{"title":"WCN25-3849 TO STUDY THE EFFICACY OF POLYMYXIN B HEMOPERFUSION IN SEPSIS","authors":"Indranil Ghosh ∗ , Sukhwinder Sangha , Gaurav Pandey , Atul Srivastava","doi":"10.1016/j.ekir.2024.11.158","DOIUrl":"10.1016/j.ekir.2024.11.158","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 2","pages":"Pages S53-S54"},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143092294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hao Hong ∗ , Ming Li , Junyao Zheng , Haimin Shi , Mengya Xiao
{"title":"WCN25-379 Predictive value of thrombomodulin in sepsis associated acute kidney injury","authors":"Hao Hong ∗ , Ming Li , Junyao Zheng , Haimin Shi , Mengya Xiao","doi":"10.1016/j.ekir.2024.11.087","DOIUrl":"10.1016/j.ekir.2024.11.087","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 2","pages":"Page S10"},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kakaraparthy sree Harsha vardhan ∗ , Dr. MAJUSHA YADLA , VIKRAM KUMAR BAKKA , SREEKANTH BURRI , P. SRINIVAS
{"title":"WCN25-2972 A STUDY OF ACUTE KIDNEY INJURY IN SEVERE ACUTE PANCREATITIS IN A TERTIARY CARE HOSPITAL","authors":"Kakaraparthy sree Harsha vardhan ∗ , Dr. MAJUSHA YADLA , VIKRAM KUMAR BAKKA , SREEKANTH BURRI , P. SRINIVAS","doi":"10.1016/j.ekir.2024.11.145","DOIUrl":"10.1016/j.ekir.2024.11.145","url":null,"abstract":"","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 2","pages":"Pages S45-S46"},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Souradip Mookerjee , Guy Whitley , Debasish Banerjee
{"title":"Stanniocalcin-1: A Novel Mediator in Diabetic Kidney Disease and Cardiovascular Disease","authors":"Souradip Mookerjee , Guy Whitley , Debasish Banerjee","doi":"10.1016/j.ekir.2024.10.040","DOIUrl":"10.1016/j.ekir.2024.10.040","url":null,"abstract":"<div><div>Diabetes mellitus represents a group of metabolic diseases characterized by hyperglycemia from defects in insulin secretion, action, or both. The prevalence of type 2 diabetes mellitus, characterized by insulin resistance, has increased over time in the UK, and is the most prevalent cause of chronic kidney disease (CKD). Cardiovascular complications are a major cause of mortality for these patients.</div><div>Stanniocalcin (STC), originally identified in bony fish as a hormone regulating calcium levels, has since been found in mammals, including humans. In fish, STC functions as an antihypercalcemic factor. Mammals possess 2 STC orthologues, STC-1 and STC-2, with STC-1 demonstrating significant sequence and functional conservation across species. Unlike fish, STC-1 is not normally present in the blood of healthy humans. However, it can be detected in certain conditions such as pregnancy, cancer, and CKD.</div><div>In humans, STC-1 has diverse roles, including modulation of calcium and phosphate homeostasis, and it is implicated in kidney and cardiovascular protection. It has been reported that STC-1 has antioxidant, anti-inflammatory, and antiapoptotic activities, playing a role in renoprotection in diabetic nephropathy.</div><div>This review explores the molecular biology of STC-1, its physiological functions, and its emerging role in GKDs, particularly diabetic and cardiovascular diseases. We highlight its potential protective mechanisms against hypercalcemia, its antioxidant and anti-inflammatory properties, and its cardioprotective properties in ischemia-reperfusion.</div><div>Further research into STC-1 could provide new insights into therapeutic strategies for managing diseases characterized by calcium imbalance and lead to new treatments for the cardiovascular morbidity associated with diabetic kidney disease.</div></div>","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 2","pages":"Pages 321-327"},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143160848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}