Kidney International Reports最新文献

{"title":"Early Determination of Tacrolimus Concentration–Dose Ratio Identifies Risk of Allograft Loss in Kidney Transplantation","authors":"Christophe Masset ,&nbsp;Marine Lorent ,&nbsp;Clarisse Kerleau ,&nbsp;Claire Garandeau ,&nbsp;Aurélie Houzet ,&nbsp;Simon Ville ,&nbsp;Diego Cantarovich ,&nbsp;Gilles Blancho ,&nbsp;Magali Giral ,&nbsp;Jacques Dantal","doi":"10.1016/j.ekir.2025.02.014","DOIUrl":"10.1016/j.ekir.2025.02.014","url":null,"abstract":"<div><h3>Introduction</h3><div>Fast tacrolimus–metabolizing kidney transplant recipients (KTRs) (i.e., tacrolimus trough-level/total daily dose [C0/D &lt; 1.05]) have poorer allograft function; however, their identification in a real-life setting is challenging. We investigated the reproducibility of tacrolimus metabolic status during the first months after transplantation and its association with long-term allograft outcomes.</div></div><div><h3>Methods</h3><div>All KTRs between 2000 and 2019 with a functional allograft at 1 month and receiving tacrolimus in our center were included. Fast or slow tacrolimus metabolizers were classified according to the time spent with a C0/D &lt; 1.05 (&gt; 75% = High, &lt; 25% = Low) at various time points posttransplantation. We first determined the earliest accurate time for patient categorization by investigating C0/D variability during the first months. Second, a multivariate cause-specific Cox model studying allograft outcomes was performed in groups identified by their status determined from the earliest accurate timepoint after transplantation.</div></div><div><h3>Results</h3><div>Among 1979 patients included in the analysis, 2 months was the earliest accurate timepoint to determine High patients (85% of High patients identified at 2 months remained High long-term, Brier score = 0.06). Multivariate analysis revealed that High patients determined at 2 months (<em>n</em> = 499) had a significantly higher risk of allograft loss (cause-specific hazard ratio [CS-HR] = 2.00, 95% confidence interval [CI] = 1.48–2.69) and allograft rejection (CS-HR = 1.71, 95% CI = 1.15–2.54) than Low patients after adjustment for confounding factors. Moreover, allograft function was lower in High patients (46.7 vs. 52.9 ml/min, at 3 years, <em>P</em> &lt; 0.0001) with a higher proportion of chronic vascular lesions at 1 year.</div></div><div><h3>Conclusion</h3><div>C0/D is a simple and pragmatic tool capable of identifying patients at risk of rejection and allograft failure as early as the second month posttransplantation.</div></div>","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 5","pages":"Pages 1428-1440"},"PeriodicalIF":5.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143922971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing Nephrology Education with POCUS: Key Insights From the American Society of Nephrology Kidney Week 2024 Precourse","authors":"Abhilash Koratala ,&nbsp;Nathaniel Reisinger","doi":"10.1016/j.ekir.2025.03.039","DOIUrl":"10.1016/j.ekir.2025.03.039","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 5","pages":"Pages 1309-1312"},"PeriodicalIF":5.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incorporating Novel Biomarkers in Definitions of Drug-Induced Acute Kidney Injury","authors":"Boon Wee Teo ,&nbsp;Chirag R. Parikh","doi":"10.1016/j.ekir.2025.03.013","DOIUrl":"10.1016/j.ekir.2025.03.013","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 5","pages":"Pages 1313-1314"},"PeriodicalIF":5.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Venous Thromboembolism Prevention in Nephrotic Syndrome: The Role of Aspirin, Vitamin K Antagonists, and Direct Oral Anticoagulants","authors":"Zohreh Gholizadeh Ghozloujeh ,&nbsp;Richard J. Glassock ,&nbsp;Ayman Al Jurdi ,&nbsp;Kenar D. Jhaveri ,&nbsp;Giv Heidari-Bateni ,&nbsp;Divya Bajpai ,&nbsp;Edgar Lerma ,&nbsp;Junnan Wu ,&nbsp;Amir Abdipour ,&nbsp;Sayna Norouzi","doi":"10.1016/j.ekir.2025.02.010","DOIUrl":"10.1016/j.ekir.2025.02.010","url":null,"abstract":"<div><div>Nephrotic syndrome (NS) is associated with a significantly elevated risk of venous thromboembolic events (VTEs), which contribute to morbidity and mortality. Current guidelines for VTE prophylaxis in patients with NS are based on limited evidence, primarily from observational studies. This review describes the complexities of hypercoagulability in NS, with a focus on aspirin as a potential prophylactic agent. We outline the pathophysiology underlying VTE in NS, highlighting factors such as hypoalbuminemia, anticoagulant loss, and heightened platelet reactivity. This review also summarizes the available data on the role of aspirin in reducing thromboembolic risk. Although aspirin may benefit select patient groups, its efficacy remains inconclusive, with some studies suggesting a combination of aspirin and anticoagulants for more effective risk reduction. Future studies, particularly large-scale randomized controlled trials (RCTs), are necessary to clarify the role of aspirin in preventing VTEs in this population. Our review underscores the need for individualized prophylactic strategies that balance thrombotic and bleeding risks in patients with NS.</div></div>","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 5","pages":"Pages 1335-1345"},"PeriodicalIF":5.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kidney Biopsy Findings in People With Metabolic Dysfunction–Associated Steatohepatitis","authors":"Evgeniya Pasternak ,&nbsp;Christopher Larsen ,&nbsp;Tiffany Caza","doi":"10.1016/j.ekir.2025.02.008","DOIUrl":"10.1016/j.ekir.2025.02.008","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 5","pages":"Pages 1575-1578"},"PeriodicalIF":5.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Evolution of Crescents in Lupus Nephritis","authors":"Ana Malvar ,&nbsp;Valeria Alberton ,&nbsp;Bruno Lococo ,&nbsp;Serventi J. Martinez ,&nbsp;Ignacio Chidid ,&nbsp;Ricardo Heguilen ,&nbsp;Brad H. Rovin","doi":"10.1016/j.ekir.2025.02.009","DOIUrl":"10.1016/j.ekir.2025.02.009","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 5","pages":"Pages 1579-1581"},"PeriodicalIF":5.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inducing Oxalobacter formigenes Colonization Reduces Urinary Oxalate in Healthy Adults","authors":"Sonia Fargue ,&nbsp;Mangesh Suryavanshi ,&nbsp;Kyle D. Wood ,&nbsp;Joseph J. Crivelli ,&nbsp;Robert A. Oster ,&nbsp;Dean G. Assimos ,&nbsp;Aaron Miller ,&nbsp;John Knight","doi":"10.1016/j.ekir.2025.02.004","DOIUrl":"10.1016/j.ekir.2025.02.004","url":null,"abstract":"<div><h3>Introduction</h3><div>Oxalate-degrading intestinal bacteria, including the oxalate-degrading specialist, <em>Oxalobacter formigenes (O formigenes),</em> have the potential to reduce urinary oxalate excretion in humans, and thus limit the risk of calcium oxalate kidney stone formation. The aim of this proof-of-concept study, which was performed in healthy adults, was to demonstrate that ingestion of live <em>O formigenes</em> is safe, can establish sustainable gut colonization, and reduce urinary oxalate excretion.</div></div><div><h3>Methods</h3><div>Twenty-two healthy adults without a history of kidney stones and not colonized with <em>O formigenes</em> ingested diets controlled in oxalate and calcium. In these participants, 24-hour urine and stool oxalate levels were quantified using ion chromatography coupled with mass spectrometry before and after ingestion of <em>O formigenes</em>.</div></div><div><h3>Results</h3><div>All 22 participants were successfully colonized after a single dose of <em>O formigenes</em> (∼10¹⁰ cells); 10 remained colonized for at least 1 year. Colonization was lost in 11 participants, of whom 9 reported antibiotic use. Six participants who lost colonization were redosed, and 5 were successfully recolonized. Stool oxalate concentration and urine oxalate excretion significantly decreased by 54% and 14%, respectively, with varied responses after colonization. Microbiome molecular analyses of precolonized stool samples highlighted the abundance and diversity of other potential oxalate-degrading bacteria, which may have influenced the effect of <em>O formigenes</em> colonization on urinary oxalate excretion.</div></div><div><h3>Conclusion</h3><div>These findings support future investigations to examine the effectiveness of <em>O formigenes</em> colonization in reducing urinary oxalate excretion in disease cohorts, including calcium oxalate kidney stone formers with enteric hyperoxaluria.</div></div>","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 5","pages":"Pages 1518-1528"},"PeriodicalIF":5.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid On-Site Histopathological Analysis of Kidney Biopsy With Dynamic Full-Field Optical Coherence Tomography","authors":"Léa Zuccarelli ,&nbsp;Quentin Bernard ,&nbsp;Georges Tarris ,&nbsp;Laurent Martin ,&nbsp;Mathilde Funes de la Vega ,&nbsp;Amélie Jacq ,&nbsp;Jean-Michel Rebibou ,&nbsp;Claire Tinel ,&nbsp;Claude Boccara ,&nbsp;Olivier Thouvenin ,&nbsp;Jean-Marie Chassot ,&nbsp;Marion Rabant ,&nbsp;Julien Zuber ,&nbsp;Christophe Legendre ,&nbsp;Jean-Pierre Quenot ,&nbsp;Marie-Noëlle Peraldi ,&nbsp;Lucile Amrouche ,&nbsp;Anne Scemla ,&nbsp;Nathalie Chavarot ,&nbsp;Dany Anglicheau ,&nbsp;Thomas Maldiney","doi":"10.1016/j.ekir.2025.01.047","DOIUrl":"10.1016/j.ekir.2025.01.047","url":null,"abstract":"<div><h3>Introduction</h3><div>Kidney histology preparation requires a multistep process that is usually responsible for delayed results. This study introduces dynamic full-field optical coherence tomography (D-FF-OCT) as a label-free alternative to overcome the limitations of traditional histopathology for on-site kidney pathology assessment.</div></div><div><h3>Methods</h3><div>Two patient cohorts were considered, with a total of 31 patients included in the study; one cohort involved patients requiring biopsy of transplant kidney, and the other involved patients requiring biopsy of native kidney. The clinical and biological data were prospectively collected. Histopathological analysis of kidney biopsies was conducted using both conventional stains and dynamic D-FF-OCT imaging.</div></div><div><h3>Results</h3><div>D-FF-OCT enabled the recognition of most kidney structures. The results showed a significant correlation between this technology and conventional stains for the evaluation of both interstitial fibrosis (IF) (<em>r</em> = 0.61, <em>P</em> &lt; 0.001) and tubular atrophy (TA) (<em>r</em> = 0.60, <em>P</em> &lt; 0.001). Although many lesions could be identified such as interstitial inflammation, acute tubular necrosis, glomerular crescents, and vascular intimal thickening; other recognitions such as glomerular membranous deposits, vascular amyloidosis, and peritubular capillaritis will require confirmation in larger cohorts.</div></div><div><h3>Conclusion</h3><div>This study demonstrates the potential of D-FF-OCT imaging for on-site analysis of kidney biopsies, providing rapid and high-resolution images without extensive sample preparation.</div></div>","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 5","pages":"Pages 1529-1537"},"PeriodicalIF":5.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143922886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prevalence and Characteristics of IgA Antibodies to β2-Spectrin and CBX3 in Immunoglobulin A Nephropathy","authors":"Ayako Koizumi ,&nbsp;Yoshihito Nihei ,&nbsp;Kazuaki Mori ,&nbsp;Ryousuke Aoki ,&nbsp;Hitoshi Suzuki ,&nbsp;Jonathan Barratt ,&nbsp;Yusuke Suzuki","doi":"10.1016/j.ekir.2025.02.025","DOIUrl":"10.1016/j.ekir.2025.02.025","url":null,"abstract":"<div><h3>Introduction</h3><div>In IgA nephropathy (IgAN), the mechanism of IgA-containing immune complexes deposition in the glomerular mesangium had been unclear. We recently reported the presence of IgA antibodies with specificity for mesangial cells (antimesangium IgA antibodies) in sera from patients with IgAN, and identified β2-spectrin (SPTBN1) and CBX3 as target antigens. However, the role of antimesangium IgA antibodies in human IgAN is unclear.</div></div><div><h3>Methods</h3><div>We measured serum anti-SPTBN1 and anti-CBX3 IgA levels in patients with IgAN (<em>n</em> = 119) and other kidney diseases (disease control [DC], <em>n</em> = 51) using 2 independent cohorts, 1 from Japan and 1 from the UK. The study also assessed the surface expression of the autoantigens on human mesangial cells and the pattern of <em>O</em>-glycosylation of serum anti-SPTBN1 and anti-CBX3 IgA antibodies.</div></div><div><h3>Results</h3><div>Overall, 30 and 3 patients with IgAN and DC, respectively, had detectable anti-SPTBN1 IgA antibodies (sensitivity, 25%; specificity, 94%); whereas 48 and 3 patients with IgAN and DC, respectively, had detectable anti-CBX3 IgA antibodies (sensitivity, 40%; specificity, 94%). In total, 62 patients (52%) with IgAN had detectable anti-SPTBN1 and/or anti-CBX3 IgA antibodies. The expression of SPTBN1 and CBX3 on the surface of human mesangial cells was confirmed by immunofluorescence (IF) microscopy. Serum anti-SPTBN1 and anti-CBX3 IgA antibodies from patients with IgAN were recognized by an antigalactose-deficient IgA1 antibody (KM55) by Western blotting.</div></div><div><h3>Conclusion</h3><div>We show that anti-SPTBN1 and anti-CBX3 IgA antibodies are detected with high specificity in patients with IgAN from Japan and the UK, and are enriched for IgA1 with poorly galactosylated <em>O</em>-glycoforms.</div></div>","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 5","pages":"Pages 1486-1494"},"PeriodicalIF":5.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143922903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"B-Cell Depletion in Glomerular and Autoimmune Diseases: Too Much of a Good Thing?","authors":"Stephen P. McAdoo","doi":"10.1016/j.ekir.2025.03.024","DOIUrl":"10.1016/j.ekir.2025.03.024","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 5","pages":"Pages 1315-1317"},"PeriodicalIF":5.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}