhar Veeranki , Priti Meena , Harbir S. Kohli , Sanjay Vikrant , Vivekanand Jha","doi":"10.1016/j.ekir.2025.02.013","DOIUrl":"10.1016/j.ekir.2025.02.013","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 5","pages":"Pages 1566-1570"},"PeriodicalIF":5.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Temperature Requirement Protein A1–Positive Membranous Nephropathy in a Patient With Chronic Lymphocytic Leukemia","authors":"Ladan Zand , Fernando C. Fervenza , Sanjeev Sethi","doi":"10.1016/j.ekir.2025.02.011","DOIUrl":"10.1016/j.ekir.2025.02.011","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 5","pages":"Pages 1600-1601"},"PeriodicalIF":5.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143922882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CKD Progression in Children: Lipid Levels are Another Red Herring","authors":"Stuart L. Goldstein","doi":"10.1016/j.ekir.2025.03.025","DOIUrl":"10.1016/j.ekir.2025.03.025","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 5","pages":"Pages 1324-1325"},"PeriodicalIF":5.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiential Evidence of Systemic Racism for Indigenous Peoples Navigating Transplantation in Canada","authors":"Simone Kennedy ,&nbsp;Robyn Wiebe ,&nbsp;Reetinder Kaur ,&nbsp;Ayumi Sasaki ,&nbsp;Adrienne Charlie ,&nbsp;Alissa Assu ,&nbsp;Allison Jaure ,&nbsp;Jagbir Gill","doi":"10.1016/j.ekir.2025.02.027","DOIUrl":"10.1016/j.ekir.2025.02.027","url":null,"abstract":"<div><h3>Introduction</h3><div>Despite previous data stating that Indigenous patients with kidney failure are 66% less likely to receive a kidney transplant compared with White Canadians, there is a very limited understanding of the barriers and challenges experienced and described by Indigenous Peoples when accessing kidney transplantation. The aim of this study was to describe the perspectives and experiences of Indigenous kidney transplant candidates and recipients, living kidney donors, and Elders on access to kidney transplantation in British Columbia, Canada in the hopes of codeveloping and implementing health services interventions to address systemic barriers to transplantation.</div></div><div><h3>Methods</h3><div>Semistructured interviews were conducted with 19 participants and 4 focus groups were conducted with 18 participants (<em>n</em> = 37). Transcripts were thematically analyzed.</div></div><div><h3>Results</h3><div>Five themes were identified as follows: (i) confronting uncertainty and risk, (ii) culture of giving, (iii) systemic racism and discrimination, (iv) navigating complexities of transplant and donation process, and (v) a lack of culturally safe care.</div></div><div><h3>Conclusion</h3><div>These findings highlight that Indigenous patients face potentially modifiable barriers that may be amenable to health system improvements, such as development of culturally safe patient education tools and Indigenous-specific navigation supports. Health services and policy interventions need to be explored and evaluated to begin to address inequities in access to transplantation.</div></div>","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 5","pages":"Pages 1538-1547"},"PeriodicalIF":5.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143922887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Program Implementation to Achieve Sustainability for Early Detecting of Kidney Diseases and Promoting Kidney Health and Transplantation in Communities","authors":"Ekamol Tantisattamo ,&nbsp;Kamyar Kalantar-Zadeh","doi":"10.1016/j.ekir.2025.03.015","DOIUrl":"10.1016/j.ekir.2025.03.015","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 5","pages":"Pages 1594-1595"},"PeriodicalIF":5.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143922892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent B Cell Depletion After Rituximab for Autoimmune and Glomerular Diseases: A Case Series","authors":"Orhan Efe ,&nbsp;Gabriel Sauvage ,&nbsp;Anushya Jeyabalan ,&nbsp;Ayman Al Jurdi ,&nbsp;Harish S. Seethapathy ,&nbsp;Katherine Cosgrove ,&nbsp;Frank B. Cortazar ,&nbsp;Karen A. Laliberte ,&nbsp;Reza Zonozi ,&nbsp;John L. Niles","doi":"10.1016/j.ekir.2025.02.002","DOIUrl":"10.1016/j.ekir.2025.02.002","url":null,"abstract":"<div><h3>Introduction</h3><div>Persistent B cell depletion is a rare complication of rituximab treatment, and its clinical implications are unknown.</div></div><div><h3>Methods</h3><div>This retrospective case series included patients with glomerular and autoimmune diseases who developed persistent B cell depletion (&lt; 5 CD19⁺CD20⁺ cells/μl persisting for &gt; 2 years) after the last rituximab dose.</div></div><div><h3>Results</h3><div>Among 1519 patients who received rituximab, 2% (<em>n</em> = 30) had persistent B cell depletion. The frequencies of persistent B cell depletion were 2.5% (22 of 878), 2.4% (2 of 82), and 0.8% (1 of 114) in antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV), systemic lupus erythematosus (SLE) or lupus nephritis, and podocytopathies, respectively. The remaining patients had ANCA-negative vasculitis (<em>n</em> = 2), anti-glomerular basement membrane disease (<em>n</em> = 1), Behcet’s disease (<em>n</em> = 1), and polymyositis (<em>n</em> = 1). The median age was 64.5 (interquartile range [IQR]: 44–77) years. Before the last dose of rituximab, all patients except 2 used cytotoxic agents, often prolonged (&gt; 1 year) or recycling courses, and 60% (18 of 30) received a period of long-term maintenance steroids. By 4 years after the last rituximab dose, only 30% had B cell repopulation. In those who experienced B cell repopulation, B cell counts remained very low, at a median of 7(6–15) cells/μl at the last follow-up. After the last rituximab dose, 83% (23 of 30) had sustained disease remission. Late-onset neutropenia, recurrent infections, and severe infections occurred in 23% (7 of 30), 47% (14 of 30), and 57% (17 of 57), respectively. Of the patients, 23% (7 of 30) required immunoglobulin replacement, and 30% (9 of 30) died, mostly from complications of chronic diseases.</div></div><div><h3>Conclusion</h3><div>Persistent B cell depletion is a rare complication of rituximab treatment, mostly affecting patients with exposure(s) to cytotoxic therapies for recurrent diseases. It is characterized by prolonged disease remission and increased infection risk.</div></div>","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 5","pages":"Pages 1441-1449"},"PeriodicalIF":5.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143922972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Pan-Inhibitor of Phosphate Transporters AP306 in Hemodialysis Patients","authors":"Nicholas S. Kowalczyk ,&nbsp;Stuart M. Sprague","doi":"10.1016/j.ekir.2025.03.011","DOIUrl":"10.1016/j.ekir.2025.03.011","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 5","pages":"Pages 1318-1320"},"PeriodicalIF":5.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective Cohort Study in Alport Syndrome Patients Under Standard Therapy","authors":"Oliver Gross ,&nbsp;Michelle N. Rheault ,&nbsp;James Simon ,&nbsp;Bertrand Knebelmann ,&nbsp;Yuqian Shen ,&nbsp;Qi Zhang ,&nbsp;Ali Hariri ,&nbsp;Julie Lin ,&nbsp;Shiguang Liu ,&nbsp;Clifford E. Kashtan","doi":"10.1016/j.ekir.2025.02.036","DOIUrl":"10.1016/j.ekir.2025.02.036","url":null,"abstract":"<div><h3>Introduction</h3><div>Patients with Alport syndrome (AS), a common genetic kidney disease, exhibit variable rates of decline in kidney function. Consequently, this global, multicenter, prospective observational study aimed to generate data useful for designing future interventional trials.</div></div><div><h3>Methods</h3><div>The study included patients aged 12 to 65 years with a confirmed diagnosis of AS and estimated glomerular filtration rate (eGFR) of 45 to 90 ml/min. For up to 120 weeks in 12-weekly intervals, blood and urine samples, patient and family history, genotype, adverse events (AEs), medications, and patient-related outcome data were collected under International Conference on Harmonization-Good Clinical Practice (ICH-GCP) standards.</div></div><div><h3>Results</h3><div>Out of 165 patients enrolled, 101 (61.2%) were classified as X-linked (62.4% females, 37.6% males) and 32 (19.4%) as autosomal (recessive or dominant) inheritance. Baseline mean eGFR was 64 ml/min per 1.73 m², and yearly eGFR slope in ml/min per 1.73 m² was −2.94 (−6.7 in X-linked males, 0.6 in X-linked females, −1.66 in heterozygous autosomal patients). Baseline urine albumin-to-creatinine ratio (UACR) was the best predictor for rapid loss of eGFR with a yearly eGFR slope of −10.16 ml/min per 1.73 m² in patients with UACR &gt; 1 g/g compared with−0.90 ml/min per 1.73 m² if UACR was ≤ 1.0 g/g. Out of 353 AEs, only 26 (7.4%) were related to AS. In addition to UACR, neutrophil gelatinase-associated lipocalin, clusterin, and kidney injury molecule-1 correlated with the eGFR slope.</div></div><div><h3>Conclusion</h3><div>In patients with AS receiving standard of care, rapid decline in kidney function strongly correlates with UACR and AEs related to the underlying medical condition are rare. Both findings enrich the design of future interventional trials.</div></div>","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 5","pages":"Pages 1360-1371"},"PeriodicalIF":5.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Retinal Vasculature and Risk of Age-Related GFR Decline — The Renal Iohexol Clearance Survey","authors":"Silje Småbrekke ,&nbsp;Karl Marius Brobakk ,&nbsp;Nikoline B. Rinde ,&nbsp;Therese Von Hanno ,&nbsp;Geir Bertelsen ,&nbsp;Bjørn Odvar Eriksen ,&nbsp;Toralf Melsom","doi":"10.1016/j.ekir.2025.02.006","DOIUrl":"10.1016/j.ekir.2025.02.006","url":null,"abstract":"<div><h3>Introduction</h3><div>Age-related decline in glomerular filtration rate (GFR) significantly contributes to chronic kidney disease (CKD). This longitudinal study in a nondiabetic population investigated whether retinal microvascular changes are associated with GFR decline.</div></div><div><h3>Methods</h3><div>The Renal Iohexol Clearance Survey (RENIS) included 1837 participants aged 50 to 62 years without self-reported diabetes, kidney or cardiovascular disease. Baseline retinal vessel measurements and retinopathy were assessed with a Visucam PRONM retinal camera. Iohexol clearance was measured over 1 to 4 visits across an 11-year median follow-up. Linear mixed models and logistic regression were used to analyze associations between retinal vessel measurements, retinopathy, mean annual GFR decline, and accelerated GFR decline.</div></div><div><h3>Results</h3><div>In multiple adjusted linear mixed models, wider central retinal venular equivalent (CRVE) and wider central retinal arteriolar equivalent (CRAE) were associated with a steeper mean measured GFR (mGFR) decline. For each SD increase, CRVE was associated with an mGFR decline of −0.08 ml/min/yr (95% confidence interval [CI]:−0.15 to −0.02; <em>P</em> = 0.012), and CRAE was associated with a decline of −0.09 ml/min/yr (95% CI:−0.15 to −0.02; <em>P</em> = 0.007). CRVE, but not CRAE, was associated with accelerated mGFR decline in the model adjusted for age, sex, and height [OR 1.31 (95% CI 1.07-1.61, <em>P</em> = 0.008]. No significant associations were observed between retinopathy, microaneurysms, and hemorrhages with annual or accelerated mGFR decline.</div></div><div><h3>Conclusion</h3><div>CRVE and CRAE, but not retinopathy, retinal microaneurysms, or hemorrhages, were associated with steeper mean mGFR, suggesting that microvascular changes may be one of the underlying mechanisms for age-related GFR loss in a general nondiabetic population.</div></div>","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 5","pages":"Pages 1384-1392"},"PeriodicalIF":5.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}